{"slug":"what-are-peptides-tirzepatide","verification":{"valid":true,"entries":6,"head":"08fc95159a091e0859a3aac9467d9f3d5164e7c47c117f302b688caab8290024"},"count":6,"sources":[{"id":"s10","type":"pubmed","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2206038","title":"Tirzepatide Once Weekly for the Treatment of Obesity","quote":"The mean percentage change in weight at week 72 was −15.0% ... −19.5% ... −20.9% ... and −3.1% with placebo","summary":"Phase 3 SURMOUNT-1 trial results showing dose-dependent weight loss in humans.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T21:40:55.747Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"dd96abf93ee33fe3f15ee3f4f395da7f623af21ae59f8cb3a2fc6bdebbc866cc"},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38078870/","title":"Continued Treatment With Tirzepatide for Maintenance of Weight Reduction","quote":"The overall mean weight reduction from week 0 to 88 was 25.3% for tirzepatide and 9.9% for placebo.","summary":"SURMOUNT-4 maintenance and withdrawal data in humans.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T21:40:55.747Z","link_status":"ok","quote_status":"verified","prev":"dd96abf93ee33fe3f15ee3f4f395da7f623af21ae59f8cb3a2fc6bdebbc866cc","hash":"1a7d3c20a408756b8254c576c1715c3a158af70287f6775740910532fdec4933"},{"id":"s6","type":"other","url":"https://coremedicalwellness.com/glp-1-medications-for-weight-loss-back-pain-and-knee-pain-relief/","title":"GLP-1 Medications for Weight Loss and Pain Relief","quote":"When patients lose 10 to 15 percent or more of their body weight with GLP-1 therapy, the mechanical stress on these structures drops significantly.","summary":"Explains mechanical load reduction from weight loss.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T21:40:55.747Z","link_status":"ok","quote_status":"verified","prev":"1a7d3c20a408756b8254c576c1715c3a158af70287f6775740910532fdec4933","hash":"3b11fece1e837b02a889e8390613379abd0215014093682fa9d9fc9b52dd8cd4"},{"id":"s22","type":"news","url":"https://www.news-medical.net/news/20250514/Animal-research-reveals-metabolic-differences-between-tirzepatide-and-semaglutide.aspx","title":"Animal research reveals metabolic differences between tirzepatide and semaglutide","quote":"tirzepatide and semaglutide lost on average 15.6g and 8.3g respectively... significant increase in energy expenditure after four days of tirzepatide treatment","summary":"Mouse study comparing energy expenditure and weight loss.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T21:40:55.747Z","link_status":"ok","quote_status":"unverified","prev":"3b11fece1e837b02a889e8390613379abd0215014093682fa9d9fc9b52dd8cd4","hash":"3b92ad12b1bd0007d211d56477bda9edc01af437c41a0890c4d624eeeb2dcbf7"},{"id":"s28","type":"reddit","url":"https://www.reddit.com/r/tirzepatidecompound/comments/1ew6qqz/less_back_pain_with_tirzepatide/","title":"Less Back Pain with Tirzepatide","quote":"I have lost 18.2 pounds... my chronic low back pain is about 70% improved!","summary":"User report of back-pain improvement after weight loss.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T21:40:55.747Z","link_status":"ok","quote_status":"unverified","prev":"3b92ad12b1bd0007d211d56477bda9edc01af437c41a0890c4d624eeeb2dcbf7","hash":"e04f8a7ad87420e9c19fa0a100c03f2400a896d15910f8e4a2c3fc18f4eb5592"},{"id":"post:24","type":"x","url":"https://x.com/Badie912/status/2070268393513505180","title":"X post on mother's tirzepatide experience","quote":"She started on a very low dose of tirzepatide 3 weeks ago and is down 8 lbs already... She had neck pain that has resolved since starting it too.","summary":"Anecdotal report of weight loss and neck-pain resolution.","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T21:40:55.747Z","link_status":"ok","quote_status":"unverified","prev":"e04f8a7ad87420e9c19fa0a100c03f2400a896d15910f8e4a2c3fc18f4eb5592","hash":"08fc95159a091e0859a3aac9467d9f3d5164e7c47c117f302b688caab8290024"}]}