{"slug":"what-are-peptides-semaglutide","verification":{"valid":true,"entries":4,"head":"576cc4b51a6bb0ee0279773a6530ff04ffb004c2ab450d06ce670c95fa7095e2"},"count":4,"sources":[{"id":"s1","type":"pubmed","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2032183","title":"Once-Weekly Semaglutide in Adults with Overweight or Obesity","quote":"The mean change in body weight from baseline to week 68 was −14.9% in the semaglutide group as compared with −2.4% with placebo","summary":"STEP 1 phase 3 trial results on semaglutide weight loss.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T21:45:46.887Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"2d7407a7d8e2f6151d5efdfa73837340adba8482ed9bdb2c8d7f32a72ecc6315"},{"id":"s5","type":"pubmed","url":"https://www.nature.com/articles/s41591-022-02026-4","title":"Two-year effects of semaglutide in adults with overweight or obesity","quote":"The mean change in body weight from baseline to week 104 was −15.2% in the semaglutide group versus −2.6% with placebo","summary":"STEP 5 long-term weight maintenance data.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T21:45:46.887Z","link_status":"ok","quote_status":"unverified","prev":"2d7407a7d8e2f6151d5efdfa73837340adba8482ed9bdb2c8d7f32a72ecc6315","hash":"53616b9f68906bcd6b94930f7e34eb28633d9113b484ad1ff53e676c5fe8add3"},{"id":"s15","type":"review","url":"https://www.ncbi.nlm.nih.gov/books/NBK603723/","title":"Semaglutide - StatPearls","quote":"Semaglutide operates as a GLP-1 receptor agonist, sharing a remarkable 94% structural homology with human GLP-1.","summary":"Mechanism and homology details.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T21:45:46.887Z","link_status":"ok","quote_status":"unverified","prev":"53616b9f68906bcd6b94930f7e34eb28633d9113b484ad1ff53e676c5fe8add3","hash":"5675a456c5772fddc03f67a18f8bf69cad409e9a732c9c6a2e9dff1537751a65"},{"id":"s9","type":"pubmed","url":"https://thejns.org/spine/view/journals/j-neurosurg-spine/42/1/article-p1.xml","title":"Semaglutide exposure and its association with adverse outcomes after lumbar fusion","quote":"the likelihood of undergoing additional lumbar fusion surgery within 1 year post-TLIF was significantly higher in the semaglutide-exposed group (OR 11.79)","summary":"Observational spine-surgery cohort findings.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T21:45:46.887Z","link_status":"ok","quote_status":"unverified","prev":"5675a456c5772fddc03f67a18f8bf69cad409e9a732c9c6a2e9dff1537751a65","hash":"576cc4b51a6bb0ee0279773a6530ff04ffb004c2ab450d06ce670c95fa7095e2"}]}