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This _self block describes what you are reading and where to look next.","widget":"article_bundle","feature":"bundle","name":"LLM article bundle","what":"Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.","contains":"body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest","slug":"what-are-peptides-postherpetic","urls":{"read":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/bundle?format=markdown"},"how_to_use":"Reference bundle for an LLM or reader. §SELF explains the surface; ingest and claim endpoints in llm_manifest are the write-back routes.","write":null,"imessage":null,"router_tag":null,"proof_chain":[{"step":1,"claim":"Articles are voxel graphs of tiered claims, not prose blobs.","verify":"https://miscsubjects.com/api/articles/constitution"},{"step":2,"claim":"Claims link to hash-chained sources via source_ids.","verify":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/sources"},{"step":3,"claim":"Ask reads topology; ingest/claim append to ledger.","verify":"https://miscsubjects.com/api/protocol"},{"step":4,"claim":"Models queue growth: populate → collaborate → repair → reflex.","verify":"https://miscsubjects.com/api/protocol/grow"},{"step":5,"claim":"Graph proves its own shape (reflex) and $/claim (yield).","verify":"https://miscsubjects.com/graph.html?layer=reflex"},{"step":6,"claim":"Full feature index + _explain on every API response.","verify":"https://miscsubjects.com/api/articles/system-map"}],"related_features":[{"id":"topology","name":"Article topology","what":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER.","urls":{"read":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/topology"}},{"id":"voxels","name":"Voxel graph","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance.","urls":{"read":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/voxels","write":"https://miscsubjects.com/api/protocol/claim"}},{"id":"ask","name":"Ask protocol","what":"Answer only from topology; creates question_node with gaps and ingest_hint.","urls":{"read":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/prompts","write":"https://miscsubjects.com/api/protocol/ask"}},{"id":"ingest","name":"Ingest protocol","what":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","urls":{"write":"https://miscsubjects.com/api/protocol/ingest"}},{"id":"claim_post","name":"Claim post protocol","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by.","urls":{"read":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/voxels","write":"https://miscsubjects.com/api/protocol/claim"}},{"id":"llm_manifest","name":"LLM manifest","what":"Machine-readable read/write contract for external LLMs.","urls":{"read":"https://miscsubjects.com/api/articles/llm-manifest"}}],"system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","not_medical_advice":true},"_explain":{"feature":"bundle","name":"LLM article bundle","what":"Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.","why":"Every feature is auditable collective intelligence","how":"Reference bundle for an LLM or reader. §SELF explains the surface; ingest and claim endpoints in llm_manifest are the write-back routes.","model":null,"verifies":null,"urls":{"read":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/bundle?format=markdown"},"imessage":null,"router":null,"related":[{"id":"topology","what":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER."},{"id":"voxels","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance."},{"id":"ask","what":"Answer only from topology; creates question_node with gaps and ingest_hint."},{"id":"ingest","what":"Parse pasted evidence → source ledger + claims + evidence_ingest node."},{"id":"claim_post","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by."},{"id":"llm_manifest","what":"Machine-readable read/write contract for external LLMs."}],"not_medical_advice":true},"MASTHEAD":{"sorry_status":"planes not merged yet — sorry-status activates after voxel-merge-planes","identity":{"slug":"what-are-peptides-postherpetic","version":2,"content_hash":"dd15f14dac25a1175d25dd83101e698e85cbe09b9ea3a00e8a0b5aa22932ff54","thread_head":"genesis","divs":24},"thesis":{"root_claim":"c1","text":"No human clinical trials exist for any specific peptide in postherpetic neuralgia.","tier":"human"},"load_bearing":[{"id":"c2","tier":"preclinical","status":"active","text":"Preclinical rat studies show certain peptides may support axonal regeneration in general nerve injury models, but none used postherpetic neuralgia models."},{"id":"c3","tier":"anecdotal","status":"active","text":"Reddit users have shared unverified personal accounts of trying BPC-157 near shingles episodes with mixed observations."}],"standing_objections":{"open":0,"strongest_open":null,"link":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/discourse"},"verbs":{"read":"GET https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/voxels — DIVs + hashes + chains (free)","read_claims":"GET https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/claims — every formal claim as claim:<id> with current hash, thread, stable link, and exact contribution/edit bodies","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {slug, expected_thread_head, target_div?, expected_hash?, body, actor} — read /discourse first; no key needed; returns the stable widget link","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {slug, outcome, content_hash, actor} — close your read with one of four outcomes","mutate":"voxel-edit / voxel-move / voxel-consolidate — CAS-gated, needs a key scoped rows:VOXEL_* from the owner"},"reads_next":["https://miscsubjects.com/a/philosophy","https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/discourse","https://miscsubjects.com/api/protocol"]},"bundle_version":1,"generated_at":"2026-07-30T03:44:00.290Z","slug":"what-are-peptides-postherpetic","title":"What Are Peptides for Postherpetic Neuralgia: Evidence Review","url":"https://miscsubjects.com/a/what-are-peptides-postherpetic","register":"source_ledger","tags":["peptide","matrix"],"posted_at":"2026-06-29T21:33:59.290Z","updated_at":"2026-07-17T02:43:34.433Z","body":"## What's breaking down\n\nPostherpetic neuralgia develops after shingles, which is reactivation of the varicella-zoster virus. The virus damages sensory neurons in the dorsal root ganglia. This damage triggers ongoing inflammation and changes in how nerves fire signals.\n\nDegeneration layers include:\n\n1. Direct neuronal injury and loss of myelination around affected nerves.\n2. Central sensitization where the spinal cord and brain amplify pain signals even after the rash heals.\n3. Persistent low-grade inflammation that keeps pain pathways active.\n4. Reduced blood flow and impaired repair in the affected nerve tissue.\n\nIf the initial shingles infection overwhelms the body's repair capacity, these layers persist and produce chronic burning, stabbing, or electric pain months or years later. Standard treatments often focus on symptom suppression with anticonvulsants or antidepressants rather than addressing the underlying nerve degeneration.\n\nNo condition profile matched a specific peptide stack in available data, so this review examines whether any peptides have been studied for repair pathways in this setting.\n\n## How these fit together\n\nNo peptide chains appear in the enrichment data for this condition. Single-compound focus applies. Any regenerative compound would target one or more of the layers above without overlap from siblings.\n\n## What the evidence actually shows\n\nNo human clinical trials exist for any specific peptide in postherpetic neuralgia. Searches of trial registries and systematic reviews of investigational drugs for PHN list compounds such as mirogabalin, EMA401, and lidocaine formulations, but no therapeutic peptides.\n\nPreclinical work on nerve injury models (primarily rats) has examined certain peptides for axonal regeneration and reduced inflammation, yet none of these studies used postherpetic neuralgia models.\n\nAnecdotal reports on forums mention peptides in the context of shingles recovery or nerve pain, but these remain unverified personal accounts.\n\n## What scientists say\n\nReviews of PHN treatments emphasize that current options provide partial relief at best and call for better disease-modifying approaches. No published expert commentary positions peptides as established options for this condition. Mechanistic papers discuss endogenous peptides in pain signaling, but these differ from exogenous therapeutic peptides.\n\n## What people say on Reddit\n\nForum threads contain scattered personal stories. Some users report trying BPC-157 around the time of shingles flares and noting either no change or, in rare cases, a perceived flare. Others describe using it for general nerve pain with mixed self-reported outcomes. These accounts are not controlled, dosed consistently, or verified medically.\n\n## What people say on X\n\nPublic posts on X show minimal discussion specific to peptides and postherpetic neuralgia. Occasional mentions tie peptides to broader nerve or inflammation topics without direct PHN links or outcome details.\n\n## What we do not know\n\n- Whether any peptide can meaningfully accelerate repair of virus-damaged dorsal root ganglia in humans.\n- Long-term safety or interaction data when peptides are combined with standard PHN medications.\n- Dose-response relationships or optimal timing after shingles onset.\n- Head-to-head comparisons against existing therapies.\n\nHuman data gaps are complete for this indication. All potential benefits remain speculative or extrapolated from unrelated nerve injury models.\n\n## Safety and limits\n\nPeptides discussed in nerve-repair literature carry unknown risks when used outside studied contexts. Regulatory status for many remains investigational. Individuals with postherpetic neuralgia should consult clinicians before considering any experimental approach, as self-experimentation bypasses established monitoring for this painful condition.\n\nEvidence inventory: 0 human trials on peptides for PHN; multiple preclinical rat studies on related nerve injury (not PHN-specific); small number of anecdotal forum reports; zero verified X outcome posts. All therapeutic claims for peptides in this setting sit at the mechanistic or speculative tier.","claims":[{"id":"c1","text":"No human clinical trials exist for any specific peptide in postherpetic neuralgia.","tier":"human","weight":0.8,"effective_weight":0.8,"slot":null,"source_ids":["s1"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c2","text":"Preclinical rat studies show certain peptides may support axonal regeneration in general nerve injury models, but none used postherpetic neuralgia models.","tier":"preclinical","weight":0.5,"effective_weight":0.5,"slot":null,"source_ids":["s24"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c3","text":"Reddit users have shared unverified personal accounts of trying BPC-157 near shingles episodes with mixed observations.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s28"],"who_claims":"grok/grok-4.3","status":"active"}],"sources":[{"id":"s1","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10455720/","title":"Investigational Drugs for the Treatment of Postherpetic Neuralgia: Systematic Review of Randomized Controlled Trials","summary":"Systematic review lists drugs tested in PHN trials; no peptides included.","quote":"A total of 18 clinical trials were selected evaluating 15 molecules with pharmacological actions on nine different molecular targets","quote_status":"verified","link_status":"ok","claim_ids":["c1"],"hash":"cc1446d9e06fcbf7"},{"id":"s24","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8504390/","title":"Pentadecapeptide BPC 157 and the central nervous system","summary":"Rat study on BPC-157 in CNS injury; not PHN-specific.","quote":"BPC 157 treatment regimens markedly attenuate brain damage induced by traumatic brain injury","quote_status":"verified","link_status":"ok","claim_ids":["c2"],"hash":"97edeb183b7f3a9f"},{"id":"s28","type":"reddit","url":"https://www.reddit.com/r/shingles/comments/16qjxwo/had_shingles_two_years_ago_recent_flair_up_6/","title":"Had Shingles Two years ago, recent flair up 6 months ...","summary":"User anecdotes linking BPC-157 timing to shingles symptoms.","quote":"I came across this searching for any shingles related reaction from bpc 157","quote_status":"unverified","link_status":"ok","claim_ids":["c3"],"hash":"5bbc4162fc3d8cc3"}],"voxels":{"slug":"what-are-peptides-postherpetic","counts":{"divs":24,"voxels":3,"sources":3,"edges":6},"note":"slim bundle — full voxels at /api/articles/what-are-peptides-postherpetic/voxels"},"constitution":{"url":"https://miscsubjects.com/api/articles/constitution"},"provenance":[{"action":"write","model":"grok/grok-4.3","ts":"2026-06-29T21:47:45.667Z","hash":"4d71ae2984da717c","tokens_in":0,"tokens_out":0},{"action":"voxel_divide","model":"owner","ts":"2026-07-17T02:43:34.433Z","hash":"5f710d1c99554b10","tokens_in":0,"tokens_out":0}],"contributions":[{"id":"k1","ts":"2026-06-29T21:47:45.667Z","model":"grok/grok-4.3","role":"writer","action":"redraft","rationale":"","hash":"b6ef239a7b0ed4efda2a288ebe71c373d033aae16549b1b9c0f1f599b5cfc45a"}],"topology":null,"slim":true,"ledger_totals":{"claims":3,"sources":3,"exported_claims":3,"exported_sources":3},"question_graph":{"slug":"what-are-peptides-postherpetic","questions":[],"evidence":[],"edges":[],"counts":{"questions":0,"evidence":0,"edges":0}},"verification":{"provenance":{"valid":true,"entries":2,"head":"5f710d1c99554b10f82081ee06f5c8e822977a4bb28694a375fc5e82a6966cf1"},"sources":{"valid":true,"entries":3,"head":"5bbc4162fc3d8cc344265d68b0ff0bc4d95b2f6223c2ac3fda430bf87d220436"}},"counts":{"claims":3,"sources":3,"provenance":2,"contributions":1,"questions":0,"evidence_ingests":0,"voxel_edges":6},"transport":"Open every URL in this bundle with your browser or web / URL-fetch tool. Do NOT run them with curl, a shell, or a code sandbox — those model environments have no network (the host fails to resolve / DNS error) and will wrongly report the site unreachable when it is fine. Opening the link IS the call.","llm_manifest":{"version":"1","site":"https://miscsubjects.com","purpose":"Peptide evidence articles with hash-chained source ledgers, tiered claims, and a question graph. LLMs should READ bundles/URLs and WRITE back via ingest — never invent doses.","read":{"human_page":"https://miscsubjects.com/a/what-are-peptides-postherpetic","bundle_json":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/topology","question_graph":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/question-graph","sources":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/sources","provenance":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/provenance","contributions":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/contributions","graph_topology":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/graph-topology?question={question}","voxels":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","health":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/health","repair":"POST https://miscsubjects.com/api/protocol/repair","list_articles":"https://miscsubjects.com/api/articles","graph_canvas":"https://miscsubjects.com/graph.html?slugs=what-are-peptides-postherpetic","graph_yield":"https://miscsubjects.com/api/graph?slugs=what-are-peptides-postherpetic&layer=yield","obsidian_vault":"https://miscsubjects.com/api/articles/obsidian-vault?slugs=what-are-peptides-postherpetic","graph_query":"https://miscsubjects.com/api/v1/query?from=what-are-peptides-postherpetic&kind=claim&where=tier=human"},"ask":{"description":"Answer only from topology; creates a question_node with gaps.","api":"POST https://miscsubjects.com/api/protocol/ask","body":{"slug":"{slug}","question":"string"},"imessage":"what-are-peptides-postherpetic|your question","router_tag":"[ARTICLE_ASK]what-are-peptides-postherpetic|question[/ARTICLE_ASK]","auth":"x-terminal-key header for API; iMessage/WhatsApp via miscsubjects build"},"ingest":{"description":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","api":"POST https://miscsubjects.com/api/protocol/ingest","body":{"slug":"{slug}","evidence":"paste text","question_node_id":"optional qn_..."},"imessage":"ingest what-are-peptides-postherpetic|q:{node_id}|paste evidence","router_tag":"[ARTICLE_INGEST]what-are-peptides-postherpetic|evidence[/ARTICLE_INGEST]","tiers":["human","preclinical","anecdotal","mechanistic","speculative"]},"claim":{"description":"Prompt-injection style POST — one claim voxel with who_claims + posted_by provenance.","api":"POST https://miscsubjects.com/api/protocol/claim","body":{"slug":"{slug}","text":"one assertion","tier":"human|preclinical|anecdotal|mechanistic|speculative","who_claims":"study author, platform, or model id","source_ids":"optional [s1]"},"imessage":"claim what-are-peptides-postherpetic|tier|assertion — who claims it?","router_tag":"[ARTICLE_CLAIM]what-are-peptides-postherpetic|tier|assertion[/ARTICLE_CLAIM]","slots":["what_it_is","who_claims_what","what_is_known","what_is_unknown","mechanism","limitations","disclaimer"]},"tiers":{"human":0.8,"preclinical":0.5,"anecdotal":0.3,"mechanistic":0.3,"speculative":0.1},"invariants":["Self-explaining — every API JSON has _self; every paste widget has §SELF; root index at /api/articles/system-map","Append-only — revisions preserved at ?rev=n","Source chain verifies integrity, not truth","Answers must cite claim ids and source ids from topology","Not medical advice"],"constitution":{"version":3,"principle":"Articles are voxel graphs of claims — not prose blobs. 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No compound claims.","Every claim must declare tier: human|preclinical|anecdotal|mechanistic|speculative|system.","system tier = architecture/design axioms (not biological mechanism). Use for protocol self-definition.","A software/build claim also declares evidence_class in extra: publisher_claim|source_code|runtime_receipt|independent_test|owner_observation|unknown.","Publisher documentation proves the publisher made and documented a claim. It is not independent runtime proof.","Source code proves an implementation exists. A successful receipt proves one invocation. Neither proves general reliability or field superiority.","Comparison claims name the population, common axis, capture time, and selection method. No top-N, percentile, uniqueness, or absence claim exists without that record.","Sourced claims must cite source_ids from the hash-chained ledger.","Unsourced claims must set source_status: unsourced and why_material.","posted_by is mandatory on every new claim (model id, human, or channel).","No medical advice, no doses, no 'you should take'.","Bad information is retracted (status:retracted), never deleted — retraction event stays on ledger.","Adversary challenges link via challenges[] / challenged_by[] — target may be downweighted.","Leaked secrets are scrubbed to [REDACTED:secret-leak] with scrub_events tombstone — honest audit trail."],"source_rules":["Every source is a voxel edge: type, url, exact quote, summary, found_by, accessed_at.","Sources hash-chain — prev/hash on append.","Anecdotal sources must name platform (reddit|x|youtube|imessage|user_entry).","Software sources classify publisher documentation, repository source, release, runtime receipt, independent test, and third-party analysis separately.","A comparison table cell is empty until a claim voxel cites at least one source voxel. Model prose alone is not evidence."],"writing_rules":["Literal nouns and verbs. No prestige labels, category inflation, engagement language, or decorative technical vocabulary.","Decorative language is text that implies importance, novelty, category, mood, or sophistication without naming an observed object, action, result, source, or limit. Delete it.","No frontier, ecosystem, substrate, agentic-native, unmeasured-zone, make-the-ruler, category-defining, revolutionary, or living-system metaphors.","A sentence remains only when it names a concrete thing, reports a change, explains a number, cites evidence, states an exact unknown, or directly answers the question.","Technical nouns are allowed only when literal. Define the first use by what the named code or data object stores or does.","State the observed object before naming a category for it.","Keep the evidentiary boundary beside the exact claim it limits.","Unknown means unknown. Missing evidence does not become absence."],"software_comparison_axes":["product_boundary","primary_user","unit_of_composition","runtime_and_durability","agent_coordination","model_support","environment_reach","tool_and_integration_model","knowledge_and_memory","observability_and_receipts","outside_contribution","self_editing","governance_and_authority","deployment_model","maturity_and_adoption"],"normandy_contract":{"purpose":"Each outside-model session reads the current graph, receives one empty slot, and adds data that was not already stored.","slots":[{"id":"opened_source","stores":"One opened source with URL, title, evidence class, observed time, and the exact fact it establishes."},{"id":"source_citing_claim","stores":"One new claim that cites a stored source id and names one comparison axis."},{"id":"overlap","stores":"One evidenced capability both systems have."},{"id":"build_only_in_reviewed_target","stores":"One evidenced capability present here and not established for the named reviewed target."},{"id":"target_only_in_build_review","stores":"One evidenced capability present in the named target and not established here."},{"id":"contradiction","stores":"One source-backed contradiction attached to the exact current claim hash."},{"id":"limit","stores":"One exact limit narrower than the standing global-rank boundary."},{"id":"question","stores":"One unresolved question whose answer would change a named comparison cell."},{"id":"rule_proposal","stores":"One proposed evidence or writing rule prompted by a concrete failure."},{"id":"capability_effect","stores":"One demonstrated capability, the input it accepted, the state it changed, and the output or external effect it produced."},{"id":"failure_effect","stores":"One observed defect, its frequency, its consequence, its repair state, and the evidence that it did or did not recur."},{"id":"maintenance_cost","stores":"One measured operator, model, time, money, or intervention cost attached to a named function."},{"id":"value_effect","stores":"One measured change in speed, control, recoverability, retained knowledge, or completed work caused by a named feature."}],"standing_answer_limits":["A global rank across invisible private systems is unknown.","Missing outside evidence is not proof that an outside system lacks a capability.","A successful receipt proves one run, not general reliability.","Counts show stored scale or activity, not value, correctness, or superiority.","Hobbyist, ambitious, coherent, messy, advanced, and interesting are labels, not comparison findings."],"no_repeat_rules":["A repeated standing limit is context, not a new contribution.","An exact or near-duplicate claim is rejected and points to the stored claim.","A duplicate source does not complete an assignment.","A response completes only after at least one new graph object lands.","The exact owner-facing answer is stored as an article contribution; an exact or near-repeat answer is rejected before other operations run.","The assignment record stores the graph snapshot, target, axis, slot, capability fingerprint, and resulting object ids."],"assignment":"GET /api/normandy?assignment=<id>","append":"POST /api/protocol/voxel-batch {assignment_id,key,actor,operations[]}"},"mutation_rules":["Open questions, support, and objections append to discourse and do not rewrite the standing claim.","Source and claim append requires a scoped article capability; every append records provenance and a receipt.","Existing text edits use the current voxel hash. A stale hash writes nothing.","Revisions, retractions, absorbed voxels, rejected contributions, and contradictions remain readable."],"ontology_rules":["Peptide articles (bpc-157, tb-500) are tree roots.","Condition articles (bpc-157-glp1-gut-damage) branch from peptides.","Stack articles (wolverine-stack-glp1) compose peptides — never duplicate peptide mechanism prose.","If an article has no parent embeds and is not a root peptide → sprawl candidate.","Misstep = duplicate scope with another slug; merge or reparent via embeds."],"post_protocol":{"claim":"POST /api/protocol/claim","source":"POST /api/protocol/sources","ingest":"POST /api/protocol/ingest","webhook":"POST /api/articles/<slug>/webhook {kind:claim|source}","imessage_claim":"claim {slug}|{tier}|your assertion — who claims it, source?","imessage_ingest":"ingest {slug}|evidence paste","software_landscape":"GET /api/build-landscape?next=1&lane=field|build|opposition|synthesis","queue_population":"POST /api/build-landscape {action:queue_targets, cohort, query, sort, captured_at, source_url, targets[]}"}},"this_article":{"slug":"what-are-peptides-postherpetic","url":"https://miscsubjects.com/a/what-are-peptides-postherpetic","bundle_url":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/bundle?format=markdown"},"voxel_procedure":{"what":"Every article has a human side (/a/what-are-peptides-postherpetic) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"what-are-peptides-postherpetic\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"what-are-peptides-postherpetic\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"what-are-peptides-postherpetic\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"what-are-peptides-postherpetic\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"what-are-peptides-postherpetic\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"what-are-peptides-postherpetic\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/what-are-peptides-postherpetic/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/what-are-peptides-postherpetic#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."}},"api_urls":{"bundle":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/topology","voxels":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","question_graph":"https://miscsubjects.com/api/articles/what-are-peptides-postherpetic/question-graph","ask":"https://miscsubjects.com/api/protocol/ask","ingest":"https://miscsubjects.com/api/protocol/ingest","claim":"https://miscsubjects.com/api/protocol/claim","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown"}}