{"slug":"what-are-peptides-glp-1","verification":{"valid":true,"entries":5,"head":"16235727a5554cb0cb7639572b4dc1672fa8ae460a01c09a0b682f9b1453715c"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2206038","title":"Tirzepatide Once Weekly for the Treatment of Obesity","quote":"The mean percentage change in weight at week 72 was −15.0% ... −20.9% ... with tirzepatide and −3.1% with placebo","summary":"Phase 3 trial results on tirzepatide weight loss efficacy.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:01:59.613Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"00b62f095c285ddcbdc758953e8f0513d4481777f7f7e91e1f9d49f100047b42"},{"id":"s3","type":"news","url":"https://www.fda.gov/drugs/drug-alerts-and-statements/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss","title":"FDA's Concerns with Unapproved GLP-1 Drugs Used for Weight Loss","quote":"As of May 31, 2026, the FDA has received: 990 reports ... compounded semaglutide ... more than 730 ... compounded tirzepatide.","summary":"Official FDA statement on compounded GLP-1 adverse events.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:01:59.613Z","link_status":"http_404","quote_status":"unverified","prev":"00b62f095c285ddcbdc758953e8f0513d4481777f7f7e91e1f9d49f100047b42","hash":"fdefe0b03b9dd6e14db3c2bf745ad8f34ebb0b7dc44c4e90c08bf616d7c364b8"},{"id":"s7","type":"pubmed","url":"https://link.springer.com/article/10.1186/s12933-022-01604-7","title":"Tirzepatide, a dual GIP/GLP-1 receptor co-agonist","quote":"Tirzepatide was significantly more effective in reducing HbA1c and body weight than the selective GLP-1 RA semaglutide","summary":"Comparative data on tirzepatide vs semaglutide.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:01:59.613Z","link_status":"ok","quote_status":"verified","prev":"fdefe0b03b9dd6e14db3c2bf745ad8f34ebb0b7dc44c4e90c08bf616d7c364b8","hash":"41dfa5623269a8f1bd235d91a6ea3d9f7ddff6ad2f9a8e83a9abce1b60f0dd4e"},{"id":"s20","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38937282/","title":"Changes in lean body mass with glucagon-like peptide-1- receptor agonists","quote":"reductions in lean mass range between 40% and 60% as a proportion of total weight lost, while other studies show lean mass reductions of approximately 15% or less ... appear to be adaptive","summary":"Review of lean mass changes in GLP-1 trials.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:01:59.613Z","link_status":"ok","quote_status":"unverified","prev":"41dfa5623269a8f1bd235d91a6ea3d9f7ddff6ad2f9a8e83a9abce1b60f0dd4e","hash":"c00b71f0e6578c9b5e4ece7ac0c2d737afc69d6dae4de82407246d2d53df4409"},{"id":"s25","type":"other","url":"https://spineteamtexas.com/resources/blog/back-pain-and-glp-1-assisted-weight-loss-a-new-path-to-relief/","title":"Back Pain and GLP-1 Assisted Weight Loss","quote":"For someone who loses 30 pounds, this could mean up to 120 pounds less pressure on the spine during movement.","summary":"Clinical blog explaining mechanical load reduction from weight loss.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:01:59.613Z","link_status":"ok","quote_status":"verified","prev":"c00b71f0e6578c9b5e4ece7ac0c2d737afc69d6dae4de82407246d2d53df4409","hash":"16235727a5554cb0cb7639572b4dc1672fa8ae460a01c09a0b682f9b1453715c"}]}