{"slug":"what-are-peptides-chemo","verification":{"valid":false,"broken_at":5,"reason":"hash mismatch"},"count":7,"sources":[{"id":"s6","type":"review","url":"https://spcare.bmj.com/content/14/3/269","title":"Gabapentinoids for chemotherapy-induced peripheral neuropathy: systematic review and meta-analysis","quote":"Gabapentinoids show no significant benefits in reducing neuropathy among chemotherapy patients, with evidence being too weak to warrant their use without further study.","summary":"2024 meta-analysis of gabapentinoids in CIPN prevention and treatment.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:08:46.940Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"8dd7c0e363a22512bbc13f67940d2d8b8a69449d7c77c5d1efb9ba8b23e02d8e"},{"id":"s10","type":"pubmed","url":"https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.23008","title":"Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy","quote":"This trial failed to demonstrate any benefit to using gabapentin to treat symptoms caused by CIPN.","summary":"2007 phase 3 crossover RCT of 115 patients.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:08:46.940Z","link_status":"ok","quote_status":"unverified","prev":"8dd7c0e363a22512bbc13f67940d2d8b8a69449d7c77c5d1efb9ba8b23e02d8e","hash":"14641ae32d8ee5a48a69695b3903c5cbc9ca22c29be4fa2c08eb225f2f6924b7"},{"id":"s13","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38936970/","title":"Gabapentinoids for chemotherapy-induced peripheral neuropathy","quote":"There is limited evidence to support the use of gabapentinoids in CIPN.","summary":"Meta-analysis abstract confirming limited evidence.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:08:46.940Z","link_status":"ok","quote_status":"verified","prev":"14641ae32d8ee5a48a69695b3903c5cbc9ca22c29be4fa2c08eb225f2f6924b7","hash":"b61bd3bd1d317351308590d348d3f0ec046806f514840cc6782ae2a725c2439f"},{"id":"s15","type":"pubmed","url":"https://ar.iiarjournals.org/content/30/7/2927","title":"Role of Pregabalin in Treatment of Oxaliplatin-induced Peripheral Neuropathy","quote":"Pregabalin significantly reduced the severity of oxaliplatin-induced sensory neuropathy.","summary":"Smaller study suggesting benefit in specific chemo type.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:08:46.940Z","link_status":"http_403","quote_status":"unverified","prev":"b61bd3bd1d317351308590d348d3f0ec046806f514840cc6782ae2a725c2439f","hash":"3c98bdd4362119c7eb551456d8c0fcdb45fd9a7c9065896a7ee27aa8f241e858"},{"id":"s16","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38936970/","title":"Gabapentinoids for chemotherapy-induced peripheral neuropathy","quote":"In prevention setting, gabapentinoids do not significantly prevent CIPN. In treatment setting, studies have been inconsistent.","summary":"Key conclusion from meta-analysis.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:08:46.940Z","link_status":"ok","quote_status":"unverified","prev":"3c98bdd4362119c7eb551456d8c0fcdb45fd9a7c9065896a7ee27aa8f241e858","hash":"0d1e450c0972ac11ec42a7f11c6f382f1584f7a09ade177c6f2a6a6cb5fd3f1b"},{"id":"s19","type":"pubmed","url":"https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.23008","title":"Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy","quote":"Gabapentin inhibits the α2δ1 subunit, reducing calcium influx and neurotransmitter release from hyperexcited neurons.","summary":"Background on mechanism from the 2007 trial paper.","claim_ids":["c3","c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:08:46.940Z","link_status":"ok","quote_status":"unverified","prev":"0d1e450c0972ac11ec42a7f11c6f382f1584f7a09ade177c6f2a6a6cb5fd3f1b","hash":"db2ec527aa643737bd463fb6534233166197d79775a6f535223cdd4bed63537f"},{"id":"s20","type":"review","url":"https://spcare.bmj.com/content/14/3/269","title":"Gabapentinoids for chemotherapy-induced peripheral neuropathy: systematic review and meta-analysis","quote":"One of the frequent side effects of chemotherapy for patients is chemotherapy-induced peripheral neuropathy (CIPN).","summary":"Introduction describing CIPN.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:08:46.940Z","link_status":"ok","quote_status":"verified","prev":"db2ec527aa643737bd463fb6534233166197d79775a6f535223cdd4bed63537f","hash":"0f9b8c871ca26bfda56fd823207548d784dae4a61c79e3a615a2cb710acd557e"}]}