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Per-claim provenance.","urls":{"read":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/voxels","write":"https://miscsubjects.com/api/protocol/claim"}},{"id":"ask","name":"Ask protocol","what":"Answer only from topology; creates question_node with gaps and ingest_hint.","urls":{"read":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/prompts","write":"https://miscsubjects.com/api/protocol/ask"}},{"id":"ingest","name":"Ingest protocol","what":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","urls":{"write":"https://miscsubjects.com/api/protocol/ingest"}},{"id":"claim_post","name":"Claim post protocol","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by.","urls":{"read":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/voxels","write":"https://miscsubjects.com/api/protocol/claim"}},{"id":"llm_manifest","name":"LLM manifest","what":"Machine-readable read/write contract for external LLMs.","urls":{"read":"https://miscsubjects.com/api/articles/llm-manifest"}}],"system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","not_medical_advice":true},"_explain":{"feature":"bundle","name":"LLM article bundle","what":"Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.","why":"Every feature is auditable collective intelligence","how":"Reference bundle for an LLM or reader. §SELF explains the surface; ingest and claim endpoints in llm_manifest are the write-back routes.","model":null,"verifies":null,"urls":{"read":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/bundle?format=markdown"},"imessage":null,"router":null,"related":[{"id":"topology","what":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER."},{"id":"voxels","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance."},{"id":"ask","what":"Answer only from topology; creates question_node with gaps and ingest_hint."},{"id":"ingest","what":"Parse pasted evidence → source ledger + claims + evidence_ingest node."},{"id":"claim_post","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by."},{"id":"llm_manifest","what":"Machine-readable read/write contract for external LLMs."}],"not_medical_advice":true},"MASTHEAD":{"sorry_status":"planes not merged yet — sorry-status activates after voxel-merge-planes","identity":{"slug":"what-are-peptides-chemo","version":2,"content_hash":"058f2f05e399f2bccfd0aa45a8d48294f7ce38b5bd537617a4f240f56ca5a86c","thread_head":"genesis","divs":18},"thesis":{"root_claim":"c1","text":"A 2007 phase 3 RCT with 115 CIPN patients found gabapentin no better than placebo on pain or neuropathy scores.","tier":"human"},"load_bearing":[{"id":"c2","tier":"human","status":"active","text":"2024 meta-analysis found pregabalin no significant benefit for average pain or QoL in CIPN prevention; treatment results inconsistent."},{"id":"c4","tier":"human","status":"active","text":"CIPN involves nerve damage from chemo leading to persistent symptoms."},{"id":"c3","tier":"mechanistic","status":"active","text":"Gabapentin/pregabalin masks pain signals without repairing nerves."}],"standing_objections":{"open":0,"strongest_open":null,"link":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/discourse"},"verbs":{"read":"GET https://miscsubjects.com/api/articles/what-are-peptides-chemo/voxels — DIVs + hashes + chains (free)","read_claims":"GET https://miscsubjects.com/api/articles/what-are-peptides-chemo/claims — every formal claim as claim:<id> with current hash, thread, stable link, and exact contribution/edit bodies","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {slug, expected_thread_head, target_div?, expected_hash?, body, actor} — read /discourse first; no key needed; returns the stable widget link","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {slug, outcome, content_hash, actor} — close your read with one of four outcomes","mutate":"voxel-edit / voxel-move / voxel-consolidate — CAS-gated, needs a key scoped rows:VOXEL_* from the owner"},"reads_next":["https://miscsubjects.com/a/philosophy","https://miscsubjects.com/api/articles/what-are-peptides-chemo/discourse","https://miscsubjects.com/api/protocol"]},"bundle_version":1,"generated_at":"2026-07-30T03:34:54.315Z","slug":"what-are-peptides-chemo","title":"What Are Peptides for Chemo","url":"https://miscsubjects.com/a/what-are-peptides-chemo","register":"source_ledger","tags":["peptide","matrix"],"posted_at":"2026-06-29T21:33:54.511Z","updated_at":"2026-07-17T02:43:30.173Z","body":"## What's breaking down\n\nChemotherapy often damages peripheral nerves. This creates chemotherapy-induced peripheral neuropathy (CIPN). Nerves lose their ability to send clear signals. Patients feel burning pain, tingling, numbness, or weakness in hands and feet. The damage comes from the chemo drugs themselves hitting nerve cells. Repair pathways in the body struggle to keep up. Symptoms can persist long after treatment ends. This is degeneration outrunning natural repair. No peptides appear in the current scope for this topic. The focus stays on available drug options that address symptoms rather than root repair.\n\n## Why Gabapentin / pregabalin matters for you\n\n1. **Drug:** Gabapentin / pregabalin.\n2. **What it does:** Masks neuropathic pain signal; does not repair nerve.\n3. **Therefore for you:** This drug suppresses a signal. It can reduce how much the pain interferes with daily life. It does not reduce mechanical load or support metabolism or nerve repair. For someone dealing with CIPN after chemo, it may trade symptom relief for no progress on the underlying nerve degeneration. That means ongoing management without fixing the breakdown.\n\n## How these fit together\n\nSingle-compound focus. Gabapentin or pregabalin targets the pain signal layer only. With no peptides in scope, there are no additional layers addressed such as potential nerve regeneration pathways.\n\n## What the evidence actually shows\n\nHuman data dominate here. A 2007 phase 3 randomized double-blind placebo-controlled crossover trial with 115 patients found gabapentin produced no benefit over placebo on pain intensity or sensory neuropathy scores from CIPN (source s10). A 2024 systematic review and meta-analysis of RCTs concluded limited evidence overall for gabapentinoids in CIPN. In prevention settings pregabalin showed no significant improvement in average pain or quality of life. Treatment setting results were inconsistent across studies with no meta-analysis possible due to heterogeneity (source s6, s13, s16). One small open-label series suggested pregabalin reduced symptoms in some oxaliplatin patients, but this is weaker than the larger negative trials (source s15). No large definitive human benefit proven for repair or consistent pain reduction beyond placebo in most rigorous tests. Preclinical rat data exist for pregabalin attenuating some neuropathy markers but do not translate directly to human outcomes.\n\n## What scientists say\n\nResearchers note insufficient evidence to confirm efficacy of these drugs specifically for CIPN even though they work in other neuropathies. Guidelines often list them as options with caveats or alternatives rather than first-line proven agents. Duloxetine has more consistent support in some reviews while gabapentinoids do not.\n\n## What people say on Reddit\n\nAnecdotal reports vary widely. Some users describe meaningful relief from burning pain with gabapentin after taxane or platinum chemo. Others report no change in symptoms or side effects like drowsiness that outweigh any benefit. Individual experiences do not replace trial data.\n\n## What people say on X\n\nPosts echo mixed personal stories. A few mention trying pregabalin for post-chemo nerve pain with partial success. Others share frustration that standard neuropathy drugs failed them. These remain unverified anecdotes.\n\n## What we do not know\n\nLong-term effects on nerve repair versus masking remain unclear. Optimal dosing or combinations for CIPN specifically lack strong head-to-head human trials. Whether any peptide approaches could target repair layers is outside current scope and unaddressed here.\n\n## Safety and limits\n\nThese drugs carry risks of dizziness, sedation, swelling, and dependence concerns with prolonged use. They do not address the degenerative process. Patients should discuss with clinicians. Evidence does not support routine use as superior to placebo for most CIPN cases based on available RCTs.","claims":[{"id":"c2","text":"2024 meta-analysis found pregabalin no significant benefit for average pain or QoL in CIPN prevention; treatment results inconsistent.","tier":"human","weight":0.8,"effective_weight":0.8,"slot":null,"source_ids":["s6","s13","s16","s15"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c4","text":"CIPN involves nerve damage from chemo leading to persistent symptoms.","tier":"human","weight":0.8,"effective_weight":0.8,"slot":null,"source_ids":["s19","s20"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c1","text":"A 2007 phase 3 RCT with 115 CIPN patients found gabapentin no better than placebo on pain or neuropathy scores.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s10"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c3","text":"Gabapentin/pregabalin masks pain signals without repairing nerves.","tier":"mechanistic","weight":0.3,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s19"],"who_claims":"grok/grok-4.3","status":"active"}],"sources":[{"id":"s6","type":"review","url":"https://spcare.bmj.com/content/14/3/269","title":"Gabapentinoids for chemotherapy-induced peripheral neuropathy: systematic review and meta-analysis","summary":"2024 meta-analysis of gabapentinoids in CIPN prevention and treatment.","quote":"Gabapentinoids show no significant benefits in reducing neuropathy among chemotherapy patients, with evidence being too weak to warrant their use without further study.","quote_status":"verified","link_status":"ok","claim_ids":["c2"],"hash":"8dd7c0e363a22512"},{"id":"s10","type":"pubmed","url":"https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.23008","title":"Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy","summary":"2007 phase 3 crossover RCT of 115 patients.","quote":"This trial failed to demonstrate any benefit to using gabapentin to treat symptoms caused by CIPN.","quote_status":"unverified","link_status":"ok","claim_ids":["c1"],"hash":"14641ae32d8ee5a4"},{"id":"s13","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38936970/","title":"Gabapentinoids for chemotherapy-induced peripheral neuropathy","summary":"Meta-analysis abstract confirming limited evidence.","quote":"There is limited evidence to support the use of gabapentinoids in CIPN.","quote_status":"verified","link_status":"ok","claim_ids":["c2"],"hash":"b61bd3bd1d317351"},{"id":"s15","type":"pubmed","url":"https://ar.iiarjournals.org/content/30/7/2927","title":"Role of Pregabalin in Treatment of Oxaliplatin-induced Peripheral Neuropathy","summary":"Smaller study suggesting benefit in specific chemo type.","quote":"Pregabalin significantly reduced the severity of oxaliplatin-induced sensory neuropathy.","quote_status":"unverified","link_status":"http_403","claim_ids":["c2"],"hash":"3c98bdd4362119c7"},{"id":"s16","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38936970/","title":"Gabapentinoids for chemotherapy-induced peripheral neuropathy","summary":"Key conclusion from meta-analysis.","quote":"In prevention setting, gabapentinoids do not significantly prevent CIPN. In treatment setting, studies have been inconsistent.","quote_status":"unverified","link_status":"ok","claim_ids":["c2"],"hash":"0d1e450c0972ac11"},{"id":"s19","type":"pubmed","url":"https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.23008","title":"Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy","summary":"Background on mechanism from the 2007 trial paper.","quote":"Gabapentin inhibits the α2δ1 subunit, reducing calcium influx and neurotransmitter release from hyperexcited neurons.","quote_status":"unverified","link_status":"ok","claim_ids":["c3","c4"],"hash":"db2ec527aa643737"},{"id":"s20","type":"review","url":"https://spcare.bmj.com/content/14/3/269","title":"Gabapentinoids for chemotherapy-induced peripheral neuropathy: systematic review and meta-analysis","summary":"Introduction describing CIPN.","quote":"One of the frequent side effects of chemotherapy for patients is chemotherapy-induced peripheral neuropathy (CIPN).","quote_status":"verified","link_status":"ok","claim_ids":["c4"],"hash":"0f9b8c871ca26bfd"}],"voxels":{"slug":"what-are-peptides-chemo","counts":{"divs":18,"voxels":4,"sources":7,"edges":12},"note":"slim bundle — full voxels at /api/articles/what-are-peptides-chemo/voxels"},"constitution":{"url":"https://miscsubjects.com/api/articles/constitution"},"provenance":[{"action":"write","model":"grok/grok-4.3","ts":"2026-06-29T22:08:49.940Z","hash":"8dd752c53597b67c","tokens_in":30997,"tokens_out":3129},{"action":"voxel_divide","model":"owner","ts":"2026-07-17T02:43:30.173Z","hash":"1dc66199c170d883","tokens_in":0,"tokens_out":0}],"contributions":[{"id":"k1","ts":"2026-06-29T22:08:49.940Z","model":"grok/grok-4.3","role":"writer","action":"redraft","rationale":"","hash":"f6d7e2210107c72c6668e4671a54ce969177a8512fc3457463d0c19c64c06456"}],"topology":null,"slim":true,"ledger_totals":{"claims":4,"sources":7,"exported_claims":4,"exported_sources":7},"question_graph":{"slug":"what-are-peptides-chemo","questions":[],"evidence":[],"edges":[],"counts":{"questions":0,"evidence":0,"edges":0}},"verification":{"provenance":{"valid":true,"entries":2,"head":"1dc66199c170d883a9d80df6931150e97825f04ef9d0a478185cf328d268bdb4"},"sources":{"valid":false,"broken_at":5}},"counts":{"claims":4,"sources":7,"provenance":2,"contributions":1,"questions":0,"evidence_ingests":0,"voxel_edges":12},"transport":"Open every URL in this bundle with your browser or web / URL-fetch tool. Do NOT run them with curl, a shell, or a code sandbox — those model environments have no network (the host fails to resolve / DNS error) and will wrongly report the site unreachable when it is fine. Opening the link IS the call.","llm_manifest":{"version":"1","site":"https://miscsubjects.com","purpose":"Peptide evidence articles with hash-chained source ledgers, tiered claims, and a question graph. LLMs should READ bundles/URLs and WRITE back via ingest — never invent doses.","read":{"human_page":"https://miscsubjects.com/a/what-are-peptides-chemo","bundle_json":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/topology","question_graph":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/question-graph","sources":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/sources","provenance":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/provenance","contributions":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/contributions","graph_topology":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/graph-topology?question={question}","voxels":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","health":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/health","repair":"POST https://miscsubjects.com/api/protocol/repair","list_articles":"https://miscsubjects.com/api/articles","graph_canvas":"https://miscsubjects.com/graph.html?slugs=what-are-peptides-chemo","graph_yield":"https://miscsubjects.com/api/graph?slugs=what-are-peptides-chemo&layer=yield","obsidian_vault":"https://miscsubjects.com/api/articles/obsidian-vault?slugs=what-are-peptides-chemo","graph_query":"https://miscsubjects.com/api/v1/query?from=what-are-peptides-chemo&kind=claim&where=tier=human"},"ask":{"description":"Answer only from topology; creates a question_node with gaps.","api":"POST https://miscsubjects.com/api/protocol/ask","body":{"slug":"{slug}","question":"string"},"imessage":"what-are-peptides-chemo|your question","router_tag":"[ARTICLE_ASK]what-are-peptides-chemo|question[/ARTICLE_ASK]","auth":"x-terminal-key header for API; iMessage/WhatsApp via miscsubjects build"},"ingest":{"description":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","api":"POST https://miscsubjects.com/api/protocol/ingest","body":{"slug":"{slug}","evidence":"paste text","question_node_id":"optional qn_..."},"imessage":"ingest what-are-peptides-chemo|q:{node_id}|paste evidence","router_tag":"[ARTICLE_INGEST]what-are-peptides-chemo|evidence[/ARTICLE_INGEST]","tiers":["human","preclinical","anecdotal","mechanistic","speculative"]},"claim":{"description":"Prompt-injection style POST — one claim voxel with who_claims + posted_by provenance.","api":"POST https://miscsubjects.com/api/protocol/claim","body":{"slug":"{slug}","text":"one assertion","tier":"human|preclinical|anecdotal|mechanistic|speculative","who_claims":"study author, platform, or model id","source_ids":"optional [s1]"},"imessage":"claim what-are-peptides-chemo|tier|assertion — who claims it?","router_tag":"[ARTICLE_CLAIM]what-are-peptides-chemo|tier|assertion[/ARTICLE_CLAIM]","slots":["what_it_is","who_claims_what","what_is_known","what_is_unknown","mechanism","limitations","disclaimer"]},"tiers":{"human":0.8,"preclinical":0.5,"anecdotal":0.3,"mechanistic":0.3,"speculative":0.1},"invariants":["Self-explaining — every API JSON has _self; every paste widget has §SELF; root index at /api/articles/system-map","Append-only — revisions preserved at ?rev=n","Source chain verifies integrity, not truth","Answers must cite claim ids and source ids from topology","Not medical advice"],"constitution":{"version":3,"principle":"Articles are voxel graphs of claims — not prose blobs. Every assertion is a claim atom with tier, weight, source_ids, and posted_by provenance.","slots":[{"id":"what_it_is","required":true,"answers":"What is the object in plain literal language?"},{"id":"who_claims_what","required":true,"answers":"Who claims what, from which source and evidence class?"},{"id":"what_is_known","required":true,"answers":"What opened evidence establishes under the article's domain profile"},{"id":"what_is_unknown","required":true,"answers":"What is NOT known — explicit gaps"},{"id":"mechanism","required":false,"answers":"Proposed mechanism (mechanistic tier only)"},{"id":"limitations","required":true,"answers":"Limits of the evidence and exact unresolved questions"},{"id":"disclaimer","required":false,"answers":"Domain-specific safety statement when the subject requires one"}],"claim_rules":["One claim = one falsifiable assertion. No compound claims.","Every claim must declare tier: human|preclinical|anecdotal|mechanistic|speculative|system.","system tier = architecture/design axioms (not biological mechanism). Use for protocol self-definition.","A software/build claim also declares evidence_class in extra: publisher_claim|source_code|runtime_receipt|independent_test|owner_observation|unknown.","Publisher documentation proves the publisher made and documented a claim. It is not independent runtime proof.","Source code proves an implementation exists. A successful receipt proves one invocation. Neither proves general reliability or field superiority.","Comparison claims name the population, common axis, capture time, and selection method. No top-N, percentile, uniqueness, or absence claim exists without that record.","Sourced claims must cite source_ids from the hash-chained ledger.","Unsourced claims must set source_status: unsourced and why_material.","posted_by is mandatory on every new claim (model id, human, or channel).","No medical advice, no doses, no 'you should take'.","Bad information is retracted (status:retracted), never deleted — retraction event stays on ledger.","Adversary challenges link via challenges[] / challenged_by[] — target may be downweighted.","Leaked secrets are scrubbed to [REDACTED:secret-leak] with scrub_events tombstone — honest audit trail."],"source_rules":["Every source is a voxel edge: type, url, exact quote, summary, found_by, accessed_at.","Sources hash-chain — prev/hash on append.","Anecdotal sources must name platform (reddit|x|youtube|imessage|user_entry).","Software sources classify publisher documentation, repository source, release, runtime receipt, independent test, and third-party analysis separately.","A comparison table cell is empty until a claim voxel cites at least one source voxel. Model prose alone is not evidence."],"writing_rules":["Literal nouns and verbs. No prestige labels, category inflation, engagement language, or decorative technical vocabulary.","Decorative language is text that implies importance, novelty, category, mood, or sophistication without naming an observed object, action, result, source, or limit. Delete it.","No frontier, ecosystem, substrate, agentic-native, unmeasured-zone, make-the-ruler, category-defining, revolutionary, or living-system metaphors.","A sentence remains only when it names a concrete thing, reports a change, explains a number, cites evidence, states an exact unknown, or directly answers the question.","Technical nouns are allowed only when literal. Define the first use by what the named code or data object stores or does.","State the observed object before naming a category for it.","Keep the evidentiary boundary beside the exact claim it limits.","Unknown means unknown. Missing evidence does not become absence."],"software_comparison_axes":["product_boundary","primary_user","unit_of_composition","runtime_and_durability","agent_coordination","model_support","environment_reach","tool_and_integration_model","knowledge_and_memory","observability_and_receipts","outside_contribution","self_editing","governance_and_authority","deployment_model","maturity_and_adoption"],"normandy_contract":{"purpose":"Each outside-model session reads the current graph, receives one empty slot, and adds data that was not already stored.","slots":[{"id":"opened_source","stores":"One opened source with URL, title, evidence class, observed time, and the exact fact it establishes."},{"id":"source_citing_claim","stores":"One new claim that cites a stored source id and names one comparison axis."},{"id":"overlap","stores":"One evidenced capability both systems have."},{"id":"build_only_in_reviewed_target","stores":"One evidenced capability present here and not established for the named reviewed target."},{"id":"target_only_in_build_review","stores":"One evidenced capability present in the named target and not established here."},{"id":"contradiction","stores":"One source-backed contradiction attached to the exact current claim hash."},{"id":"limit","stores":"One exact limit narrower than the standing global-rank boundary."},{"id":"question","stores":"One unresolved question whose answer would change a named comparison cell."},{"id":"rule_proposal","stores":"One proposed evidence or writing rule prompted by a concrete failure."},{"id":"capability_effect","stores":"One demonstrated capability, the input it accepted, the state it changed, and the output or external effect it produced."},{"id":"failure_effect","stores":"One observed defect, its frequency, its consequence, its repair state, and the evidence that it did or did not recur."},{"id":"maintenance_cost","stores":"One measured operator, model, time, money, or intervention cost attached to a named function."},{"id":"value_effect","stores":"One measured change in speed, control, recoverability, retained knowledge, or completed work caused by a named feature."}],"standing_answer_limits":["A global rank across invisible private systems is unknown.","Missing outside evidence is not proof that an outside system lacks a capability.","A successful receipt proves one run, not general reliability.","Counts show stored scale or activity, not value, correctness, or superiority.","Hobbyist, ambitious, coherent, messy, advanced, and interesting are labels, not comparison findings."],"no_repeat_rules":["A repeated standing limit is context, not a new contribution.","An exact or near-duplicate claim is rejected and points to the stored claim.","A duplicate source does not complete an assignment.","A response completes only after at least one new graph object lands.","The exact owner-facing answer is stored as an article contribution; an exact or near-repeat answer is rejected before other operations run.","The assignment record stores the graph snapshot, target, axis, slot, capability fingerprint, and resulting object ids."],"assignment":"GET /api/normandy?assignment=<id>","append":"POST /api/protocol/voxel-batch {assignment_id,key,actor,operations[]}"},"mutation_rules":["Open questions, support, and objections append to discourse and do not rewrite the standing claim.","Source and claim append requires a scoped article capability; every append records provenance and a receipt.","Existing text edits use the current voxel hash. A stale hash writes nothing.","Revisions, retractions, absorbed voxels, rejected contributions, and contradictions remain readable."],"ontology_rules":["Peptide articles (bpc-157, tb-500) are tree roots.","Condition articles (bpc-157-glp1-gut-damage) branch from peptides.","Stack articles (wolverine-stack-glp1) compose peptides — never duplicate peptide mechanism prose.","If an article has no parent embeds and is not a root peptide → sprawl candidate.","Misstep = duplicate scope with another slug; merge or reparent via embeds."],"post_protocol":{"claim":"POST /api/protocol/claim","source":"POST /api/protocol/sources","ingest":"POST /api/protocol/ingest","webhook":"POST /api/articles/<slug>/webhook {kind:claim|source}","imessage_claim":"claim {slug}|{tier}|your assertion — who claims it, source?","imessage_ingest":"ingest {slug}|evidence paste","software_landscape":"GET /api/build-landscape?next=1&lane=field|build|opposition|synthesis","queue_population":"POST /api/build-landscape {action:queue_targets, cohort, query, sort, captured_at, source_url, targets[]}"}},"this_article":{"slug":"what-are-peptides-chemo","url":"https://miscsubjects.com/a/what-are-peptides-chemo","bundle_url":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/bundle?format=markdown"},"voxel_procedure":{"what":"Every article has a human side (/a/what-are-peptides-chemo) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"what-are-peptides-chemo\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"what-are-peptides-chemo\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"what-are-peptides-chemo\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"what-are-peptides-chemo\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"what-are-peptides-chemo\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"what-are-peptides-chemo\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/what-are-peptides-chemo/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/what-are-peptides-chemo/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/what-are-peptides-chemo#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."}},"api_urls":{"bundle":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/topology","voxels":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","question_graph":"https://miscsubjects.com/api/articles/what-are-peptides-chemo/question-graph","ask":"https://miscsubjects.com/api/protocol/ask","ingest":"https://miscsubjects.com/api/protocol/ingest","claim":"https://miscsubjects.com/api/protocol/claim","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown"}}