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This reduces immediate load on the nervous system but trades off long-term repair by promoting tolerance and dependence. The drug does not address underlying mechanisms of receptor adaptation or support endogenous GABA tone restoration.","status":"active","vx_hash":"6ecf126f00c580ec47879984e0b08a0dd442fac16300ab98c2e77384f7f7000a","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"5dbb370dc6f530f5f2ae4875f4d42217cb7bf7ed111ee9bb473cdd4578069ac9","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"3ee88bc8c7055e4cea27605eea537a33cec63dda729bc698610638890c421b7d","detail":{"divided_from":"body","block":4,"kind":"list"},"prev":"genesis","hash":"5dbb370dc6f530f5f2ae4875f4d42217cb7bf7ed111ee9bb473cdd4578069ac9"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d4"},{"id":"d5","kind":"h","type":null,"order":5,"text":"## How these fit together","status":"active","vx_hash":"794d1a7de320c5093e63c53e52b838e9eeff477ae7816ea4b4626276b61bf69f","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"572391bd624cb65b2ae69d73f6c2ccda7954a718bd3f9b59867fb269e41b734e","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"255677f13849515d0e42f067e34911236d8b3298d6c16100bfa19e68c3074d62","detail":{"divided_from":"body","block":5,"kind":"h"},"prev":"genesis","hash":"572391bd624cb65b2ae69d73f6c2ccda7954a718bd3f9b59867fb269e41b734e"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d5"},{"id":"d6","kind":"p","type":null,"order":6,"text":"Single-compound focus on benzodiazepines. 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Mice receiving both showed attenuated tolerance development and delayed onset of withdrawal signs compared to diazepam alone (source s1). No human trials replicate this.","status":"active","vx_hash":"c89660354b9925ba8b56dcae5268c694a5ec5dd8fb1f9f212d5d602a932460d1","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"55b78ea5582568842b882294b01f4d20cec64513973d97ae51c7215088cb73c3","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"7dc95e075ce56162a6f9a5f602c78409f97284938d8ec0f80967cf93ee9d56fe","detail":{"divided_from":"body","block":8,"kind":"p"},"prev":"genesis","hash":"55b78ea5582568842b882294b01f4d20cec64513973d97ae51c7215088cb73c3"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d8"},{"id":"d9","kind":"p","type":null,"order":9,"text":"Russian clinical observations (human tier, small studies) report Selank producing anxiolytic effects comparable to low-dose benzodiazepines in generalized anxiety disorder without sedation, cognitive impairment, or reported dependence (sources s5, s6). These studies are not large Western RCTs.","status":"active","vx_hash":"49f75d5d947b847489a18d9c6319ea51b88c93e127c73eb142d1433a05c267a2","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"a3c40f560e928e5808346e69db48abbdda30c8d700cfdd9932243b666b34bd9f","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"5e4e824f69b250a95dfa8cd814646d399edd11b09152bb14f45bd2056180ceff","detail":{"divided_from":"body","block":9,"kind":"p"},"prev":"genesis","hash":"a3c40f560e928e5808346e69db48abbdda30c8d700cfdd9932243b666b34bd9f"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d9"},{"id":"d10","kind":"p","type":null,"order":10,"text":"An ongoing clinical trial examines intranasal oxytocin for benzodiazepine withdrawal symptoms (human tier, not yet completed) (source s25).","status":"active","vx_hash":"82dac8da3f2868cd4464212dd0334cfa27a30a1548f15c204ee79238d876d6cc","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"2245cc6a1aa3002d27981c7d51009b26393551f52e4475e909b5ccf33c9717f9","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"08ab1729b714286474da32e10918ae00ed2b3c567f49a3e4b588f8ad37d5a0c1","detail":{"divided_from":"body","block":10,"kind":"p"},"prev":"genesis","hash":"2245cc6a1aa3002d27981c7d51009b26393551f52e4475e909b5ccf33c9717f9"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d10"},{"id":"d11","kind":"p","type":null,"order":11,"text":"No large-scale human randomized controlled trials demonstrate peptides preventing or reversing benzodiazepine tolerance or dependence.","status":"active","vx_hash":"f5af41cda871ab881cbbd3aadd3e052fd4615b371d829144f6fa62d8f1f8571b","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"ef086569237f0d96b818e519b7869f3285b8ed09a0299950685d36186fbe63ca","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"b5cd2caa493d7ae4f18a862b7f8268475612915a0dbe5d8f7bc0fea102600197","detail":{"divided_from":"body","block":11,"kind":"p"},"prev":"genesis","hash":"ef086569237f0d96b818e519b7869f3285b8ed09a0299950685d36186fbe63ca"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d11"},{"id":"d12","kind":"h","type":null,"order":12,"text":"## What scientists say","status":"active","vx_hash":"80ab84d69b7b292d1a6ba46fd6fddc4809486f9920cd37e07384a5a461dc1902","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"63316cdf4140c1367e156a141d502f4b382affbc6384cf8f6647bd9c76c7db22","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"2f1dd55083de1fa734f2f06a8337a050d5a0b3f635bfc8bb709abab75705a1ef","detail":{"divided_from":"body","block":12,"kind":"h"},"prev":"genesis","hash":"63316cdf4140c1367e156a141d502f4b382affbc6384cf8f6647bd9c76c7db22"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d12"},{"id":"d13","kind":"p","type":null,"order":13,"text":"Researchers note BPC-157 may favor GABA receptor complex homeostasis in animal models, distinct from benzodiazepine mechanisms (source s24). Selank studies suggest selective GABA modulation that overlaps with benzodiazepine effects on anxiety but avoids global suppression (source s5). Experts emphasize limited Western human data and call for further controlled research on peptides in withdrawal contexts.","status":"active","vx_hash":"350dce871157946fd6c33c9c75bd22364cab4fca24d2160f8f6c28cd7b7fa90d","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"085476be7aae1cc9e924ac7fa29ea11c942513b89a352abf1cc8d41a46952580","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"7ff1b7ed51ffc1e7371f358b631b9928eb9f78a937fbf3b82178a90f41bf4261","detail":{"divided_from":"body","block":13,"kind":"p"},"prev":"genesis","hash":"085476be7aae1cc9e924ac7fa29ea11c942513b89a352abf1cc8d41a46952580"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d13"},{"id":"d14","kind":"h","type":null,"order":14,"text":"## What people say on Reddit","status":"active","vx_hash":"a871b6b95ad5d80b8257ef85d2566ca1033fb8b238c1fc584e21ec7862fabeb5","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"c3f31df87598da55646a2e91036b6280d61b617ebde4c3083de078c678626f69","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"feb303756a303788527cf602bf2c3c6b00ab8c384fb9fff4baa9ffc53e0049c3","detail":{"divided_from":"body","block":14,"kind":"h"},"prev":"genesis","hash":"c3f31df87598da55646a2e91036b6280d61b617ebde4c3083de078c678626f69"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d14"},{"id":"d15","kind":"p","type":null,"order":15,"text":"Users in peptide communities report exploring BPC-157 or Selank during benzodiazepine tapering for perceived GABA support or reduced withdrawal discomfort (anecdotal tier) (source s27). Experiences vary widely; some describe subjective calm without sedation, others note no clear benefit. These are self-reports, not controlled observations.","status":"active","vx_hash":"adad98eb43d33a9ca979d5faf28e0e22e60bc2156df0296d096249cf07d9a280","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"e8f66236470f94a69a1be5059dffed480fe3b1df1398f29cc5b6b5e4b10299ab","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"f9717f8f7d357f68decc61eadd9ab2e069de52afdb40490dad0bf48e4d65fa7e","detail":{"divided_from":"body","block":15,"kind":"p"},"prev":"genesis","hash":"e8f66236470f94a69a1be5059dffed480fe3b1df1398f29cc5b6b5e4b10299ab"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d15"},{"id":"d16","kind":"h","type":null,"order":16,"text":"## What people say on X","status":"active","vx_hash":"ef96ee53980ca04c79bf52826a8be90deb4eba0f4e6db8501359f68bf75a3aed","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"3c92b753774f28d0e37af4ae0631572cb64e732bac318295957947c00fb07eb2","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"4dd8bbfdb0452cc6235c2300209b5132daba3913b8f54ab179b1a73109c298dd","detail":{"divided_from":"body","block":16,"kind":"h"},"prev":"genesis","hash":"3c92b753774f28d0e37af4ae0631572cb64e732bac318295957947c00fb07eb2"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d16"},{"id":"d17","kind":"p","type":null,"order":17,"text":"Discussions on X mirror Reddit anecdotes, with individuals mentioning Selank or BPC-157 alongside benzodiazepine reduction efforts. Posts often highlight interest in non-sedating options but stress the experimental nature and lack of medical guidance (anecdotal tier).","status":"active","vx_hash":"91931a4b0f0694ca9e7ae1457341365f403562456eaaf7a23bcca2cfc21aced1","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"b605c11fdffd7c388febdfa3abfa2adcabdacc3d082788985e22de8a122b4b97","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"63902b41fbc1c850046e8d523c73c4ba1758a3b4b53c177f96bf11d20de079c3","detail":{"divided_from":"body","block":17,"kind":"p"},"prev":"genesis","hash":"b605c11fdffd7c388febdfa3abfa2adcabdacc3d082788985e22de8a122b4b97"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d17"},{"id":"d18","kind":"h","type":null,"order":18,"text":"## What we do not know","status":"active","vx_hash":"99c933824e392c483b6ce111fb3cd459e5b9838a53547db4ae321fd5df8560df","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"b8525a0fc80c0a3e0b30eeef92efb886d359c8035bc911172ebffa70009fadb8","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"7d96a49fba77f6a48c0321db2ae4180a902beae62e2aac0d23408fbf8333a177","detail":{"divided_from":"body","block":18,"kind":"h"},"prev":"genesis","hash":"b8525a0fc80c0a3e0b30eeef92efb886d359c8035bc911172ebffa70009fadb8"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d18"},{"id":"d19","kind":"p","type":null,"order":19,"text":"Long-term human safety and efficacy of peptides specifically for benzodiazepine-related tolerance or withdrawal remain unknown. Mechanisms in humans are not fully mapped. Interactions with tapering protocols or other medications lack systematic study. Most peptide data for this context derives from animal models or small non-Western trials.","status":"active","vx_hash":"39b48cd409bc4d01af0221006e4c15c1d32d9769e39e7d64f190896576ea3bf6","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"75963a53c74b9598511c8cbae2c999b7811011afffb0bde79a3020b7b9b71c55","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"0701c5f00329e6946fd781b82523592e7bdcd6382a3e05299a6dba0d06ed2ffd","detail":{"divided_from":"body","block":19,"kind":"p"},"prev":"genesis","hash":"75963a53c74b9598511c8cbae2c999b7811011afffb0bde79a3020b7b9b71c55"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d19"},{"id":"d20","kind":"h","type":null,"order":20,"text":"## Safety and limits","status":"active","vx_hash":"0eb4424af6efaf9fa96130004e7522ae54ba8b30fbffabd6d4a8fad46b658d2e","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"75e6d3f54399d2a6038267a07a06609f3c9999532e5987c6a20f6353ed256985","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"404f7427c043c6ec7a5cb4416bbec9ec336e19f8757fb217be5c5c2161ff8cb6","detail":{"divided_from":"body","block":20,"kind":"h"},"prev":"genesis","hash":"75e6d3f54399d2a6038267a07a06609f3c9999532e5987c6a20f6353ed256985"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d20"},{"id":"d21","kind":"p","type":null,"order":21,"text":"Benzodiazepine tapering should occur under medical supervision due to seizure risk and other withdrawal complications. Peptides discussed here carry their own unknowns, including absence of large safety databases in this population. No peptide is established as a replacement or adjunct for benzodiazepine management. Evidence grading separates clear preclinical signals from sparse human data and anecdotes; claims beyond reported findings are speculative.","status":"active","vx_hash":"073834700b509962f73e85e1426e9572267c7f735ce917a77d77fbbbb70f04c8","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"7ebbcec0773a5ca0564c5e01ce784551903abaea51fd15d1aa30500f78738f1c","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:29.591Z","actor":"owner","text_sha":"d3f0c1e0583418ff3efd4a506972cc5f84e2946d42c2312ce25e008d8502b00f","detail":{"divided_from":"body","block":21,"kind":"p"},"prev":"genesis","hash":"7ebbcec0773a5ca0564c5e01ce784551903abaea51fd15d1aa30500f78738f1c"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:29.591Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/what-are-peptides-benzodiazepines/d21"}],"voxels":[{"id":"c1","div_id":"claim:c1","kind":"claim","text":"A 1999 mouse study showed BPC-157 co-administered with diazepam attenuated tolerance and delayed 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article has a human side (/a/what-are-peptides-benzodiazepines) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"what-are-peptides-benzodiazepines\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"what-are-peptides-benzodiazepines\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"what-are-peptides-benzodiazepines\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"what-are-peptides-benzodiazepines\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"what-are-peptides-benzodiazepines\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. 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Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. 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