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Per-claim provenance."}],"not_medical_advice":true},"slug":"vip","title":"vip","register":"standard","tags":[],"updated_at":"2026-07-17T02:43:21.378Z","body_excerpt":"## Overview\nEvidence is being populated by Grok web search.","ranking":"safety-first (interaction_risk/limitations), then quote-gated effective_weight","claims":[],"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41498509/","title":"Elevated vasoactive intestinal peptide concentrations ...","quote":"Our findings suggest that elevated VIP concentrations are not predictive for a VIPoma and most patients with elevated VIP do not have a VIPoma. 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In parallel, ...","summary":"VIP promotes chondrogenic differentiation (2026).","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"e42d5ebc952f1752ebbd67a3c44945bbee2bd886d2e5008e0883ebf6daabfe6c"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41554595/","title":"Neuron-specific overexpression of human vasoactive ...","quote":"Neuron-specific overexpression of human vasoactive intestinal peptide receptor 2 in mice causes cognitive dysfunction and abnormal dendritic morphology in the ...","summary":"Overexpression of VIP receptor 2 linked to cognitive issues in mice (2026).","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"47a8da63688bebbdd0728e79df033297e06afa5587c5c77eb8e4bf9d4cbd1aae"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41571149/","title":"Neuronal VIP wires the intestinal epithelial cell function","quote":"show that neuron-derived vasoactive intestinal peptide (VIP ) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its ...","summary":"Neuronal VIP regulates gut epithelial and immune function (2026).","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"4d129353adef977f1e6631a881f93e42077f9e8fd09a09f92a33db847500c791"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41421442/","title":"Myopia pathogenesis and vasoactive intestinal peptide: Molecular mechanisms, experimental models, and clinical implications","quote":"This review summarizes current knowledge about myopia pathogenesis and the diverse factors involved, focusing on the molecular, genetic, pharmacological, and clinical findings regarding VIP/VIPR2 signaling in the eye. Evidence from animal models reveals a complex interaction between VIP and myopia, with VIP agonists/antagonists either protecting from or promoting myopia depending on model and dosage, VIPR2 knockout mice developing spontaneous myopia, and VIP interacting with circadian rhythms and atropine signaling.","summary":"2026 review on VIP/VIPR2 role in myopia pathogenesis, models, and therapeutic potential.","claim_ids":[],"link_status":"ok","quote_status":"verified","hash":"79e7ca903c8fc602cb346e8145c25e603af003c024a6778f7ed6928c527d4c73"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42216340/","title":"Vasoactive intestinal peptide associated 8-gene signature with prognostic and immune associations in melanoma","quote":"Vasoactive intestinal peptide (VIP) plays a multifaceted role in cancer biology, yet its prognostic and immunological implications in melanoma remain underexplored. This study aimed to construct a VIP-related gene signature for risk stratification and to explore its potential associations with the tumor immune microenvironment and drug sensitivity in melanoma.","summary":"2026 study develops VIP-related 8-gene prognostic signature in melanoma linked to immune microenvironment.","claim_ids":[],"link_status":"ok","quote_status":"verified","hash":"fff2fb9576ec3b435eaac71b5f9b1e142e222ee649d72eed48cc774b84d95308"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41177440/","title":"Stress-type specific changes of VIP signaling in limbic brain areas","quote":"Vasoactive intestinal peptide (VIP ) is a highly abundant neuropeptide in the central nervous system, implicated in the regulation of numerous behavioral and ...","summary":"Discusses stress-type specific changes in VIP signaling in limbic areas.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"a7f79de1cc36b27f8774dc14118798b5f68de22b8a1987ad051b948c3881062e"},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41795422/","title":"Neuronal VIP shapes intestinal stem cell activity and regeneration","quote":"by C Anastasio · 2026 — Li et al. 1 identified neuronal vasoactive intestinal peptide (VIP ) as a brake on ISCs through VIPR1 to limit regeneration. In Nature Immunology, Jakob et al.","summary":"Neuronal VIP regulates intestinal stem cells and regeneration.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"7a28d677e8e996998132a286e8aa694fa149f93a96ca10f674b6cca73001ada7"},{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41891524/","title":"Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway","quote":"by L Li · 2026 — Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway · Authors · Affiliations.","summary":"VIP induces autophagy and cytotoxicity in renal cell carcinoma.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"d2d5624528e079f3877afa4d1dc774195df7519c3637518c67a80a7ff178b76d"},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41580986/","title":"Dorsal Raphe VIP Neurons Are Critical for Survival and Adaptive Responses to Threat","quote":"by A Guillaumin — A subset of these neurons expresses vasoactive-intestinal-peptide (VIP ) and projects to two key regions for adaptive threat responses: the central amygdala ...","summary":"Dorsal raphe VIP neurons critical for threat responses.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"591e11c47fb27d200e49b0c0c7ab96927bcfcdd1d10ef58439d874062c4cfa1a"},{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42283917/","title":"Motor Cortex VIP Interneurons Participate in Diurnal Regulation of Motor Activity","quote":"by W Wang · 2026 — Vasoactive intestinal peptide (VIP)-expressing neurons within the motor cortex (MC) exhibit diurnal variation in excitability and may participate in the ...","summary":"Motor cortex VIP interneurons in diurnal motor activity regulation.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"afbaa4203052df466e399f07a0b5ec4ef6046f0318709168494c09b32f7000db"}],"anecdotal_sources":[],"scientific_sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41498509/","title":"Elevated vasoactive intestinal peptide concentrations ...","quote":"Our findings suggest that elevated VIP concentrations are not predictive for a VIPoma and most patients with elevated VIP do not have a VIPoma. 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In parallel, ...","summary":"VIP promotes chondrogenic differentiation (2026).","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"e42d5ebc952f1752ebbd67a3c44945bbee2bd886d2e5008e0883ebf6daabfe6c"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41554595/","title":"Neuron-specific overexpression of human vasoactive ...","quote":"Neuron-specific overexpression of human vasoactive intestinal peptide receptor 2 in mice causes cognitive dysfunction and abnormal dendritic morphology in the ...","summary":"Overexpression of VIP receptor 2 linked to cognitive issues in mice (2026).","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"47a8da63688bebbdd0728e79df033297e06afa5587c5c77eb8e4bf9d4cbd1aae"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41571149/","title":"Neuronal VIP wires the intestinal epithelial cell function","quote":"show that neuron-derived vasoactive intestinal peptide (VIP ) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its ...","summary":"Neuronal VIP regulates gut epithelial and immune function (2026).","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"4d129353adef977f1e6631a881f93e42077f9e8fd09a09f92a33db847500c791"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41421442/","title":"Myopia pathogenesis and vasoactive intestinal peptide: Molecular mechanisms, experimental models, and clinical implications","quote":"This review summarizes current knowledge about myopia pathogenesis and the diverse factors involved, focusing on the molecular, genetic, pharmacological, and clinical findings regarding VIP/VIPR2 signaling in the eye. Evidence from animal models reveals a complex interaction between VIP and myopia, with VIP agonists/antagonists either protecting from or promoting myopia depending on model and dosage, VIPR2 knockout mice developing spontaneous myopia, and VIP interacting with circadian rhythms and atropine signaling.","summary":"2026 review on VIP/VIPR2 role in myopia pathogenesis, models, and therapeutic potential.","claim_ids":[],"link_status":"ok","quote_status":"verified","hash":"79e7ca903c8fc602cb346e8145c25e603af003c024a6778f7ed6928c527d4c73"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42216340/","title":"Vasoactive intestinal peptide associated 8-gene signature with prognostic and immune associations in melanoma","quote":"Vasoactive intestinal peptide (VIP) plays a multifaceted role in cancer biology, yet its prognostic and immunological implications in melanoma remain underexplored. 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In Nature Immunology, Jakob et al.","summary":"Neuronal VIP regulates intestinal stem cells and regeneration.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"7a28d677e8e996998132a286e8aa694fa149f93a96ca10f674b6cca73001ada7"},{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41891524/","title":"Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway","quote":"by L Li · 2026 — Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway · Authors · Affiliations.","summary":"VIP induces autophagy and cytotoxicity in renal cell carcinoma.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"d2d5624528e079f3877afa4d1dc774195df7519c3637518c67a80a7ff178b76d"},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41580986/","title":"Dorsal Raphe VIP Neurons Are Critical for Survival and Adaptive Responses to Threat","quote":"by A Guillaumin — A subset of these neurons expresses vasoactive-intestinal-peptide (VIP ) and projects to two key regions for adaptive threat responses: the central amygdala ...","summary":"Dorsal raphe VIP neurons critical for threat responses.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"591e11c47fb27d200e49b0c0c7ab96927bcfcdd1d10ef58439d874062c4cfa1a"},{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42283917/","title":"Motor Cortex VIP Interneurons Participate in Diurnal Regulation of Motor Activity","quote":"by W Wang · 2026 — Vasoactive intestinal peptide (VIP)-expressing neurons within the motor cortex (MC) exhibit diurnal variation in excitability and may participate in the ...","summary":"Motor cortex VIP interneurons in diurnal motor activity regulation.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"afbaa4203052df466e399f07a0b5ec4ef6046f0318709168494c09b32f7000db"}],"user_reports":[],"related_articles":[],"question_graph":{"slug":"vip","questions":[],"evidence":[],"edges":[],"counts":{"questions":0,"evidence":0,"edges":0}},"honesty":{"active_claims":0,"retracted_claims":0,"cut_claims":0,"challenges":0,"scrub_events":0,"note":"Retracted/cut claims stay on ledger but are excluded from ask unless ?include_inactive=1"},"counts":{"claims":0,"claims_total":0,"sources":12,"anecdotal":0,"scientific":12,"user_reports":0,"questions":0,"evidence_ingests":0}}