{"slug":"vip","verification":{"valid":true,"entries":4,"head":"76a37e286b8e1adf169d436eb6b75aa7040d21a7505f07589fb03fae4fcc62fa"},"count":4,"models":["grok-4.3"],"yield":{"passes":4,"energy_spent_rows":0,"total_cost_usd":0,"waste_cost_usd":0,"total_tokens":0,"material_outputs":0,"usd_per_output":null,"models":[{"model":"grok-4.3","passes":4,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T16:56:01.904Z","model":"grok-4.3","role":"writer","action":"draft","payload":{"title":"vip","register":"standard","body":"## Overview\nEvidence is being populated by Grok web search.","claims":[],"sources":[]},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"genesis","hash":"d91f77e029103f3848e59b29d45f28f169e2fd13b7c031d1a2ae5e7461b1aa33"},{"seq":1,"id":"k2","ts":"2026-06-29T16:56:21.034Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41498509/","title":"Elevated vasoactive intestinal peptide concentrations ...","quote":"Our findings suggest that elevated VIP concentrations are not predictive for a VIPoma and most patients with elevated VIP do not have a VIPoma. We recommend ...","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40118798/","title":"Serum Vasoactive Intestinal Peptide as a Novel Biomarker ...","quote":"Serum VIP levels are higher in patients with atrial fibrillation with LVAs , suggesting its potential as a noninvasive biomarker for detecting these areas.","link_status":"ok","quote_status":"unverified"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42178419","title":"Vasoactive intestinal peptide advances chondrogenesis ...","quote":"VIP accelerated chondrogenic differentiation by inducing earlier mRNA and protein expression of chondrogenic markers and enhancing GAG production. In parallel, ...","link_status":"ok","quote_status":"unverified"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41554595/","title":"Neuron-specific overexpression of human vasoactive ...","quote":"Neuron-specific overexpression of human vasoactive intestinal peptide receptor 2 in mice causes cognitive dysfunction and abnormal dendritic morphology in the ...","link_status":"ok","quote_status":"unverified"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41571149/","title":"Neuronal VIP wires the intestinal epithelial cell function","quote":"show that neuron-derived vasoactive intestinal peptide (VIP ) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"d91f77e029103f3848e59b29d45f28f169e2fd13b7c031d1a2ae5e7461b1aa33","hash":"8f4096d2fd6409d355977ff6f63dbb0bb4fe490ed6a82c770ca305b3d1db56e0"},{"seq":2,"id":"k3","ts":"2026-06-29T16:56:40.864Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41421442/","title":"Myopia pathogenesis and vasoactive intestinal peptide: Molecular mechanisms, experimental models, and clinical implications","quote":"This review summarizes current knowledge about myopia pathogenesis and the diverse factors involved, focusing on the molecular, genetic, pharmacological, and clinical findings regarding VIP/VIPR2 signaling in the eye. Evidence from animal models reveals a complex interaction between VIP and myopia, with VIP agonists/antagonists either protecting from or promoting myopia depending on model and dosage, VIPR2 knockout mice developing spontaneous myopia, and VIP interacting with circadian rhythms and atropine signaling.","link_status":"ok","quote_status":"verified"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42216340/","title":"Vasoactive intestinal peptide associated 8-gene signature with prognostic and immune associations in melanoma","quote":"Vasoactive intestinal peptide (VIP) plays a multifaceted role in cancer biology, yet its prognostic and immunological implications in melanoma remain underexplored. This study aimed to construct a VIP-related gene signature for risk stratification and to explore its potential associations with the tumor immune microenvironment and drug sensitivity in melanoma.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"8f4096d2fd6409d355977ff6f63dbb0bb4fe490ed6a82c770ca305b3d1db56e0","hash":"3ae2706f0531fceedc62a6cb9b5da0e3e9984d754e714a6c1e529d7488d5c426"},{"seq":3,"id":"k4","ts":"2026-06-29T16:57:00.616Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41177440/","title":"Stress-type specific changes of VIP signaling in limbic brain areas","quote":"Vasoactive intestinal peptide (VIP ) is a highly abundant neuropeptide in the central nervous system, implicated in the regulation of numerous behavioral and ...","link_status":"ok","quote_status":"unverified"},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41795422/","title":"Neuronal VIP shapes intestinal stem cell activity and regeneration","quote":"by C Anastasio · 2026 — Li et al. 1 identified neuronal vasoactive intestinal peptide (VIP ) as a brake on ISCs through VIPR1 to limit regeneration. In Nature Immunology, Jakob et al.","link_status":"ok","quote_status":"unverified"},{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41891524/","title":"Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway","quote":"by L Li · 2026 — Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway · Authors · Affiliations.","link_status":"ok","quote_status":"unverified"},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41580986/","title":"Dorsal Raphe VIP Neurons Are Critical for Survival and Adaptive Responses to Threat","quote":"by A Guillaumin — A subset of these neurons expresses vasoactive-intestinal-peptide (VIP ) and projects to two key regions for adaptive threat responses: the central amygdala ...","link_status":"ok","quote_status":"unverified"},{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42283917/","title":"Motor Cortex VIP Interneurons Participate in Diurnal Regulation of Motor Activity","quote":"by W Wang · 2026 — Vasoactive intestinal peptide (VIP)-expressing neurons within the motor cortex (MC) exhibit diurnal variation in excitability and may participate in the ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"3ae2706f0531fceedc62a6cb9b5da0e3e9984d754e714a6c1e529d7488d5c426","hash":"76a37e286b8e1adf169d436eb6b75aa7040d21a7505f07589fb03fae4fcc62fa"}]}