{"slug":"vip-trigeminal","verification":{"valid":true,"entries":4,"head":"2fdf48a47544abb95ae1c0bdfedf6c79f6bee01fe041e0058eba1e5658561dd7"},"count":4,"sources":[{"id":"s1","type":"pubmed","url":"https://www.sciencedirect.com/science/article/abs/pii/S030384671630052X","title":"Clinical study of cerebrospinal fluid neuropeptides in patients with primary trigeminal neuralgia","quote":"the concentrations of CGRP, SP, and VIP were significantly higher in TN patients as compared to those in the controls","summary":"Human study measuring elevated VIP in TN patients' CSF and blood","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:13:44.981Z","link_status":"http_400","quote_status":"unverified","prev":"genesis","hash":"22a0df6cd97b1877a7a586eb47d1e1239837ee6c6172d9ceae07f6638672013f"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/12593198/","title":"Observation of vasoactive intestinal polypeptide in patients with trigeminal neuralgia","quote":"During the attacks of trigeminal neuralgia the levels of VIP in the ...","summary":"Human observation of VIP changes during TN attacks","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:13:44.981Z","link_status":"ok","quote_status":"unverified","prev":"22a0df6cd97b1877a7a586eb47d1e1239837ee6c6172d9ceae07f6638672013f","hash":"ea18828635f9b1b3b37b55cde1d5141e8ba98a4a0efbf09dccf95382fde42947"},{"id":"s3","type":"pubmed","url":"https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2019.01326/full","title":"Distinct VIP and PACAP Functions in the Distal Nerve Stump Following Peripheral Nerve Injury","quote":"VIP and PACAP treatment not only inhibits TNFα, MCP-1, ILα, ILβ, and IL6 expression in Schwann cells","summary":"Mouse study on VIP after nerve injury and anti-inflammatory effects","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:13:44.981Z","link_status":"ok","quote_status":"verified","prev":"ea18828635f9b1b3b37b55cde1d5141e8ba98a4a0efbf09dccf95382fde42947","hash":"e5203047c569fe99c620a814d6a292177be3c4fc2bf4552da401de37ea8c204b"},{"id":"s4","type":"pubmed","url":"https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2782759","title":"Effect of Vasoactive Intestinal Polypeptide on Development of Migraine Attacks","quote":"15 patients (71%) developed migraine attacks after VIP","summary":"Human trial showing VIP can induce migraine and vasodilation","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:13:44.981Z","link_status":"http_403","quote_status":"unverified","prev":"e5203047c569fe99c620a814d6a292177be3c4fc2bf4552da401de37ea8c204b","hash":"2fdf48a47544abb95ae1c0bdfedf6c79f6bee01fe041e0058eba1e5658561dd7"}]}