{"slug":"vip-sciatica","verification":{"valid":true,"entries":7,"head":"31cd5b3c99d6ff4ede84fd1f3c8d20334dbaab38c2c446f71cd774d2d9657cc3"},"count":7,"sources":[{"id":"s12","type":"pubmed","url":"https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2019.01326/full","title":"Distinct VIP and PACAP Functions in the Distal Nerve Stump Following Peripheral Nerve Injury","quote":"Our results provide evidence that VIP and PACAP could have important functions in the distal nerve stump following injury to promote remyelination and regulate the inflammatory response.","summary":"Mouse sciatic nerve transection study showing VIP receptor upregulation in Schwann cells and macrophages; VIP effects on cytokine balance and remyelination in explants.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:20:40.938Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"54b0859957caf0f6dc5e9ed118930f7d443bb9c85f87eda153e65a3186e78395"},{"id":"s17","type":"pubmed","url":"https://www.dovepress.com/the-effects-of-vasoactive-intestinal-peptide-in-the-rat-model-of-exper-peer-reviewed-fulltext-article-DDDT","title":"The effects of vasoactive intestinal peptide in the rat model of experimental autoimmune neuritis","quote":"The study showed that in a rat model of EAN, treatment with VIP resulted in functional improvement, reduced inflammation of the sciatic nerve.","summary":"Rat EAN model demonstrating VIP's impact on sciatic nerve inflammation and function.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:20:40.938Z","link_status":"ok","quote_status":"unverified","prev":"54b0859957caf0f6dc5e9ed118930f7d443bb9c85f87eda153e65a3186e78395","hash":"4b936bda570070228b23aea64c92da41c8a2281e97619db90e311e241c4f4f18"},{"id":"s1","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6604284/","title":"Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats","quote":"In animals, BPC 157 has an anti-inflammatory effect and therapeutic effects in functional recovery and the rescue of somatosensory neurons in the sciatic nerve after transection.","summary":"Rat studies on BPC-157 after nerve and spinal injury showing recovery metrics.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:20:40.938Z","link_status":"ok","quote_status":"unverified","prev":"4b936bda570070228b23aea64c92da41c8a2281e97619db90e311e241c4f4f18","hash":"defbe6352634dc3911a2af56f3077354b4dc7e96544a639fb9a284958c3d6734"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31266512/","title":"Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats","quote":"BPC 157 application largely counteracted changes at the microscopic level... in the rat caudal nerve.","summary":"Detailed rat spinal cord compression model with BPC-157 outcomes.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:20:40.938Z","link_status":"ok","quote_status":"unverified","prev":"defbe6352634dc3911a2af56f3077354b4dc7e96544a639fb9a284958c3d6734","hash":"181d98b7dea8442c94d581e842232ae17ed332e75de336a9ea4d605d0d86ea86"},{"id":"s29","type":"news","url":"https://www.regenerx.com/2015-05-08-Researchers-Report-that-Long-Term-Administration-of-Thymosin-B4-in-a-Diabetic-Animal-Model-Prevents-Progression-of-Peripheral-Neuropathy-and-Restores-Sciatic-Nerve-Function","title":"Researchers Report that Long-Term Administration of Thymosin B4 in a Diabetic Animal Model Prevents Progression of Peripheral Neuropathy and Restores Sciatic Nerve Function","quote":"diabetic mice treated long-term with Thymosin B4 (TB4) have significantly improved motor and sensory function in the sciatic nerve compared to the untreated animals.","summary":"Press release on mouse diabetic neuropathy model with TB4 functional recovery data.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:20:40.938Z","link_status":"ok","quote_status":"unverified","prev":"181d98b7dea8442c94d581e842232ae17ed332e75de336a9ea4d605d0d86ea86","hash":"59480a62c9444bbd24382e301af8880dc9b57a64395ca79769438afd91e8b5fa"},{"id":"s33","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5741312/","title":"Targeting the innate repair receptor to treat neuropathy","quote":"In humans, ARA290 has been evaluated in patients with small fiber neuropathy associated with sarcoidosis or type 2 diabetes mellitus... ARA290 significantly improved neuropathic and autonomic symptoms... initiated a regrowth of small nerve fibers in the cornea.","summary":"Review summarizing human ARA290 trials in neuropathy populations.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:20:40.938Z","link_status":"ok","quote_status":"unverified","prev":"59480a62c9444bbd24382e301af8880dc9b57a64395ca79769438afd91e8b5fa","hash":"8997009dcc61d582551c626f91fba445d24d73873b10a9ef6cd6d396f81c95d6"},{"id":"s34","type":"pubmed","url":"https://journals.lww.com/painrpts/fulltext/2016/08000/targeting_the_innate_repair_receptor_to_treat.2.aspx","title":"Targeting the innate repair receptor to treat neuropathy","quote":"In patients with sarcoidosis, ARA290 significantly improved neuropathic and autonomic symptoms, as well as quality of life... In patients with T2D, the results were similar...","summary":"Human clinical outcomes for ARA290 in sarcoidosis and diabetic neuropathy.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:20:40.938Z","link_status":"http_403","quote_status":"unverified","prev":"8997009dcc61d582551c626f91fba445d24d73873b10a9ef6cd6d396f81c95d6","hash":"31cd5b3c99d6ff4ede84fd1f3c8d20334dbaab38c2c446f71cd774d2d9657cc3"}]}