{"slug":"vip-ppis","verification":{"valid":true,"entries":5,"head":"ea30227eec15fee452288fa9274562dfd0943ab2e6aec1144a164a7c8848781f"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://www.researchgate.net/publication/246500942_Lansoprazole_Raises_Somatostatin_Calcitonin_Gene-Related_Peptide_and_Substance_P_Levels_in_Healthy_Human_Plasma","title":"Lansoprazole Raises Somatostatin, Calcitonin Gene-Related Peptide and Substance P Levels in Healthy Human Plasma","quote":"Proton pump inhibitors (PPIs) are known to increase levels of vasoactive intestinal peptide (VIP)","summary":"Notes PPI effect on VIP in human plasma context","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:21:40.171Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"ba90e018a091243e54520edf9f1b00f5554c8a9315ebd6e7e96866619df92948"},{"id":"s2","type":"pubmed","url":"https://bpb.pharm.or.jp/abst/200502/ab28020370.html","title":"Omeprazole Raises Somatostatin and Motilin in Human Plasma","quote":"we examined the effects of omeprazole on the levels of gastrointestinal peptides (somatostatin, motilin, gastrin, vasoactive intestinal peptide (VIP)","summary":"Documents omeprazole raising VIP and related peptides in humans","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:21:40.171Z","link_status":"ok","quote_status":"verified","prev":"ba90e018a091243e54520edf9f1b00f5554c8a9315ebd6e7e96866619df92948","hash":"bc0d8439ee30c3e2234ab84e3d08993e879cc654e8c5b42907c95edebaedc10c"},{"id":"s3","type":"pubmed","url":"https://onlinelibrary.wiley.com/doi/10.1111/nmo.13841","title":"Proton pump inhibitors enhance intestinal permeability via mast cell-VIP axis","quote":"Moreover, both vasoactive intestinal peptide (VIP) receptor antagonist and ketotifen significantly reversed the effect of PPI on intestinal permeability","summary":"Preclinical link between PPIs, permeability, and VIP pathway","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:21:40.171Z","link_status":"ok","quote_status":"unverified","prev":"bc0d8439ee30c3e2234ab84e3d08993e879cc654e8c5b42907c95edebaedc10c","hash":"1bff643684befe1ac3e47073a3c0c91b55e58b37ce2e49cc9210d2b4e599678b"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/19661153/","title":"Vasoactive intestinal peptide ameliorates intestinal barrier dysfunction","quote":"The aim of this study was to examine whether VIP treatment modulated Citrobacter rodentium-induced disruption of intestinal barrier integrity","summary":"Animal model showing VIP support for barrier function","claim_ids":[],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:21:40.171Z","link_status":"ok","quote_status":"verified","prev":"1bff643684befe1ac3e47073a3c0c91b55e58b37ce2e49cc9210d2b4e599678b","hash":"77fa95a540d6c20284259748930132b5373ec789d043a8edc8e156792384eca1"},{"id":"s5","type":"review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6743256/","title":"Recent advances in vasoactive intestinal peptide physiology","quote":"Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a vasodilator in 1970, has multiple physiological and pathological effects.","summary":"Comprehensive review of VIP gut actions including acid inhibition","claim_ids":["c3","c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:21:40.171Z","link_status":"ok","quote_status":"unverified","prev":"77fa95a540d6c20284259748930132b5373ec789d043a8edc8e156792384eca1","hash":"ea30227eec15fee452288fa9274562dfd0943ab2e6aec1144a164a7c8848781f"}]}