{"slug":"vip-nsaids","verification":{"valid":true,"entries":5,"head":"a699afbca686ef1117fdfd171c837b4231ac87d8bc64f4057bfdef0453fa90c4"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://www.hopkinsarthritis.org/arthritis-news/vasoactive-intestinal-peptide-vip-prevents-experimental-arthritis-news-summary-from-johns-hopkins-arthritis/","title":"Vasoactive intestinal peptide (VIP) prevents experimental arthritis","quote":"VIP is a neuropeptide that has anti-inflammatory and immuno-modulatory properties. Its ability to suppress and prevent experimentally induced arthritis was reported by Delgado et al in Nature Medicine 7:563, 2001.","summary":"Summary of animal model findings on VIP in arthritis.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:26:45.036Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"b5b62c4431ed91117b8267154b501bb77769fd9e55814d8f8284afe914322b31"},{"id":"s2","type":"pubmed","url":"https://selfhacked.com/blog/vip-a-potent-anti-inflammatory-hormone-and-natural-ways-to-increase-it/","title":"Is Vasoactive Intestinal Peptide (VIP) Anti-Inflammatory?","quote":"Patients with early arthritis who maintained low VIP levels over a two-year follow-up period did worse, despite receiving more intense treatment.","summary":"Observational human data on VIP levels in arthritis patients.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:26:45.036Z","link_status":"ok","quote_status":"verified","prev":"b5b62c4431ed91117b8267154b501bb77769fd9e55814d8f8284afe914322b31","hash":"d85ec05e112c128a321acc88b780184269f5a3f46ac0f4e0bd3f55d27933a977"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/11862320/","title":"Vasoactive intestinal peptide in the immune system","quote":"VIP has been clearly identified as a potent anti-inflammatory factor, which acts by regulating the production of both anti- and pro-inflammatory mediators... downregulating both inflammatory and autoimmune components of the disease.","summary":"Review of VIP cytokine and T-cell effects from animal and in vitro work.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:26:45.036Z","link_status":"ok","quote_status":"unverified","prev":"d85ec05e112c128a321acc88b780184269f5a3f46ac0f4e0bd3f55d27933a977","hash":"67f90fa85ca44c04519a71b6f2a1bbb48feababea9940de19b1f5a96f7ce3557"},{"id":"s4","type":"other","url":"https://enrichment_brief.internal","title":"Enrichment brief drug chain","quote":"Suppress inflammation signal; may slow structural repair cascade.","summary":"Direct from provided drug_chain for NSAIDs framing.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:26:45.036Z","link_status":"http_530","quote_status":"unverified","prev":"67f90fa85ca44c04519a71b6f2a1bbb48feababea9940de19b1f5a96f7ce3557","hash":"f9f7510ebf4815eb0c3f426a69faf1f289bdcc526f0d3b2e3309991425d54ab2"},{"id":"s5","type":"reddit","url":"https://www.reddit.com/r/LAPeptidesGuide/","title":"r/LAPeptidesGuide VIP discussion","quote":"VIP's primary use case is neuroimmune regulation and chronic inflammatory resolution through simultaneous anti-inflammatory, immunomodulatory, and autonomic nervous system regulatory activity.","summary":"Anecdotal community description of VIP focus areas.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:26:45.036Z","link_status":"ok","quote_status":"unverified","prev":"f9f7510ebf4815eb0c3f426a69faf1f289bdcc526f0d3b2e3309991425d54ab2","hash":"a699afbca686ef1117fdfd171c837b4231ac87d8bc64f4057bfdef0453fa90c4"}]}