{"slug":"vip-muscle-loss","verification":{"valid":true,"entries":5,"head":"53091e66d70c3d8574697008c1e145422d7f58c47c03fd736a54001244801f13"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/15649881/","title":"Activation of the vasoactive intestinal peptide 2 receptor modulates skeletal muscle mass and force","quote":"activation of VPAC2R, but not VPAC1R, reduced the loss of skeletal muscle mass and force during conditions of skeletal muscle disuse","summary":"2005 rodent study on VPAC2 activation and muscle preservation.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:28:03.811Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"3111b5552a2752892fb9b82c4c30848f5e72c8eef17cf6ef3497166eeb354e05"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/9149300/","title":"Ischemic-reperfused rat skeletal muscle: the effect of vasoactive intestinal peptide","quote":"VIP administration at the onset of reperfusion significantly increased skeletal muscle contractile force and tissue oxygenation even higher than baseline","summary":"1997 rat ischemia-reperfusion study with VIP.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:28:03.811Z","link_status":"ok","quote_status":"verified","prev":"3111b5552a2752892fb9b82c4c30848f5e72c8eef17cf6ef3497166eeb354e05","hash":"3ba4cff0b6f683143275cc76bdc8a0fe276a307ea41d3c7c01722ce54d78a240"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/27535909/","title":"Vasoactive intestinal peptide-deficient mice show altered body composition","quote":"VIP−/− mice showed a lower body weight and fat mass and an increased lean mass","summary":"Mouse knockout study on VIP and lean mass.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:28:03.811Z","link_status":"ok","quote_status":"unverified","prev":"3ba4cff0b6f683143275cc76bdc8a0fe276a307ea41d3c7c01722ce54d78a240","hash":"b8730b4ebfff780f7d940b4a1e847a8ed2e0b5d0f15091cd2fd61712aa6d38ce"},{"id":"s4","type":"review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6743256/","title":"Recent advances in vasoactive intestinal peptide physiology","quote":"VIP has multiple physiological and pathological effects","summary":"2019 review confirming lack of muscle-specific human trials.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:28:03.811Z","link_status":"ok","quote_status":"unverified","prev":"b8730b4ebfff780f7d940b4a1e847a8ed2e0b5d0f15091cd2fd61712aa6d38ce","hash":"800dff28eae0c90a4f2adfe84701fd1a5cffe07147800015fde0e1811beb1b13"},{"id":"s5","type":"reddit","url":"https://www.reddit.com/r/Biohack_Blueprint/comments/1u31ihv/the_peptide_nobody_talks_about_but_everyone/","title":"The peptide nobody talks about but everyone should: VIP","quote":"Mold illness and chronic inflammation does not get the same hype as fat loss or muscle growth. Two, VIP requires patience.","summary":"Anecdotal Reddit discussion on VIP uses.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:28:03.811Z","link_status":"ok","quote_status":"unverified","prev":"800dff28eae0c90a4f2adfe84701fd1a5cffe07147800015fde0e1811beb1b13","hash":"53091e66d70c3d8574697008c1e145422d7f58c47c03fd736a54001244801f13"}]}