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Epithelial cells fail to repair quickly enough. Nerve signaling in the gut wall shifts. These layers compound: barrier leak allows more triggers, immune imbalance sustains damage, and autonomic control of motility and secretion falters. Regeneration falls behind degeneration, so the condition continues.","status":"active","vx_hash":"ea47fb421e0d36e5bdf32ffbd2151539b4916099f812fef2876702cb5ef5a10a","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"195990284c718e97b98b62e059b8480ef6a7a94d583c74125a600528b458ad89","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"94ec4d731e0a201c18905c4999dcc0d117476f571d76f8b11a668070a6a289c5","detail":{"divided_from":"body","block":2,"kind":"p"},"prev":"genesis","hash":"195990284c718e97b98b62e059b8480ef6a7a94d583c74125a600528b458ad89"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d2"},{"id":"d3","kind":"h","type":null,"order":3,"text":"## Why VIP might help you","status":"active","vx_hash":"1f28ede6217470468faf58a0793e7f570e7577abc1b6a50eff2ac1f43422ee21","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"6e8d819ae868872c31181d69fdd2f32c5b36fe4c812660aa8e03bede9b7fffb9","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"2a6ba0f8b2ed4582e06cb2080e8de8e2c0adea0f26a4fbd7054aff027cad5a62","detail":{"divided_from":"body","block":3,"kind":"h"},"prev":"genesis","hash":"6e8d819ae868872c31181d69fdd2f32c5b36fe4c812660aa8e03bede9b7fffb9"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d3"},{"id":"d4","kind":"list","type":null,"order":4,"text":"1. You are reading about IBD (Crohn's / colitis) — what breaks down matters before any compound name.\n2. Therefore for you: If the immune / autonomic layer is part of your problem, VIP is discussed because it targets repair (tissue) — not because it masks pain.","status":"active","vx_hash":"4dec0c19e6ff39c5d4359c05c2f88f09440321dc1c65af649cd7ba468b17b52b","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"2c1bf7a2e7ee603fc981854e7baec3a94c52cd2b77ae590cab6af94e1adc9dfd","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"db0810c16505eae53ea30f970200af26a23889843355fe1920ade34af4eb9cd8","detail":{"divided_from":"body","block":4,"kind":"list"},"prev":"genesis","hash":"2c1bf7a2e7ee603fc981854e7baec3a94c52cd2b77ae590cab6af94e1adc9dfd"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d4"},{"id":"d5","kind":"p","type":null,"order":5,"text":"If immune over-activation drives your mucosal damage, VIP pathways connect to reduced pro-inflammatory signals and better epithelial recovery in studied models. If autonomic imbalance affects gut motility or secretion, VIP's natural role in those systems aligns with restoring balance rather than suppression alone.","status":"active","vx_hash":"e62742cf64c583450c90e42ddb53de6e005c19d0890b73e3dd5b0b82b6d60258","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"07fd9ba125f840e91e3183bf8357c8c9e2a46b3531c530afad1c9327d8e8f25f","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"c0977e698b41f84eafe5a7bfbe384137c009c0ee3661b7d01139fbec97758fb3","detail":{"divided_from":"body","block":5,"kind":"p"},"prev":"genesis","hash":"07fd9ba125f840e91e3183bf8357c8c9e2a46b3531c530afad1c9327d8e8f25f"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d5"},{"id":"d6","kind":"h","type":null,"order":6,"text":"## How these fit together","status":"active","vx_hash":"99fa34fe0f184df15245bdd6179287e2495609255e55f79e62028fefb3b6a674","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"a8e84e9e3a7ef113062831d70341717469a8b3a4275f166d8d635deeb00b1d60","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"255677f13849515d0e42f067e34911236d8b3298d6c16100bfa19e68c3074d62","detail":{"divided_from":"body","block":6,"kind":"h"},"prev":"genesis","hash":"a8e84e9e3a7ef113062831d70341717469a8b3a4275f166d8d635deeb00b1d60"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d6"},{"id":"d7","kind":"p","type":null,"order":7,"text":"Single-compound focus — if your condition profile includes a multi-peptide stack, siblings target other layers listed in the condition profile.","status":"active","vx_hash":"e9d5c983dc2010eb61dccb3bf3f2b835ae7b79b18f81d35093c428f4f2711c42","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"653215b5102e073a070c44c237d8b89aea5125ec68f1b5c93dfed5ebe1c20823","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"c2ad98828fc97845a2d8301bcbb28499a499eca01d27b8754f58a5bd039ad6e9","detail":{"divided_from":"body","block":7,"kind":"p"},"prev":"genesis","hash":"653215b5102e073a070c44c237d8b89aea5125ec68f1b5c93dfed5ebe1c20823"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d7"},{"id":"d8","kind":"list","type":null,"order":8,"text":"- VIP → immune / autonomic","status":"active","vx_hash":"ce20f7e0d55d192d8ba9de56d6b3392ba6b5e7a68a8697bf7b5b000c8a818e6a","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"bdf0c6513829d02200a8d060dfaa0638f79c694837ebd042b61f1d5b9ea3efd0","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"6f6cf3086f6713cae2a9df297b4698f4715a84b0e6b142dd5efa7c35a97e5d0f","detail":{"divided_from":"body","block":8,"kind":"list"},"prev":"genesis","hash":"bdf0c6513829d02200a8d060dfaa0638f79c694837ebd042b61f1d5b9ea3efd0"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d8"},{"id":"d9","kind":"h","type":null,"order":9,"text":"## What the evidence actually shows","status":"active","vx_hash":"26f54b1e13074dfea025a654b29f7e7767b033b2aa7f3e6ae5fa865a9c224ea1","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"80a1116e29d863ed62e1a9bc267409bb8edce7e1a37fa8bfec18046deabb02a5","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"a7a051e6a294dc45c15b7d4859b7020d561e719fe73844f03e3a8f9e7fed8de1","detail":{"divided_from":"body","block":9,"kind":"h"},"prev":"genesis","hash":"80a1116e29d863ed62e1a9bc267409bb8edce7e1a37fa8bfec18046deabb02a5"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d9"},{"id":"d10","kind":"p","type":null,"order":10,"text":"Human data: Observational only. One cross-sectional and prospective study of 115 adults with IBD measured VIP concentrations and found variable plasma levels that differed by disease severity (source s1). Another examined VIP nerves in Crohn's tissue and noted consistent increases and abnormal appearance in rectal samples (source s2). These show associations, not treatment effects.","status":"active","vx_hash":"31ce90baa4d780829bd07d3c5d13188ef1307e7a79219bd6df7ef342d34fadc7","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"dd9d25f62a843ba595bc2fc09c2f34a2038c0618b5e98b8c1e66635e253c0e0b","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"cf5b16f1b9f6f09de4799c88a45232af2e586b021ce7168738f17985c6e5ca82","detail":{"divided_from":"body","block":10,"kind":"p"},"prev":"genesis","hash":"dd9d25f62a843ba595bc2fc09c2f34a2038c0618b5e98b8c1e66635e253c0e0b"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d10"},{"id":"d11","kind":"p","type":null,"order":11,"text":"Preclinical data: Multiple mouse and rat studies. In TNBS-induced colitis (model sharing features with Crohn's), VIP treatment reduced clinical signs including weight loss, diarrhea, and histologic inflammation (source s3). VIP nanomedicine in DSS and TNBS mouse colitis lowered pro-inflammatory cytokines, improved histology, and supported tight junction proteins (source s4). VIP-deficient mice showed greater susceptibility to chemically induced colitis in some experiments, with exogenous VIP rescuing barrier features (source s5). Results are mixed across studies; some report exacerbation depending on model and microbiota (source s5).","status":"active","vx_hash":"7e632b42ef621f98edabfc5928456cd9473148489682ac69566fc87c9aedc819","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"6d83074ccddb62da885dc54389c934d48fcce8165e4e9cb9c68366e4548b565e","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"c0b834bf0f50286f712558fda5ab87a13e71ac9b90e871c62d1f7ad435564833","detail":{"divided_from":"body","block":11,"kind":"p"},"prev":"genesis","hash":"6d83074ccddb62da885dc54389c934d48fcce8165e4e9cb9c68366e4548b565e"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d11"},{"id":"d12","kind":"p","type":null,"order":12,"text":"Anecdotal data: Limited. One Reddit thread states VIP is among the better researched compounds for Crohn's via upstream immune effects on gut lining (source s6). Other posts discuss VIP in unrelated contexts such as CIRS or Raynaud's with no IBD-specific outcomes reported.","status":"active","vx_hash":"e8f50192fc14f64b3968cb06462cdaa7c25ed2e96094a40990ac142008d94a4c","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"e856802f4b1126a0d005bb785f3fe399a7ed3cc664e641c92704d33cddf9fdb2","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"9380b9d0eba82d65567bc0767ab69f674abd94bca2a4c8e72f4b66fc57e40e79","detail":{"divided_from":"body","block":12,"kind":"p"},"prev":"genesis","hash":"e856802f4b1126a0d005bb785f3fe399a7ed3cc664e641c92704d33cddf9fdb2"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d12"},{"id":"d13","kind":"h","type":null,"order":13,"text":"## What scientists say","status":"active","vx_hash":"dcf0d9125e465d2e7ab791692a80baf75f0c82b124c84c5d1a133103f1de4676","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"c86b674d2f5f0ec42712cbe308a3e312f551e941ef8b9ecf201ecf79cf4f3864","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"2f1dd55083de1fa734f2f06a8337a050d5a0b3f635bfc8bb709abab75705a1ef","detail":{"divided_from":"body","block":13,"kind":"h"},"prev":"genesis","hash":"c86b674d2f5f0ec42712cbe308a3e312f551e941ef8b9ecf201ecf79cf4f3864"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d13"},{"id":"d14","kind":"p","type":null,"order":14,"text":"Researchers note VIP's immunomodulatory properties in colitis models and suggest it as a candidate for further testing in Crohn's, while highlighting inconsistent findings in knockout models and human expression data (sources s3, s5). Emphasis remains on preclinical promise rather than clinical translation.","status":"active","vx_hash":"953e31611c5eb8657019f3a033565ca82bd548380cee3cf706f9f2965c32ec20","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"91adc881f978134e55841cc2d16f339d74be82aa4ad768021398b0dfcbc4a635","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"0a9a90238bf980db3d9b159be9fb4d938ec86916a8635115c2638e14729e8a4c","detail":{"divided_from":"body","block":14,"kind":"p"},"prev":"genesis","hash":"91adc881f978134e55841cc2d16f339d74be82aa4ad768021398b0dfcbc4a635"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d14"},{"id":"d15","kind":"h","type":null,"order":15,"text":"## What people say on Reddit","status":"active","vx_hash":"fd23857e0698c90b905fc7bc43b9b84c1f959bd59c3c9bb75d3b3f275d7c11bc","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"f85a3a62372d9914502a9d7f515b05328f48f7e6b8511cde382b95ad680d70ab","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"feb303756a303788527cf602bf2c3c6b00ab8c384fb9fff4baa9ffc53e0049c3","detail":{"divided_from":"body","block":15,"kind":"h"},"prev":"genesis","hash":"f85a3a62372d9914502a9d7f515b05328f48f7e6b8511cde382b95ad680d70ab"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d15"},{"id":"d16","kind":"p","type":null,"order":16,"text":"Discussions are sparse. Users mention VIP's anti-inflammatory profile and one notes specific research interest in Crohn's. No detailed personal outcome reports tied to IBD treatment appear in top results.","status":"active","vx_hash":"0df3678c23b44b6281682fae3a6a369d143d091bec9172ab2771543443338a9f","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"412c2ce374b141e9d267d8a6bc5bd1f0188a0cae7cedbff9a328fcd1ae919625","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"2c8a98c335360f5f48255cf003fd2e5efc2cf632ea2425036afca0319e67838b","detail":{"divided_from":"body","block":16,"kind":"p"},"prev":"genesis","hash":"412c2ce374b141e9d267d8a6bc5bd1f0188a0cae7cedbff9a328fcd1ae919625"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d16"},{"id":"d17","kind":"h","type":null,"order":17,"text":"## What people say on X","status":"active","vx_hash":"a225a35aafe2a5971799ab44df3847a7b839f3967c4ade8d31a392287b07d3f4","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"2af56549b4b66d1729f4df4c3c0636fb398c25858f03036877217ea56e5a696f","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"4dd8bbfdb0452cc6235c2300209b5132daba3913b8f54ab179b1a73109c298dd","detail":{"divided_from":"body","block":17,"kind":"h"},"prev":"genesis","hash":"2af56549b4b66d1729f4df4c3c0636fb398c25858f03036877217ea56e5a696f"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d17"},{"id":"d18","kind":"p","type":null,"order":18,"text":"No relevant patient experiences or outcome reports surfaced in searches for VIP in IBD contexts.","status":"active","vx_hash":"1dd882c0b5a60d56af64926366b9bb51f67d6d9feaafab291344a41c8a44f7d9","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"6f4c8120a76ef6061cdc577117649d7cfb29758b58b543e47d4e9fa3f7aa86fb","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"ddfcfaffb2cb00d9b9844a582ad76201ef81d1df61231481b2cddc82ccd61c95","detail":{"divided_from":"body","block":18,"kind":"p"},"prev":"genesis","hash":"6f4c8120a76ef6061cdc577117649d7cfb29758b58b543e47d4e9fa3f7aa86fb"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d18"},{"id":"d19","kind":"h","type":null,"order":19,"text":"## What we do not know","status":"active","vx_hash":"6fd2fc0a41318f05b66628aeeb02d9de391cf8b9341e898866bbee093446dcd7","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"6dd9dbfffaaa490deb145514c9e00bb42d8ff8c4c9cda83618d166c9a7928aaa","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"7d96a49fba77f6a48c0321db2ae4180a902beae62e2aac0d23408fbf8333a177","detail":{"divided_from":"body","block":19,"kind":"h"},"prev":"genesis","hash":"6dd9dbfffaaa490deb145514c9e00bb42d8ff8c4c9cda83618d166c9a7928aaa"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d19"},{"id":"d20","kind":"p","type":null,"order":20,"text":"No published human intervention trials test VIP administration for IBD symptom control or mucosal healing. Optimal delivery, duration, and patient selection remain untested in controlled settings. Long-term effects on human gut microbiota or barrier repair are unknown.","status":"active","vx_hash":"979f065c95f509995ce4de7626be5cf4d79dc2eb37a344ff077be68d995dada5","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"46bd845547ea13210c65a8277b013c3d71ea042496a749957ea4ef079f0c265b","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"923beb71e9270e51225160841354a5270672c7109d2e1cb529ace10b2e863cef","detail":{"divided_from":"body","block":20,"kind":"p"},"prev":"genesis","hash":"46bd845547ea13210c65a8277b013c3d71ea042496a749957ea4ef079f0c265b"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d20"},{"id":"d21","kind":"h","type":null,"order":21,"text":"## Safety and limits","status":"active","vx_hash":"74b02d6441f4f090947c26635008f69f22d363f2e378546effe98940db315c68","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"537b1728d543fd9dcaf982207f5b9d5c9dd45005deeffd0fa03402f3d28b8b2c","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"404f7427c043c6ec7a5cb4416bbec9ec336e19f8757fb217be5c5c2161ff8cb6","detail":{"divided_from":"body","block":21,"kind":"h"},"prev":"genesis","hash":"537b1728d543fd9dcaf982207f5b9d5c9dd45005deeffd0fa03402f3d28b8b2c"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d21"},{"id":"d22","kind":"p","type":null,"order":22,"text":"VIP is a naturally occurring peptide with documented effects in animal colitis models, but human safety data for therapeutic use in IBD do not exist in the reviewed sources. Observational human studies report no direct safety signals from measurement alone. All therapeutic claims rest on preclinical work.","status":"active","vx_hash":"4579fbfb801783ac73adfb571c733e42fe70a72d37b277b1d28b82b435ba7895","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"70cf5e62a10075d51ed0cdd8725e78790c058a882b30ec7d9be3b15109ee7c8a","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:43:24.692Z","actor":"owner","text_sha":"3eae7b31ec3e093f25ef3b993c5e32c8f098df3b05d4bc229dd09ff40fa89f9b","detail":{"divided_from":"body","block":22,"kind":"p"},"prev":"genesis","hash":"70cf5e62a10075d51ed0cdd8725e78790c058a882b30ec7d9be3b15109ee7c8a"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:43:24.692Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/vip-ibd/d22"}],"voxels":[{"id":"c1","div_id":"claim:c1","kind":"claim","text":"VIP treatment reduced clinical and histologic severity in TNBS-induced colitis in 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article has a human side (/a/vip-ibd) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"vip-ibd\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"vip-ibd\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"vip-ibd\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"vip-ibd\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"vip-ibd\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"vip-ibd\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/vip-ibd/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/vip-ibd/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/vip-ibd#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."},"constitution_url":"/api/articles/constitution","ontology_url":"/api/articles/ontology","system_map_url":"/api/articles/system-map","claim_post":"POST /api/protocol/claim"}