{"slug":"vip-ibd","verification":{"valid":true,"entries":6,"head":"d7f83bf06126e68fe70ae305e514ea16679779771ba4acf1b2066ac59b3a3eee"},"count":6,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/2791804/","title":"Vasoactive intestinal peptide as a laboratory supplement to clinical testing in inflammatory bowel disease","quote":"One hundred-fifteen adult IBD patients were studied cross-sectionally and prospectively, 48 with ulcerative colitis (UC) and 67 with Crohn's disease (CD).","summary":"Observational measurement of VIP in IBD patients.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:29:32.935Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"fee95fb26e17ba61c05e452055063c3908e4ebd22d57d53cd82a56ef6e993b4e"},{"id":"s2","type":"pubmed","url":"https://gut.bmj.com/content/25/1/57","title":"Vasoactive intestinal peptide concentrations and immunocytochemistry in the colon of patients with Crohn's disease","quote":"Immunocytochemistry revealed a consistent increase in, and abnormal appearance of, VIP nerves in patients with Crohn's disease not only those with rectal...","summary":"Tissue findings in Crohn's patients.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:29:32.935Z","link_status":"http_403","quote_status":"unverified","prev":"fee95fb26e17ba61c05e452055063c3908e4ebd22d57d53cd82a56ef6e993b4e","hash":"d52d9ae4269ca5e80ee1e794e78b6d34d032d7b686efb06d6b9ae55e149de473"},{"id":"s3","type":"pubmed","url":"https://www.gastrojournal.org/article/S0016-5085(03)00055-6/fulltext","title":"Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease","quote":"Treatment with VIP reduced the clinical and histopathologic severity of TNBS-induced colitis, abrogating body weight loss, diarrhea, and macroscopic and microscopic intestinal inflammation.","summary":"Mouse TNBS colitis study showing reduced severity.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:29:32.935Z","link_status":"http_403","quote_status":"unverified","prev":"d52d9ae4269ca5e80ee1e794e78b6d34d032d7b686efb06d6b9ae55e149de473","hash":"126f99982f20657e48b5770f8c0e525f89652a833a8c0ecdf30fb69b7d4cdfb4"},{"id":"s4","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6053281/","title":"Vasoactive Intestinal Peptide Nanomedicine for the Treatment of Inflammatory Bowel Disease","quote":"We demonstrate the therapeutic benefit of VIP-SSM over free peptide in reversing severe colitis associated with IBD.","summary":"Nanomedicine improved inflammation and barrier markers in mouse models.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:29:32.935Z","link_status":"ok","quote_status":"verified","prev":"126f99982f20657e48b5770f8c0e525f89652a833a8c0ecdf30fb69b7d4cdfb4","hash":"4b8b21ae33c77c99fc987b09fd23dc1187bad497c4a9b03692618a2bcf8edbbc"},{"id":"s5","type":"pubmed","url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.02689/full","title":"Vasoactive Intestinal Peptide Deficiency Is Associated With Dysbiosis and Altered Short-Chain Fatty Acid Levels in the Gastrointestinal Tract","quote":"In some studies, VIP knockout mice were more susceptible to chemically-induced intestinal inflammation, and human inflammatory bowel disease (IBD) patients show a reduction in VIP positive nerves proximal to severe mucosal damage.","summary":"Reviews mixed preclinical and human expression data.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:29:32.935Z","link_status":"ok","quote_status":"verified","prev":"4b8b21ae33c77c99fc987b09fd23dc1187bad497c4a9b03692618a2bcf8edbbc","hash":"ca265033e771dbdca1d8650d256ae91c52e1b1619fb4bb52da0404dc97aa1952"},{"id":"s6","type":"reddit","url":"https://www.reddit.com/r/Biohack_Blueprint/comments/1u31ihv/the_peptide_nobody_talks_about_but_everyone/","title":"The peptide nobody talks about but everyone should: VIP","quote":"VIP is actually one of the better researched compounds for Crohn's specifically. it works upstream on the immune response in the gut lining ...","summary":"Community comment on research relevance.","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:29:32.935Z","link_status":"ok","quote_status":"unverified","prev":"ca265033e771dbdca1d8650d256ae91c52e1b1619fb4bb52da0404dc97aa1952","hash":"d7f83bf06126e68fe70ae305e514ea16679779771ba4acf1b2066ac59b3a3eee"}]}