{"slug":"vip-ibd","verification":{"valid":true,"entries":2,"head":"f166b51d2487059804034ffaec44d3ff5d841148eed249f8cfe00dd198300320"},"energy":{"passes":2,"tokens_in":14853,"tokens_out":2907,"tokens_total":17760,"cost_usd":0,"models":{"grok/grok-4.3":1,"owner":1},"head":"f166b51d2487059804034ffaec44d3ff5d841148eed249f8cfe00dd198300320"},"provenance":[{"ts":"2026-06-29T22:29:35.771Z","model":"grok/grok-4.3","action":"write","prompt":"","input":"Write a data-first, evidence-graded article: Vip for Ibd\nSlug: vip-ibd\nAudience: readers researching peptide evidence for this specific condition or drug cross.\nRules: label every claim tier (human|preclinical|anecdotal|mechanistic|speculative). Separate human trials from rat studies from Reddit/X anecdotes. No medical claims. Repair-vs-suppression framing. register: source_ledger.\n\nENRICHMENT BRIEF (binding section logic — one ## per compound):\n{\"voice\":\"enrichment\",\"article_shape\":\"single_cross\",\"condition\":\"IBD (Crohn's / colitis)\",\"condition_key\":\"ibd-crohns-colitis\",\"primary_peptide\":\"vip\",\"peptides_in_scope\":[{\"id\":\"vip\",\"name\":\"VIP\"}],\"drugs_in_scope\":[],\"weight_sensitive\":false,\"stimulant_context\":false,\"breaking_down\":{\"section_title\":\"What's breaking down if you have IBD (Crohn's / colitis)\",\"degenerative_why\":[],\"degenerative_layers\":[],\"note\":\"No condition profile matched — infer degeneration layers from slug/title and ledger claims.\"},\"peptide_chains\":[{\"peptide\":\"vip\",\"name\":\"VIP\",\"section_title\":\"Why VIP might help you\",\"layer\":\"immune / autonomic\",\"steps\":[\"You are reading about **IBD (Crohn's / colitis)** — what breaks down matters before any compound name.\",\"**Therefore for you:** If that layer is part of your problem, VIP is discussed because it targets repair (tissue) — not because it masks pain.\"],\"prose\":\"1. You are reading about **IBD (Crohn's / colitis)** — what breaks down matters before any compound name.\\n2. **Therefore for you:** If that layer is part of your problem, VIP is discussed because it targets repair (tissue) — not because it masks pain.\"}],\"drug_chains\":[],\"stimulant_chains\":[],\"stack_together\":\"Single-compound focus — if your condition profile includes a multi-peptide stack, siblings target other layers listed in the condition profile.\\n- **VIP** → immune / autonomic\",\"section_headings\":[\"What's breaking down if you have IBD (Crohn's / colitis)\",\"Why VIP might help you\",\"How these fit together\",\"What the evidence actually show","response":"{\n  \"slug\": \"vip-ibd\",\n  \"title\": \"VIP for IBD: Evidence Graded Review of Vasoactive Intestinal Peptide in Crohn's Disease and Colitis\",\n  \"body\": \"## What's breaking down if you have IBD (Crohn's / colitis)\\n\\nIf your intestinal lining loses barrier integrity, immune cells over-respond and inflammation persists. Epithelial cells fail to repair quickly enough. Nerve signaling in the gut wall shifts. These layers compound: barrier leak allows more triggers, immune imbalance sustains damage, and autonomic control of motility and secretion falters. Regeneration falls behind degeneration, so the condition continues.\\n\\n## Why VIP might help you\\n\\n1. You are reading about IBD (Crohn's / colitis) — what breaks down matters before any compound name.\\n2. Therefore for you: If the immune / autonomic layer is part of your problem, VIP is discussed because it targets repair (tissue) — not because it masks pain.\\n\\nIf immune over-activation drives your mucosal damage, VIP pathways connect to reduced pro-inflammatory signals and better epithelial recovery in studied models. If autonomic imbalance affects gut motility or secretion, VIP's natural role in those systems aligns with restoring balance rather than suppression alone.\\n\\n## How these fit together\\n\\nSingle-compound focus — if your condition profile includes a multi-peptide stack, siblings target other layers listed in the condition profile.\\n- VIP → immune / autonomic\\n\\n## What the evidence actually shows\\n\\nHuman data: Observational only. One cross-sectional and prospective study of 115 adults with IBD measured VIP concentrations and found variable plasma levels that differed by disease severity (source s1). Another examined VIP nerves in Crohn's tissue and noted consistent increases and abnormal appearance in rectal samples (source s2). These show associations, not treatment effects.\\n\\nPreclinical data: Multiple mouse and rat studies. In TNBS-induced colitis (model sharing features with Crohn's), VIP treatment reduc","tokens_in":14853,"tokens_out":2907,"cost":0,"prev":"genesis","hash":"a94782d019f0b75f086062abb34cf43f39739266220e124c6161e8416bae1a8e"},{"ts":"2026-07-17T02:43:24.692Z","model":"owner","action":"voxel_divide","prompt":"","input":"vip-ibd","response":"22 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"a94782d019f0b75f086062abb34cf43f39739266220e124c6161e8416bae1a8e","hash":"f166b51d2487059804034ffaec44d3ff5d841148eed249f8cfe00dd198300320"}]}