{"slug":"vip-cognition","verification":{"valid":true,"entries":5,"head":"67d44403935007db9acc7b32573d59b96931e009f67642a151562d1d0fb83f71"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://www.nature.com/articles/s41598-020-80873-2","title":"Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females","quote":"VIP plasma levels to be negatively associated with overall low symptoms of anxiety and depression in healthy individuals.","summary":"Observational human study linking plasma VIP to lower affective symptoms and brain metrics.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:34:15.656Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"84cf6ee5b4fcec9e3063adb256ceff341d80a21d6582f8f1f898c679b9b30703"},{"id":"s15","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/30498985/","title":"Vasoactive Intestinal Peptide Decreases β-Amyloid Accumulation and Prevents Brain Atrophy in the 5xFAD Mouse Model of Alzheimer's Disease","quote":"Chronic administration of VIP significantly decreased the levels of Aβ40 and Aβ42 plaques... and preserved against atrophy.","summary":"Preclinical study showing amyloid reduction and volume preservation in AD mice.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:34:15.656Z","link_status":"ok","quote_status":"unverified","prev":"84cf6ee5b4fcec9e3063adb256ceff341d80a21d6582f8f1f898c679b9b30703","hash":"b44b0526f9a1dc964da0b7c2a7f10d17c78ae9c9d75fc768bd43d1dadca24113"},{"id":"s3","type":"pubmed","url":"https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2020.00153/full","title":"VIP Modulation of Hippocampal Synaptic Plasticity: A Role for VIP Receptors as Therapeutic Targets in Cognitive Decline and Mesial Temporal Lobe Epilepsy","quote":"VIP-mediated hippocampal disinhibition of pyramidal cell activity was shown to play a crucial role in goal-directed spatial learning tasks.","summary":"Review detailing VIP interneuron function in hippocampal learning.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:34:15.656Z","link_status":"ok","quote_status":"unverified","prev":"b44b0526f9a1dc964da0b7c2a7f10d17c78ae9c9d75fc768bd43d1dadca24113","hash":"d0dbe74b35290e696a65e99392319b26a86b84b1b85bf7a74d0ecd9b3725cdbe"},{"id":"s39","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/2178250/","title":"Select cognitive deficits in Vasoactive Intestinal Peptide deficient mice","quote":"The VIP-deficient mice exhibited a significant reduction in recall when tested 48-hours or longer after training.","summary":"Demonstrates memory deficits in VIP knockout mice.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:34:15.656Z","link_status":"ok","quote_status":"unverified","prev":"d0dbe74b35290e696a65e99392319b26a86b84b1b85bf7a74d0ecd9b3725cdbe","hash":"f726e98b28e36389a61ade5e65d91a7ee514f53cbfc7ae06ca1eabeb96b3be3f"},{"id":"s24","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1c6p3s4/vip_seemed_to_improve_cognitive_function_but/","title":"VIP seemed to improve cognitive function but increased depression/irritability","quote":"VIP seemed to improve cognitive function but increased depression/irritability. grumpiness, irritability/impatience, and general discontent.","summary":"Single user anecdote on mixed cognitive and mood effects.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:34:15.656Z","link_status":"ok","quote_status":"unverified","prev":"f726e98b28e36389a61ade5e65d91a7ee514f53cbfc7ae06ca1eabeb96b3be3f","hash":"67d44403935007db9acc7b32573d59b96931e009f67642a151562d1d0fb83f71"}]}