{"slug":"vip-chemo","verification":{"valid":true,"entries":5,"head":"4c48f50db0ca655c47da46c7b949202768126c6c45e5d55d131f1f2115582fc8"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://www.nature.com/articles/cddis2017226","title":"Cytoprotective effect of neuropeptides on cancer stem cells","quote":"Of the several neuropeptides tested, only VIP could protect CSCs from drug-induced apoptosis.","summary":"2017 preclinical study on VIP protecting cancer stem cells from chemo drugs","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:34:59.068Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"d21dd1ec7ee249676b199fb9e1c262404607c800aa1d81f11e281bac68a7045e"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/17544169/","title":"Vasoactive intestinal peptide enhances growth and angiogenesis in prostate cancer","quote":"We show that vasoactive intestinal peptide (VIP) exerts trophic and proangiogenic activities in experimental prostate cancer in vivo.","summary":"2007 mouse xenograft study","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:34:59.068Z","link_status":"ok","quote_status":"verified","prev":"d21dd1ec7ee249676b199fb9e1c262404607c800aa1d81f11e281bac68a7045e","hash":"cf9c05417caf1c79994dfdba463c2993855761bc31ee9b3b51526707b45cd865"},{"id":"s3","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4768440/","title":"Pregabalin in Chemotherapy Induced Neuropathic Pain","quote":"We present a case series of patients with chemotherapy-induced peripheral neuropathy who were successfully treated with pregabalin","summary":"2016 human case series","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:34:59.068Z","link_status":"ok","quote_status":"verified","prev":"cf9c05417caf1c79994dfdba463c2993855761bc31ee9b3b51526707b45cd865","hash":"1519d44062d606f43fd72542b50021acec180ddfc47f7b18a70258a357cb1cb1"},{"id":"s4","type":"review","url":"https://www.cancernetwork.com/view/new-practical-approaches-chemotherapy-induced-neuropathic-pain-prevention-assessment-and-treatment","title":"New Practical Approaches to Chemotherapy-Induced Neuropathic Pain","quote":"a recent systematic review finding “insufficient evidence to confirm the efficacy” of central nervous system (CNS) drugs for CIPN","summary":"2016 review on CIPN treatments","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:34:59.068Z","link_status":"ok","quote_status":"verified","prev":"1519d44062d606f43fd72542b50021acec180ddfc47f7b18a70258a357cb1cb1","hash":"2cc76ae826e7023da7425b002b4db774a6b910451eec6c763911ebe35af967c2"},{"id":"s5","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT03989817","title":"The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP)","quote":"The main study is a double-blind, randomized, cross-over trial among placebo... and VIP","summary":"Trial not in chemo patients","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:34:59.068Z","link_status":"ok","quote_status":"unverified","prev":"2cc76ae826e7023da7425b002b4db774a6b910451eec6c763911ebe35af967c2","hash":"4c48f50db0ca655c47da46c7b949202768126c6c45e5d55d131f1f2115582fc8"}]}