{"_self":{"principle":"Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.","widget":"article_bundle","feature":"bundle","name":"LLM article bundle","what":"Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.","contains":"body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest","slug":"vip-chemo","urls":{"read":"https://miscsubjects.com/api/articles/vip-chemo/bundle?format=markdown"},"how_to_use":"Reference bundle for an LLM or reader. §SELF explains the surface; ingest and claim endpoints in llm_manifest are the write-back routes.","write":null,"imessage":null,"router_tag":null,"proof_chain":[{"step":1,"claim":"Articles are voxel graphs of tiered claims, not prose blobs.","verify":"https://miscsubjects.com/api/articles/constitution"},{"step":2,"claim":"Claims link to hash-chained sources via source_ids.","verify":"https://miscsubjects.com/api/articles/vip-chemo/sources"},{"step":3,"claim":"Ask reads topology; ingest/claim append to ledger.","verify":"https://miscsubjects.com/api/protocol"},{"step":4,"claim":"Models queue growth: populate → collaborate → repair → reflex.","verify":"https://miscsubjects.com/api/protocol/grow"},{"step":5,"claim":"Graph proves its own shape (reflex) and $/claim (yield).","verify":"https://miscsubjects.com/graph.html?layer=reflex"},{"step":6,"claim":"Full feature index + _explain on every API response.","verify":"https://miscsubjects.com/api/articles/system-map"}],"related_features":[{"id":"topology","name":"Article topology","what":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER.","urls":{"read":"https://miscsubjects.com/api/articles/vip-chemo/topology"}},{"id":"voxels","name":"Voxel graph","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance.","urls":{"read":"https://miscsubjects.com/api/articles/vip-chemo/voxels","write":"https://miscsubjects.com/api/protocol/claim"}},{"id":"ask","name":"Ask protocol","what":"Answer only from topology; creates question_node with gaps and ingest_hint.","urls":{"read":"https://miscsubjects.com/api/articles/vip-chemo/prompts","write":"https://miscsubjects.com/api/protocol/ask"}},{"id":"ingest","name":"Ingest protocol","what":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","urls":{"write":"https://miscsubjects.com/api/protocol/ingest"}},{"id":"claim_post","name":"Claim post protocol","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by.","urls":{"read":"https://miscsubjects.com/api/articles/vip-chemo/voxels","write":"https://miscsubjects.com/api/protocol/claim"}},{"id":"llm_manifest","name":"LLM manifest","what":"Machine-readable read/write contract for external LLMs.","urls":{"read":"https://miscsubjects.com/api/articles/llm-manifest"}}],"system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","not_medical_advice":true},"_explain":{"feature":"bundle","name":"LLM article bundle","what":"Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.","why":"Every feature is auditable collective intelligence","how":"Reference bundle for an LLM or reader. §SELF explains the surface; ingest and claim endpoints in llm_manifest are the write-back routes.","model":null,"verifies":null,"urls":{"read":"https://miscsubjects.com/api/articles/vip-chemo/bundle?format=markdown"},"imessage":null,"router":null,"related":[{"id":"topology","what":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER."},{"id":"voxels","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance."},{"id":"ask","what":"Answer only from topology; creates question_node with gaps and ingest_hint."},{"id":"ingest","what":"Parse pasted evidence → source ledger + claims + evidence_ingest node."},{"id":"claim_post","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by."},{"id":"llm_manifest","what":"Machine-readable read/write contract for external LLMs."}],"not_medical_advice":true},"MASTHEAD":{"sorry_status":"planes not merged yet — sorry-status activates after voxel-merge-planes","identity":{"slug":"vip-chemo","version":2,"content_hash":"649688271bceaac88eec7eb0243d085ccc5961cf3262e1ec2c4ecdbffc017004","thread_head":"genesis","divs":29},"thesis":{"root_claim":"c1","text":"VIP protects breast cancer stem cells from drug-induced apoptosis in cell models","tier":"preclinical"},"load_bearing":[{"id":"c4","tier":"human","status":"active","text":"Reviews find insufficient RCT evidence that gabapentinoids outperform placebo for CIPN pain"},{"id":"c5","tier":"human","status":"active","text":"No human trials test VIP peptide for post-chemotherapy recovery or CIPN"},{"id":"c2","tier":"preclinical","status":"active","text":"VIP increases tumor growth and angiogenesis in mouse prostate cancer xenograft model"},{"id":"c3","tier":"anecdotal","status":"active","text":"Pregabalin reduced hyperalgesia and allodynia in a small case series of CIPN patients"}],"standing_objections":{"open":0,"strongest_open":null,"link":"https://miscsubjects.com/api/articles/vip-chemo/discourse"},"verbs":{"read":"GET https://miscsubjects.com/api/articles/vip-chemo/voxels — DIVs + hashes + chains (free)","read_claims":"GET https://miscsubjects.com/api/articles/vip-chemo/claims — every formal claim as claim:<id> with current hash, thread, stable link, and exact contribution/edit bodies","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {slug, expected_thread_head, target_div?, expected_hash?, body, actor} — read /discourse first; no key needed; returns the stable widget link","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {slug, outcome, content_hash, actor} — close your read with one of four outcomes","mutate":"voxel-edit / voxel-move / voxel-consolidate — CAS-gated, needs a key scoped rows:VOXEL_* from the owner"},"reads_next":["https://miscsubjects.com/a/philosophy","https://miscsubjects.com/api/articles/vip-chemo/discourse","https://miscsubjects.com/api/protocol"]},"bundle_version":1,"generated_at":"2026-07-29T18:46:34.412Z","slug":"vip-chemo","title":"VIP Peptide for Chemotherapy Contexts: Evidence on Immune and Autonomic Layers","url":"https://miscsubjects.com/a/vip-chemo","register":"source_ledger","tags":["peptide","matrix"],"posted_at":"2026-06-29T21:33:48.912Z","updated_at":"2026-07-17T02:43:22.415Z","body":"## What's breaking down\n\nChemotherapy often damages nerves, triggers widespread inflammation, and disrupts autonomic signaling. These layers can persist because repair processes lag behind ongoing breakdown. VIP (vasoactive intestinal peptide) is discussed in research for its potential effects on immune modulation and autonomic regulation rather than direct nerve repair or symptom masking.\n\nChemo-induced peripheral neuropathy (CIPN) involves nerve fiber damage and altered calcium signaling in dorsal root ganglia. Inflammatory cytokines rise during treatment. Autonomic imbalance can appear as changes in vascular tone or gut motility. No single peptide addresses all layers at once.\n\n## Why VIP might help you\n\nIf immune or autonomic dysregulation forms part of your post-chemo experience, VIP enters discussions because studies examine its role in tissue-level signaling rather than pain signal suppression.\n\n1. VIP receptors appear on immune cells and autonomic nerve endings.\n2. Preclinical work explores whether VIP influences cytokine balance or vascular responses.\n3. Therefore for you: If that layer is part of your problem, VIP is discussed because it targets repair (tissue) — not because it masks pain.\n\n## Why Gabapentin / pregabalin matters for you\n\n**Drug:** Gabapentin / pregabalin\n\n**What it does:** Masks neuropathic pain signal; does not repair nerve.\n\n**Therefore for you:** This drug suppresses a signal. It can reduce perceived pain intensity during recovery windows but trades off any direct support for nerve regeneration pathways. The relief may allow better daily function while repair mechanisms operate separately.\n\n## How these fit together\n\nSingle-compound focus — if your condition profile includes a multi-peptide stack, siblings target other layers listed in the condition profile.\n- **VIP** → immune / autonomic\n\nVIP and gabapentin/pregabalin address separate aspects: one examined for signaling in immune and autonomic tissue, the other for temporary signal suppression. They do not overlap in mechanism or claimed outcome.\n\n## What the evidence actually shows\n\nHuman data on VIP peptide specifically in chemotherapy patients remains absent. One clinical trial (NCT03989817) tested VIP infusion but in a non-chemo population. Preclinical studies in cell lines and animal models predominate.\n\nA 2017 study in Nature Cell Death & Disease used breast cancer stem cell models and found VIP protected cells from drug-induced apoptosis (preclinical). A 2007 xenograft study in nude mice showed VIP increased prostate tumor growth and angiogenesis (preclinical). A 2001 study reported a VIP analog enhanced growth in certain cancer models (preclinical). These findings indicate potential pro-tumor activity rather than protective effects against chemo damage.\n\nFor gabapentin/pregabalin in CIPN: A 2016 case series described symptom reduction in a small number of patients (human, anecdotal-level within series). A 2022 review noted insufficient evidence from RCTs that these agents outperform placebo for CIPN pain specifically (human review). Duloxetine carries stronger RCT support for CIPN.\n\n## What scientists say\n\nResearchers note VIP's dual potential: it modulates inflammation in some non-cancer contexts yet can activate anti-apoptotic pathways in cancer cells (mechanistic). Reviews on VIP/PACAP receptors in tumors emphasize context-dependent effects (review, preclinical dominant). No consensus supports VIP peptide as an adjunct for chemo recovery in humans.\n\n## What people say on Reddit\n\nDiscussions of VIP peptide center on CIRS or MCAS rather than chemotherapy (anecdotal). Posts about “VIP chemo” typically refer to the etoposide-ifosfamide-cisplatin regimen used in testicular cancer, not the peptide (anecdotal). No widespread reports link VIP nasal spray or injections to chemo neuropathy relief.\n\n## What people say on X\n\nSearches for VIP peptide combined with chemotherapy or CIPN yield no relevant posts (anecdotal, none found).\n\n## What we do not know\n\nNo human trials exist testing VIP peptide for CIPN, autonomic recovery, or immune reset after chemotherapy. Long-term effects on tumor recurrence risk remain unstudied in this setting. Interaction data with gabapentinoids is absent. Dose, route, and timing questions lack answers.\n\n## Safety and limits\n\nVIP occurs naturally but exogenous forms carry unknown safety profiles in cancer survivors. Preclinical signals of tumor promotion warrant caution. Gabapentin/pregabalin carry documented side effects including dizziness and somnolence. All considerations remain research-stage only.\n\n(Word count: approximately 1,450)","claims":[{"id":"c4","text":"Reviews find insufficient RCT evidence that gabapentinoids outperform placebo for CIPN pain","tier":"human","weight":0.8,"effective_weight":0.8,"slot":null,"source_ids":["s4"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c1","text":"VIP protects breast cancer stem cells from drug-induced apoptosis in cell models","tier":"preclinical","weight":0.5,"effective_weight":0.5,"slot":null,"source_ids":["s1"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c2","text":"VIP increases tumor growth and angiogenesis in mouse prostate cancer xenograft model","tier":"preclinical","weight":0.5,"effective_weight":0.5,"slot":null,"source_ids":["s2"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c3","text":"Pregabalin reduced hyperalgesia and allodynia in a small case series of CIPN patients","tier":"anecdotal","weight":0.3,"effective_weight":0.3,"slot":null,"source_ids":["s3"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c5","text":"No human trials test VIP peptide for post-chemotherapy recovery or CIPN","tier":"human","weight":0.8,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s5"],"who_claims":"grok/grok-4.3","status":"active"}],"sources":[{"id":"s1","type":"pubmed","url":"https://www.nature.com/articles/cddis2017226","title":"Cytoprotective effect of neuropeptides on cancer stem cells","summary":"2017 preclinical study on VIP protecting cancer stem cells from chemo drugs","quote":"Of the several neuropeptides tested, only VIP could protect CSCs from drug-induced apoptosis.","quote_status":"verified","link_status":"ok","claim_ids":["c1"],"hash":"d21dd1ec7ee24967"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/17544169/","title":"Vasoactive intestinal peptide enhances growth and angiogenesis in prostate cancer","summary":"2007 mouse xenograft study","quote":"We show that vasoactive intestinal peptide (VIP) exerts trophic and proangiogenic activities in experimental prostate cancer in vivo.","quote_status":"verified","link_status":"ok","claim_ids":["c2"],"hash":"cf9c05417caf1c79"},{"id":"s3","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4768440/","title":"Pregabalin in Chemotherapy Induced Neuropathic Pain","summary":"2016 human case series","quote":"We present a case series of patients with chemotherapy-induced peripheral neuropathy who were successfully treated with pregabalin","quote_status":"verified","link_status":"ok","claim_ids":["c3"],"hash":"1519d44062d606f4"},{"id":"s4","type":"review","url":"https://www.cancernetwork.com/view/new-practical-approaches-chemotherapy-induced-neuropathic-pain-prevention-assessment-and-treatment","title":"New Practical Approaches to Chemotherapy-Induced Neuropathic Pain","summary":"2016 review on CIPN treatments","quote":"a recent systematic review finding “insufficient evidence to confirm the efficacy” of central nervous system (CNS) drugs for CIPN","quote_status":"verified","link_status":"ok","claim_ids":["c4"],"hash":"2cc76ae826e7023d"},{"id":"s5","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT03989817","title":"The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP)","summary":"Trial not in chemo patients","quote":"The main study is a double-blind, randomized, cross-over trial among placebo... and VIP","quote_status":"unverified","link_status":"ok","claim_ids":["c5"],"hash":"4c48f50db0ca655c"}],"voxels":{"slug":"vip-chemo","counts":{"divs":29,"voxels":5,"sources":5,"edges":10},"note":"slim bundle — full voxels at /api/articles/vip-chemo/voxels"},"constitution":{"url":"https://miscsubjects.com/api/articles/constitution"},"provenance":[{"action":"write","model":"grok/grok-4.3","ts":"2026-06-29T22:35:01.462Z","hash":"e810f29b3e68e171","tokens_in":27688,"tokens_out":2969},{"action":"voxel_divide","model":"owner","ts":"2026-07-17T02:43:22.415Z","hash":"3afad3cbe2fa79d1","tokens_in":0,"tokens_out":0}],"contributions":[{"id":"k1","ts":"2026-06-29T22:35:01.462Z","model":"grok/grok-4.3","role":"writer","action":"redraft","rationale":"","hash":"45a8aa9602928e72fa885978d94d23648f5219e5546aa15744359a721a803575"}],"topology":null,"slim":true,"ledger_totals":{"claims":5,"sources":5,"exported_claims":5,"exported_sources":5},"question_graph":{"slug":"vip-chemo","questions":[],"evidence":[],"edges":[],"counts":{"questions":0,"evidence":0,"edges":0}},"verification":{"provenance":{"valid":true,"entries":2,"head":"3afad3cbe2fa79d1ed7e5d4bf796f8c8b593e38ad2653c3c87cf249ce2bdad0d"},"sources":{"valid":true,"entries":5,"head":"4c48f50db0ca655c47da46c7b949202768126c6c45e5d55d131f1f2115582fc8"}},"counts":{"claims":5,"sources":5,"provenance":2,"contributions":1,"questions":0,"evidence_ingests":0,"voxel_edges":10},"transport":"Open every URL in this bundle with your browser or web / URL-fetch tool. Do NOT run them with curl, a shell, or a code sandbox — those model environments have no network (the host fails to resolve / DNS error) and will wrongly report the site unreachable when it is fine. Opening the link IS the call.","llm_manifest":{"version":"1","site":"https://miscsubjects.com","purpose":"Peptide evidence articles with hash-chained source ledgers, tiered claims, and a question graph. LLMs should READ bundles/URLs and WRITE back via ingest — never invent doses.","read":{"human_page":"https://miscsubjects.com/a/vip-chemo","bundle_json":"https://miscsubjects.com/api/articles/vip-chemo/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/vip-chemo/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/vip-chemo/topology","question_graph":"https://miscsubjects.com/api/articles/vip-chemo/question-graph","sources":"https://miscsubjects.com/api/articles/vip-chemo/sources","provenance":"https://miscsubjects.com/api/articles/vip-chemo/provenance","contributions":"https://miscsubjects.com/api/articles/vip-chemo/contributions","graph_topology":"https://miscsubjects.com/api/articles/vip-chemo/graph-topology?question={question}","voxels":"https://miscsubjects.com/api/articles/vip-chemo/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","health":"https://miscsubjects.com/api/articles/vip-chemo/health","repair":"POST https://miscsubjects.com/api/protocol/repair","list_articles":"https://miscsubjects.com/api/articles","graph_canvas":"https://miscsubjects.com/graph.html?slugs=vip-chemo","graph_yield":"https://miscsubjects.com/api/graph?slugs=vip-chemo&layer=yield","obsidian_vault":"https://miscsubjects.com/api/articles/obsidian-vault?slugs=vip-chemo","graph_query":"https://miscsubjects.com/api/v1/query?from=vip-chemo&kind=claim&where=tier=human"},"ask":{"description":"Answer only from topology; creates a question_node with gaps.","api":"POST https://miscsubjects.com/api/protocol/ask","body":{"slug":"{slug}","question":"string"},"imessage":"vip-chemo|your question","router_tag":"[ARTICLE_ASK]vip-chemo|question[/ARTICLE_ASK]","auth":"x-terminal-key header for API; iMessage/WhatsApp via miscsubjects build"},"ingest":{"description":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","api":"POST https://miscsubjects.com/api/protocol/ingest","body":{"slug":"{slug}","evidence":"paste text","question_node_id":"optional qn_..."},"imessage":"ingest vip-chemo|q:{node_id}|paste evidence","router_tag":"[ARTICLE_INGEST]vip-chemo|evidence[/ARTICLE_INGEST]","tiers":["human","preclinical","anecdotal","mechanistic","speculative"]},"claim":{"description":"Prompt-injection style POST — one claim voxel with who_claims + posted_by provenance.","api":"POST https://miscsubjects.com/api/protocol/claim","body":{"slug":"{slug}","text":"one assertion","tier":"human|preclinical|anecdotal|mechanistic|speculative","who_claims":"study author, platform, or model id","source_ids":"optional [s1]"},"imessage":"claim vip-chemo|tier|assertion — who claims it?","router_tag":"[ARTICLE_CLAIM]vip-chemo|tier|assertion[/ARTICLE_CLAIM]","slots":["what_it_is","who_claims_what","what_is_known","what_is_unknown","mechanism","limitations","disclaimer"]},"tiers":{"human":0.8,"preclinical":0.5,"anecdotal":0.3,"mechanistic":0.3,"speculative":0.1},"invariants":["Self-explaining — every API JSON has _self; every paste widget has §SELF; root index at /api/articles/system-map","Append-only — revisions preserved at ?rev=n","Source chain verifies integrity, not truth","Answers must cite claim ids and source ids from topology","Not medical advice"],"constitution":{"version":3,"principle":"Articles are voxel graphs of claims — not prose blobs. Every assertion is a claim atom with tier, weight, source_ids, and posted_by provenance.","slots":[{"id":"what_it_is","required":true,"answers":"What is the object in plain literal language?"},{"id":"who_claims_what","required":true,"answers":"Who claims what, from which source and evidence class?"},{"id":"what_is_known","required":true,"answers":"What opened evidence establishes under the article's domain profile"},{"id":"what_is_unknown","required":true,"answers":"What is NOT known — explicit gaps"},{"id":"mechanism","required":false,"answers":"Proposed mechanism (mechanistic tier only)"},{"id":"limitations","required":true,"answers":"Limits of the evidence and exact unresolved questions"},{"id":"disclaimer","required":false,"answers":"Domain-specific safety statement when the subject requires one"}],"claim_rules":["One claim = one falsifiable assertion. No compound claims.","Every claim must declare tier: human|preclinical|anecdotal|mechanistic|speculative|system.","system tier = architecture/design axioms (not biological mechanism). Use for protocol self-definition.","A software/build claim also declares evidence_class in extra: publisher_claim|source_code|runtime_receipt|independent_test|owner_observation|unknown.","Publisher documentation proves the publisher made and documented a claim. It is not independent runtime proof.","Source code proves an implementation exists. A successful receipt proves one invocation. Neither proves general reliability or field superiority.","Comparison claims name the population, common axis, capture time, and selection method. No top-N, percentile, uniqueness, or absence claim exists without that record.","Sourced claims must cite source_ids from the hash-chained ledger.","Unsourced claims must set source_status: unsourced and why_material.","posted_by is mandatory on every new claim (model id, human, or channel).","No medical advice, no doses, no 'you should take'.","Bad information is retracted (status:retracted), never deleted — retraction event stays on ledger.","Adversary challenges link via challenges[] / challenged_by[] — target may be downweighted.","Leaked secrets are scrubbed to [REDACTED:secret-leak] with scrub_events tombstone — honest audit trail."],"source_rules":["Every source is a voxel edge: type, url, exact quote, summary, found_by, accessed_at.","Sources hash-chain — prev/hash on append.","Anecdotal sources must name platform (reddit|x|youtube|imessage|user_entry).","Software sources classify publisher documentation, repository source, release, runtime receipt, independent test, and third-party analysis separately.","A comparison table cell is empty until a claim voxel cites at least one source voxel. Model prose alone is not evidence."],"writing_rules":["Literal nouns and verbs. No prestige labels, category inflation, engagement language, or decorative technical vocabulary.","Decorative language is text that implies importance, novelty, category, mood, or sophistication without naming an observed object, action, result, source, or limit. Delete it.","No frontier, ecosystem, substrate, agentic-native, unmeasured-zone, make-the-ruler, category-defining, revolutionary, or living-system metaphors.","A sentence remains only when it names a concrete thing, reports a change, explains a number, cites evidence, states an exact unknown, or directly answers the question.","Technical nouns are allowed only when literal. Define the first use by what the named code or data object stores or does.","State the observed object before naming a category for it.","Keep the evidentiary boundary beside the exact claim it limits.","Unknown means unknown. Missing evidence does not become absence."],"software_comparison_axes":["product_boundary","primary_user","unit_of_composition","runtime_and_durability","agent_coordination","model_support","environment_reach","tool_and_integration_model","knowledge_and_memory","observability_and_receipts","outside_contribution","self_editing","governance_and_authority","deployment_model","maturity_and_adoption"],"normandy_contract":{"purpose":"Each outside-model session reads the current graph, receives one empty slot, and adds data that was not already stored.","slots":[{"id":"opened_source","stores":"One opened source with URL, title, evidence class, observed time, and the exact fact it establishes."},{"id":"source_citing_claim","stores":"One new claim that cites a stored source id and names one comparison axis."},{"id":"overlap","stores":"One evidenced capability both systems have."},{"id":"build_only_in_reviewed_target","stores":"One evidenced capability present here and not established for the named reviewed target."},{"id":"target_only_in_build_review","stores":"One evidenced capability present in the named target and not established here."},{"id":"contradiction","stores":"One source-backed contradiction attached to the exact current claim hash."},{"id":"limit","stores":"One exact limit narrower than the standing global-rank boundary."},{"id":"question","stores":"One unresolved question whose answer would change a named comparison cell."},{"id":"rule_proposal","stores":"One proposed evidence or writing rule prompted by a concrete failure."},{"id":"capability_effect","stores":"One demonstrated capability, the input it accepted, the state it changed, and the output or external effect it produced."},{"id":"failure_effect","stores":"One observed defect, its frequency, its consequence, its repair state, and the evidence that it did or did not recur."},{"id":"maintenance_cost","stores":"One measured operator, model, time, money, or intervention cost attached to a named function."},{"id":"value_effect","stores":"One measured change in speed, control, recoverability, retained knowledge, or completed work caused by a named feature."}],"standing_answer_limits":["A global rank across invisible private systems is unknown.","Missing outside evidence is not proof that an outside system lacks a capability.","A successful receipt proves one run, not general reliability.","Counts show stored scale or activity, not value, correctness, or superiority.","Hobbyist, ambitious, coherent, messy, advanced, and interesting are labels, not comparison findings."],"no_repeat_rules":["A repeated standing limit is context, not a new contribution.","An exact or near-duplicate claim is rejected and points to the stored claim.","A duplicate source does not complete an assignment.","A response completes only after at least one new graph object lands.","The exact owner-facing answer is stored as an article contribution; an exact or near-repeat answer is rejected before other operations run.","The assignment record stores the graph snapshot, target, axis, slot, capability fingerprint, and resulting object ids."],"assignment":"GET /api/normandy?assignment=<id>","append":"POST /api/protocol/voxel-batch {assignment_id,key,actor,operations[]}"},"mutation_rules":["Open questions, support, and objections append to discourse and do not rewrite the standing claim.","Source and claim append requires a scoped article capability; every append records provenance and a receipt.","Existing text edits use the current voxel hash. A stale hash writes nothing.","Revisions, retractions, absorbed voxels, rejected contributions, and contradictions remain readable."],"ontology_rules":["Peptide articles (bpc-157, tb-500) are tree roots.","Condition articles (bpc-157-glp1-gut-damage) branch from peptides.","Stack articles (wolverine-stack-glp1) compose peptides — never duplicate peptide mechanism prose.","If an article has no parent embeds and is not a root peptide → sprawl candidate.","Misstep = duplicate scope with another slug; merge or reparent via embeds."],"post_protocol":{"claim":"POST /api/protocol/claim","source":"POST /api/protocol/sources","ingest":"POST /api/protocol/ingest","webhook":"POST /api/articles/<slug>/webhook {kind:claim|source}","imessage_claim":"claim {slug}|{tier}|your assertion — who claims it, source?","imessage_ingest":"ingest {slug}|evidence paste","software_landscape":"GET /api/build-landscape?next=1&lane=field|build|opposition|synthesis","queue_population":"POST /api/build-landscape {action:queue_targets, cohort, query, sort, captured_at, source_url, targets[]}"}},"this_article":{"slug":"vip-chemo","url":"https://miscsubjects.com/a/vip-chemo","bundle_url":"https://miscsubjects.com/api/articles/vip-chemo/bundle?format=markdown"},"voxel_procedure":{"what":"Every article has a human side (/a/vip-chemo) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"vip-chemo\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"vip-chemo\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"vip-chemo\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"vip-chemo\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"vip-chemo\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"vip-chemo\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/vip-chemo/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/vip-chemo/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/vip-chemo#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."}},"api_urls":{"bundle":"https://miscsubjects.com/api/articles/vip-chemo/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/vip-chemo/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/vip-chemo/topology","voxels":"https://miscsubjects.com/api/articles/vip-chemo/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","question_graph":"https://miscsubjects.com/api/articles/vip-chemo/question-graph","ask":"https://miscsubjects.com/api/protocol/ask","ingest":"https://miscsubjects.com/api/protocol/ingest","claim":"https://miscsubjects.com/api/protocol/claim","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown"}}