{"slug":"tirzepatide-sciatica","verification":{"valid":true,"entries":5,"head":"5ab8ee4509bac375e418df4c1071a15dd0c34d0ef345f5e4dadd4cca7441c4d1"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2206038","title":"Tirzepatide Once Weekly for the Treatment of Obesity","quote":"The mean percentage change in weight at week 72 was −15.0% ... with 5-mg ... −19.5% ... with 10-mg doses, and −20.9% ... with 15-mg doses and −3.1% ... with placebo","summary":"SURMOUNT-1 phase 3 trial results on weight loss.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:40:03.759Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"5f74fa79f8b73e1ae2332145fd42a3575d3f421d12ca99c7508930c2f303e369"},{"id":"s2","type":"pubmed","url":"https://acrabstracts.org/abstract/impact-of-tirzepatide-on-musculoskeletal-pain-and-high-risk-analgesic-use-among-non-diabetic-patients-with-overweight-or-obesity-a-propensity-score-matched-active-comparator-new-user-study/","title":"Impact of Tirzepatide on Musculoskeletal Pain...","quote":"Tirzepatide users were more likely to achieve normal BMI ... with lower risk of joint pain (HR 0.91 ...), ... lower risk of NSAID (HR 0.88) and opioid prescriptions (HR 0.86)","summary":"Propensity-matched real-world evidence on pain and analgesic use.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:40:03.759Z","link_status":"ok","quote_status":"unverified","prev":"5f74fa79f8b73e1ae2332145fd42a3575d3f421d12ca99c7508930c2f303e369","hash":"bd54a323f28c34b130d0ed9b0aad1ed31e86e3c45fbc5c25270967f39ecee707"},{"id":"s3","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6604284/","title":"Stable gastric pentadecapeptide BPC 157 can improve ...","quote":"In animals, BPC 157 has an anti-inflammatory effect and therapeutic effects in functional recovery and the rescue of somatosensory neurons in the sciatic nerve","summary":"Rat sciatic nerve injury model results.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:40:03.759Z","link_status":"ok","quote_status":"verified","prev":"bd54a323f28c34b130d0ed9b0aad1ed31e86e3c45fbc5c25270967f39ecee707","hash":"1981fe5ff65c0b0c288f61789a4fe6038dfba835de7a7b80cf3d48b340071f96"},{"id":"s4","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5741312/","title":"Targeting the innate repair receptor to treat neuropathy","quote":"In patients with sarcoidosis, ARA290 significantly improved neuropathic and autonomic symptoms... In a phase 2 study in patients with type 2 diabetes... improvement in ... neuropathic symptoms","summary":"Human Phase 2 data on ARA-290 for neuropathy.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:40:03.759Z","link_status":"ok","quote_status":"unverified","prev":"1981fe5ff65c0b0c288f61789a4fe6038dfba835de7a7b80cf3d48b340071f96","hash":"c182748bbd8ae348fab8dd60091e27fc19fb506688033af967c5ebb3b2d5c5ff"},{"id":"s5","type":"other","url":"https://spineteamtexas.com/resources/blog/back-pain-and-glp-1-assisted-weight-loss-a-new-path-to-relief/","title":"Back Pain and GLP-1 Assisted Weight Loss","quote":"For someone who loses 30 pounds, this could mean up to 120 pounds less pressure on the spine during movement.","summary":"Clinical site summary of load reduction biomechanics.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:40:03.759Z","link_status":"ok","quote_status":"verified","prev":"c182748bbd8ae348fab8dd60091e27fc19fb506688033af967c5ebb3b2d5c5ff","hash":"5ab8ee4509bac375e418df4c1071a15dd0c34d0ef345f5e4dadd4cca7441c4d1"}]}