{"slug":"tirzepatide-muscle-loss","verification":{"valid":true,"entries":3,"head":"155806350e6fd84d1a09b457a9fe10aeb4c4d5f0f94d34f005efbbc5c1debb61"},"count":3,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39996356/","title":"Body composition changes during weight reduction with tirzepatide in the SURMOUNT-1 study","quote":"The change in body weight, fat mass and lean mass from baseline to Week 72 was -21.3%, -33.9% and -10.9% with tirzepatide and -5.3%, -8.2% and -2.6% with placebo, respectively... Of the body weight lost, approximately 75% was fat mass and 25% was lean mass for both tirzepatide and placebo.","summary":"DXA substudy results showing proportional composition changes.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:45:57.965Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"59d23763d41c6d5b347c0e21eddb32776e55119bb4c2aa3533d2bd1f84c09089"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40318682/","title":"Tirzepatide and muscle composition changes in people with type 2 diabetes","quote":"observed muscle volume changes across all tirzepatide doses were similar to population-based estimated changes... observed reductions in muscle fat infiltration... were significantly greater than population-based estimates","summary":"MRI data on muscle volume and fat infiltration.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:45:57.965Z","link_status":"ok","quote_status":"unverified","prev":"59d23763d41c6d5b347c0e21eddb32776e55119bb4c2aa3533d2bd1f84c09089","hash":"541d593b724d09c85909001b024036cd06041f326642fb3d7569e727cfdd4408"},{"id":"s3","type":"reddit","url":"https://www.reddit.com/r/Zepbound/comments/1kg1gm0/tirz_and_muscle_mass/","title":"Tirz and muscle mass","quote":"Using MRI, the authors found that muscle fat decreased in the Tirz groups, without a decrease in actual 'muscle'.","summary":"User discussion referencing trial MRI findings and personal experience.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:45:57.965Z","link_status":"ok","quote_status":"unverified","prev":"541d593b724d09c85909001b024036cd06041f326642fb3d7569e727cfdd4408","hash":"155806350e6fd84d1a09b457a9fe10aeb4c4d5f0f94d34f005efbbc5c1debb61"}]}