{"slug":"tirzepatide-gut","verification":{"valid":true,"entries":4,"head":"3e9762377428471042c3eec33b58c200555b493023c167bf2ae9a86197e6111e"},"count":4,"sources":[{"id":"s1","type":"pubmed","url":"https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.16275","title":"Body composition changes during weight reduction with tirzepatide","quote":"The change in body weight, fat mass and lean mass from baseline to Week 72 was −21.3%, −33.9% and −10.9% with tirzepatide","summary":"SURMOUNT-1 DXA substudy quantifying fat vs lean loss proportions.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:47:05.673Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"d056701e3294d37875124049ad7f9aef11c59806fca862ee3e6fbe7bfdf89af3"},{"id":"s2","type":"pubmed","url":"https://www.sciencedirect.com/science/article/abs/pii/S0014299925005813","title":"The role of gut microbiota in Tirzepatide-mediated metabolic benefits","quote":"tirzepatide has the potential to alleviate high-fat diet-induced gut microbiota dysbiosis in mice","summary":"Preclinical mouse data on microbiota restoration.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:47:05.673Z","link_status":"http_403","quote_status":"unverified","prev":"d056701e3294d37875124049ad7f9aef11c59806fca862ee3e6fbe7bfdf89af3","hash":"4552e4682f7547a3ffbe799be890c6cccfd1600ffac7ba5c821f2174531ec18f"},{"id":"s3","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12542916/","title":"Gastrointestinal safety of semaglutide and tirzepatide vs placebo","quote":"tirzepatide showing a greater risk (RR 2.94, 95% CI=2.61, 3.32)","summary":"Meta-analysis of GI adverse events from trials.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:47:05.673Z","link_status":"ok","quote_status":"verified","prev":"4552e4682f7547a3ffbe799be890c6cccfd1600ffac7ba5c821f2174531ec18f","hash":"bf54c28414108ab6f658e73e0b2542c3ff8f212ea0891118c9a512c07bc0ca6f"},{"id":"s4","type":"review","url":"https://www.tandfonline.com/doi/full/10.1080/17512433.2025.2559907","title":"Dual incretin agonism and the gut microbiome","quote":"the evidence remains limited to preclinical models, with robust human data currently lacking","summary":"Editorial highlighting human data gap on microbiome effects.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:47:05.673Z","link_status":"http_403","quote_status":"unverified","prev":"bf54c28414108ab6f658e73e0b2542c3ff8f212ea0891118c9a512c07bc0ca6f","hash":"3e9762377428471042c3eec33b58c200555b493023c167bf2ae9a86197e6111e"}]}