{"slug":"tirzepatide-glp-1","verification":{"valid":true,"entries":5,"head":"b87b309348fdfc0833644a2fe27f82de21cf204627874781a05f00a3a70d1540"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2206038","title":"Tirzepatide Once Weekly for the Treatment of Obesity","quote":"The mean percentage change in weight at week 72 was −15.0% ... with 5-mg ... −19.5% ... with 10-mg ... −20.9% ... with 15-mg doses and −3.1% ... with placebo","summary":"Phase 3 RCT results for SURMOUNT-1.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:48:02.154Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"fcac4196683ab5b4724b89bce901f8b085e34cd3c10fba2b97461c5574691e6f"},{"id":"s2","type":"medical","url":"https://www.fellahealth.com/guide/does-glp-1-help-with-joint-pain","title":"Does GLP-1 Help With Joint Pain? Evidence and ...","quote":"Weight loss from GLP-1 therapy reduces biomechanical loading on joints, with each pound lost decreasing knee force by approximately 3-4 pounds during walking.","summary":"Biomechanical explanation of load reduction.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:48:02.154Z","link_status":"ok","quote_status":"verified","prev":"fcac4196683ab5b4724b89bce901f8b085e34cd3c10fba2b97461c5574691e6f","hash":"1a8efc0072119afe983f2165a7ea4f5567c24776c2c639fb6503795fca2a21e4"},{"id":"s3","type":"pubmed","url":"https://acrabstracts.org/abstract/impact-of-tirzepatide-on-musculoskeletal-pain-and-high-risk-analgesic-use-among-non-diabetic-patients-with-overweight-or-obesity-a-propensity-score-matched-active-comparator-new-user-study/","title":"Impact of Tirzepatide on Musculoskeletal Pain...","quote":"Tirzepatide users were more likely to achieve normal BMI ... with lower risk of joint pain (HR 0.91 ...), ... lower risk of NSAID (HR 0.88 ...) and opioid prescriptions (HR 0.86 ...)","summary":"Observational study on pain and analgesic outcomes.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:48:02.154Z","link_status":"ok","quote_status":"unverified","prev":"1a8efc0072119afe983f2165a7ea4f5567c24776c2c639fb6503795fca2a21e4","hash":"a3946a7487d6f7f9bb54e7e7f77a7d3b2fc3183a2d919f1e93839edfe6aa67f2"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/Mounjaro/comments/1ay99nz/the_mounjaro_back_pain_is_out_of_control/","title":"The Mounjaro back pain is out of control","quote":"The extra sleeping, the joint pain, the muscle aches: it's an auto-immune response to the tirzepatide.","summary":"Example of mixed anecdotal reports.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:48:02.154Z","link_status":"ok","quote_status":"unverified","prev":"a3946a7487d6f7f9bb54e7e7f77a7d3b2fc3183a2d919f1e93839edfe6aa67f2","hash":"c44acd515be112b63075c6d958ba131760f53800fd7390ebada581381d18c38b"},{"id":"s5","type":"x","url":"https://x.com/suchnerve/status/2004076012821491988","title":"X post on tirzepatide for foot and back pain","quote":"My doctor prescribed tirzepatide ... to indirectly treat my foot and back pain by reducing how much weight they have to support","summary":"Example of X anecdotes on indirect relief.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:48:02.154Z","link_status":"ok","quote_status":"unverified","prev":"c44acd515be112b63075c6d958ba131760f53800fd7390ebada581381d18c38b","hash":"b87b309348fdfc0833644a2fe27f82de21cf204627874781a05f00a3a70d1540"}]}