{"slug":"tirzepatide-cognition","verification":{"valid":true,"entries":5,"head":"f72adcbe976dbb7abf16f678c722255c7650be1f42406142f5f67ae8a157974e"},"count":5,"sources":[{"id":"s2","type":"pubmed","url":"https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2836412","title":"Neurodegeneration and Stroke After Semaglutide and Tirzepatide","quote":"those treated with semaglutide or tirzepatide had significantly lower risks of dementia","summary":"Large cohort study showing reduced dementia risk with GLP-1/GIP agonists.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:51:01.632Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"f8c52571deefa6920cfbb3a5f9ca0375fae650b5b95e2b4cc34b66be13967999"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41825212/","title":"Tirzepatide versus semaglutide for the prevention of mild cognitive impairment, dementia, and Alzheimer's disease in type 2 diabetes","quote":"initiation of tirzepatide was associated with a lower risk of MCI (RR 0.12)","summary":"Real-world retrospective comparison of cognitive outcomes.","claim_ids":[],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:51:01.632Z","link_status":"ok","quote_status":"unverified","prev":"f8c52571deefa6920cfbb3a5f9ca0375fae650b5b95e2b4cc34b66be13967999","hash":"ef8c09fe2d3263a5b339d8872587f78877aee25dc24c7a121bf7c6ad3ae77a1d"},{"id":"s25","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10493299/","title":"Tirzepatide ameliorates spatial learning and memory impairment","quote":"tirzepatide improved abilities with spatial learning and memory","summary":"Preclinical diabetic rat study on cognition.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:51:01.632Z","link_status":"ok","quote_status":"verified","prev":"ef8c09fe2d3263a5b339d8872587f78877aee25dc24c7a121bf7c6ad3ae77a1d","hash":"9013ac4e516abd2a785ff279b49517dc18bfcc335fa9c203e888eb9137e0d61c"},{"id":"s16","type":"other","url":"https://coremedicalwellness.com/glp-1-medications-for-weight-loss-back-pain-and-knee-pain-relief/","title":"GLP-1 Medications for Weight Loss and Pain Relief","quote":"Every extra pound of body weight places several additional pounds of force on your knees and lower back","summary":"Explains mechanical load reduction with weight loss.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:51:01.632Z","link_status":"ok","quote_status":"verified","prev":"9013ac4e516abd2a785ff279b49517dc18bfcc335fa9c203e888eb9137e0d61c","hash":"5dda19096c1b1b41fac6f6fcf4ebaeb54ee0265e179d4b183395b97128f52b2c"},{"id":"s20","type":"reddit","url":"https://www.reddit.com/r/tirzepatidecompound/comments/1ej546m/tirz_induced_mental_clarity/","title":"Tirz induced mental clarity?","quote":"I have felt so good on this drug including less depression/anxiety, no brain fog","summary":"User report of cognitive benefits.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:51:01.632Z","link_status":"ok","quote_status":"unverified","prev":"5dda19096c1b1b41fac6f6fcf4ebaeb54ee0265e179d4b183395b97128f52b2c","hash":"f72adcbe976dbb7abf16f678c722255c7650be1f42406142f5f67ae8a157974e"}]}