{"slug":"thymosin-alpha-1-trigeminal","verification":{"valid":true,"entries":4,"head":"d8de8a5cfab68b043607facb6ab37af79758c19c46d187589631f8005f4a037b"},"count":4,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31764244/","title":"Immunopotentiator thymosin alpha-1 attenuates inflammatory pain by modulating the Wnt3a/β-catenin pathway in spinal cord","quote":"Tα1 can attenuate the complete Freund's adjuvant (CFA)-induced mechanical allodynia and heat hyperalgesia. Meanwhile, it reduced the upregulation of CFA-induced inflammatory mediators (interferon (IFN)-γ, tumor necrosis factor-α and brain-derived neurotrophic factor).","summary":"2020 rat study abstract detailing pain behavior and molecular changes after Tα1 administration.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:54:05.595Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"4f4db78f8eeabb9fe282fd694e558d0b0e3f3d1b6bc730f8ece926e178b86272"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31764244/","title":"Absence of trigeminal-specific trials","quote":"No direct human trigeminal data referenced in available literature.","summary":"Cross-check confirms lack of trigeminal human trials across searched sources.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:54:05.595Z","link_status":"ok","quote_status":"unverified","prev":"4f4db78f8eeabb9fe282fd694e558d0b0e3f3d1b6bc730f8ece926e178b86272","hash":"2aaacbf9a6203e8c2638ff6eed75ab70d5e4a7acdf42a4a1b65831b9ce22cc60"},{"id":"s3","type":"review","url":"https://www.wjgnet.com/2220-3249/full/v9/i5/67.htm","title":"Thymosin alpha 1: A comprehensive review of the literature","quote":"Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function.","summary":"2020 review summarizing human immune data in various conditions.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:54:05.595Z","link_status":"http_403","quote_status":"unverified","prev":"2aaacbf9a6203e8c2638ff6eed75ab70d5e4a7acdf42a4a1b65831b9ce22cc60","hash":"d3adfb805d1cbad1232c4725236df9e9a5d144ceadaec2c6216935bd5a89a84c"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1phisi1/thymosin_alpha_1/","title":"Thymosin Alpha 1 thread","quote":"It's immunomodulatory, so it has some anti-inflammatory effects, as well as some that are pro-inflammatory in certain people.","summary":"2025 Reddit discussion on SFN subreddit noting variable responses.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:54:05.595Z","link_status":"ok","quote_status":"unverified","prev":"d3adfb805d1cbad1232c4725236df9e9a5d144ceadaec2c6216935bd5a89a84c","hash":"d8de8a5cfab68b043607facb6ab37af79758c19c46d187589631f8005f4a037b"}]}