{"slug":"thymosin-alpha-1-sciatica","verification":{"valid":true,"entries":6,"head":"4237b59532f0978a832f68af44f4a072bd675866df936fd5727247bd1c73bbd1"},"count":6,"sources":[{"id":"s0","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6616621/","title":"Thymosin Alpha-1 Inhibits Complete Freund's Adjuvant-Induced Pain and Spinal Microglial Activation","quote":"These results suggest that Tα1 plays a therapeutic role in inflammatory pain and in the modulation of microglia-induced pro-inflammatory cytokine production.","summary":"Rodent CFA pain model showing Tα1 effects on allodynia, hyperalgesia, cytokines, and microglia.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:58:04.686Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"7e6d58e4c12f34b7488f493440f3c6a15f2535bd88abd102dab5246a9fa7cd89"},{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31764244/","title":"Immunopotentiator thymosin alpha-1 attenuates complete Freund's adjuvant-induced pain","quote":"Tα1 can attenuate the complete Freund's adjuvant (CFA)-induced mechanical allodynia and heat hyperalgesia.","summary":"Confirms attenuation of inflammatory pain behaviors in rats.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:58:04.686Z","link_status":"ok","quote_status":"verified","prev":"7e6d58e4c12f34b7488f493440f3c6a15f2535bd88abd102dab5246a9fa7cd89","hash":"6185647c3a0b97c938819b8a922283179ee3c842991a20e872e5ca6c712c3168"},{"id":"s16","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31266512/","title":"Stable gastric pentadecapeptide BPC 157 can improve the function after spinal cord injury in rats","quote":"BPC 157 has an anti-inflammatory effect and therapeutic effects in functional recovery and the rescue of somatosensory neurons in the sciatic nerve after transection...","summary":"Rat compression and transection models with functional and histological recovery data.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:58:04.686Z","link_status":"ok","quote_status":"unverified","prev":"6185647c3a0b97c938819b8a922283179ee3c842991a20e872e5ca6c712c3168","hash":"5c71c68dc3dd763050b3e8d98e6d1a5cde7bbfc0ca1b682db1d6e9c5819c1ead"},{"id":"s23","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3533234/","title":"Thymosin β4 Promotes the Recovery of Peripheral Neuropathy in Diabetic Mice","quote":"Tβ4 significantly improved sciatic nerve vascular function and peripheral nerve function in a mouse model.","summary":"Diabetic mouse sciatic nerve recovery with vascular and functional endpoints.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:58:04.686Z","link_status":"ok","quote_status":"unverified","prev":"5c71c68dc3dd763050b3e8d98e6d1a5cde7bbfc0ca1b682db1d6e9c5819c1ead","hash":"f7be8a66a704c722bb58ac4b58006d9caa32efb0733ef23c9c74990adba1b08a"},{"id":"s32","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5741312/","title":"Targeting the innate repair receptor to treat neuropathy","quote":"After sciatic nerve injury, ARA290 produced a rapid and long-term relief of mechanical and cold allodynia in normal mice...","summary":"Rodent and early clinical data on ARA290 in neuropathy models.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:58:04.686Z","link_status":"ok","quote_status":"unverified","prev":"f7be8a66a704c722bb58ac4b58006d9caa32efb0733ef23c9c74990adba1b08a","hash":"cf1a62ed4842a461986f4fff65e6c848d7fadc5ee71868a517ac280382a728db"},{"id":"s15","type":"other","url":"https://friscorehab.com/can-bpc-157-heal-a-herniated-disc-what-patients-with-back-pain-should-know/","title":"Can BPC-157 Heal a Herniated Disc?","quote":"There is currently no strong clinical evidence showing BPC-157 can repair or reverse a herniated disc in humans.","summary":"Review noting absence of human disc repair data.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T22:58:04.686Z","link_status":"ok","quote_status":"unverified","prev":"cf1a62ed4842a461986f4fff65e6c848d7fadc5ee71868a517ac280382a728db","hash":"4237b59532f0978a832f68af44f4a072bd675866df936fd5727247bd1c73bbd1"}]}