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Per-claim provenance."},{"id":"ask","what":"Answer only from topology; creates question_node with gaps and ingest_hint."},{"id":"ingest","what":"Parse pasted evidence → source ledger + claims + evidence_ingest node."},{"id":"claim_post","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by."},{"id":"llm_manifest","what":"Machine-readable read/write contract for external LLMs."}],"not_medical_advice":true},"MASTHEAD":{"sorry_status":"planes not merged yet — sorry-status activates after voxel-merge-planes","identity":{"slug":"thymosin-alpha-1-postherpetic","version":2,"content_hash":"1343e58a50ef834eba742d997c0e915368846aa6947865bcb046ae06da053c05","thread_head":"genesis","divs":21},"thesis":{"root_claim":"c1","text":"No randomized controlled human trials test Thymosin Alpha-1 specifically in postherpetic neuralgia.","tier":"human"},"load_bearing":[{"id":"c3","tier":"human","status":"active","text":"Human trials of Thymosin Alpha-1 exist in hepatitis, sepsis, and COVID-19 involving thousands of participants with mixed results."},{"id":"c2","tier":"preclinical","status":"active","text":"A rodent study showed thymosin alpha-1 reduced pain behaviors and spinal inflammation in an adjuvant pain model."},{"id":"c4","tier":"anecdotal","status":"active","text":"Reddit users discuss Thymosin Alpha-1 mainly for long COVID, MCAS, and neuropathy symptoms with self-reported variable outcomes."},{"id":"c5","tier":"anecdotal","status":"active","text":"X posts occasionally reference Thymosin Alpha-1 in shingles or immune support contexts but remain individual accounts."}],"standing_objections":{"open":0,"strongest_open":null,"link":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/discourse"},"verbs":{"read":"GET https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/voxels — DIVs + hashes + chains (free)","read_claims":"GET https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/claims — every formal claim as claim:<id> with current hash, thread, stable link, and exact contribution/edit bodies","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {slug, expected_thread_head, target_div?, expected_hash?, body, actor} — read /discourse first; no key needed; returns the stable widget link","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {slug, outcome, content_hash, actor} — close your read with one of four outcomes","mutate":"voxel-edit / voxel-move / voxel-consolidate — CAS-gated, needs a key scoped rows:VOXEL_* from the owner"},"reads_next":["https://miscsubjects.com/a/philosophy","https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/discourse","https://miscsubjects.com/api/protocol"]},"bundle_version":1,"generated_at":"2026-07-30T03:39:59.741Z","slug":"thymosin-alpha-1-postherpetic","title":"Thymosin Alpha 1 for Postherpetic Neuralgia: Evidence Review","url":"https://miscsubjects.com/a/thymosin-alpha-1-postherpetic","register":"source_ledger","tags":["peptide","matrix"],"posted_at":"2026-06-29T21:33:41.030Z","updated_at":"2026-07-17T02:43:09.215Z","body":"## What's breaking down\n\nPostherpetic neuralgia (PHN) follows shingles, which is reactivation of latent varicella-zoster virus (VZV). After the rash clears, some people experience persistent burning, stabbing, or shooting pain along the affected nerve dermatome. This stems from nerve damage during the acute infection, ongoing low-level inflammation, and altered immune surveillance that fails to fully suppress the virus in dorsal root ganglia.\n\nDegeneration layers include direct neuronal injury from viral replication, central and peripheral sensitization creating chronic pain signals, and impaired cell-mediated immunity that normally keeps VZV latent. If your immune response to the virus is weakened by age, stress, or other factors, the virus can linger in a way that sustains nerve irritation rather than allowing full repair.\n\nThe condition persists when breakdown (nerve damage and inflammation) outruns repair (immune clearance and tissue recovery). Standard approaches often focus on symptom suppression with anticonvulsants, antidepressants, or opioids, which do not address the underlying immune control of the virus.\n\n## Why Thymosin Alpha-1 might help you\n\nThymosin Alpha-1 is discussed for its studied effects on immune modulation. If impaired cell-mediated immunity is part of your postherpetic picture, the peptide is examined because it supports T-cell function and cytokine balance rather than simply masking pain signals.\n\n1. Therefore for you: If viral latency control is a layer in your case, Thymosin Alpha-1 is discussed because studies examine its role in enhancing immune recognition of infected cells.\n2. If chronic inflammation contributes to ongoing nerve sensitivity, the compound is noted for observed shifts toward balanced immune responses in other infection contexts.\n3. Therefore for you: If tissue repair pathways matter after shingles-related damage, it targets restoration mechanisms instead of suppression alone.\n\n## How these fit together\n\nSingle-compound focus. Thymosin Alpha-1 maps to immune modulation. If your profile includes additional layers such as direct nerve repair or pain pathway modulation, other compounds would target those separately without overlap in this review.\n\n## What the evidence actually shows\n\nNo randomized controlled human trials specifically test Thymosin Alpha-1 in postherpetic neuralgia or shingles patients (tier: human - absent for this indication). Preclinical work includes one rodent study where thymosin alpha-1 reduced pain behaviors and spinal microglia-driven cytokines in a complete Freund's adjuvant model (tier: preclinical). General human data on Thymosin Alpha-1 come from trials in chronic hepatitis B, sepsis, and COVID-19, where it showed variable effects on immune markers and clinical outcomes across thousands of participants (tier: human). One 2025 multicenter sepsis trial found no reduction in 28-day mortality overall (tier: human). Reviews summarize use in over 11,000 subjects across 30+ trials for immune-related conditions, but none isolate PHN (tier: human - general). Anecdotal reports exist on forums but lack controls (tier: anecdotal).\n\n## What scientists say\n\nResearchers describe Thymosin Alpha-1 as an immune modulator that enhances T-cell maturation and response in viral and chronic disease settings. Publications note potential in infectious disease adjunctive use but emphasize the need for condition-specific trials. Reviews highlight inconsistent results in some acute settings and call for more targeted studies in post-viral syndromes (sources: PMC reviews and clinical trial reports).\n\n## What people say on Reddit\n\nUsers in long COVID, MCAS, and small fiber neuropathy communities report trying Thymosin Alpha-1 for immune-related fatigue or symptoms, with mixed self-described outcomes ranging from noticeable improvement to no change. Posts specifically linking it to shingles or PHN are rare; most discussion centers on general immune support or post-viral issues (tier: anecdotal).\n\n## What people say on X\n\nScattered posts mention Thymosin Alpha-1 alongside shingles recovery or vaccination discussions, often in context of immune support during or after outbreaks. Users reference it alongside other peptides for lingering symptoms, but reports remain individual and unverified (tier: anecdotal).\n\n## What we do not know\n\nDirect evidence for PHN is missing. It is unknown whether any immune changes observed in other diseases translate to reduced PHN pain or faster nerve recovery. Long-term effects, optimal timing after shingles, and interactions with standard PHN medications lack study. Human data specific to VZV reactivation or PHN do not exist in published trials.\n\n## Safety and limits\n\nClinical reviews of Thymosin Alpha-1 across large subject pools describe it as generally well-tolerated in studied populations. Individual responses vary, and self-experimentation carries unknown risks outside controlled settings. Regulatory status differs by region, with some restrictions noted in certain jurisdictions. This is not medical advice; consult qualified professionals for personal health decisions. Evidence remains limited for this specific use case.","claims":[{"id":"c5","text":"X posts occasionally reference Thymosin Alpha-1 in shingles or immune support contexts but remain individual accounts.","tier":"anecdotal","weight":0.3,"effective_weight":0.3,"slot":null,"source_ids":["s6"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c1","text":"No randomized controlled human trials test Thymosin Alpha-1 specifically in postherpetic neuralgia.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s1"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c3","text":"Human trials of Thymosin Alpha-1 exist in hepatitis, sepsis, and COVID-19 involving thousands of participants with mixed results.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s3","s4"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c2","text":"A rodent study showed thymosin alpha-1 reduced pain behaviors and spinal inflammation in an adjuvant pain model.","tier":"preclinical","weight":0.5,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s2"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c4","text":"Reddit users discuss Thymosin Alpha-1 mainly for long COVID, MCAS, and neuropathy symptoms with self-reported variable outcomes.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s5"],"who_claims":"grok/grok-4.3","status":"active"}],"sources":[{"id":"s1","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10940365/","title":"Trigeminal Postherpetic Neuralgia review mentioning thymosin alpha-1 pain model","summary":"Mentions preclinical pain data but no PHN trials for the peptide.","quote":"Thymosin alpha-1 inhibits complete Freund's adjuvant-induced pain...","quote_status":"unverified","link_status":"ok","claim_ids":["c1"],"hash":"8658962cd803b994"},{"id":"s2","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10940365/","title":"Preclinical pain study reference","summary":"Rodent model data only.","quote":"Thymosin alpha-1 inhibits complete Freund's adjuvant-induced pain and production of microglia-mediated pro-inflammatory cytokines in spinal ...","quote_status":"unverified","link_status":"ok","claim_ids":["c2"],"hash":"0e84a6624b1f81e6"},{"id":"s3","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/","title":"Thymosin alpha 1 comprehensive review","summary":"Summarizes human studies in multiple conditions.","quote":"Thymosin alpha 1 has been utilized in various cases to enhance cell-mediated immunity...","quote_status":"unverified","link_status":"ok","claim_ids":["c3"],"hash":"a64ba1a4a499cd3e"},{"id":"s4","type":"pubmed","url":"https://www.bmj.com/content/388/bmj-2024-082583","title":"Sepsis trial of thymosin α1","summary":"Recent large human trial with null primary outcome.","quote":"This trial found no clear evidence to suggest that thymosin α1 decreases 28 day all cause mortality...","quote_status":"unverified","link_status":"http_403","claim_ids":["c3"],"hash":"4c3084f2fc649b4b"},{"id":"s5","type":"reddit","url":"https://www.reddit.com/r/covidlonghaulers/comments/1r5ekd8/5_years_long_covid_thymosin_alpha_1_peptide_wow/","title":"Long COVID user experience post","summary":"Anecdotal reports from related communities.","quote":"I am now testing Thymosin Alpha 1 Peptide and I have to say WOW!","quote_status":"unverified","link_status":"ok","claim_ids":["c4"],"hash":"1ce5b86d71995710"},{"id":"s6","type":"x","url":"https://x.com/sonii/status/2067417612758512078","title":"X post on peptides and shingles","summary":"Social media mention of use with shingles.","quote":"Been natty my whole life brotha. Am taking Thymosin Alpha 1, BPC-157, KPV peptides tho to deal with tail end of shingles kek","quote_status":"verified","link_status":"ok","claim_ids":["c5"],"hash":"61d1eb7ad5b4b22d"}],"voxels":{"slug":"thymosin-alpha-1-postherpetic","counts":{"divs":21,"voxels":5,"sources":6,"edges":11},"note":"slim bundle — full voxels at /api/articles/thymosin-alpha-1-postherpetic/voxels"},"constitution":{"url":"https://miscsubjects.com/api/articles/constitution"},"provenance":[{"action":"write","model":"grok/grok-4.3","ts":"2026-06-29T22:58:58.481Z","hash":"651a2066821c2fad","tokens_in":25146,"tokens_out":3139},{"action":"voxel_divide","model":"owner","ts":"2026-07-17T02:43:09.215Z","hash":"5cbc6e0aa75a3287","tokens_in":0,"tokens_out":0}],"contributions":[{"id":"k1","ts":"2026-06-29T22:58:58.481Z","model":"grok/grok-4.3","role":"writer","action":"redraft","rationale":"","hash":"1036ef289389558b4f6eca66bd9f77b052163ae370d90c1d6cd0729b2b656f96"}],"topology":null,"slim":true,"ledger_totals":{"claims":5,"sources":6,"exported_claims":5,"exported_sources":6},"question_graph":{"slug":"thymosin-alpha-1-postherpetic","questions":[],"evidence":[],"edges":[],"counts":{"questions":0,"evidence":0,"edges":0}},"verification":{"provenance":{"valid":true,"entries":2,"head":"5cbc6e0aa75a3287fe0451ad028bc139cfdfef2b78061f78d9377fec8bf4f3a0"},"sources":{"valid":true,"entries":6,"head":"61d1eb7ad5b4b22d27700ca5acbf5c293560c6449b3efca08c1e70102698440f"}},"counts":{"claims":5,"sources":6,"provenance":2,"contributions":1,"questions":0,"evidence_ingests":0,"voxel_edges":11},"transport":"Open every URL in this bundle with your browser or web / URL-fetch tool. Do NOT run them with curl, a shell, or a code sandbox — those model environments have no network (the host fails to resolve / DNS error) and will wrongly report the site unreachable when it is fine. Opening the link IS the call.","llm_manifest":{"version":"1","site":"https://miscsubjects.com","purpose":"Peptide evidence articles with hash-chained source ledgers, tiered claims, and a question graph. LLMs should READ bundles/URLs and WRITE back via ingest — never invent doses.","read":{"human_page":"https://miscsubjects.com/a/thymosin-alpha-1-postherpetic","bundle_json":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/topology","question_graph":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/question-graph","sources":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/sources","provenance":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/provenance","contributions":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/contributions","graph_topology":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/graph-topology?question={question}","voxels":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","health":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/health","repair":"POST https://miscsubjects.com/api/protocol/repair","list_articles":"https://miscsubjects.com/api/articles","graph_canvas":"https://miscsubjects.com/graph.html?slugs=thymosin-alpha-1-postherpetic","graph_yield":"https://miscsubjects.com/api/graph?slugs=thymosin-alpha-1-postherpetic&layer=yield","obsidian_vault":"https://miscsubjects.com/api/articles/obsidian-vault?slugs=thymosin-alpha-1-postherpetic","graph_query":"https://miscsubjects.com/api/v1/query?from=thymosin-alpha-1-postherpetic&kind=claim&where=tier=human"},"ask":{"description":"Answer only from topology; creates a question_node with gaps.","api":"POST https://miscsubjects.com/api/protocol/ask","body":{"slug":"{slug}","question":"string"},"imessage":"thymosin-alpha-1-postherpetic|your question","router_tag":"[ARTICLE_ASK]thymosin-alpha-1-postherpetic|question[/ARTICLE_ASK]","auth":"x-terminal-key header for API; iMessage/WhatsApp via miscsubjects build"},"ingest":{"description":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","api":"POST https://miscsubjects.com/api/protocol/ingest","body":{"slug":"{slug}","evidence":"paste text","question_node_id":"optional qn_..."},"imessage":"ingest thymosin-alpha-1-postherpetic|q:{node_id}|paste evidence","router_tag":"[ARTICLE_INGEST]thymosin-alpha-1-postherpetic|evidence[/ARTICLE_INGEST]","tiers":["human","preclinical","anecdotal","mechanistic","speculative"]},"claim":{"description":"Prompt-injection style POST — one claim voxel with who_claims + posted_by provenance.","api":"POST https://miscsubjects.com/api/protocol/claim","body":{"slug":"{slug}","text":"one assertion","tier":"human|preclinical|anecdotal|mechanistic|speculative","who_claims":"study author, platform, or model id","source_ids":"optional [s1]"},"imessage":"claim thymosin-alpha-1-postherpetic|tier|assertion — who claims it?","router_tag":"[ARTICLE_CLAIM]thymosin-alpha-1-postherpetic|tier|assertion[/ARTICLE_CLAIM]","slots":["what_it_is","who_claims_what","what_is_known","what_is_unknown","mechanism","limitations","disclaimer"]},"tiers":{"human":0.8,"preclinical":0.5,"anecdotal":0.3,"mechanistic":0.3,"speculative":0.1},"invariants":["Self-explaining — every API JSON has _self; every paste widget has §SELF; root index at /api/articles/system-map","Append-only — revisions preserved at ?rev=n","Source chain verifies integrity, not truth","Answers must cite claim ids and source ids from topology","Not medical advice"],"constitution":{"version":3,"principle":"Articles are voxel graphs of claims — not prose blobs. Every assertion is a claim atom with tier, weight, source_ids, and posted_by provenance.","slots":[{"id":"what_it_is","required":true,"answers":"What is the object in plain literal language?"},{"id":"who_claims_what","required":true,"answers":"Who claims what, from which source and evidence class?"},{"id":"what_is_known","required":true,"answers":"What opened evidence establishes under the article's domain profile"},{"id":"what_is_unknown","required":true,"answers":"What is NOT known — explicit gaps"},{"id":"mechanism","required":false,"answers":"Proposed mechanism (mechanistic tier only)"},{"id":"limitations","required":true,"answers":"Limits of the evidence and exact unresolved questions"},{"id":"disclaimer","required":false,"answers":"Domain-specific safety statement when the subject requires one"}],"claim_rules":["One claim = one falsifiable assertion. No compound claims.","Every claim must declare tier: human|preclinical|anecdotal|mechanistic|speculative|system.","system tier = architecture/design axioms (not biological mechanism). Use for protocol self-definition.","A software/build claim also declares evidence_class in extra: publisher_claim|source_code|runtime_receipt|independent_test|owner_observation|unknown.","Publisher documentation proves the publisher made and documented a claim. It is not independent runtime proof.","Source code proves an implementation exists. A successful receipt proves one invocation. Neither proves general reliability or field superiority.","Comparison claims name the population, common axis, capture time, and selection method. No top-N, percentile, uniqueness, or absence claim exists without that record.","Sourced claims must cite source_ids from the hash-chained ledger.","Unsourced claims must set source_status: unsourced and why_material.","posted_by is mandatory on every new claim (model id, human, or channel).","No medical advice, no doses, no 'you should take'.","Bad information is retracted (status:retracted), never deleted — retraction event stays on ledger.","Adversary challenges link via challenges[] / challenged_by[] — target may be downweighted.","Leaked secrets are scrubbed to [REDACTED:secret-leak] with scrub_events tombstone — honest audit trail."],"source_rules":["Every source is a voxel edge: type, url, exact quote, summary, found_by, accessed_at.","Sources hash-chain — prev/hash on append.","Anecdotal sources must name platform (reddit|x|youtube|imessage|user_entry).","Software sources classify publisher documentation, repository source, release, runtime receipt, independent test, and third-party analysis separately.","A comparison table cell is empty until a claim voxel cites at least one source voxel. Model prose alone is not evidence."],"writing_rules":["Literal nouns and verbs. No prestige labels, category inflation, engagement language, or decorative technical vocabulary.","Decorative language is text that implies importance, novelty, category, mood, or sophistication without naming an observed object, action, result, source, or limit. Delete it.","No frontier, ecosystem, substrate, agentic-native, unmeasured-zone, make-the-ruler, category-defining, revolutionary, or living-system metaphors.","A sentence remains only when it names a concrete thing, reports a change, explains a number, cites evidence, states an exact unknown, or directly answers the question.","Technical nouns are allowed only when literal. Define the first use by what the named code or data object stores or does.","State the observed object before naming a category for it.","Keep the evidentiary boundary beside the exact claim it limits.","Unknown means unknown. Missing evidence does not become absence."],"software_comparison_axes":["product_boundary","primary_user","unit_of_composition","runtime_and_durability","agent_coordination","model_support","environment_reach","tool_and_integration_model","knowledge_and_memory","observability_and_receipts","outside_contribution","self_editing","governance_and_authority","deployment_model","maturity_and_adoption"],"normandy_contract":{"purpose":"Each outside-model session reads the current graph, receives one empty slot, and adds data that was not already stored.","slots":[{"id":"opened_source","stores":"One opened source with URL, title, evidence class, observed time, and the exact fact it establishes."},{"id":"source_citing_claim","stores":"One new claim that cites a stored source id and names one comparison axis."},{"id":"overlap","stores":"One evidenced capability both systems have."},{"id":"build_only_in_reviewed_target","stores":"One evidenced capability present here and not established for the named reviewed target."},{"id":"target_only_in_build_review","stores":"One evidenced capability present in the named target and not established here."},{"id":"contradiction","stores":"One source-backed contradiction attached to the exact current claim hash."},{"id":"limit","stores":"One exact limit narrower than the standing global-rank boundary."},{"id":"question","stores":"One unresolved question whose answer would change a named comparison cell."},{"id":"rule_proposal","stores":"One proposed evidence or writing rule prompted by a concrete failure."},{"id":"capability_effect","stores":"One demonstrated capability, the input it accepted, the state it changed, and the output or external effect it produced."},{"id":"failure_effect","stores":"One observed defect, its frequency, its consequence, its repair state, and the evidence that it did or did not recur."},{"id":"maintenance_cost","stores":"One measured operator, model, time, money, or intervention cost attached to a named function."},{"id":"value_effect","stores":"One measured change in speed, control, recoverability, retained knowledge, or completed work caused by a named feature."}],"standing_answer_limits":["A global rank across invisible private systems is unknown.","Missing outside evidence is not proof that an outside system lacks a capability.","A successful receipt proves one run, not general reliability.","Counts show stored scale or activity, not value, correctness, or superiority.","Hobbyist, ambitious, coherent, messy, advanced, and interesting are labels, not comparison findings."],"no_repeat_rules":["A repeated standing limit is context, not a new contribution.","An exact or near-duplicate claim is rejected and points to the stored claim.","A duplicate source does not complete an assignment.","A response completes only after at least one new graph object lands.","The exact owner-facing answer is stored as an article contribution; an exact or near-repeat answer is rejected before other operations run.","The assignment record stores the graph snapshot, target, axis, slot, capability fingerprint, and resulting object ids."],"assignment":"GET /api/normandy?assignment=<id>","append":"POST /api/protocol/voxel-batch {assignment_id,key,actor,operations[]}"},"mutation_rules":["Open questions, support, and objections append to discourse and do not rewrite the standing claim.","Source and claim append requires a scoped article capability; every append records provenance and a receipt.","Existing text edits use the current voxel hash. A stale hash writes nothing.","Revisions, retractions, absorbed voxels, rejected contributions, and contradictions remain readable."],"ontology_rules":["Peptide articles (bpc-157, tb-500) are tree roots.","Condition articles (bpc-157-glp1-gut-damage) branch from peptides.","Stack articles (wolverine-stack-glp1) compose peptides — never duplicate peptide mechanism prose.","If an article has no parent embeds and is not a root peptide → sprawl candidate.","Misstep = duplicate scope with another slug; merge or reparent via embeds."],"post_protocol":{"claim":"POST /api/protocol/claim","source":"POST /api/protocol/sources","ingest":"POST /api/protocol/ingest","webhook":"POST /api/articles/<slug>/webhook {kind:claim|source}","imessage_claim":"claim {slug}|{tier}|your assertion — who claims it, source?","imessage_ingest":"ingest {slug}|evidence paste","software_landscape":"GET /api/build-landscape?next=1&lane=field|build|opposition|synthesis","queue_population":"POST /api/build-landscape {action:queue_targets, cohort, query, sort, captured_at, source_url, targets[]}"}},"this_article":{"slug":"thymosin-alpha-1-postherpetic","url":"https://miscsubjects.com/a/thymosin-alpha-1-postherpetic","bundle_url":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/bundle?format=markdown"},"voxel_procedure":{"what":"Every article has a human side (/a/thymosin-alpha-1-postherpetic) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"thymosin-alpha-1-postherpetic\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"thymosin-alpha-1-postherpetic\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"thymosin-alpha-1-postherpetic\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"thymosin-alpha-1-postherpetic\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"thymosin-alpha-1-postherpetic\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"thymosin-alpha-1-postherpetic\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/thymosin-alpha-1-postherpetic/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/thymosin-alpha-1-postherpetic#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."}},"api_urls":{"bundle":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/topology","voxels":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","question_graph":"https://miscsubjects.com/api/articles/thymosin-alpha-1-postherpetic/question-graph","ask":"https://miscsubjects.com/api/protocol/ask","ingest":"https://miscsubjects.com/api/protocol/ingest","claim":"https://miscsubjects.com/api/protocol/claim","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown"}}