{"slug":"thymosin-alpha-1-ibd","verification":{"valid":true,"entries":5,"head":"64129705ef44a5be31fabdd990fdcbf58fac6198f2bc0f2e143af1771d9d87fd"},"count":5,"sources":[{"id":"web:0","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7441522/","title":"Thymosin α1 protects from CTLA-4 intestinal immunopathology","quote":"We demonstrate that thymosin α1 (Tα1), an endogenous peptide with immunomodulatory activities, can protect mice from intestinal toxicity.","summary":"Mouse study on protection from colitis induced by checkpoint inhibitors.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:03:12.995Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"dd4f765ff15f2ae5a4303f7527ee0ea68796ee32f90ce405596a98aa2fc8e236"},{"id":"web:9","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/","title":"Thymosin alpha 1: A comprehensive review of the literature","quote":"Thymosin alpha 1 and its synthetic analogue thymalfasin have well-studied safety profiles and are well-tolerated with only minor side effects.","summary":"Review covering safety across thousands of patients in various indications.","claim_ids":["c1","c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:03:12.995Z","link_status":"ok","quote_status":"unverified","prev":"dd4f765ff15f2ae5a4303f7527ee0ea68796ee32f90ce405596a98aa2fc8e236","hash":"147f46e466c423e7c6da18c501cc1a557cdd094913bac7c429ef038e09dd92f7"},{"id":"web:15","type":"pubmed","url":"https://www.sciencedirect.com/science/article/abs/pii/0016508580901419","title":"Thymosin-dependent T-lymphocyte response in inflammatory bowel disease","quote":"Incubation with thymosin resulted in a significant increase in “avid” ER in patients with CD and UC.","summary":"1980 in vitro study on patient T-cells.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:03:12.995Z","link_status":"http_403","quote_status":"unverified","prev":"147f46e466c423e7c6da18c501cc1a557cdd094913bac7c429ef038e09dd92f7","hash":"a8a8593f3b8fdb87c052b4d68872e5d6ebd4ca60ed5c390ddafdc6a8dfc56d4d"},{"id":"web:29","type":"reddit","url":"https://www.reddit.com/r/PeptidePathways/comments/1sb0nxo/peptide_research_for_crohns_disease/","title":"Peptide Research for Crohn's Disease","quote":"Thymosin Alpha-1 modulates T-cell function and restores immune balance in autoimmune conditions.","summary":"Discussion of peptides including TA1 in colitis model context.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:03:12.995Z","link_status":"ok","quote_status":"unverified","prev":"a8a8593f3b8fdb87c052b4d68872e5d6ebd4ca60ed5c390ddafdc6a8dfc56d4d","hash":"546c39cb6374988d457c6885e6de6e1b5185559f25c699a8ee0935e36cca9f2a"},{"id":"post:39","type":"x","url":"https://x.com/BowTiedUM/status/1760474750730568092","title":"X post on Thymosin Alpha 1 benefits","quote":"Ta1 appears to have an ability to not only stimulate immune response but also modulate the immune system in a way that could be beneficial for treating certain autoimmune diseases.","summary":"Biohacker post on modulation for autoimmunity.","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:03:12.995Z","link_status":"ok","quote_status":"verified","prev":"546c39cb6374988d457c6885e6de6e1b5185559f25c699a8ee0935e36cca9f2a","hash":"64129705ef44a5be31fabdd990fdcbf58fac6198f2bc0f2e143af1771d9d87fd"}]}