{"slug":"thymosin-alpha-1-chemo","verification":{"valid":true,"entries":6,"head":"d9c697b2ac974f2d27f938fd0a0439d5b648ac6006f421ae9295651a022e475a"},"count":6,"sources":[{"id":"s9","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6742685/","title":"A Reappraisal of Thymosin Alpha1 in Cancer Therapy","quote":"Studies in animal models and human patients have shown promising results in different types of malignancies, especially when Tα1 was used in combination with chemotherapy.","summary":"Review of Tα1 in cancer with chemo combination data.","claim_ids":["c7"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:08:58.951Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"cf97e5bf780e203e4cec04d0d3b340f2d71d534d5c687d538b3b7d3f87f14525"},{"id":"s11","type":"pubmed","url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1237978/full","title":"Mechanism and clinical application of thymosin in the treatment of lung cancer","quote":"Thymosin plus NP was found to increase overall response rate (ORR) (odds ratio (OR) 1.86) ... and the addition of thymosin also increased tumor control rate (TCR) (OR 3.06), 1-year survival rate (OR 3.05)","summary":"Meta-analyses of RCTs in NSCLC showing response and survival gains.","claim_ids":["c1","c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:08:58.951Z","link_status":"ok","quote_status":"unverified","prev":"cf97e5bf780e203e4cec04d0d3b340f2d71d534d5c687d538b3b7d3f87f14525","hash":"5b8f8a5d529af4c1cbb41a335956829cef2a4ecbb4adfd7653d90c0142c2832f"},{"id":"s14","type":"pubmed","url":"https://www.tandfonline.com/doi/full/10.2147/CMAR.S555975","title":"Thymosin α1 Elevates Lymphocyte Counts and Improves Prognosis in Patients With Advanced Cancer","quote":"Tα1 treatment for 7 days significantly increased the median counts of peripheral blood total T cells (422.5/μL to 614.0 /μL, P<0.001)","summary":"Human cohort data on lymphocyte recovery.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:08:58.951Z","link_status":"http_403","quote_status":"unverified","prev":"5b8f8a5d529af4c1cbb41a335956829cef2a4ecbb4adfd7653d90c0142c2832f","hash":"f067965c33c31ae2b29527598764cc763dc4088fac6972ec5d383531bb0f1b6a"},{"id":"s17","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38308608/","title":"Comprehensive Review of the Safety and Efficacy of Thymosin Alpha 1","quote":"This study aims to assess the safety and efficacy of Thymosin Alpha 1 (Tα1) through a comprehensive narrative review of clinical studies involving over 11 000 human subjects in more than 30 trials.","summary":"Broad human safety review.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:08:58.951Z","link_status":"ok","quote_status":"verified","prev":"f067965c33c31ae2b29527598764cc763dc4088fac6972ec5d383531bb0f1b6a","hash":"dcc1c9118bc991b76335a78f78c1d15d800c97e704e7144cc302e13bf2b9d2de"},{"id":"s20","type":"pubmed","url":"https://www.nature.com/nature-index/topics/l4/thymosin-alpha-1-applications-in-immunotherapy","title":"Thymosin Alpha 1 Applications in Immunotherapy","quote":"In a zebrafish xenograft of human lung carcinoma, co-administration of Tα1 with vinorelbine reduced tumour burden more effectively than chemotherapy alone, preserved macrophage and T-cell counts","summary":"Preclinical immune-preservation data.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:08:58.951Z","link_status":"ok","quote_status":"verified","prev":"dcc1c9118bc991b76335a78f78c1d15d800c97e704e7144cc302e13bf2b9d2de","hash":"b390ac6a20a74d4cf66810c73926574f42055c20ccb1acad2b80164754b30088"},{"id":"s31","type":"pubmed","url":"https://spcare.bmj.com/content/14/3/269","title":"Gabapentinoids for chemotherapy-induced peripheral neuropathy","quote":"For the prevention setting, our meta-analysis shows that pregabalin did not significantly improve average pain (standardised mean difference (SMD) −0.14, 95% CI −0.51 to 0.23)","summary":"Meta-analysis on CIPN outcomes.","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:08:58.951Z","link_status":"http_403","quote_status":"unverified","prev":"b390ac6a20a74d4cf66810c73926574f42055c20ccb1acad2b80164754b30088","hash":"d9c697b2ac974f2d27f938fd0a0439d5b648ac6006f421ae9295651a022e475a"}]}