{"slug":"tesamorelin","verification":{"valid":true,"entries":5,"head":"853bbca219795e5e5a1825104340e3c7020244c0910c40ee6861ceb960cf1b90"},"count":5,"sources":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/41545261/","title":"Body composition, hepatic fat, metabolic, and safety outcomes of Tesamorelin, a GHRH analogue, in HIV-associated lipodystrophy: A meta-analysis of randomized controlled trials","quote":"Tesamorelin improves body composition, hepatic fat, lean body mass, and IGF-1 levels in HIV-associated lipodystrophy, without serious side effects","summary":"2026 meta-analysis of RCTs concluding tesamorelin benefits body composition and hepatic fat in HIV lipodystrophy with favorable safety.","author":"","publisher":"","date":"","claim_ids":["c1"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:02:16.304Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"deafc06c6a5f7dd98046e0b6a03e987a26199afe00bced2939cfbffb562e4a2a"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39813152/","title":"Effects of Tesamorelin on Neurocognitive Impairment in Persons With HIV and Abdominal Obesity","quote":"Tesamorelin, a growth hormone-releasing hormone, reduces AO and increases IGF-1, suggesting that it might mitigate NCI in people with HIV and viral suppression.","summary":"2025 clinical study on tesamorelin effects on neurocognitive impairment in HIV patients with abdominal obesity.","author":"","publisher":"","date":"","claim_ids":["c2"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:02:16.304Z","link_status":"ok","quote_status":"verified","prev":"deafc06c6a5f7dd98046e0b6a03e987a26199afe00bced2939cfbffb562e4a2a","hash":"55299462964e592ea141f1e0dc057b544541bcbbfc813ba0e518e9a99671f493"},{"id":"s3","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT06554717","title":"Tesamorelin as an Adjunct to Exercise for Improving Physical Function and Muscle Health in Adults With HIV (TRIUMPH Trial)","quote":"The goal of this clinical trial is to learn whether the medication tesamorelin will improve physical function and muscle health in adults with HIV when combined with exercise.","summary":"Ongoing 2026 Phase 2 trial evaluating tesamorelin plus exercise in HIV patients for physical function and muscle health.","author":"","publisher":"","date":"","claim_ids":["c3"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:02:16.304Z","link_status":"ok","quote_status":"unverified","prev":"55299462964e592ea141f1e0dc057b544541bcbbfc813ba0e518e9a99671f493","hash":"6de042dc8ae1370de1f77c3484269d514dbb51fb7a337c1117e3fb8e6a339c99"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38905488/","title":"Efficacy and safety of tesamorelin in people with HIV on integrase inhibitors","quote":"The current analysis provides the first dedicated data on the efficacy and safety of tesamorelin among PWH on INSTI-based regimens. Despite the association of INSTI use with weight gain and adipose tissue dysfunction, tesamorelin had beneficial effects on body composition with no exacerbation of glycemic control.","summary":"2024 subanalysis of RCT showing tesamorelin reduces visceral fat, hepatic fat, and improves fat distribution in HIV patients on integrase inhibitors, well-tolerated.","author":"","publisher":"","date":"","claim_ids":["c4"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:02:38.241Z","link_status":"ok","quote_status":"verified","prev":"6de042dc8ae1370de1f77c3484269d514dbb51fb7a337c1117e3fb8e6a339c99","hash":"66cdb2a41d7ebb7b1d409e1b48f6d5cd17e0858f7c8c16ba81fd9f424b989abb"},{"id":"s5","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT07481734","title":"Tesamorelin for Reduction of Liver Fat in Adults With Fatty Liver Disease (Mock Study)","quote":"This randomized, double-blind, placebo-controlled Phase II study evaluates whether daily subcutaneous tesamorelin (a growth hormone-releasing hormone analog) reduces liver fat in adults with fatty liver disease.","summary":"New 2026 Phase II trial protocol for tesamorelin in MASLD/NAFLD.","author":"","publisher":"","date":"","claim_ids":["c5"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:02:38.241Z","link_status":"ok","quote_status":"unverified","prev":"66cdb2a41d7ebb7b1d409e1b48f6d5cd17e0858f7c8c16ba81fd9f424b989abb","hash":"853bbca219795e5e5a1825104340e3c7020244c0910c40ee6861ceb960cf1b90"}]}