{"slug":"tesamorelin-tirzepatide","verification":{"valid":true,"entries":8,"head":"4fe393083364e1f185be89bf75f7912b3eed680ffaec7eec68663601cdaad4e2"},"count":8,"sources":[{"id":"s1","type":"pubmed","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa2206038","title":"Tirzepatide Once Weekly for the Treatment of Obesity","quote":"mean percentage change in weight at week 72 was −15.0% ... −19.5% ... −20.9% ... and −3.1% with placebo","summary":"Phase 3 RCT showing dose-dependent weight loss in adults with obesity.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:12:07.670Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"d743d333ce64bbc36e23e6c808c2be8be8aebb8bc5a5fe8350bc43749faf3142"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38078870/","title":"The SURMOUNT-4 Randomized Clinical Trial","quote":"overall mean weight reduction from week 0 to 88 was 25.3% for tirzepatide and 9.9% for placebo","summary":"Withdrawal trial confirming maintenance of weight loss.","claim_ids":["c2","c8"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:12:07.670Z","link_status":"ok","quote_status":"verified","prev":"d743d333ce64bbc36e23e6c808c2be8be8aebb8bc5a5fe8350bc43749faf3142","hash":"950f87bf874c5f00d7622b5ae9070c45265983872c03789cbf19a8903ed7fc79"},{"id":"s3","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10159347/","title":"Weight loss efficiency and safety of tirzepatide","quote":"significant loss body weight in the tirzepatide group versus the placebo by -9.81 kg","summary":"Meta-analysis of 10 RCTs on weight outcomes.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:12:07.670Z","link_status":"ok","quote_status":"verified","prev":"950f87bf874c5f00d7622b5ae9070c45265983872c03789cbf19a8903ed7fc79","hash":"3ad5aa637cc89c79b60e504e698f2eaa96c2d796fbe4eb0394f063aeb106a503"},{"id":"s4","type":"pubmed","url":"https://www.ncbi.nlm.nih.gov/books/NBK539127/","title":"Clinical Review Report: Tesamorelin (Egrifta)","quote":"LS mean differences ... −19.6% ... −11.7% ... −16.6%","summary":"Pooled analysis of phase 3 VAT reduction trials.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:12:07.670Z","link_status":"ok","quote_status":"unverified","prev":"3ad5aa637cc89c79b60e504e698f2eaa96c2d796fbe4eb0394f063aeb106a503","hash":"edf72540e84d57ac9d1fd9ec3c8d23639cc4a8704abddd7ab4e4c19d9e53a83e"},{"id":"s5","type":"pubmed","url":"https://jamanetwork.com/journals/jama/fullarticle/1889139","title":"Effect of Tesamorelin on Visceral Fat and Liver Fat in HIV-Infected Patients","quote":"Tesamorelin significantly reduced visceral adipose tissue (mean change, -34 cm2 ... treatment effect, -42 cm2 ... P = .005) and liver fat","summary":"RCT with VAT and hepatic fat endpoints.","claim_ids":["c4","c5","c8"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:12:07.670Z","link_status":"http_403","quote_status":"unverified","prev":"edf72540e84d57ac9d1fd9ec3c8d23639cc4a8704abddd7ab4e4c19d9e53a83e","hash":"00cf1616a7b2cc7ffb148dc626c9148911764046ed88cfeff200d1c29853558c"},{"id":"s6","type":"other","url":"https://www.drugs.com/drug-interactions/tesamorelin-with-tirzepatide-3283-0-4363-0.html","title":"Tesamorelin + Tirzepatide Interactions","quote":"Tesamorelin may interfere with blood glucose control and reduce the effectiveness of tirzepatide","summary":"Database entry on potential glucose interaction.","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:12:07.670Z","link_status":"http_403","quote_status":"unverified","prev":"00cf1616a7b2cc7ffb148dc626c9148911764046ed88cfeff200d1c29853558c","hash":"9eeac398ceb1a88613c18aa96a4c2cd8f286d34d15828e52be3b39d996740606"},{"id":"s7","type":"reddit","url":"https://www.reddit.com/r/tirzepatidecompound/comments/1ev9ol7/tirzepatide_and_tesamorelin/","title":"Tirzepatide and tesamorelin","quote":"I've been taking Sermorelin ... haven't lost an ounce of muscle mass.","summary":"Thread with user reports of stacking for muscle retention.","claim_ids":["c7"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:12:07.670Z","link_status":"ok","quote_status":"unverified","prev":"9eeac398ceb1a88613c18aa96a4c2cd8f286d34d15828e52be3b39d996740606","hash":"084112bb555eea47f900d12123e5dde24128e1ae7cef371b1e5afef5becb26f4"},{"id":"s8","type":"x","url":"https://x.com/archibaldcrane/status/2045135132781408273","title":"X post on Tesamorelin experience","quote":"Wrote up my experience with the peptide Tesamorelin ... for sleep issue from retatrutide / tirzepatide","summary":"Single anecdotal mention of sleep context.","claim_ids":[],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:12:07.670Z","link_status":"ok","quote_status":"unverified","prev":"084112bb555eea47f900d12123e5dde24128e1ae7cef371b1e5afef5becb26f4","hash":"4fe393083364e1f185be89bf75f7912b3eed680ffaec7eec68663601cdaad4e2"}]}