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This lowers IGF-1, slowing protein synthesis while catabolic processes continue. Visceral fat accumulation adds mechanical and inflammatory stress that can further impair muscle quality. In HIV-related lipodystrophy, excess abdominal fat pairs with muscle fat infiltration and reduced lean area. Repair pathways lag behind breakdown when GH pulses weaken. Tesamorelin is discussed here because studies examine its effect on the GH axis and downstream tissue changes rather than symptom masking.","status":"active","vx_hash":"9bad4938140847d89fe69ec74bdf59825a4f9293784b3b1585a87c2f4fb58100","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"accc8b7d39e5af5502363d1f8ae39c19847ba5683721198ca4d99958141efc6f","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"4a0b39231dd0e841410a9ca0a9e617fb08e17f283ce58b954e4980335f8ee2f9","detail":{"divided_from":"body","block":2,"kind":"p"},"prev":"genesis","hash":"accc8b7d39e5af5502363d1f8ae39c19847ba5683721198ca4d99958141efc6f"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d2"},{"id":"d3","kind":"h","type":null,"order":3,"text":"## Why Tesamorelin might help you","status":"active","vx_hash":"f4ee8f1d78c217a9465824a2c36fd726ad66d6a20930f870277cd7013fd6c4e4","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"9cf26994685b5624ba1e1b03a184f8efcf697a92e06624850ff8cc7e447f3d6a","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"cac037f5a3a7b6a910985e3c46a49e8140ffcb8c63a3ff09f2b7c5701e3943d2","detail":{"divided_from":"body","block":3,"kind":"h"},"prev":"genesis","hash":"9cf26994685b5624ba1e1b03a184f8efcf697a92e06624850ff8cc7e447f3d6a"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d3"},{"id":"d4","kind":"p","type":null,"order":4,"text":"If your muscle loss involves low GH/IGF-1 activity or excess visceral fat, the logic chain runs like this. Tesamorelin stimulates the pituitary to release endogenous GH in a more physiologic pattern. That raises circulating IGF-1. Higher IGF-1 supports protein synthesis in muscle tissue. In people who respond with visceral fat reduction, CT scans showed measurable gains in trunk muscle density and lean muscle area over 26 weeks. Therefore, if visceral fat or poor muscle quality is part of your profile, the compound is studied for its potential to shift the balance toward tissue-level repair signals instead of only lowering fat mass.","status":"active","vx_hash":"0c591ef0bb557bb92179f7801bf1e345b8dafa6164dc70ad3d0466b1ca60d77a","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"3d7ee60ead597462d5d07e257a7118ca6020bff06e969f69e4fda48ab6a8161a","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"1af3b3e2b15d79ad1cfd8ee920d96096b141fe711f13ce6b921a6a34725f249a","detail":{"divided_from":"body","block":4,"kind":"p"},"prev":"genesis","hash":"3d7ee60ead597462d5d07e257a7118ca6020bff06e969f69e4fda48ab6a8161a"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d4"},{"id":"d5","kind":"p","type":null,"order":5,"text":"Step 1: GH release increases. Step 2: IGF-1 rises in a pulsatile way. Step 3: Muscle protein turnover favors synthesis. Step 4: In responders, muscle fat decreases and lean area increases on imaging. This targets the regenerative side of the equation for the layers listed above.","status":"active","vx_hash":"89e9aa9719527e1e2eb83faf9d0441479d6b1884afc1a33fb4fcacd6a20acfd0","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"37b4d90f145ec6af5257717ae34db85a4919b7cf9b570f3b81a4530a48c8e168","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"c60a41941c4b160bf36b4280aea2c82f003212ba71a33f0aadd6d57335121944","detail":{"divided_from":"body","block":5,"kind":"p"},"prev":"genesis","hash":"37b4d90f145ec6af5257717ae34db85a4919b7cf9b570f3b81a4530a48c8e168"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d5"},{"id":"d6","kind":"h","type":null,"order":6,"text":"## How these fit together","status":"active","vx_hash":"99fa34fe0f184df15245bdd6179287e2495609255e55f79e62028fefb3b6a674","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"660ac86639a948b216dfa9c0765744d2e20cc1164b4c125fab9922e1335b1aff","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"255677f13849515d0e42f067e34911236d8b3298d6c16100bfa19e68c3074d62","detail":{"divided_from":"body","block":6,"kind":"h"},"prev":"genesis","hash":"660ac86639a948b216dfa9c0765744d2e20cc1164b4c125fab9922e1335b1aff"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d6"},{"id":"d7","kind":"p","type":null,"order":7,"text":"Single-compound focus. Tesamorelin maps directly to the GH axis and visceral fat layer. If your situation includes multiple degeneration layers, this agent addresses the endocrine and body-composition component. Other approaches would need separate evaluation for neural, sleep, or direct anabolic layers.","status":"active","vx_hash":"d75c693a9ecfd86f2313a90d89aaa9b8494fb1a8e89bb5d8b01c5f7039d14bb1","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"073477f5846d4423c0f0056d796ed5c3fa6939278cbb57ee8b15955e063edbf9","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"fed67357002ba2edd91041e67d93c4f2b9708b6f2031fd9dd557867f4c051152","detail":{"divided_from":"body","block":7,"kind":"p"},"prev":"genesis","hash":"073477f5846d4423c0f0056d796ed5c3fa6939278cbb57ee8b15955e063edbf9"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d7"},{"id":"d8","kind":"h","type":null,"order":8,"text":"## What the evidence actually shows","status":"active","vx_hash":"cc4ebc3460a9c2cbb8449cc93ed6fd5084508f247dbbd0fa81115f8b97b95f53","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"ee291ef70dbb4533dc077733e2a313a103319c242681a269e52d1c0aa98bf63f","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"a7a051e6a294dc45c15b7d4859b7020d561e719fe73844f03e3a8f9e7fed8de1","detail":{"divided_from":"body","block":8,"kind":"h"},"prev":"genesis","hash":"ee291ef70dbb4533dc077733e2a313a103319c242681a269e52d1c0aa98bf63f"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d8"},{"id":"d9","kind":"p","type":null,"order":9,"text":"Human data come from secondary analyses of randomized trials in adults with HIV and abdominal obesity. One key study (Adrian et al.) restricted analysis to tesamorelin responders who lost at least 8% visceral adipose tissue. Compared with placebo, these participants showed statistically significant increases in muscle density (1.56–4.86 Hounsfield units across trunk muscle groups) and lean muscle area (0.64–1.08 cm²). A later meta-analysis reported a mean lean body mass increase of 1.42 kg. An ongoing trial (NCT06554717) is testing tesamorelin plus exercise for physical function in HIV. No large human trials exist for primary sarcopenia in non-HIV populations. Animal data on muscle-specific outcomes with tesamorelin are not prominent in the reviewed sources. Reddit and X reports remain anecdotal.","status":"active","vx_hash":"3eb962001d4f26a9f352a3f180bbdc4c368e93d7a18d395813333cc00e739cc8","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"e954f8c18720cb9e20b8154a1ac57a2729d18fe33d5dcd38932472c18b4d2615","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"61f30a4b191bec9716bd357fdbd928585933efac68936a1fe3406bc7c3c669b7","detail":{"divided_from":"body","block":9,"kind":"p"},"prev":"genesis","hash":"e954f8c18720cb9e20b8154a1ac57a2729d18fe33d5dcd38932472c18b4d2615"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d9"},{"id":"d10","kind":"h","type":null,"order":10,"text":"## What scientists say","status":"active","vx_hash":"f4615e0485952271f91e96cf870a6cee54ab2f3888558f633cbc6a9d6b120279","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"cbc4a76723e3987ba2884be1a70fcccc880b66ec69fa057dc11f0a3e32d89e71","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"2f1dd55083de1fa734f2f06a8337a050d5a0b3f635bfc8bb709abab75705a1ef","detail":{"divided_from":"body","block":10,"kind":"h"},"prev":"genesis","hash":"cbc4a76723e3987ba2884be1a70fcccc880b66ec69fa057dc11f0a3e32d89e71"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d10"},{"id":"d11","kind":"p","type":null,"order":11,"text":"The authors of the 2019 Journal of Frailty & Aging paper conclude that among responders, tesamorelin increased skeletal muscle area and density. They note the changes occurred alongside visceral fat reduction and call for longer-term studies on functional impact outside HIV. Reviews emphasize that lean mass gains occur without proportional subcutaneous fat loss or major glycemic disruption in the studied cohorts. Researchers highlight that benefits appear tied to visceral fat responders rather than universal.","status":"active","vx_hash":"75229bdb19f9efed565b8a718fdfd77196326e1b6168954d030227cc902272e5","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"d3e3a590663c03d8ef098e6fc503ddb74d9d264f16030993f040dddf92ab832f","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"042773b78b982bcbe8727713bb9107248b1d0e43b6c9ff4bf7f09445c364df51","detail":{"divided_from":"body","block":11,"kind":"p"},"prev":"genesis","hash":"d3e3a590663c03d8ef098e6fc503ddb74d9d264f16030993f040dddf92ab832f"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d11"},{"id":"d12","kind":"h","type":null,"order":12,"text":"## What people say on Reddit","status":"active","vx_hash":"f8110c1b19fc0ad9f23e20fafcf6cf9c56b4ecab0709c776198ec98672151b73","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"c7d3151af54f0b13169a0f42a4b1c8a6dfac6c424e80a31370a1f06d86e91eee","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"feb303756a303788527cf602bf2c3c6b00ab8c384fb9fff4baa9ffc53e0049c3","detail":{"divided_from":"body","block":12,"kind":"h"},"prev":"genesis","hash":"c7d3151af54f0b13169a0f42a4b1c8a6dfac6c424e80a31370a1f06d86e91eee"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d12"},{"id":"d13","kind":"p","type":null,"order":13,"text":"Users in peptide communities describe tesamorelin as helping preserve lean mass during calorie deficits. One post states: “Tesa is a tool that raises IGF-1 levels which can in turn preserves muscle mass in a calories deficit and potentially build lean muscle.” Another reports: “Even with zero exercise my lean muscle mass increased by about 15%, visceral fat reduction by 80%.” Several mention better recovery and visible muscle definition when combined with training, though scale weight often stays stable because fat loss offsets any lean gain. Experiences vary; some note waist reduction without overall weight change.","status":"active","vx_hash":"f427e50a15639be2434a1b8e4ffc1c9b5394b8158bddca21e865e2296f5a2d8d","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"1c660e6044969b7b0bf05e66d3242ff0025dd67e7c5a57392b3c6d818548c2d3","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"a99cbe519d557a1503b5a264e128cf3b2da5acf27925e1ce7f392222cb76a4fa","detail":{"divided_from":"body","block":13,"kind":"p"},"prev":"genesis","hash":"1c660e6044969b7b0bf05e66d3242ff0025dd67e7c5a57392b3c6d818548c2d3"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d13"},{"id":"d14","kind":"h","type":null,"order":14,"text":"## What people say on X","status":"active","vx_hash":"39f89af2c4e34ca33211d0c7f87cc3c4cb68e0f8ffd674f7ee6c9dfbf41b716c","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"dfd917b2252a17de92732cd59e64183b4e9aa80f11604adac78237b49cf3b768","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"4dd8bbfdb0452cc6235c2300209b5132daba3913b8f54ab179b1a73109c298dd","detail":{"divided_from":"body","block":14,"kind":"h"},"prev":"genesis","hash":"dfd917b2252a17de92732cd59e64183b4e9aa80f11604adac78237b49cf3b768"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d14"},{"id":"d15","kind":"p","type":null,"order":15,"text":"Public posts on X referencing tesamorelin and muscle are sparse in current searches. Most discussion echoes the clinical focus on visceral fat reduction and secondary lean mass observations from the HIV trials. Anecdotal functional claims appear less frequently than on Reddit.","status":"active","vx_hash":"15358b54ce045f563955ea653b321018de945d35dfca611a128df7ae46f25b20","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"9fe4a21d46dedb84c60aba84cf187a7401be28a7c5c05dc1b3edccc9f33078e7","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"1006dccba06c0e3f1353a56bfb2eb65e0455cb49f9c6d3f1728b76768d6a7dfa","detail":{"divided_from":"body","block":15,"kind":"p"},"prev":"genesis","hash":"9fe4a21d46dedb84c60aba84cf187a7401be28a7c5c05dc1b3edccc9f33078e7"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d15"},{"id":"d16","kind":"h","type":null,"order":16,"text":"## What we do not know","status":"active","vx_hash":"6b42d6b52880d8974bf3ff2613e934e526ae74e6a6a249d2ed2c0534c5d21e85","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"c6c0ca9ed0aaddce44ae8caac3f9800b8bb6ef1986f96240607630a6f08512f4","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:24.087Z","actor":"owner","text_sha":"7d96a49fba77f6a48c0321db2ae4180a902beae62e2aac0d23408fbf8333a177","detail":{"divided_from":"body","block":16,"kind":"h"},"prev":"genesis","hash":"c6c0ca9ed0aaddce44ae8caac3f9800b8bb6ef1986f96240607630a6f08512f4"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:24.087Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-muscle-loss/d16"},{"id":"d17","kind":"p","type":null,"order":17,"text":"Human evidence is concentrated in HIV populations with abdominal obesity. Direct trials in age-related sarcopenia or non-HIV muscle loss are absent. Long-term (>26 weeks) effects on muscle strength, physical performance, or fracture risk remain unmeasured in published data. Whether gains persist after stopping treatment is unknown. Interactions with resistance training protocols or other body-composition interventions need further controlled study. 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article has a human side (/a/tesamorelin-muscle-loss) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"tesamorelin-muscle-loss\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"tesamorelin-muscle-loss\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"tesamorelin-muscle-loss\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"tesamorelin-muscle-loss\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"tesamorelin-muscle-loss\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"tesamorelin-muscle-loss\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/tesamorelin-muscle-loss/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/tesamorelin-muscle-loss/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/tesamorelin-muscle-loss#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."},"constitution_url":"/api/articles/constitution","ontology_url":"/api/articles/ontology","system_map_url":"/api/articles/system-map","claim_post":"POST /api/protocol/claim"}