{"slug":"tesamorelin-insomnia","verification":{"valid":true,"entries":1,"head":"ed2861fb5ab22f52a4866ebdcb80c65cb2d81a292610fa10f1d3bca0b4fa9c87"},"count":1,"models":["grok/grok-4.3"],"yield":{"passes":1,"energy_spent_rows":0,"total_cost_usd":0.023091,"waste_cost_usd":0,"total_tokens":15974,"material_outputs":0,"usd_per_output":null,"models":[{"model":"grok/grok-4.3","passes":1,"cost_usd":0.023091,"tokens_total":15974,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T23:20:04.031Z","model":"grok/grok-4.3","role":"writer","action":"redraft","payload":{"title":"Tesamorelin for Insomnia: Evidence Review","register":"source_ledger","body":"## What's breaking down\n\nInsomnia involves disrupted sleep architecture, reduced slow-wave sleep, and impaired overnight repair processes. Growth hormone release normally peaks during deep sleep stages. Declines in this axis or excess visceral fat can fragment sleep and blunt recovery signals. Tesamorelin targets the GH axis directly rather than suppressing symptoms.\n\n## Why Tesamorelin might help you\n\n1. **Therefore for you:** If GH axis decline contributes to your fragmented sleep, Tesamorelin is discussed because it stimulates endogenous pulsatile GH release aligned with natural nighttime peaks.\n2. **Therefore for you:** If visceral fat load interferes with sleep continuity, Tesamorelin is discussed because it reduces visceral adipose tissue in studied populations, which may ease mechanical or metabolic strain on rest.\n3. **Therefore for you:** If your problem centers on tissue repair outpacing breakdown during sleep, Tesamorelin is discussed because it amplifies GH/IGF-1 pathways linked to overnight regeneration rather than masking wakefulness.\n\n## How these fit together\n\nSingle-compound focus. Tesamorelin addresses the GH axis and visceral fat layer. If your profile includes other degeneration layers, additional compounds would target them separately without overlap.\n\n## What the evidence actually shows\n\nNo completed human trials specifically test Tesamorelin for insomnia treatment. Early development documents noted phase II exploration for sleep maintenance insomnia, but results are not publicly detailed and the compound advanced for HIV lipodystrophy instead. Human trials in HIV patients show visceral fat reduction and increased overnight GH but do not report primary sleep outcome measures. Side-effect listings from regulatory sources include insomnia and trouble sleeping in 1-10% of participants. Preclinical or mechanistic data link GHRH analogs to slow-wave sleep promotion in general models, but direct Tesamorelin studies in animals for sleep are absent from available records.\n\n## What scientists say\n\nResearchers note that GH secretion ties closely to slow-wave sleep, yet current Tesamorelin trials prioritize body composition over sleep architecture. Direct evidence for insomnia benefit remains limited; most data derive from metabolic endpoints in specific patient groups.\n\n## What people say on Reddit\n\nAnecdotal reports are mixed. Some users describe disrupted sleep or lighter rest when injecting at night and switch to morning dosing. Others report deeper slow-wave sleep and better recovery after adjustment or consistent evening use. Individual responses vary widely with timing, dose titration, and fasting status around injection.\n\n## What people say on X\n\nLimited public posts echo Reddit patterns: occasional mentions of improved nighttime recovery when timed with natural GH pulses, alongside reports of initial sleep interference that resolves with schedule changes.\n\n## What we do not know\n\nLong-term effects on sleep architecture in non-HIV populations. Whether visceral fat reduction directly improves insomnia independent of weight or metabolic changes. Optimal timing for sleep outcomes versus other goals. Head-to-head data against other sleep interventions.\n\n## Safety and limits\n\nCommon side effects include injection-site reactions, joint pain, and fluid retention. Insomnia appears in some safety databases. Monitoring IGF-1 and glucose is standard in studied uses. Not approved for insomnia; evidence grade for this use is low.","claims":[{"id":"c1","text":"Tesamorelin was noted in early development for potential treatment of sleep maintenance insomnia.","section":"What the evidence actually shows","tier":"mechanistic","source_ids":["s1"],"source_status":"sourced","why_material":"Establishes historical intent but no completed efficacy data.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"slot":null,"who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:20:03.597Z","model":"grok/grok-4.3","rationale":""},"extra":{}},{"id":"c2","text":"No completed human trials test Tesamorelin specifically for insomnia outcomes.","section":"What the evidence actually shows","tier":"human","source_ids":["s2"],"source_status":"sourced","why_material":"Clarifies evidence gap for readers.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"slot":null,"who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:20:03.597Z","model":"grok/grok-4.3","rationale":""},"extra":{}},{"id":"c3","text":"Regulatory side-effect data list insomnia and trouble sleeping in 1-10% of Tesamorelin users.","section":"What the evidence actually shows","tier":"human","source_ids":["s3","s4"],"source_status":"sourced","why_material":"Documents reported adverse effects on sleep.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"slot":null,"who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:20:03.597Z","model":"grok/grok-4.3","rationale":""},"extra":{}},{"id":"c4","text":"Reddit users report mixed sleep effects with Tesamorelin, some improved deep sleep and others disruption resolved by timing changes.","section":"What people say on Reddit","tier":"anecdotal","source_ids":["s5"],"source_status":"sourced","why_material":"Captures real-world user variation.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"slot":null,"who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:20:03.597Z","model":"grok/grok-4.3","rationale":""},"extra":{}},{"id":"c5","text":"GHRH analogs can promote slow-wave sleep in mechanistic models.","section":"What the evidence actually shows","tier":"mechanistic","source_ids":["s2"],"source_status":"sourced","why_material":"Provides biological rationale without direct Tesamorelin proof.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"slot":null,"who_claims":"grok/grok-4.3","posted_by":{"actor":"grok/grok-4.3","channel":"protocol/draft","ts":"2026-06-29T23:20:03.597Z","model":"grok/grok-4.3","rationale":""},"extra":{}}],"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/17086939/","title":"tesamorelin, a synthetic human growth hormone releasing factor analog","quote":"Theratechnologies... phase II clinical trials for sleep disorder...","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"other","url":"https://www.empowersleep.com/articles/tesamorelin-and-sleep-what-does-the-science-say","title":"Tesamorelin and Sleep: What Does the Science Say?","quote":"While studies of GHRH suggest it can promote slow-wave sleep, evidence directly linking Tesamorelin to improved sleep remains limited.","link_status":"ok","quote_status":"verified"},{"id":"s3","type":"medical","url":"https://www.mayoclinic.org/drugs-supplements/tesamorelin-subcutaneous-route/description/drg-20074632","title":"Tesamorelin (subcutaneous route) - Side effects & dosage","quote":"unable to sleep; trouble sleeping","link_status":"http_403","quote_status":"unverified"},{"id":"s4","type":"medical","url":"https://www.drugs.com/sfx/tesamorelin-side-effects.html","title":"Tesamorelin Side Effects","quote":"Common (1% to 10%): ... insomnia","link_status":"http_403","quote_status":"unverified"},{"id":"s5","type":"reddit","url":"https://www.reddit.com/r/Peptidesource/comments/1o91wy1/tesamorelin_cant_sleep/","title":"Tesamorelin, Can't sleep","quote":"It affected my sleep... switch to evening injections. Works really well for me and I don’t experience insomnia.","link_status":"ok","quote_status":"unverified"}]},"rationale":"","tokens_in":13475,"tokens_out":2499,"cost":0.02309125,"prev_hash":"genesis","hash":"ed2861fb5ab22f52a4866ebdcb80c65cb2d81a292610fa10f1d3bca0b4fa9c87"}]}