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Platinum drugs, taxanes, and vinca alkaloids hit sensory axons first. This leads to axon degeneration, myelin sheath disruption, and slowed nerve conduction. Inflammation and oxidative stress add layers. Symptoms often include numbness, tingling, pain, and balance issues that can persist or worsen after treatment ends (coasting effect). The core issue is repair lagging behind ongoing degeneration. 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You are reading about **Chemotherapy-induced neuropathy (CIPN)** — what breaks down matters before any compound name.\n2. **Therefore for you:** If the GH/IGF-1 axis and tissue repair pathways are part of your problem, Tesamorelin is discussed because it targets repair (tissue) — not because it masks pain.","status":"active","vx_hash":"cdaffbed5e16a070645614f854c627a4f5a0a5c70020f72a4c45eff18c20c87b","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"3a016bfe6d29d119a2cd860e06a710145bee9815265e83d79903b36b14c29b53","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"28f185d83d7764a9aa7f2483ecb05d80acfc25cf9eb5eda587bc06182f83cc33","detail":{"divided_from":"body","block":4,"kind":"list"},"prev":"genesis","hash":"3a016bfe6d29d119a2cd860e06a710145bee9815265e83d79903b36b14c29b53"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d4"},{"id":"d5","kind":"p","type":null,"order":5,"text":"Tesamorelin stimulates growth hormone release. Higher GH can raise IGF-1 levels. IGF-1 supports axon growth and Schwann cell function in lab models. If your neuropathy involves stalled regeneration, this pathway could matter. It does not directly block pain signals.","status":"active","vx_hash":"4966bb4af8f8b08d7a8671d71a823ea5eeb9bafba4fb58638cfbd6a6bc9cbeb4","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"4c2b3bd5e3cf9b73273096e5f07822c1049e098bb715e263af466dc60b78e692","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"f03baca713a176c58243d7898c480d01453a28bf26866dfccabf672043e9f53d","detail":{"divided_from":"body","block":5,"kind":"p"},"prev":"genesis","hash":"4c2b3bd5e3cf9b73273096e5f07822c1049e098bb715e263af466dc60b78e692"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d5"},{"id":"d6","kind":"h","type":null,"order":6,"text":"## Why Gabapentin / pregabalin matters for you","status":"active","vx_hash":"99114c2cc5b392865bf8bf41ee4631cdc2471c4f77dee902e6a7aba3faaf85ee","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"89f89f25df7d4caa93f9e70d6112fbf0a628a3ad095fe47ba05099d6154a778d","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"a89512f8aa2c485b62dd6e5ee18e36970e0a163bfab19607c1922ff06d26071b","detail":{"divided_from":"body","block":6,"kind":"h"},"prev":"genesis","hash":"89f89f25df7d4caa93f9e70d6112fbf0a628a3ad095fe47ba05099d6154a778d"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d6"},{"id":"d7","kind":"p","type":null,"order":7,"text":"**Drug:** Gabapentin / pregabalin\n**What it does:** Masks neuropathic pain signal; does not repair nerve.\n**Therefore for you:** This drug suppresses a signal. It can reduce pain intensity so daily function improves, but it does not address axon damage or support regeneration. Symptom relief may let you stay active while repair pathways (if any) work, yet it trades off by not fixing the underlying breakdown.","status":"active","vx_hash":"dfee20d49588afda7d799766f475e26a21890ca1ca93fe97bc0331bc0eb8036e","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"334b8303a86a1dd20b5638ca6c2686151e48081eb86f1eb00aa2e3a7a874a536","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"f93a1a545040978cd04c24dcc14fde0f23178f77d88c61142d1f0a06bfb1b524","detail":{"divided_from":"body","block":7,"kind":"p"},"prev":"genesis","hash":"334b8303a86a1dd20b5638ca6c2686151e48081eb86f1eb00aa2e3a7a874a536"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d7"},{"id":"d8","kind":"h","type":null,"order":8,"text":"## How these fit together","status":"active","vx_hash":"c6a9232294369043bb12e7d1ce7211d9aa47a75b561bbfc4a183d4775708cbfb","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"0fdd081468924f34fd086355d15fca8ad8e7a067ab7ca36132a70341fbcf5b82","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"255677f13849515d0e42f067e34911236d8b3298d6c16100bfa19e68c3074d62","detail":{"divided_from":"body","block":8,"kind":"h"},"prev":"genesis","hash":"0fdd081468924f34fd086355d15fca8ad8e7a067ab7ca36132a70341fbcf5b82"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d8"},{"id":"d9","kind":"p","type":null,"order":9,"text":"Single-compound focus — if your condition profile includes a multi-peptide stack, siblings target other layers listed in the condition profile.","status":"active","vx_hash":"0023ec78c1269d925bccb6a40d8259ead53e75b8d1df6e8211eb89d3810ab6d5","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"9cca82d950945faecf2355d5ab0ab3d78d61d965587ef79fdb3bd57e29eb9159","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"c2ad98828fc97845a2d8301bcbb28499a499eca01d27b8754f58a5bd039ad6e9","detail":{"divided_from":"body","block":9,"kind":"p"},"prev":"genesis","hash":"9cca82d950945faecf2355d5ab0ab3d78d61d965587ef79fdb3bd57e29eb9159"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d9"},{"id":"d10","kind":"list","type":null,"order":10,"text":"- **Tesamorelin** → GH axis / visceral fat","status":"active","vx_hash":"06368c0fa3791b1fed003f0a5a291405c7899791d708f4a60ab3b3105fcde0b5","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"66cb03b0b7ff8da39439186f1ce065ecebbe0d00859f9efa1171e19b6ae2c0e5","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"51adb58f3262f54e20c44eb0f8d864be729ae247f48e3bcb5134d7a53bea4ce5","detail":{"divided_from":"body","block":10,"kind":"list"},"prev":"genesis","hash":"66cb03b0b7ff8da39439186f1ce065ecebbe0d00859f9efa1171e19b6ae2c0e5"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d10"},{"id":"d11","kind":"p","type":null,"order":11,"text":"Tesamorelin aims at a repair layer via GH/IGF-1. Gabapentin/pregabalin handles symptom load. They address different parts: one potential regeneration support, one signal suppression. No overlap in mechanism, so they could run in parallel if both layers matter to you.","status":"active","vx_hash":"8fe9b61afa3f9ed574486e67fb61190c14c785c251960c261c98a68e5dc22f46","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"34ae131d7d9bc9e93de06dfb458f3f38370f05ee54a90b62736b4aa8e4b77bf0","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"25cae562ea1d529079d89d5453ea220b5eddeecbb2d34d8c8926b38a923be40b","detail":{"divided_from":"body","block":11,"kind":"p"},"prev":"genesis","hash":"34ae131d7d9bc9e93de06dfb458f3f38370f05ee54a90b62736b4aa8e4b77bf0"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d11"},{"id":"d12","kind":"h","type":null,"order":12,"text":"## What the evidence actually shows","status":"active","vx_hash":"c508566aa7eded5cd76d3e0aa7b43f978b733accc127201e5dfd4caa8e9e6a5e","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"ec94c388da07bc03c2a99927039c343e6665b3de3339c81242965ac566e9c1eb","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"a7a051e6a294dc45c15b7d4859b7020d561e719fe73844f03e3a8f9e7fed8de1","detail":{"divided_from":"body","block":12,"kind":"h"},"prev":"genesis","hash":"ec94c388da07bc03c2a99927039c343e6665b3de3339c81242965ac566e9c1eb"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d12"},{"id":"d13","kind":"p","type":null,"order":13,"text":"No published human trials test Tesamorelin specifically for CIPN. One ongoing Phase 2 randomized, double-blind, placebo-controlled trial (NCT03150511) examines Tesamorelin after surgical repair of peripheral nerve injuries such as ulnar nerve lacerations. It measures motor and sensory recovery over one year. Results are not yet available (human tier: none for CIPN; preclinical/mechanistic only for nerve regeneration concepts).","status":"active","vx_hash":"68f53c1ef0c2da0dc5f3676efbc8ed1011f015f0be1a9826fd51bb5cd140e3fd","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"1e9112a85e4da67657dcce64e3b133c36925ba814e4623a9eeb031979f09d092","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"40ee0e9d64703d78b85b523fda351bfca80f7d36d9278dc661e17cbfb41b8882","detail":{"divided_from":"body","block":13,"kind":"p"},"prev":"genesis","hash":"1e9112a85e4da67657dcce64e3b133c36925ba814e4623a9eeb031979f09d092"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d13"},{"id":"d14","kind":"p","type":null,"order":14,"text":"Animal data on GH/IGF-1 and nerve repair exist but do not include Tesamorelin or CIPN models directly. FAERS database analysis links Tesamorelin reports to carpal tunnel syndrome (anecdotal tier from pharmacovigilance).","status":"active","vx_hash":"4b242d9bdb1bed705d6dd0562aa1c6d42c972739aab9c31898dde40db480e7ea","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"140c33708cf3a93022a1670732d16bbc90c4584d8ab774d246ba747a05a6193a","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"12f77e08166ac468a809b26f1decb0ba1103bdf926e65a791f0c33c9e186449f","detail":{"divided_from":"body","block":14,"kind":"p"},"prev":"genesis","hash":"140c33708cf3a93022a1670732d16bbc90c4584d8ab774d246ba747a05a6193a"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d14"},{"id":"d15","kind":"p","type":null,"order":15,"text":"Gabapentin and pregabalin have multiple human trials showing modest pain reduction in CIPN and other neuropathies (human tier).","status":"active","vx_hash":"7d7166efab531d813d9ef16ccc7458ed3baae18c294b61a9d5fbb2c633d6e64f","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"c5759c3803f07f6d3630b223a74fd89d996af768120bdd0ef34a6f9ab78c9d98","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"d5feb610fe6c75c4f3ff8209705df33e4427134fea86f0bea3e4d1ea1b9a0196","detail":{"divided_from":"body","block":15,"kind":"p"},"prev":"genesis","hash":"c5759c3803f07f6d3630b223a74fd89d996af768120bdd0ef34a6f9ab78c9d98"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d15"},{"id":"d16","kind":"h","type":null,"order":16,"text":"## What scientists say","status":"active","vx_hash":"f11b5ac76ca27647a41b6639792f971264e25aa8ad443760b3431930fa1d34b5","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"bcc103186c6ddfb54f9ce510042533ba95e980747779561e312984416617ee6f","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"2f1dd55083de1fa734f2f06a8337a050d5a0b3f635bfc8bb709abab75705a1ef","detail":{"divided_from":"body","block":16,"kind":"h"},"prev":"genesis","hash":"bcc103186c6ddfb54f9ce510042533ba95e980747779561e312984416617ee6f"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d16"},{"id":"d17","kind":"p","type":null,"order":17,"text":"Researchers note GH/IGF-1 can promote axonal regeneration and reduce muscle atrophy after nerve injury in preclinical settings. The Johns Hopkins trial tests whether Tesamorelin translates this to humans after traumatic nerve cuts. No statements exist on CIPN specifically. IGF-1 mechanisms remain under study for various neuropathies (mechanistic tier).","status":"active","vx_hash":"b43226e8fcefc7a387521e104cfdd7ebb2086735592065cb460762a18b6e04f9","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"80eb9d0d52986fb7c8453d40ac35b6b776da6b85985e839364548d91860686b9","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"1679877f8020bb7410567fb97b4ad9a0c0f873f6cfc0ac8890f4e85baafe4293","detail":{"divided_from":"body","block":17,"kind":"p"},"prev":"genesis","hash":"80eb9d0d52986fb7c8453d40ac35b6b776da6b85985e839364548d91860686b9"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d17"},{"id":"d18","kind":"h","type":null,"order":18,"text":"## What people say on Reddit","status":"active","vx_hash":"06b7d47028be1a40985f19ba23fc39c8e714e989d78340355151463bfc3c5ddf","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"67882234081d44470fda9d3aae7c0939cd79187fecf075d8a639ac5d6df1c5b1","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"feb303756a303788527cf602bf2c3c6b00ab8c384fb9fff4baa9ffc53e0049c3","detail":{"divided_from":"body","block":18,"kind":"h"},"prev":"genesis","hash":"67882234081d44470fda9d3aae7c0939cd79187fecf075d8a639ac5d6df1c5b1"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d18"},{"id":"d19","kind":"p","type":null,"order":19,"text":"Limited mentions. One post discusses the peripheral nerve injury trial but no personal CIPN experience. Other threads note Tesamorelin side effects like hand numbness or wrist discomfort in non-CIPN users. No consistent reports of CIPN improvement (anecdotal tier, very low volume).","status":"active","vx_hash":"76be98fcd5f9e7d98e88a35ffe3925d94755ad035cb7f1d73038f1cfae4ace06","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"365c7be5d37abdf60f5b0b72cf07914a16bd17dad1eefbc847e8e4a1023cb3c1","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"7ba0d0181488b23f9ca23a07b3cdd0fee3a48f5414582ad223266540f816e0da","detail":{"divided_from":"body","block":19,"kind":"p"},"prev":"genesis","hash":"365c7be5d37abdf60f5b0b72cf07914a16bd17dad1eefbc847e8e4a1023cb3c1"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d19"},{"id":"d20","kind":"h","type":null,"order":20,"text":"## What people say on X","status":"active","vx_hash":"7cd35ee759918860ff88643bb62f375c2354a7e57375bc8d6e5250e1a724ec36","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"5885e86d0e1e0289954cf8548bb2c39529b29543ee32e1f5160e49b9ec837d91","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"4dd8bbfdb0452cc6235c2300209b5132daba3913b8f54ab179b1a73109c298dd","detail":{"divided_from":"body","block":20,"kind":"h"},"prev":"genesis","hash":"5885e86d0e1e0289954cf8548bb2c39529b29543ee32e1f5160e49b9ec837d91"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d20"},{"id":"d21","kind":"p","type":null,"order":21,"text":"No identifiable posts linking Tesamorelin use to CIPN outcomes or experiences (anecdotal tier: none found).","status":"active","vx_hash":"d26217d04bd2b406586f8ca440f21cf8714b1d81e248bec2781e14d9c4c01aa9","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"a6dbe0613c2435d9966eb95c902472783ceb5c408efe650b83cab3354e7b8b16","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"32d6630add4f1c14e08b1c89c6e637ac0e70ae2545e7423431741837ff9b46b5","detail":{"divided_from":"body","block":21,"kind":"p"},"prev":"genesis","hash":"a6dbe0613c2435d9966eb95c902472783ceb5c408efe650b83cab3354e7b8b16"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d21"},{"id":"d22","kind":"h","type":null,"order":22,"text":"## What we do not know","status":"active","vx_hash":"16db44365c3d714d55673ccb5248225c478ba485d6675c2f43548c292b29e21c","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"3f1dfeb73c7cdd31a6b8c2ce757c033974c60d33d27e641cea37a4f8ef5aa7eb","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"7d96a49fba77f6a48c0321db2ae4180a902beae62e2aac0d23408fbf8333a177","detail":{"divided_from":"body","block":22,"kind":"h"},"prev":"genesis","hash":"3f1dfeb73c7cdd31a6b8c2ce757c033974c60d33d27e641cea37a4f8ef5aa7eb"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d22"},{"id":"d23","kind":"p","type":null,"order":23,"text":"Whether Tesamorelin improves CIPN symptoms, nerve conduction, or quality of life in humans remains unknown. The ongoing trial targets traumatic injuries, not chemo-related damage. Long-term effects on cancer survivors, interactions with chemo history, and optimal timing are unstudied. IGF-1 elevation safety after cancer treatment lacks specific data.","status":"active","vx_hash":"6619eee9c68be103512ea0604df07d9681b347ca1f403bee6c42490567669d52","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"89317448b8cef9bdbc1a9e4044555f7f18f7fb4dbd51be80819163385adce0c4","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"b56478596508c155717925989db7be9d7e21440d89f25428bf1c2515c7ee750b","detail":{"divided_from":"body","block":23,"kind":"p"},"prev":"genesis","hash":"89317448b8cef9bdbc1a9e4044555f7f18f7fb4dbd51be80819163385adce0c4"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d23"},{"id":"d24","kind":"h","type":null,"order":24,"text":"## Safety and limits","status":"active","vx_hash":"335e4c0d839ab2af1ee2c18f471be5bf8eb233afad72341fe210953675522171","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"f9f60d98d3eb30c4a678391e4d04f69b9c22abf7834193fdb14ddcb019d04910","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"404f7427c043c6ec7a5cb4416bbec9ec336e19f8757fb217be5c5c2161ff8cb6","detail":{"divided_from":"body","block":24,"kind":"h"},"prev":"genesis","hash":"f9f60d98d3eb30c4a678391e4d04f69b9c22abf7834193fdb14ddcb019d04910"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d24"},{"id":"d25","kind":"p","type":null,"order":25,"text":"Tesamorelin is FDA-approved for HIV-associated lipodystrophy; common effects include injection site reactions, joint pain, and fluid retention. It raises IGF-1, which requires monitoring in some contexts. Gabapentin/pregabalin carry dizziness, sedation, and dependence risks with long-term use. Neither compound repairs nerves. All information here is for evidence review only; consult qualified clinicians for personal health decisions.","status":"active","vx_hash":"38eb6e29a66f73195dd801e6ebaed5324191363691b508590a3bd870f606c87c","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"d22542f9210914b80fe9efc1e0056f0ce8634f539a14e4ef0e149a51038bc24a","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:21.257Z","actor":"owner","text_sha":"2c50fcde4bda47a0e1815cd87765b79cf49468527f9ebc2fcc22f819e84fb86c","detail":{"divided_from":"body","block":25,"kind":"p"},"prev":"genesis","hash":"d22542f9210914b80fe9efc1e0056f0ce8634f539a14e4ef0e149a51038bc24a"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:21.257Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tesamorelin-chemo-neuropathy/d25"}],"voxels":[{"id":"c1","div_id":"claim:c1","kind":"claim","text":"No 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article has a human side (/a/tesamorelin-chemo-neuropathy) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"tesamorelin-chemo-neuropathy\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"tesamorelin-chemo-neuropathy\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"tesamorelin-chemo-neuropathy\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"tesamorelin-chemo-neuropathy\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"tesamorelin-chemo-neuropathy\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"tesamorelin-chemo-neuropathy\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/tesamorelin-chemo-neuropathy/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/tesamorelin-chemo-neuropathy/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/tesamorelin-chemo-neuropathy#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."},"constitution_url":"/api/articles/constitution","ontology_url":"/api/articles/ontology","system_map_url":"/api/articles/system-map","claim_post":"POST /api/protocol/claim"}