{"slug":"tesamorelin-brain-fog","verification":{"valid":true,"entries":4,"head":"7d37c60feb1129543440d685db9f1835493261c919252dfa7361dcd7b1e4b317"},"count":4,"sources":[{"id":"s1","type":"pubmed","url":"https://jamanetwork.com/journals/jamaneurology/fullarticle/1306261","title":"Effects of Growth Hormone–Releasing Hormone on Cognitive Function in Adults With Mild Cognitive Impairment and Healthy Older Adults","quote":"Twenty weeks of GHRH administration had favorable effects on cognition in both adults with MCI and healthy older adults.","summary":"Baker 2012 RCT details and results on cognition.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:27:12.367Z","link_status":"http_403","quote_status":"unverified","prev":"genesis","hash":"8f3c7e67a77a13b59bded158b269395831a09b58fdd17371c4c2100415be774f"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39813152/","title":"Effects of Tesamorelin on Neurocognitive Impairment in Persons With HIV and Abdominal Obesity","quote":"While tesamorelin reduced WC, the cognitive benefits did not significantly differ between groups.","summary":"Ellis 2025 trial outcomes on WC and cognition.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:27:12.367Z","link_status":"ok","quote_status":"verified","prev":"8f3c7e67a77a13b59bded158b269395831a09b58fdd17371c4c2100415be774f","hash":"ac5d6a82c068a111a91e17d9cc54403a974d7d829dd2fdbd0924d02cee9c7f7f"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/23689947/","title":"Growth hormone-releasing hormone effects on brain γ-aminobutyric acid and N-acetylaspartylglutamate","quote":"After 20 weeks of GHRH administration, GABA levels were increased in all brain regions (P < .04)... Consistent with the results of the parent trial, a favorable treatment effect on cognition was observed.","summary":"Friedman 2013 brain imaging substudy findings.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:27:12.367Z","link_status":"ok","quote_status":"unverified","prev":"ac5d6a82c068a111a91e17d9cc54403a974d7d829dd2fdbd0924d02cee9c7f7f","hash":"c4309b452ca9f1d5c924e80d5731c0658da77441b06352f0ec426ccd5ed98392"},{"id":"s4","type":"review","url":"https://www.lipid.org/lipid-spin/summer-2020/guest-editorial-statins-and-brain-fog-confusing-patients-prescribers-and-me","title":"Statins and Brain Fog: Confusing for Patients, Prescribers, and Me","quote":"Neurocognitive effects have been prospectively and retrospectively assessed in multiple statin trials and there is no signal of consistent effect.","summary":"Summary of statin cognitive evidence level.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:27:12.367Z","link_status":"ok","quote_status":"verified","prev":"c4309b452ca9f1d5c924e80d5731c0658da77441b06352f0ec426ccd5ed98392","hash":"7d37c60feb1129543440d685db9f1835493261c919252dfa7361dcd7b1e4b317"}]}