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When breakdown stays ahead of repair, injury or disease persists. Most drugs block signals such as pain or swelling without rebuilding the tissue that created the signal. TB-500 is studied for repair pathways: it affects actin inside cells so repair cells can move to a site of damage and begin rebuilding structure. This places TB-500 in the regeneration column of the ledger.","status":"active","vx_hash":"5008f1752eef45e1ba6e104d8dc181b84c0eef4c44fab20a328a8b2dc4c86766","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"fa3aa2c53308c8448614122d68db376aa30ee474a9e08f1c98df380581407bca","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"4dfba5fa64669a60e2b47d4f47a92ad5d91121ace799148c3ec66c353631df24","detail":{"divided_from":"body","block":2,"kind":"p"},"prev":"genesis","hash":"fa3aa2c53308c8448614122d68db376aa30ee474a9e08f1c98df380581407bca"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d2"},{"id":"d3","kind":"h","type":null,"order":3,"text":"## What it is","status":"active","vx_hash":"364e6a6bffc3a78e19bf441f04c6773cf28a2fe7dbeceee295025b52dd0fb826","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"08c4bdee7bf47574011f46985c6a51323fddc6b7fc280dbfa08883e4939206bb","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"86be443f45b5a4fcc2177c164ba3d0e83fba48637131bb846415144f9ff2b345","detail":{"divided_from":"body","block":3,"kind":"h"},"prev":"genesis","hash":"08c4bdee7bf47574011f46985c6a51323fddc6b7fc280dbfa08883e4939206bb"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d3"},{"id":"d4","kind":"p","type":null,"order":4,"text":"TB-500 is a fragment of thymosin beta-4, a 43-amino-acid peptide found in most mammalian cells. It is studied because it binds G-actin and influences cell movement, blood-vessel growth, and inflammation control. The ledger records 35 sources total on this compound.","status":"active","vx_hash":"5f944786bd0b0ee09fb5e3b11c5438d924b04c51ffbfde370327dcd76d86eebb","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"8660e67290fb42c7004d55bf3914a0a9c24fe778425764109cd94ba56526e1a3","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"bb7203089f25609e95e5ba12196504265ce6e6163cafca51bf1eb040623d8a77","detail":{"divided_from":"body","block":4,"kind":"p"},"prev":"genesis","hash":"8660e67290fb42c7004d55bf3914a0a9c24fe778425764109cd94ba56526e1a3"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d4"},{"id":"d5","kind":"h","type":null,"order":5,"text":"## How it works","status":"active","vx_hash":"cc4d012adedacf58c10820b6b11633398902ba862eb24e97be0102a63793fbe3","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"07cc97c5bc5e7dd61244505bc8f2c40e6bb23e4407ec049a6545dff92ef18bae","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"5ae438610cf16e31eb584a453d76f45d94f6d1bb14751446ac4e99e3e37c33a8","detail":{"divided_from":"body","block":5,"kind":"h"},"prev":"genesis","hash":"07cc97c5bc5e7dd61244505bc8f2c40e6bb23e4407ec049a6545dff92ef18bae"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d5"},{"id":"d6","kind":"p","type":null,"order":6,"text":"Step 1: TB-500 binds free G-actin inside cells.\nStep 2: This binding frees up actin monomers for new filament assembly at the leading edge of a cell.\nStep 3: Cells can therefore migrate toward injury sites.\nStep 4: Migrating cells release signals that support new vessel formation and reduce excess inflammation.\nStep 5: The net result is faster re-closure of wounds and faster deposition of repair matrix in animal models.","status":"active","vx_hash":"ec8684fe3ba0c5df348ab12c73619457d87022b153e6ba522e0269b789ac4056","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"0fa404a7f6ecb9577b7cbd88a9a854ba07d4f633638cb39de60bc5f497e0028a","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"f8bc4736b4e1212a903aef6606fe31b7a1cc35b3802a21ab69b2e796d2b1759e","detail":{"divided_from":"body","block":6,"kind":"p"},"prev":"genesis","hash":"0fa404a7f6ecb9577b7cbd88a9a854ba07d4f633638cb39de60bc5f497e0028a"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d6"},{"id":"d7","kind":"h","type":null,"order":7,"text":"## Why it would work (logic chain)","status":"active","vx_hash":"4b968fd46dd86de4100a1a564b5d90d1ade914fcc454c539f2bc90a2f22d26f0","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"2f2cdd2aaedaa9336ec63ab1cf1cb14e2f92c3eb09dd98270cd127eb4dfc2453","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"4d2830fe66086d6e85c12196286ee2de9920cbad3c3c98da2c874707a0885815","detail":{"divided_from":"body","block":7,"kind":"h"},"prev":"genesis","hash":"2f2cdd2aaedaa9336ec63ab1cf1cb14e2f92c3eb09dd98270cd127eb4dfc2453"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d7"},{"id":"d8","kind":"p","type":null,"order":8,"text":"If actin sequestration lets cells move, then more repair cells reach the wound. If more cells reach the wound, then re-epithelialization and matrix deposition increase. If matrix deposition increases, then structural repair occurs sooner than in controls. Each link follows from the prior step.","status":"active","vx_hash":"2503c1c04b6b392df306a7d34dc5c2e0d3c74f5260187788a0bdac4d517fca22","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"58d26a9fdb59cb3466d270c5b34ae6a3344e854d9a4500b6f4ed862a1299aff9","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"4e3eaa4b2a4a14ab871476f537cace8b77886fc4f358cd6f72328d7f571a83f0","detail":{"divided_from":"body","block":8,"kind":"p"},"prev":"genesis","hash":"58d26a9fdb59cb3466d270c5b34ae6a3344e854d9a4500b6f4ed862a1299aff9"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d8"},{"id":"d9","kind":"h","type":null,"order":9,"text":"## Why people take it","status":"active","vx_hash":"f4f567c1bc4dc90e46779810ea2d33a8f96df7c903a39c4040449c3cc4fab333","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"82c792b9ce1529915b0d5fc6448f4a4dc5b31e7666b9a54ef5fcb1ab48c1b327","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"b8c1f34ace0034b5eeca4d5e279fa8f6cec55f2537e1196408c3146788efc8b6","detail":{"divided_from":"body","block":9,"kind":"h"},"prev":"genesis","hash":"82c792b9ce1529915b0d5fc6448f4a4dc5b31e7666b9a54ef5fcb1ab48c1b327"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d9"},{"id":"d10","kind":"p","type":null,"order":10,"text":"People take it when they want support for tissue that is slow to repair: tendons, ligaments, muscle tears, skin ulcers, or post-surgical sites. The goal is to shift the balance toward regeneration rather than prolonged degeneration.","status":"active","vx_hash":"a868269009b4004b3e76d8a910d6125c4321a9fd6d7df498db1219736695a1d0","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"d7932c21788610896fe421bc6e96c25784c1fd71aa237c8e5f4a9c2bb67edd9a","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"17af8d92b7c832fb59c01760a223b5a213b28e6000938fa51eff8201713cc8a0","detail":{"divided_from":"body","block":10,"kind":"p"},"prev":"genesis","hash":"d7932c21788610896fe421bc6e96c25784c1fd71aa237c8e5f4a9c2bb67edd9a"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d10"},{"id":"d11","kind":"h","type":null,"order":11,"text":"## How many people take it","status":"active","vx_hash":"540bbeb0ad32e2cca2cc54663c2dfc50a4bb92c21bab45ea0a223d8d73be9549","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"33c12ac008a6aab019e3f898d5f762fd4bc7857f8c6649836d98d9e142ebc7ea","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"ecaf3b2a00962679296b05d11a617f36afb9c5c0fa08ef38581bba97bbe6e9d0","detail":{"divided_from":"body","block":11,"kind":"h"},"prev":"genesis","hash":"33c12ac008a6aab019e3f898d5f762fd4bc7857f8c6649836d98d9e142ebc7ea"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d11"},{"id":"d12","kind":"p","type":null,"order":12,"text":"The ledger does not contain population counts. No reliable figure exists for total users.","status":"active","vx_hash":"38ab676e63729203eacb1d228dae9162dcb0021855c20658d2ea30b3b36caa7a","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"c745e4c14f776a9414284e2146a5d48bb7cbe1b8a2e1778c35ead74d1bcefc9b","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"fc077554fe1a7ac365ae15a133d8ff51a2b50c235fdd01475908a99f5b167a6b","detail":{"divided_from":"body","block":12,"kind":"p"},"prev":"genesis","hash":"c745e4c14f776a9414284e2146a5d48bb7cbe1b8a2e1778c35ead74d1bcefc9b"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d12"},{"id":"d13","kind":"h","type":null,"order":13,"text":"## Evidence inventory","status":"active","vx_hash":"d54c3a4c7a74c3f4d440d2bf908611df23f2e59b3a6a7927502ab015b6caff00","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"a5fec6ca2b5b39f4db191b8954bfc42f58de62b2b4e70a439ae1fc6efa8f1b88","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"1a923749300b98146490d68bea892e058931a4f71936ca9b8303d9bf31c8d483","detail":{"divided_from":"body","block":13,"kind":"h"},"prev":"genesis","hash":"a5fec6ca2b5b39f4db191b8954bfc42f58de62b2b4e70a439ae1fc6efa8f1b88"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d13"},{"id":"d14","kind":"list","type":null,"order":14,"text":"- 1 human safety study (source s3)\n- 2 human wound-healing trials (sources s4, s15)\n- 28 preclinical or mechanistic sources (animal, cell, or review)\n- 7 Reddit posts (sources s10, s11, s16, s18, s19, s27, s28)\n- 3 other anecdote sources (sources s17, s20, s21)\n- 0 X posts","status":"active","vx_hash":"60d212c80e03f458660972584750c6ebb530e7620e195b17bab096b6fce51ae7","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"6a23833531b52ae7b84fc8e30ac7d32377a86b753c1a3b1f64077f1c0d02ae95","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"bb7a7e43c48bee3f4bf123e9dbbc30b722d267b7e2d630832fe4f6c95ac0e542","detail":{"divided_from":"body","block":14,"kind":"list"},"prev":"genesis","hash":"6a23833531b52ae7b84fc8e30ac7d32377a86b753c1a3b1f64077f1c0d02ae95"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d14"},{"id":"d15","kind":"p","type":null,"order":15,"text":"Total sources: 35. Human data remain sparse; most evidence is preclinical or anecdotal.","status":"active","vx_hash":"46c0f63962436c7eecd2225b2ead8d3e0e70ff13a867b44266b95b365d7ef5b7","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"04d38152d4518e96ea0d0be412f48d0c4cda6b274a6c3ee046c4a8e3665b214f","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"6bea705044f5cb7d46165ef67b8bc7afdb81e238ee4d20231c05688192049869","detail":{"divided_from":"body","block":15,"kind":"p"},"prev":"genesis","hash":"04d38152d4518e96ea0d0be412f48d0c4cda6b274a6c3ee046c4a8e3665b214f"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d15"},{"id":"d16","kind":"h","type":null,"order":16,"text":"## What scientists say","status":"active","vx_hash":"f11b5ac76ca27647a41b6639792f971264e25aa8ad443760b3431930fa1d34b5","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"249710171dd5f7e4c2738354cb39669e628a3186f5f7e8f642c0ffdf9b50a262","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"2f1dd55083de1fa734f2f06a8337a050d5a0b3f635bfc8bb709abab75705a1ef","detail":{"divided_from":"body","block":16,"kind":"h"},"prev":"genesis","hash":"249710171dd5f7e4c2738354cb39669e628a3186f5f7e8f642c0ffdf9b50a262"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d16"},{"id":"d17","kind":"p","type":null,"order":17,"text":"Source s1 (review) states thymosin beta-4 “plays a vital role in the repair and regeneration of injured cells and tissues.”\nSource s2 (rat study) found topical or intraperitoneal thymosin beta-4 increased re-epithelialization by 42 % at day 4 and up to 61 % at day 7 versus saline. This proves faster closure in that model but does not prove the same result in humans.\nSource s3 (Phase 1) gave intravenous thymosin beta-4 to healthy volunteers at doses from 42 mg to 1260 mg; it was well tolerated with no dose-limiting toxicity. This shows short-term safety in that setting but does not test efficacy.\nSource s4 (Phase 2) reported that topical thymosin beta-4 accelerated healing by nearly one month in some patients with stasis or pressure ulcers who healed. This shows a possible benefit in those wound types but leaves open the question of consistency across all patients.\nSource s6 (2026 review) notes preclinical promise in tissue repair yet states human orthopaedic data are lacking. Source s7 (2024) developed analytical methods and screened wound-healing activity in vitro. Source s13 tested an enzyme-responsive hydrogel containing TB-500 on corneal injury in an animal model and observed repair. Source s14 reviews thymosin beta-4 for kidney fibrosis and inflammation. Source s22 reports an engineered tandem peptide version improved corneal healing in a 2025 study. Source s33 links thymosin beta-4 to vascular repair via interaction with CCN5. All these findings remain preclinical or early-stage; none establish routine clinical use.","status":"active","vx_hash":"e4a9380192f9ee1a617126e317e67ebb6a1a9f1ed0699500d862aa8fb79a422f","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"e51fc11a00d8a44a9e6c8967761bd9dfc7a9897b2b18284ffffdd81f5a581333","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"61eec5cf6ce1767045c9bb10c04915d3057bdc74c7fb3e64c6839c2e307226a4","detail":{"divided_from":"body","block":17,"kind":"p"},"prev":"genesis","hash":"e51fc11a00d8a44a9e6c8967761bd9dfc7a9897b2b18284ffffdd81f5a581333"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d17"},{"id":"d18","kind":"h","type":null,"order":18,"text":"## What people say on Reddit","status":"active","vx_hash":"06b7d47028be1a40985f19ba23fc39c8e714e989d78340355151463bfc3c5ddf","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"9520964f63524e83c2aafcd0401e8d9b95d90e4f410c0570471a9388f51c0eee","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"feb303756a303788527cf602bf2c3c6b00ab8c384fb9fff4baa9ffc53e0049c3","detail":{"divided_from":"body","block":18,"kind":"h"},"prev":"genesis","hash":"9520964f63524e83c2aafcd0401e8d9b95d90e4f410c0570471a9388f51c0eee"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d18"},{"id":"d19","kind":"p","type":null,"order":19,"text":"Source s10 describes TB-500 as studied for systemic tissue regeneration separate from blood-flow effects of BPC-157.\nSource s11 reports a user combined TB-500 with BPC-157 after a meniscus tear when surgery was declined.\nSource s16 documents use of the “Wolverine Stack” (BPC-157 + TB-500) after ACL and meniscus surgery.\nSource s18 describes a user who developed hives, throat swelling, and was hospitalized after continuing TB-500 following an adverse reaction to BPC-157.\nSource s19 discusses strange side effects in a thread about the same combination.\nSource s27 covers genetics and oral versus injectable forms.\nSource s28 states one user experienced “3 months of healing in a few weeks” with zero negatives after ACL recovery. Anecdotes supply real-world timing and symptom reports but cannot replace controlled trials.","status":"active","vx_hash":"463790a6ed5c7946a37ce3c40d970378b8eb89aabed3313443fe405212e5c647","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"c8f4f152b38713e733e75c83bd55a308e78776d9e6878f4a49719d4b3e1eeed4","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"0fb6ab904b9560d56bdb6c27509cffce1ab4aa3ebd9872713aa28069dd5b63e7","detail":{"divided_from":"body","block":19,"kind":"p"},"prev":"genesis","hash":"c8f4f152b38713e733e75c83bd55a308e78776d9e6878f4a49719d4b3e1eeed4"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d19"},{"id":"d20","kind":"h","type":null,"order":20,"text":"## What people say on X","status":"active","vx_hash":"7cd35ee759918860ff88643bb62f375c2354a7e57375bc8d6e5250e1a724ec36","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"41f14b3b7af8d98d336d2b3f00eb05a3cb477ecbc89167497cf39d1887c0c864","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"4dd8bbfdb0452cc6235c2300209b5132daba3913b8f54ab179b1a73109c298dd","detail":{"divided_from":"body","block":20,"kind":"h"},"prev":"genesis","hash":"41f14b3b7af8d98d336d2b3f00eb05a3cb477ecbc89167497cf39d1887c0c864"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d20"},{"id":"d21","kind":"p","type":null,"order":21,"text":"The ledger records zero X posts.","status":"active","vx_hash":"385d383fd89266ff15434874b0ba6ac182afbcd969f161e18c44374200e1f91a","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"40e9e1a2d984fa872a8a8ccbeb8c305543d80a6a3904fbbcb5253c21af08c346","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"0cfe8972777fbf55c23e45b83133cfa2e615f509d059d37ea6d5b781ce32e07e","detail":{"divided_from":"body","block":21,"kind":"p"},"prev":"genesis","hash":"40e9e1a2d984fa872a8a8ccbeb8c305543d80a6a3904fbbcb5253c21af08c346"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d21"},{"id":"d22","kind":"h","type":null,"order":22,"text":"## What we do not know","status":"active","vx_hash":"16db44365c3d714d55673ccb5248225c478ba485d6675c2f43548c292b29e21c","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"39366f4ffac59a54773fad87fa38a094f8fd893d1dbb4e2a33ceee354349775e","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"7d96a49fba77f6a48c0321db2ae4180a902beae62e2aac0d23408fbf8333a177","detail":{"divided_from":"body","block":22,"kind":"h"},"prev":"genesis","hash":"39366f4ffac59a54773fad87fa38a094f8fd893d1dbb4e2a33ceee354349775e"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d22"},{"id":"d23","kind":"p","type":null,"order":23,"text":"It is unknown whether the wound-healing rates seen in rat and early human ulcer trials repeat across diverse human injuries or patient groups (source s1, source s6). Human orthopaedic data remain absent. Long-term safety beyond the listed Phase 1 window is not catalogued. Product quality of commercial versions varies; source s8 found inconsistencies and adulteration in tested internet products. Expression changes of thymosin beta-4 in Alzheimer models are noted (source s12) but functional outcomes in humans are not established.","status":"active","vx_hash":"52b31076bec1ca514fff9d1b1c1bc013c2713e420af06b1aedb2ed968a0a36d6","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"a9cd79140f5f7c4c1b50a9ef0362badcde88dff696bf9b014a38b5cbd51d73a8","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"b2c3f30a467726d6efabf2105b1cb3b29bf35c261b80964e68648911a447d23f","detail":{"divided_from":"body","block":23,"kind":"p"},"prev":"genesis","hash":"a9cd79140f5f7c4c1b50a9ef0362badcde88dff696bf9b014a38b5cbd51d73a8"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d23"},{"id":"d24","kind":"h","type":null,"order":24,"text":"## Safety and limits","status":"active","vx_hash":"335e4c0d839ab2af1ee2c18f471be5bf8eb233afad72341fe210953675522171","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"cf1f948c2a97fc6eafbaba123e369ec8aea61bc2a3ad41f75b7608b53e454ef5","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:42:11.927Z","actor":"owner","text_sha":"404f7427c043c6ec7a5cb4416bbec9ec336e19f8757fb217be5c5c2161ff8cb6","detail":{"divided_from":"body","block":24,"kind":"h"},"prev":"genesis","hash":"cf1f948c2a97fc6eafbaba123e369ec8aea61bc2a3ad41f75b7608b53e454ef5"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:42:11.927Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/tb-500/d24"},{"id":"d25","kind":"p","type":null,"order":25,"text":"Source s3 found no dose-limiting toxicity in short-term intravenous use in healthy volunteers. Source s18 records one severe allergic reaction leading to hospitalization. Source s6 notes both thymosin beta-4 and TB-500 remain banned in sports. Commercial product analysis (source s8) shows variability in content. 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