{"_self":{"principle":"Self-explaining payload — no external context required. 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Core claim: Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration (c1, s1). Preclinical support includes rat full-thickness wound models showing accelerated re-epithelialization (c2, s2). Human data are limited to safety (c3, s3) and specific wound-healing trials (c4, s4); no new mechanistic evidence is present.","confidence":"high","status":"answered","parent_node_id":null,"gaps":[],"needs_user_info":[],"cited_claim_ids":["c1","c2","c3","c4"],"cited_source_ids":["s1","s2","s3","s4"],"channel":"selftest","author":"graph_selftest","hash":"390da20d84640e5b48bd7c8dbfe6333b645fee1429f06acadaf67bbe59dd4e77"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_241eb02b","ts":"2026-07-11T14:38:41.428Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what does the catalogue say now about anecdotes?","answer_preview":"The catalogue lists three tiers of herniated-disc anecdotes for BPC-157: (1) one Reddit user with L4-L5 herniation reported reduced radicular pain after 8 weeks of BPC-157 plus physical therapy (global_id bpc-157:c5, tier=anecdotal, weight=0.3); (2) several self-test posts describe reduced back or knee pain after eight weeks but include no imaging follow-up (bpc-157 section “What people say on Reddit”); (3) duplicate nausea reports (multiple instances of the same anecdote, each labeled anecdotal n=1, weight=0.3). No other slugs in the topology contain herniated-disc anecdotes. All listed items are pre-ranked as low-weight anecdotal claims; interaction_risk / limitations claims (c120, c67) are cited first per safety-first ordering.","confidence":"medium","status":"enriched","parent_node_id":null,"gaps":["No imaging-confirmed outcomes; no long-term follow-up; no interaction data specific to herniated-disc patients or common spine medications."],"needs_user_info":[],"cited_claim_ids":["c5","c120","c67"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"48f991e2315a93cbf21a35b1c623cef22caf053ca87390f380aa6bfe85563d5a"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_50c640ac","ts":"2026-07-11T14:38:17.208Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what peptide stack does the catalogue cover, and what gaps remain?","answer_preview":"Catalogue covers BPC-157 (bpc-157) and TB-500 (tb-500) in the context of herniated-disc recovery. One anecdotal claim (global_id recovery-stack-herniated-disc:c5) describes a single user reporting reduced radicular pain after 8 weeks of BPC-157 plus physical therapy for L4-L5 herniation. Additional anecdotal claims note BPC-157/TB-500 combinations for systemic tissue and tendon healing (bpc-157:c111). Limitations claims state human data are sparse, long-term safety unknown, and no dosing or protocol recommendations exist (bpc-157:c120, c67). No dedicated stack articles for herniated discs appear in the topology beyond the intro and BPC/TB-500 mentions.","confidence":"low","status":"enriched","parent_node_id":null,"gaps":["No controlled human trials for herniated-disc outcomes","No data on BPC-157/TB-500 interactions or safety in disc pathology","No coverage of other peptides (e.g., ARA-290) for herniated discs in the provided slugs"],"needs_user_info":[],"cited_claim_ids":["bpc-157:c5","bpc-157:c111","bpc-157:c120","bpc-157:c67"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"44acb22aa47103bebdd2e83cff2f68f753634aae351dc69043ce6e762dc28117"},{"node_id":"qn_tb_500_selftest_graph_what_is_documented_about_t_1b217ea4","ts":"2026-07-07T05:18:10.136Z","primary_slug":"tb-500","slugs":["tb-500"],"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer_preview":"Documented mechanism from the ledger: TB-500 (Tβ4 fragment) binds free G-actin inside cells, freeing actin monomers for new filament assembly at the leading edge; this enables cell migration toward injury sites, release of signals supporting new vessel formation, and modulation of inflammation, leading to faster wound re-closure and repair matrix deposition in animal models. Core claims: c1 (actin sequestration, cell migration, angiogenesis, inflammation modulation; tier human, source s1), c3 (Phase 1 IV safety/tolerability in healthy volunteers; tier human, source s3), c4 (Phase 2 topical acceleration in some stasis/pressure ulcer patients; tier human, source s4), c2 (rat wound re-epithelialization increase; tier preclinical, source s2). No new evidence; human data sparse, most evidence preclinical or anecdotal. Quote-gated claims (e.g., c6, c13, c16, c27, c40, c41, c42, c46) treated as low-confidence. No interaction_risk/limitations claims present in the provided topology.","confidence":"medium","status":"gap","parent_node_id":null,"gaps":["No interaction_risk or limitations-slot claims available","No dosing, patient-specific, or combination safety data","Human orthopaedic and systemic data lacking per s6"],"needs_user_info":[],"cited_claim_ids":["c1","c3","c4","c2"],"cited_source_ids":["s1","s3","s4","s2"],"channel":"selftest","author":"graph_selftest","hash":"f841cae37d5443fc5dd3d9e65c256f4421e08a358874306957f6cbb824e53bda"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_7d3887e7","ts":"2026-07-07T05:18:02.500Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what does the catalogue say now about anecdotes?","answer_preview":"Catalogue lists one direct herniated-disc anecdote: c5 (global_id bpc-157:c5) — one Reddit user with L4-L5 herniation reported reduced radicular pain after 8 weeks of BPC-157 plus PT (anecdotal, n=1, tier=anecdotal, weight=0.3). Additional anecdotes exist for tendon/muscle/gut issues (e.g., c101, c111) but are not disc-specific. No interaction_risk or limitations-slot claims appear for herniated discs. Multiple duplicate nausea reports (c6, c122–c162) are catalogued as anecdotal negative outcomes.","confidence":"medium","status":"enriched","parent_node_id":null,"gaps":["No controlled human data for herniated discs; anecdotes are n=1, self-reported, no imaging follow-up."],"needs_user_info":[],"cited_claim_ids":["bpc-157:c5","bpc-157:c6","bpc-157:c101","bpc-157:c111"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"9e2dce074b1cc5ba18ae5541e0c30d9b36bbe047f91880ce0470704a828b6545"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_5f30a319","ts":"2026-07-07T05:17:49.886Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what peptide stack does the catalogue cover, and what gaps remain?","answer_preview":"Catalogue covers: BPC-157 (preclinical tendon/muscle/gut models + 1 anecdotal L4-L5 herniation report of reduced radicular pain after 8 weeks with PT — c5:bpc-157); BPC-157 + TB-500 anecdotal stack for systemic tissue/tendon healing (c111:bpc-157); recovery-stack-herniated-disc and bpc-ara-herniated-disc slugs exist but contain no populated claims in the provided topology. Gaps: no human trials, no imaging outcomes, no interaction_risk data, no ARA-290 or TB-500 standalone herniated-disc claims, long-term safety unknown (c67:bpc-157), and all human evidence is sparse/pilot only. No dosing or treatment information is present.","confidence":"medium","status":"enriched","parent_node_id":null,"gaps":["no human controlled data for disc herniation","no interaction data","no ARA-290 or TB-500 herniated-disc coverage in topology","long-term safety absent"],"needs_user_info":["specific disc levels and symptoms","current medications or conditions","prior treatments tried"],"cited_claim_ids":["c5","c67","c111","c120"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"55704c06abb3c3fee07a6aa6e20c9ff75edf4e45de4cabd4e5e735d720ee1168"},{"node_id":"qn_tb_500_selftest_graph_what_is_documented_about_t_6e5d6ef8","ts":"2026-07-07T04:40:45.011Z","primary_slug":"tb-500","slugs":["tb-500"],"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer_preview":"Documented mechanism of TB-500 (Tβ4 fragment) in the ledger: binds free G-actin, sequesters it, frees monomers for new filament assembly at the leading edge of cells, enabling cell migration to injury sites; migrating cells then release signals supporting angiogenesis and reduced excess inflammation, leading to faster wound re-closure and repair-matrix deposition in animal models. Core claim supported by review source s1 (c1) and mechanistic description in the body; no new evidence added. Safety-first: no interaction_risk or limitations-slot claims present for mechanism. All human data remain sparse; most evidence preclinical or anecdotal.","confidence":"high","status":"answered","parent_node_id":null,"gaps":[],"needs_user_info":[],"cited_claim_ids":["c1"],"cited_source_ids":["s1"],"channel":"selftest","author":"graph_selftest","hash":"ca930d58df03f2cb35e1c68fff036bee705821cfb7cfd8685a2742879f4a3cb0"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_4527b1d6","ts":"2026-07-07T04:40:41.667Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what does the catalogue say now about anecdotes?","answer_preview":"The catalogue lists two BPC-157 herniated-disc anecdotes (global_id bpc-157:c5 and bpc-157:c6). c5 is a single Reddit-style self-report of reduced radicular pain after 8 weeks with PT (tier:anecdotal, weight 0.3). c6 is a single self-report of nausea leading to discontinuation (tier:anecdotal, weight 0.3). No other herniated-disc anecdotes appear in the listed slugs. Interaction_risk / limitations claims (bpc-157:c120, bpc-157:c67) are present and should be cited first for safety questions. All anecdotes are quote_gated:false but carry low weight; the topology contains no controlled human data on disc herniation.","confidence":"medium","status":"gap","parent_node_id":null,"gaps":["No human imaging follow-up data","No controlled trials for disc herniation","Long-term safety unknown"],"needs_user_info":[],"cited_claim_ids":["bpc-157:c5","bpc-157:c6","bpc-157:c120","bpc-157:c67"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"1f4bcadeebf10d15569dc3a4292ca98c8dde8cf468081be16de33381f7c82677"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_149821d9","ts":"2026-07-07T04:40:36.928Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what peptide stack does the catalogue cover, and what gaps remain?","answer_preview":"The catalogue covers BPC-157 (slug bpc-157) and TB-500 (slug tb-500) plus recovery-stack articles (recovery-stack-herniated-disc, recovery-stack-intro, bpc-ara-herniated-disc, ara-290-herniated-disc) that mention these peptides for herniated-disc contexts. Evidence is almost entirely preclinical (rat tendon/muscle models) or anecdotal (one L4-L5 herniation report of reduced radicular pain after 8 weeks BPC-157 + PT; several nausea reports leading to discontinuation). No human RCTs for disc herniation exist in the topology. Interaction_risk / limitations claims (c120, c67) must be cited first: long-term human safety unknown, no dosing data, source monoculture problem, and the catalogue is not medical advice. Gaps: no data on stacking BPC-157 with ARA-290 or other peptides for discs; no imaging-confirmed outcomes; no interaction data with common pain meds or spine conditions.","confidence":"low","status":"gap","parent_node_id":null,"gaps":["no human disc-herniation trials","no established stacks for herniated discs","no long-term safety data","no interaction data"],"needs_user_info":["specific disc levels and symptoms","current medications or conditions","prior treatments tried","imaging confirmation status"],"cited_claim_ids":["c120","c67","c5","c6","c1","c3","c30","c76"],"cited_source_ids":["s1","s3","s25","s58"],"channel":"selftest","author":"graph_selftest","hash":"83de4fe0d8850210706f9d181577d6dcc5db3b3924205aa92f57691761648ca6"},{"node_id":"qn_tb_500_selftest_graph_what_is_documented_about_t_db376414","ts":"2026-07-07T04:09:37.854Z","primary_slug":"tb-500","slugs":["tb-500"],"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer_preview":"Documented mechanism from ledger: TB-500 (Tβ4 fragment) binds free G-actin, frees monomers for new filament assembly at the leading edge, enabling cell migration toward injury; migrating cells then release signals supporting new vessel formation and reducing excess inflammation, producing faster wound re-closure and repair-matrix deposition in animal models (c1, c2). No new evidence supplied; all claims drawn from existing topology only.","confidence":"high","status":"answered","parent_node_id":null,"gaps":[],"needs_user_info":[],"cited_claim_ids":["c1","c2"],"cited_source_ids":["s1","s2"],"channel":"selftest","author":"graph_selftest","hash":"b1e365a5ed961e77d4068eb344b4c787ee12d164491e69dd083843ac4717acb2"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_cb92603c","ts":"2026-07-07T04:09:35.082Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what does the catalogue say now about anecdotes?","answer_preview":"Catalogue covers 2 explicit herniated-disc anecdotes under BPC-157 (global_id bpc-157:c5: one user with L4-L5 herniation reported reduced radicular pain after 8 weeks BPC-157 + PT; bpc-157:c6: one user reported nausea within two weeks and discontinued). Broader anecdotal tier (bpc-157:c101, c111 and others) mentions tissue/tendon healing or gut effects but does not reference discs. Multiple duplicate nausea reports (c122–c158) are low-weight repeats. No interaction_risk or limitations-slot claims are present for this condition. Recovery-stack-herniated-disc, bpc-ara-herniated-disc and ara-290-herniated-disc slugs are listed in the graph but supply no additional anecdote text in the provided topology.","confidence":"medium","status":"gap","parent_node_id":null,"gaps":["No dosing, duration, route, or imaging-confirmed outcomes are stated; long-term safety unknown (bpc-157:c67)."],"needs_user_info":[],"cited_claim_ids":["bpc-157:c5","bpc-157:c6","bpc-157:c101","bpc-157:c111","bpc-157:c120"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"e1ae8e75c59f11910047c52a3155f64d7ed05a49899e8fd89d8806d7abe877be"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_2926070f","ts":"2026-07-07T04:09:28.389Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what peptide stack does the catalogue cover, and what gaps remain?","answer_preview":"Catalogue covers BPC-157 (bpc-157) with one L4-L5 herniation anecdote (reduced radicular pain after 8 weeks + PT, n=1) plus general tendon/muscle healing preclinical claims; recovery-stack-herniated-disc and bpc-ara-herniated-disc slugs exist but contain no populated claims on stacks for herniated discs; TB-500 appears only in one combined anecdotal claim for systemic tissue/tendon healing (not disc-specific); ARA-290 slugs exist with no disc claims; limitations slot (c120) and long-term safety unknown (c67) must be cited first. Gaps: no human data on disc healing, no interaction_risk data, no dosing information, no stack protocols, no imaging-confirmed outcomes.","confidence":"low","status":"gap","parent_node_id":null,"gaps":["no human disc-healing studies","no stack protocols in topology","no interaction data","no long-term safety data","anecdotes are n=1 only"],"needs_user_info":["specific disc level(s) and symptoms","current medications or conditions","prior imaging or diagnosis details","what the person has already tried"],"cited_claim_ids":["c120","c67","c5","c111","c1","c3"],"cited_source_ids":["s1","s3"],"channel":"selftest","author":"graph_selftest","hash":"4b2cfff6a6977daf02ed643b65a37f0a37c54ba778bade9010dbeb895be47e8e"},{"node_id":"qn_tb_500_selftest_graph_what_is_documented_about_t_6cac59fb","ts":"2026-07-07T04:07:30.001Z","primary_slug":"tb-500","slugs":["tb-500"],"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer_preview":"Documented mechanism in the ledger: TB-500 (synthetic fragment of thymosin beta-4) binds free G-actin inside cells. This frees actin monomers for new filament assembly at the leading edge of a cell, allowing repair cells to migrate toward injury sites. Migrating cells then release signals that support new vessel formation and reduce excess inflammation, resulting in faster wound re-closure and repair matrix deposition in animal models. Core claim (c1, source s1) states Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration. Preclinical support (c2, source s2) shows accelerated re-epithelialization in rat wound models. Human data on mechanism itself are absent; safety (c3, source s3) and limited wound-healing signals (c4, source s4) exist but do not address mechanism in humans.","confidence":"medium","status":"gap","parent_node_id":null,"gaps":["No direct human mechanistic studies; all mechanism data are preclinical or inferred from animal/cell models."],"needs_user_info":[],"cited_claim_ids":["c1","c2","c3","c4"],"cited_source_ids":["s1","s2","s3","s4"],"channel":"selftest","author":"graph_selftest","hash":"871f0b0864536a4227aad2f7ca6a484a767e0cb33f34888261355499ed0c08ad"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_b612d44e","ts":"2026-07-07T04:07:26.266Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what does the catalogue say now about anecdotes?","answer_preview":"Catalogue contains one explicit herniated-disc anecdote for BPC-157 (c5): a single Reddit-style report of reduced radicular pain after 8 weeks with PT, labeled anecdotal n=1. Multiple duplicate nausea reports (c6, c122–c156) also exist as anecdotes. All other herniated-disc content in the graph is preclinical or mechanistic; no controlled human data on discs. Interaction_risk / limitations claims (c120, c67) rank first for safety questions.","confidence":"medium","status":"gap","parent_node_id":null,"gaps":["No imaging-confirmed disc anecdotes; no long-term safety data; no interaction data with common disc treatments."],"needs_user_info":[],"cited_claim_ids":["c5","c6","c120","c67"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"80ce412784c1fa8d043f4dc29a0e603c3467a938407b39fa77f21ffff6cae19d"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_474e952c","ts":"2026-07-07T04:07:21.812Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what peptide stack does the catalogue cover, and what gaps remain?","answer_preview":"Catalogue covers BPC-157 (angiogenesis/collagen/fibroblast mechanisms in animal tendon/muscle/gut models; 2 human pilot safety reports) plus TB-500 (anecdotal combined use with BPC-157 for systemic tissue/tendon healing) and limited ARA-290 mentions. Herniated-disc-specific entries exist under recovery-stack-herniated-disc and bpc-ara-herniated-disc. One anecdotal claim (c5) notes reduced radicular pain after 8 weeks BPC-157 + PT in L4-L5 herniation. Safety-first limitations (c120, c67) and interaction_risk slots are present. Gaps: no human herniated-disc trials, no dosing data, no long-term safety, unknown interactions with disc medications or conditions, no ARA-290 or TB-500 herniated-disc studies catalogued. Needs_user_info: disc level(s), symptom duration, current treatments/medications, imaging status, other health conditions.","confidence":"medium","status":"gap","parent_node_id":null,"gaps":["no human herniated-disc trials","no dosing data","no long-term safety","unknown drug/condition interactions","no ARA-290 or TB-500 herniated-disc studies"],"needs_user_info":["disc level(s)","symptom duration","current treatments/medications","imaging status","other health conditions"],"cited_claim_ids":["c120","c67","c5","c111","c3","c1"],"cited_source_ids":["s1","s3"],"channel":"selftest","author":"graph_selftest","hash":"1ac4aa91b4bdebbcd0ad116110e4b6a3df58aa9e542f6c606cf4f63ddccd8961"},{"node_id":"qn_tb_500_selftest_graph_what_is_documented_about_t_90f77457","ts":"2026-07-07T03:50:54.771Z","primary_slug":"tb-500","slugs":["tb-500"],"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer_preview":"Documented TB-500 mechanism in the ledger centers on actin sequestration: TB-500 binds free G-actin (c1), freeing monomers for new filament assembly at the cell leading edge, enabling cell migration to injury sites, release of signals supporting angiogenesis, and modulation of inflammation. Net effect reported as faster wound re-closure and repair-matrix deposition in animal models. Source s1 (review) states thymosin beta-4 “plays a vital role in the repair and regeneration of injured cells and tissues.” Preclinical support includes rat full-thickness wound models (c2, source s2). Human data are limited to safety (c3, source s3) and specific wound-healing signals (c4, source s4); no new evidence added.","confidence":"medium","status":"gap","parent_node_id":null,"gaps":["No human orthopaedic efficacy data; product quality/adulteration concerns noted but no interaction_risk claims present."],"needs_user_info":[],"cited_claim_ids":["c1","c2","c3","c4"],"cited_source_ids":["s1","s2","s3","s4"],"channel":"selftest","author":"graph_selftest","hash":"1ab62be7cc723f03393c27d0c87b1dac91c8a4b9d16659808b3435157d31a24d"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_22fc7bfb","ts":"2026-07-07T03:50:49.858Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what does the catalogue say now about anecdotes?","answer_preview":"Catalogue covers 1 explicit herniated-disc anecdote (L4-L5 user reported reduced radicular pain after 8 weeks BPC-157 + PT; global_id bpc-157:c5). All other anecdotes are non-specific (elbow, knee, back pain without imaging) or gut/tendon related. Safety-first limitations slot (bpc-157:c120) states evidence mix is predominantly preclinical/anecdotal with sparse human data; no dosing or treatment claims. Multiple duplicate nausea anecdotes exist but remain low-weight. Quote-gated reviews note limited human evidence.","confidence":"medium","status":"gap","parent_node_id":null,"gaps":["No imaging-confirmed disc healing anecdotes","No interaction data for herniated disc + common meds"],"needs_user_info":[],"cited_claim_ids":["bpc-157:c5","bpc-157:c120","bpc-157:c67"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"31cc1564e0b13f5eb8376ec1b7ad37599b9803954c3a045e0bbb0d489e07a08b"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_afcccb0b","ts":"2026-07-07T03:50:43.383Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what peptide stack does the catalogue cover, and what gaps remain?","answer_preview":"Catalogue covers BPC-157 (slug:bpc-157) with one anecdotal report of reduced radicular pain in L4-L5 herniation after 8 weeks with PT (global_id bpc-157:c5, tier:anecdotal) plus general preclinical tendon/muscle healing claims (global_id bpc-157:c30, c76). Recovery-stack-herniated-disc and bpc-ara-herniated-disc slugs exist but contain no populated claims in the provided topology. TB-500 (slug:tb-500) is referenced only via one anecdotal positive for combined BPC-157/TB-500 in tendon healing (global_id bpc-157:c111, tier:anecdotal). No ARA-290 or recovery-stack-intro claims address herniated discs. Interaction_risk / limitations claims (global_id bpc-157:c120, c67, c66) are cited first: long-term human safety unknown, no dosing/protocol, sparse human data, source monoculture problem. No stack is described or recommended.","confidence":"low","status":"gap","parent_node_id":null,"gaps":["No populated claims in recovery-stack-herniated-disc, bpc-ara-herniated-disc, ara-290-herniated-disc, ara-290, recovery-stack-intro, or tb-500 slugs for disc herniation.","No interaction data for any peptides with herniated-disc context.","No human controlled studies for any peptide in disc herniation.","No dosing, duration, or combination protocols present."],"needs_user_info":[],"cited_claim_ids":["bpc-157:c5","bpc-157:c30","bpc-157:c76","bpc-157:c111","bpc-157:c120","bpc-157:c67","bpc-157:c66"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"6fee7083130e7b4f057ed29e6dd7388d8f6d59931a75e1822160aceac17ab64a"},{"node_id":"qn_tb_500_selftest_graph_what_is_documented_about_t_f9e3a866","ts":"2026-07-07T03:48:51.595Z","primary_slug":"tb-500","slugs":["tb-500"],"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer_preview":"Documented mechanism per ledger: TB-500 (Tβ4 fragment) binds free G-actin, freeing monomers for new filament assembly at the leading edge, enabling cell migration toward injury. Migrating cells then release signals supporting angiogenesis and reduced excess inflammation, yielding faster wound re-closure and repair-matrix deposition in animal models (c1 tier human from s1; c2 tier preclinical from s2). No new evidence added; all claims drawn from existing ledger entries.","confidence":"high","status":"answered","parent_node_id":null,"gaps":[],"needs_user_info":[],"cited_claim_ids":["c1","c2"],"cited_source_ids":["s1","s2"],"channel":"selftest","author":"graph_selftest","hash":"c16c20908dd7007a9d831e8f16050215de52119ca8814b52e8b3d5b57be2f10f"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_0569b743","ts":"2026-07-07T03:48:48.336Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what does the catalogue say now about anecdotes?","answer_preview":"Catalogue covers herniated-disc anecdotes in bpc-157 and recovery-stack-herniated-disc: one Reddit-style report (c5) of reduced radicular pain after 8 weeks BPC-157 + PT (L4-L5, n=1, anecdotal tier). Multiple nausea/discontinuation reports appear as low-weight anecdotes (c6, c122 and duplicates). All such claims sit in 'anecdotal' tier, weight 0.3, explicitly separated from human (weight 0.8) or preclinical (weight 0.5) tiers. Limitations slot (c120) states evidence mix is 'predominantly preclinical and anecdotal; human data are sparse.' No interaction_risk claims are present for this context. Quote-gated claims are absent from the herniated-disc anecdotes.","confidence":"high","status":"gap","parent_node_id":null,"gaps":["No imaging follow-up or controlled data attached to the anecdotes; long-term safety unknown (c67)."],"needs_user_info":[],"cited_claim_ids":["c5","c6","c120","c122"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"c606ab049264b22bedd7b082ac2776fa0605fcba47cf1e41a6d4316d58189467"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_478d87d8","ts":"2026-07-07T03:48:40.647Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what peptide stack does the catalogue cover, and what gaps remain?","answer_preview":"Catalogue covers BPC-157 (slug bpc-157) for herniated-disc context via one anecdotal claim (c5) of reduced radicular pain after 8 weeks with PT (L4-L5, n=1, tier:anecdotal). It also covers recovery-stack-herniated-disc and bpc-ara-herniated-disc stacks that include BPC-157 plus TB-500 (anecdotal positive for combined use in systemic/tendon healing at c111) and ARA-290 (slugs ara-290-herniated-disc, ara-290). TB-500 appears in recovery stacks. Safety-first limitations claim c120 (limitations slot) and long-term safety unknown claim c67 are present. No human controlled data for disc herniation; all disc-specific evidence is anecdotal or preclinical. Gaps: no interaction_risk data, no dosing, no imaging-confirmed outcomes, no human trials for herniated discs.","confidence":"low","status":"gap","parent_node_id":null,"gaps":["no controlled human trials for herniated discs","no interaction data","no dosing information","limited to single anecdotal report for BPC-157 in disc context"],"needs_user_info":["specific disc levels and symptoms","current medications or conditions","prior imaging or diagnosis details","any known allergies or contraindications"],"cited_claim_ids":["c5","c111","c120","c67"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"6359d5d2a3af0e4b81a2a5485cc01b374fa2848525aca44c984ca2f1c49180a5"},{"node_id":"qn_tb_500_selftest_graph_what_is_documented_about_t_d5adc2ef","ts":"2026-07-07T03:46:26.458Z","primary_slug":"tb-500","slugs":["tb-500"],"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer_preview":"Documented mechanism in the ledger: TB-500 (synthetic fragment of thymosin beta-4) binds free G-actin, freeing monomers for new filament assembly at the cell leading edge, enabling repair-cell migration to injury sites; migrating cells then release signals supporting vessel formation and reduced excess inflammation, yielding faster wound re-closure and repair-matrix deposition in animal models (c1 from s1; steps 1–5 in body excerpt). Core claim is actin sequestration promoting cell migration, angiogenesis, and inflammation modulation (c1). Preclinical support includes rat full-thickness wound models showing accelerated re-epithelialization (c2 from s2). Human data are limited to one Phase 1 safety study (well tolerated, no dose-limiting toxicity, c3 from s3) and two wound-healing trials (c4 from s4; c16 from s15, quote-gated). No new evidence added; interaction_risk and limitations slots contain no safety signals for this query.","confidence":"high","status":"gap","parent_node_id":null,"gaps":["No dosing, patient-specific, or combination-safety data in ledger for this query"],"needs_user_info":[],"cited_claim_ids":["c1","c2","c3","c4","c16"],"cited_source_ids":["s1","s2","s3","s4","s15"],"channel":"selftest","author":"graph_selftest","hash":"0801b217dee0d46d58d6492914e8e922453b153a3ca921ed46e4b722f7b5f634"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_8ffeee1d","ts":"2026-07-07T03:46:20.606Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what does the catalogue say now about anecdotes?","answer_preview":"Catalogue covers 30 anecdotal claims total for BPC-157. One specific herniated-disc anecdote (global_id bpc-157:c5) states: 'One Reddit user with L4-L5 herniation reported reduced radicular pain after 8 weeks of BPC-157 with PT (anecdotal, n=1)'. Additional anecdotal claims exist for tendon/muscle/gut contexts but are not specific to discs. No interaction_risk or limitations-slot claims flag safety issues for this use-case. Multiple duplicate nausea anecdotes (c6, c122–c150) are recorded as single-user reports. All anecdotes are tier 'anecdotal' weight 0.3 and explicitly separated from human or preclinical data.","confidence":"medium","status":"gap","parent_node_id":null,"gaps":["no imaging confirmation in the anecdote","no dose/route/duration details supplied in the claim"],"needs_user_info":[],"cited_claim_ids":["c5","c6","c120","c65"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"5de8a093d8cb0871fe5ef2b37726a192155bdc4d92f1ac1f6ad9675f489f894e"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_f7936d50","ts":"2026-07-07T03:46:13.649Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what peptide stack does the catalogue cover, and what gaps remain?","answer_preview":"Catalogue covers: BPC-157 (bpc-157) with one anecdotal report of reduced radicular pain after 8 weeks in L4-L5 herniation when used with PT (c5); recovery-stack-herniated-disc and bpc-ara-herniated-disc slugs exist but contain no active claims; TB-500 appears only in one anecdotal combined-use claim (c111). No interaction_risk or limitations-slot claims specific to disc herniation are present. Gaps: no controlled human data on any peptide for herniated discs; no ara-290 or recovery-stack claims populated for this condition; long-term safety, dosing, and imaging outcomes unknown.","confidence":"low","status":"gap","parent_node_id":null,"gaps":["no human trials for peptides in disc herniation","no interaction data specific to spine pathology","no ara-290 or TB-500 herniated-disc claims","no recovery-stack protocols catalogued"],"needs_user_info":["imaging confirmation and severity of herniation","current symptoms and duration","other treatments or medications in use","medical history relevant to spine or vascular conditions"],"cited_claim_ids":["c5","c111","c120","c67"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"5cbeedc690d950fd6244d023478fa7361a5a526ce9e7ce50a2900f1b68714ad4"}],"evidence":[{"ingest_id":"ev_c80ff6a253ba","ts":"2026-06-29T11:04:30.643Z","slug":"tb-500","question_node_id":null,"channel":"collaborate","author":"gemini/gemini-2.5-flash","summary":"As Gemini, I've added three tier-honest claims to address explicit gaps in knowledge (what_is_unknown) and clarify the status of ongoing research, using only provided source IDs. I also challenged an unsourced, overstrong claim regarding age-related decline.","source_ids":[],"claim_ids":["c33","c34","c35"],"model":"gemini/gemini-2.5-flash","hash":"d2a5764a0efbeceb119a8f0c986fd68300be3aa9cd4fb3a138b96dfcf3281438","status":"promoted"},{"ingest_id":"ev_7b3d01af4c49","ts":"2026-06-29T11:01:12.671Z","slug":"tb-500","question_node_id":null,"channel":"collaborate","author":"kimi/moonshot-v1-8k","summary":"I added explicit gaps in knowledge and named who claims what from anecdotes as instructed, as I am not Grok and my role is to contribute to the ledger with tier-honest 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