{"slug":"tb-500","verification":{"valid":true,"entries":51,"head":"aeca9c816a0f4d3d57303d3f6c9cfcd6bc9bbea0e265adea14dfe74398e833f7"},"count":51,"models":["grok/grok-4.3","grok-4.3","kimi/moonshot-v1-8k","gemini/gemini-2.5-flash","system/audit-repair"],"yield":{"passes":51,"energy_spent_rows":0,"total_cost_usd":0.235009,"waste_cost_usd":0,"total_tokens":186938,"material_outputs":7,"usd_per_output":0.033573,"models":[{"model":"gemini/gemini-2.5-flash","passes":1,"cost_usd":0.000337,"tokens_total":2878,"outputs":4,"waste_passes":0,"usd_per_output":0.000084},{"model":"kimi/moonshot-v1-8k","passes":1,"cost_usd":0.00046,"tokens_total":3065,"outputs":3,"waste_passes":0,"usd_per_output":0.000153},{"model":"grok-4.3","passes":21,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"system/audit-repair","passes":3,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"grok/grok-4.3","passes":25,"cost_usd":0.234213,"tokens_total":180995,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T08:31:03.974Z","model":"grok/grok-4.3","role":"writer","action":"redraft","payload":{"title":"TB-500: Thymosin Beta-4","register":"source_ledger","body":"## Overview\nTB-500 is a synthetic peptide fragment corresponding to the active region of thymosin beta-4 (Tβ4).\n\n## Mechanism\nTβ4 sequesters actin and promotes cell migration to sites of injury; it modulates inflammation and supports angiogenesis (mechanistic).\n\n## Evidence by Tier\n### Preclinical (Animal/Cell)\nMultiple rat and mouse models show accelerated wound re-epithelialization and angiogenesis with topical or systemic Tβ4 (preclinical).\n\n### Human Trials\nPhase 1 intravenous safety studies in healthy volunteers reported good tolerability with no dose-limiting toxicity (human).\nPhase 2 topical trials in stasis and pressure ulcers noted accelerated healing in responders (human).\n\n### Age-Related Production\nNo direct human quantification of Tβ4 decline with age identified in searched sources (no human data).\n\n## Distinctions\nTB-500 is a fragment; full Tβ4 data predominate in literature. No controlled trials specific to TB-500 fragment (preclinical dominant for fragment).","claims":[{"id":"c1","text":"Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration.","section":"Mechanism","tier":"mechanistic","source_ids":["s1"],"source_status":"sourced","why_material":"Core described activity separating repair from suppression.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c2","text":"Topical or systemic Tβ4 accelerates wound healing and re-epithelialization in rat full-thickness wound models.","section":"Preclinical","tier":"preclinical","source_ids":["s2"],"source_status":"sourced","why_material":"Distinguishes rat data from human.","evidence_basis":"derived_inference","weight":0.5,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c3","text":"Intravenous synthetic Tβ4 was well tolerated in Phase 1 single- and multiple-dose studies in healthy volunteers with no dose-limiting toxicity.","section":"Human Trials","tier":"human","source_ids":["s3"],"source_status":"sourced","why_material":"Direct human safety evidence.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c4","text":"Topical Tβ4 accelerated healing by nearly one month in Phase 2 trials of stasis and pressure ulcers in some patients who healed.","section":"Human Trials","tier":"human","source_ids":["s4"],"source_status":"sourced","why_material":"Human efficacy signal limited to specific indications.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c5","text":"Tβ4 production declines approximately 60% by age 60.","section":"Overview","tier":"speculative","source_ids":[],"source_status":"unsourced","why_material":"Prompt-supplied figure; no supporting human data located.","evidence_basis":"derived_inference","weight":0.1,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}}],"sources":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/22074294/","title":"Thymosin β4: a multi-functional regenerative peptide","quote":"Thymosin β(4), a low molecular weight, naturally-occurring peptide plays a vital role in the repair and regeneration of injured cells and tissues.","link_status":"ok","quote_status":"verified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/10469335/","title":"Thymosin beta4 accelerates wound healing","quote":"Addition of Tbeta4 topically or intraperitoneally increased reepithelialization by 42% over saline controls at 4 d and by as much as 61% at 7 d post-wounding.","link_status":"ok","quote_status":"verified"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/20536472/","title":"A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers","quote":"Synthetic Tbeta4 given intravenously as a single dose or in multiple daily doses for 14 days over a dose range of 42-1260 mg was well tolerated with no evidence of dose limiting toxicity.","link_status":"ok","quote_status":"verified"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/23050815/","title":"The Regenerative Peptide Thymosin β4 Accelerates the Rate of Dermal Healing","quote":"Furthermore, in two phase 2 clinical trials of stasis and pressure ulcers, it was found to accelerate healing by almost a month in those patients that did heal.","link_status":"ok","quote_status":"verified"}]},"rationale":"","tokens_in":0,"tokens_out":0,"prev_hash":"genesis","hash":"2581d9a5b173bcbdb6019f5285227235146bb2c809b2d7cd95917c7e927c625e"},{"seq":1,"id":"k2","ts":"2026-06-29T09:36:04.257Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s5","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/41490200/","title":"Therapeutic Peptides in Orthopaedics: Applications, ...","quote":"Wound-healing peptides such as BPC-157, TB-500 , and GHK-Cu promote angiogenesis, integrin-mediated extracellular matrix remodeling, and fibroblast activation","link_status":"ok","quote_status":"unverified"},{"id":"s6","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/41476424/","title":"Injectable Peptide Therapy: A Primer for Orthopaedic and ...","quote":"TB-4 and its derivative TB-500 promoted angiogenesis and tissue repair in preclinical models, but human orthopaedic data are lacking, and both remain banned substances in sports.","link_status":"ok","quote_status":"verified"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38382158/","title":"Simultaneous quantification of TB-500 and its metabolites ...","quote":"Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro","link_status":"ok","quote_status":"verified"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/36482504/","title":"TB500/TB1000 and SGF1000: A scientific approach for a ...","quote":"We provide an extensive analysis of three misbranded and adulterated products sold over the internet named TB500 , TB1000, and SGF1000.","link_status":"ok","quote_status":"unverified"},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41229390/","title":"Recombinant human thymosin beta 4 improves ischemic ...","quote":"This study aims to explore the therapeutic potential of recombinant human thymosin beta 4 (rhTB4) in both murine models subjected to I/R and in ...","link_status":"ok","quote_status":"unverified"},{"id":"s10","type":"reddit","url":"https://www.reddit.com/r/ScienceBioTechnology/comments/1rvehfa/the_ultimate_guide_to_peptides_for_injuries/","title":"BPC-157, TB-500, and The Wolverine Stack Explained","quote":"TB-500 is a synthetic fragment of Thymosin Beta-4, a naturally occurring protein. While BPC-157 focuses on blood flow, TB-500 is studied for its systemic ability to regenerate tissue.","link_status":"ok","quote_status":"unverified"},{"id":"s11","type":"reddit","url":"https://www.reddit.com/r/AskMenOver30/comments/1stcht0/any_experience_with_muscletissue_repair_tb500/","title":"Any experience with muscle/tissue repair? Tb-500?","quote":"I took bpc-157 and tb-500 after surgery was off the table for a minor meniscus tear...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"2581d9a5b173bcbdb6019f5285227235146bb2c809b2d7cd95917c7e927c625e","hash":"1430d570145a1a3348efda398c6aa2d21048250fdf88ff891b86d1d5f800b89f"},{"seq":2,"id":"k3","ts":"2026-06-29T09:36:23.605Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40816274/","title":"Thymosin beta 4 as an Alzheimer disease intervention","quote":"Interestingly, the expression level of the gene TMSB4X that encodes thymosin beta 4 (Tβ4) significantly decreased both in fAD organoids' neurons and AD patients ...","link_status":"ok","quote_status":"unverified"},{"id":"s13","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41359360/","title":"Alkaline Phosphatase-Triggered Spatiotemporal Repair of Corneal Injury with TB500 Peptide Hydrogel","quote":"This study presents a novel spatiotemporal repair strategy for corneal wounds, utilizing an alkaline phosphatase (ALP)-triggered, lesion-responsive peptide hydrogel that incorporates TB500...","link_status":"ok","quote_status":"verified"},{"id":"s14","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41570941/","title":"Thymosin beta 4: An emerging therapeutic candidate for kidney diseases","quote":"Thymosin β4 (Tβ4), a highly conserved 43-amino-acid peptide encoded by the X-linked TMSB4x gene, is the predominant β-thymosin in mammalian cells and a multifunctional regulator of cellular homeostasis.","link_status":"ok","quote_status":"verified"},{"id":"s15","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT05485818","title":"Safety and Efficacy Study of Thymosin Beta 4 in Patients With Acute Myocardial Infarction","quote":"Phase IIa Clinical Study of Efficacy and Safety of Injectable Recombinant Human Thymosin Beta 4 in Patients With Acute Myocardial Infarction.","link_status":"ok","quote_status":"unverified"},{"id":"s16","type":"reddit","url":"https://www.reddit.com/r/ACL/comments/1jwe0oe/documenting_my_aclr_meniscus_repair_journey/","title":"Documenting My ACLR + Meniscus Repair Journey – Trying the “Wolverine Stack” (BPC-157 + TB-500)","quote":"I started taking BPC-157 and TB-500 —a combo often called the “Wolverine Stack”—to help support my recovery.","link_status":"ok","quote_status":"unverified"},{"id":"s17","type":"youtube","url":"https://www.youtube.com/watch?v=C9FOnvFDlSo","title":"What Science ACTUALLY Says About TB 500 Benefits","quote":"What does science actually say about TB 500 benefits? Is TB-500 the breakthrough compound that could change the way we think about injury recovery?","link_status":"http_429","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"1430d570145a1a3348efda398c6aa2d21048250fdf88ff891b86d1d5f800b89f","hash":"96c34347140c407859ef8b7d5018d6f03c085b4793b3ae410902e483e08b8bd8"},{"seq":3,"id":"k4","ts":"2026-06-29T09:36:52.043Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s18","type":"reddit","url":"https://www.reddit.com/r/PeptidePathways/comments/1ruolbw/i_was_hospitalised_after_running_tb500/","title":"I was hospitalised after running TB-500","quote":"All was ok for the first week, running 2MCG of each per day. However one evening the BP157 gave me an intense tingling sensation down one side of my body - it could be that i irritated a nerve, but i decided to stop. I continued with the TB500 until i hit the final dose of a 10mg bottle. The next day, i noticed hives coming out across my ribs and armpits on both sides. ... I went to bed about 3am and noticed more hives - this time worse. 3 hours later i woke up with my throat closing up, swollen lips and tongue and incredible hives.","link_status":"ok","quote_status":"unverified"},{"id":"s19","type":"reddit","url":"https://www.reddit.com/r/bpc_157/comments/1nl0bb9/strange_side_effects_of_bpc_157_and_tb_500/","title":"Strange side effects of BPC 157 and TB 500","quote":"Strange side effects of BPC 157 and TB 500 . Discussion. I recently ... My experience using BPC-157 + TB 500 .","link_status":"ok","quote_status":"unverified"},{"id":"s20","type":"youtube","url":"https://www.youtube.com/watch?v=GFVspd1by7w","title":"I Took The Wolverine Stack & My Thoughts On BPC-157 & TB-500","quote":"I can tell you personally that I believe that while I was taking this type of supplementation or this type of injection that it did allow me to heal a little faster. It did reduce some inflammation and I found that my flare-ups were a little bit less soon as I implemented taking this stuff with a very low-level rehab program.","link_status":"http_429","quote_status":"unverified"},{"id":"s21","type":"youtube","url":"https://www.youtube.com/watch?v=oi0Ou-fK9o8","title":"TB-500 for Injury Recovery – Does it Work and is it Safe?","quote":"[@venom999333 - 37 likes]: I started TB500 a couple weeks ago. Injections, so internally. TB500 & BPC 157 together. Pain went away rapidly. Within a few hours. Been using them everyday for 2 weeks now.","link_status":"http_429","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"prev_hash":"96c34347140c407859ef8b7d5018d6f03c085b4793b3ae410902e483e08b8bd8","hash":"2bf9bb1f37da1ee0820988614b920366a66a3f0361f6cc8c90bf2ebb4aec80d2"},{"seq":4,"id":"k5","ts":"2026-06-29T09:37:13.143Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s22","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41235866/","title":"Engineered Tandem Thymosin Peptide Promotes Corneal Wound Healing","quote":"Thymosin beta-4 (TB4) is a small peptide upregulated in injured tissues, playing roles in cell migration, angiogenesis, inflammation, and oxidative stress.","link_status":"ok","quote_status":"verified"},{"id":"s23","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40362372/","title":"Thymosin Beta-4 Modulates Cardiac Remodeling by Promoting Myocardial Cell Survival","quote":"Thymosin beta-4 (TB4), a short, secreted peptide, was shown to possess a beneficial impact regarding myocardial cell survival, coronary re-growth and progenitor cell mobilization.","link_status":"ok","quote_status":"unverified"},{"id":"s24","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT04555824","title":"A Phase 1a Study of Thymosin Beta 4 in Healthy Volunteers","quote":"A Phase 1a Study of Thymosin Beta 4 in Healthy Volunteers","link_status":"ok","quote_status":"unverified"},{"id":"s25","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT01311518","title":"A Study of the Safety and Efficacy of Injectable Thymosin Beta 4","quote":"The objective of this study is to evaluate the safety and tolerability of two active doses of RGN-352 (thymosin beta 4, Tβ4, Injectable Solution) in patients","link_status":"ok","quote_status":"unverified"},{"id":"s26","type":"review","url":"https://www.mdpi.com/2076-3417/16/12/6202","title":"Thymosin Beta-4 and TB-500 in Tissue Healing and Musculoskeletal Medicine","quote":"Thymosin beta-4 (TB4) and the related compound commonly referred to as TB-500 are widely discussed in tissue healing and musculoskeletal medicine","link_status":"http_403","quote_status":"unverified"},{"id":"s27","type":"reddit","url":"https://www.reddit.com/r/geneticlifehacks/comments/1sao0q8/thymosin_beta_4_genetics_supplemental_peptides/","title":"Thymosin Beta 4: Genetics & Supplemental Peptides","quote":"Thymosin beta 4 is available as a full-length peptide that is usually injected or as a fragment of the peptide that is available orally. Note that TB-500 and ...","link_status":"ok","quote_status":"unverified"},{"id":"s28","type":"reddit","url":"https://www.reddit.com/r/ACL/comments/1rzwqf3/bpc_157_tb500_experience/","title":"BPC 157 & TB500 -experience ?","quote":"My personal experience of bpc and tb was very good. Gave me 3 months of healing in a few weeks, with zero negatives.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 4","tokens_in":0,"tokens_out":0,"prev_hash":"2bf9bb1f37da1ee0820988614b920366a66a3f0361f6cc8c90bf2ebb4aec80d2","hash":"b533d4b87bacd85a3e7718fc494638645795dfdf36eb3fcadcd46707cb23d98e"},{"seq":5,"id":"k6","ts":"2026-06-29T11:01:12.671Z","model":"kimi/moonshot-v1-8k","role":"collaborator","action":"collaborate","payload":{"claims_added":["c30","c31"],"challenge_id":"c32","rationale":"I added explicit gaps in knowledge and named who claims what from anecdotes as instructed, as I am not Grok and my role is to contribute to the ledger with tier-honest claims."},"rationale":"I added explicit gaps in knowledge and named who claims what from anecdotes as instructed, as I am not Grok and my role is to contribute to the ledger with tier-honest claims.","tokens_in":2667,"tokens_out":398,"prev_hash":"b533d4b87bacd85a3e7718fc494638645795dfdf36eb3fcadcd46707cb23d98e","hash":"103701951b257bb712aee25c571061389b6d0506da4e900a2f7abccfa9829789"},{"seq":6,"id":"k7","ts":"2026-06-29T11:04:30.643Z","model":"gemini/gemini-2.5-flash","role":"collaborator","action":"collaborate","payload":{"claims_added":["c33","c34","c35"],"challenge_id":"c36","rationale":"As Gemini, I've added three tier-honest claims to address explicit gaps in knowledge (what_is_unknown) and clarify the status of ongoing research, using only provided source IDs. 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Lots of us guys over 40 take them together 3x a week at 500mcg each to keep pain down from old injuries or nagging problems.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"d236c1cfac78955190211841a95326c2b82d67363ed50cbd90e7dbf49cafd4ea","hash":"2984ece9f8b6a6f6c9a86e04e318e5b34b04ff0f460b7ca00ac07ead658ba011"},{"seq":21,"id":"k22","ts":"2026-06-29T17:03:52.670Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s74","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1snsl9z/has_anyone_used_bpc157_tb500_for_a_pulled/","title":"Has anyone used BPC-157 + TB-500 for a pulled hamstring?","quote":"157 definitely helped with the healing, and last time it happened I got the 500 too which made a difference, they are not miracles in a vial though, you still need to give it time and do plenty of rehab, massage, rolling/scraping etc.","link_status":"ok","quote_status":"unverified"},{"id":"s75","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1svj73f/my_experience_using_bpc157_and_tb500_for_a_torn/","title":"My experience using BPC-157 and TB-500 for a torn ...","quote":"It's TB4 - confirmed from the COA. Seconded on the dosing schedule. yes bro science.","link_status":"ok","quote_status":"unverified"},{"id":"s76","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1tbsnp0/tb500_for_l5s1_disc_bulge_and_lower_back_pain_did/","title":"TB-500 for L5/S1 disc bulge and lower back pain - did it work?","quote":"I've been reading a lot about TB-500 and BPC-157 and saw many people saying it helped them with injuries and inflammation. Has anyone here used TB-500 for lower ...","link_status":"ok","quote_status":"unverified"},{"id":"s77","type":"reddit","url":"https://www.reddit.com/r/NTNPerformance/comments/1uehmjh/peptide_tb500_vs_tb4_why_the_thing_in_the_vial/","title":"Peptide TB-500 vs TB-4: Why the Thing in the Vial Often Isn't What You Think","quote":"TB-500 retains the actin-binding activity, so the cell-migration and wound-repair signaling that depends on that domain still works. 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Would it be better for me to go up to the 2 mg twice a week, or is it fine for me to stay on the protocol that I'm doing since I don't have an injury.","link_status":"ok","quote_status":"unverified"},{"id":"s86","type":"reddit","url":"https://www.reddit.com/r/ORIF/comments/1r5vk9q/unique_ways_that_speed_up_recovery_30_f_5_weeks/","title":"Unique ways that speed up recovery: 30 F 5 weeks post op left ankle fracture","quote":"I ordered a peptide BPC 157 and TB 500. BPC 157 promotes healing in tissues like tendons, muscles, ligaments, and bones by stimulating new blood vessel growth and heals your gut. TB 500 promotes wound healing, reducing inflammation, and aiding tissue regeneration. I severely damaged my cartilage and I am at risk of arthritis in the future.","link_status":"ok","quote_status":"unverified"},{"id":"s87","type":"reddit","url":"https://www.reddit.com/r/AchillesRupture/comments/1lx556v/comprehensive_overview_of_my_achilles_rupture/","title":"Comprehensive overview of my Achilles rupture treatment ...","quote":"Injection site: I am injecting BPC-157 and TB-500 subcutaneous in my abdomen. You see a lot of online anecdotes that it is optimal to inject closer to injury ...","link_status":"ok","quote_status":"unverified"},{"id":"s88","type":"x","url":"https://x.com/LiveWellWithDrG/status/2069467154508808610","title":"How TB-500 Works post","quote":"🧬 How TB-500 Works: The Cellular Blueprint of Tissue Repair ... TB-500 (a synthetic fragment of the naturally occurring peptide Thymosin Beta-4) intervenes directly at the genomic and cellular level to force structural remodeling. ... This ensures that new muscle and tendon fibers align perfectly in parallel, restoring pristine tissue flexibility and explosive structural strength rather than a stiff, knotted patch.","link_status":"ok","quote_status":"unverified"},{"id":"s89","type":"x","url":"https://x.com/AvengedxWolf/status/2069530639464849720","title":"Side effects mention","quote":"damn... Mine was close to organs being affected... the side effects are real.... joiny and muscle pain","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"2964107f6fd7c3f98a484e41a7aa17a80e6a46eadc778bf6fdc0a3ae1a6f0c52","hash":"c2ecbece1147ed39d9d1a3175199a31ff02684088a0cf13e98a463449e5b7d13"},{"seq":25,"id":"k26","ts":"2026-06-29T17:06:40.016Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s90","type":"x","url":"https://x.com/JayCampbell333/status/2071592420387455315","title":"Jay Campbell on GLOW blend with TB-500","quote":"Then there's the GLOW blend (BPC-157 + TB-500 + GHK-Cu). Three compounds, one objective: Keep the repair signal switched ON. Most people don't realize how much of aging is simply a failure to repair.","link_status":"ok","quote_status":"unverified"},{"id":"s91","type":"x","url":"https://x.com/gr8tful88/status/2071404994192974208","title":"gr8tful88 post on peptides for muscle recovery","quote":"Muscle recovery: BPC-157, TB-500. Repair tendons, ligaments, and soft tissue damage faster than rest alone.","link_status":"ok","quote_status":"verified"},{"id":"s92","type":"x","url":"https://x.com/premierpeptides/status/2071555855330181302","title":"Premier Peptides on Wolverine Stack","quote":"Glacier Aminos has BPC-157 and TB-500 in stock! ... other popular recovery and tissue repair peptides, including the Wolverine Stack.","link_status":"ok","quote_status":"unverified"},{"id":"s93","type":"reddit","url":"https://www.reddit.com/r/covidlonghaulers/comments/19c7c8b/tb4_peptide_recovery_post_anyone_else_tried_this/","title":"TB4 Peptide recovery post -- anyone else tried this???","quote":"Studies show that thymosin beta 4 promotes wound healing, differentiation of stem cells, and reduces inflammation. I have not tried TB-500 since ...","link_status":"ok","quote_status":"unverified"},{"id":"s94","type":"x","url":"https://x.com/PeakYearUS/status/2071440390981648767","title":"YearPeak on Wolverine Stack with TB-500","quote":"Stop mixing your BPC-157 and TB-500 manually. ... The YearPeak™ Wolverine Stack features 10mg BPC-157 + 10mg TB-500 Co-Lyophilized in a single matrix. High-purity structural synergy for cellular repair.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"c2ecbece1147ed39d9d1a3175199a31ff02684088a0cf13e98a463449e5b7d13","hash":"69e8c50248c20ac628a24f2b36f1c4603fd27a94bedae95c70d4c28c0124d912"},{"seq":26,"id":"k27","ts":"2026-06-29T17:07:11.659Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s95","type":"reddit","url":"https://www.reddit.com/r/AchillesRupture/comments/1ikfhhw/bpc_157_and_tb500/","title":"BPC 157 and TB500","quote":"I took them both at the same time in the evenings but from Separate vials/syringes. Took them starting about two months into my recovery, and then again after my re-ruptured. So about four months worth.","link_status":"ok","quote_status":"unverified"},{"id":"s96","type":"reddit","url":"https://www.reddit.com/r/fitness40plus/comments/1oqc5uv/tendonitis_experiences_with_bpc157/","title":"Tendonitis - Experiences with BPC-157","quote":"Tore my distal bicep tendon 6 months ago made the decision to take injectable bpc157 and tb500. Took it for 8 weeks. I healed fast. At the 10 week mark I was in the gym lifting light weights, 14 week mark I was lifting fairly heavy and at the 5 month mark I was lifting as heavy as I wanted.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"69e8c50248c20ac628a24f2b36f1c4603fd27a94bedae95c70d4c28c0124d912","hash":"ce013ce5ee5b58e2a7698f9797b2a601e53fc48be61a70f44956e81c7523bffe"},{"seq":27,"id":"k28","ts":"2026-06-29T17:22:23.652Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s97","type":"reddit","url":"https://www.reddit.com/r/workout/comments/1jzyxev/anyone_use_bpc157tb500/","title":"Anyone use BPC-157+TB-500?","quote":"Just purchased 20mg’s for a 20 days “cycle” hoping ti get rid of a few nagging injuries","link_status":"ok","quote_status":"unverified"},{"id":"s98","type":"reddit","url":"https://www.reddit.com/r/KneeInjuries/comments/1nprc3k/my_bpctb500_experience_with_site_injections_for/","title":"My BPC/TB500 experience with site injections for the knee","quote":"TLDR: local site injections of BPC-157/ TB500 for my right knee worked infinitely better and I can now jog for the first time in a year without ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"ce013ce5ee5b58e2a7698f9797b2a601e53fc48be61a70f44956e81c7523bffe","hash":"c2733e0e387c2437f5054f30dab72505d4c55bde85ba7f038509f2876fe8c9e0"},{"seq":28,"id":"k29","ts":"2026-07-01T11:29:18.678Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented TB-500 (Tβ4 fragment) mechanism in the ledger: Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration (c1, tier human, source s1). Stepwise: binds free G-actin inside cells → frees actin monomers for new filament assembly at the leading edge → cells migrate toward injury sites → migrating cells release signals supporting new vessel formation and reduced excess inflammation → net result faster wound re-closure and repair matrix deposition in animal models. All other mechanistic claims (vascular repair via CCN5 (c44, s33), axon regeneration (c45, s34), kidney fibrosis/inflammation (c15, s14)) remain at mechanistic or preclinical tier.","cited_claim_ids":["c1","c44","c15","c45"],"cited_source_ids":["s1","s33","s14","s34"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":225,"cost":0.00962375,"prev_hash":"c2733e0e387c2437f5054f30dab72505d4c55bde85ba7f038509f2876fe8c9e0","hash":"91338d98660603c86e7d6ba43c7810168c5f6d0f697f08c16d469539f02bf939"},{"seq":29,"id":"k30","ts":"2026-07-01T23:11:39.055Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism in the ledger: TB-500 (Tβ4 fragment) binds free G-actin inside cells, freeing actin monomers for new filament assembly at the leading edge; this enables cell migration toward injury sites, supports new vessel formation (angiogenesis), and modulates inflammation. Net result described is faster wound re-closure and repair matrix deposition in animal models. Core claim (c1) cites source s1. No interaction_risk or limitations-slot claims present. Preclinical support (c2) from rat wound models (source s2). Human data limited to safety (c3, source s3) and specific wound types (c4, source s4); orthopaedic and other uses remain without established human evidence (quote-gated claims c6, c27, c41 etc. treated as low-confidence). Anecdotes (tier:anecdotal, e.g. c56, c57) separated and lower weight.","cited_claim_ids":["c1","c2","c3","c4"],"cited_source_ids":["s1","s2","s3","s4"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":268,"cost":0.00973125,"prev_hash":"91338d98660603c86e7d6ba43c7810168c5f6d0f697f08c16d469539f02bf939","hash":"2a287952a2570d77ee7dfbf093c8cab8d925a1d36619f0c7bfd283df7dc3671b"},{"seq":30,"id":"k31","ts":"2026-07-01T23:55:01.451Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism in the ledger: TB-500 (fragment of thymosin beta-4) binds free G-actin inside cells; this frees actin monomers for new filament assembly at the leading edge of a cell; cells can therefore migrate toward injury sites; migrating cells release signals that support new vessel formation and reduce excess inflammation; the net result is faster re-closure of wounds and faster deposition of repair matrix in animal models (c1, s1).","cited_claim_ids":["c1"],"cited_source_ids":["s1"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":155,"cost":0.00944875,"prev_hash":"2a287952a2570d77ee7dfbf093c8cab8d925a1d36619f0c7bfd283df7dc3671b","hash":"cf1cc94cd4a1f95c6bc56a543391b2ff196769508d4fef8aae6d3cc19063aad2"},{"seq":31,"id":"k32","ts":"2026-07-03T00:02:09.471Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented TB-500 mechanism in the ledger: binds free G-actin inside cells, freeing actin monomers for new filament assembly at the leading edge, enabling cell migration toward injury sites; migrating cells then release signals supporting new vessel formation and reduced excess inflammation, resulting in faster wound re-closure and repair matrix deposition in animal models (c1, c2). Human evidence is limited to one Phase 1 safety study (well tolerated, no dose-limiting toxicity) and two Phase 2 wound-healing trials (topical use accelerated healing in some stasis/pressure ulcer patients); most data are preclinical or anecdotal (c3, c4). No interaction_risk or limitations-slot claims exist for mechanism.","cited_claim_ids":["c1","c2","c3","c4"],"cited_source_ids":["s1","s2","s3","s4"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":220,"cost":0.00961125,"prev_hash":"cf1cc94cd4a1f95c6bc56a543391b2ff196769508d4fef8aae6d3cc19063aad2","hash":"245a641362346e2eb051546c6f6ee0a0ab3219ad075f8bb74005619b84d970ec"},{"seq":32,"id":"k33","ts":"2026-07-03T00:04:27.979Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"The ledger documents TB-500 (Tβ4 fragment) mechanism as: binds free G-actin, frees monomers for new filament assembly at the cell leading edge, enabling migration of repair cells toward injury; migrating cells then support angiogenesis and modulate inflammation, resulting in faster wound re-closure and repair-matrix deposition in animal models (c1; s1). Preclinical support includes rat full-thickness wound models showing accelerated re-epithelialization (c2; s2). Human data are limited to Phase 1 safety (well tolerated, no dose-limiting toxicity; c3; s3) and one Phase 2 signal in specific ulcers (c4; s4). No new evidence is present; marketing volume is noted separately (c7).","cited_claim_ids":["c1","c2","c3","c4","c7"],"cited_source_ids":["s1","s2","s3","s4"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":233,"cost":0.00964375,"prev_hash":"245a641362346e2eb051546c6f6ee0a0ab3219ad075f8bb74005619b84d970ec","hash":"108b35eb40b036395d0bfad06a08e0c677c2793a61fadf6d3320be25ab374be0"},{"seq":33,"id":"k34","ts":"2026-07-03T04:45:47.124Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism (no new evidence): TB-500 (fragment of thymosin beta-4) binds free G-actin inside cells, freeing actin monomers for new filament assembly at the leading edge. This enables cell migration toward injury sites; migrating cells then release signals supporting new vessel formation and reduced excess inflammation. Net result observed in animal models is faster wound re-closure and repair-matrix deposition. Core claim rests on actin sequestration promoting cell migration, angiogenesis, and inflammation modulation (c1, tier human, source s1). Preclinical rat wound model showed accelerated re-epithelialization (c2, tier preclinical, source s2). Human safety data exist (Phase 1 intravenous tolerability, c3, tier human, source s3) but no new mechanistic human data are recorded. Several quote-gated claims (c6, c13, c16, c27, c40–42, c46, c10, c9, c24, c33, c45) and anecdotal reports (multiple c56–c102) are present but do not alter the documented mechanism.","cited_claim_ids":["c1","c2","c3"],"cited_source_ids":["s1","s2","s3"],"needs_user_info":[],"gaps":["No new mechanistic evidence beyond ledger contents; human efficacy data remain limited to specific wound types (stasis/pressure ulcers)."],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":322,"cost":0.00986625,"prev_hash":"108b35eb40b036395d0bfad06a08e0c677c2793a61fadf6d3320be25ab374be0","hash":"49683eb034d42569f9bccd814b23bdf0f77c5f9ea73eff55acb7ac68e4af3312"},{"seq":34,"id":"k35","ts":"2026-07-03T05:05:29.044Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism for TB-500 in the ledger: TB-500 (synthetic fragment of thymosin beta-4) binds free G-actin inside cells, freeing actin monomers for new filament assembly at the leading edge of cells. This enables cell migration toward injury sites. Migrating cells release signals that support new vessel formation and reduce excess inflammation. Net result: faster wound re-closure and repair matrix deposition in animal models. Core claim (c1, source s1): “Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration.” Preclinical support (c2, source s2): topical or systemic Tβ4 accelerates wound healing and re-epithelialization in rat full-thickness wound models. No interaction_risk or limitations-slot claims present. All other listed claims are efficacy, marketing, or anecdotal and not required for mechanism.","cited_claim_ids":["c1","c2"],"cited_source_ids":["s1","s2"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":243,"cost":0.00966875,"prev_hash":"49683eb034d42569f9bccd814b23bdf0f77c5f9ea73eff55acb7ac68e4af3312","hash":"9e835c7bde94ecd8f63ed35bbea3a21c82a4c462d4a09bf08ebf1e70da85d27d"},{"seq":35,"id":"k36","ts":"2026-07-03T05:11:50.916Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism in the ledger: TB-500 (Tβ4 fragment) binds free G-actin (c1, source s1), freeing actin monomers for new filament assembly at the leading edge of cells (c1). This enables cell migration toward injury sites (c1), followed by release of signals supporting new vessel formation (angiogenesis) and reduced excess inflammation (c1). Net result in models is faster wound re-closure and repair-matrix deposition (c2, source s2). No new evidence added; all claims drawn from existing ledger entries. Human data remain sparse (s3, s4); most sources are preclinical or anecdotal.","cited_claim_ids":["c1","c2"],"cited_source_ids":["s1","s2"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":200,"cost":0.00956125,"prev_hash":"9e835c7bde94ecd8f63ed35bbea3a21c82a4c462d4a09bf08ebf1e70da85d27d","hash":"165f74d9ccde992e5dbd9fd07ede2fd1a99e362846e4fa6a96738995a4178944"},{"seq":36,"id":"k37","ts":"2026-07-03T17:43:10.228Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism for TB-500 (Tβ4 fragment) in the ledger: binds free G-actin inside cells, freeing actin monomers for new filament assembly at the leading edge. This enables cell migration toward injury sites. Migrating cells release signals supporting new vessel formation and reduced excess inflammation. Net result in models: faster wound re-closure and repair-matrix deposition. Core claim c1 (tier human, source s1) states: 'Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration.'","cited_claim_ids":["c1"],"cited_source_ids":["s1"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":169,"cost":0.00948375,"prev_hash":"165f74d9ccde992e5dbd9fd07ede2fd1a99e362846e4fa6a96738995a4178944","hash":"cd3130dc6749519c7e7e44e6a9001a1ba9bf1d6f355be9123a1721375a791651"},{"seq":37,"id":"k38","ts":"2026-07-04T22:09:15.362Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented TB-500 mechanism in the ledger: Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration (c1, tier human, source s1). Stepwise description: binds free G-actin, frees monomers for new filament assembly at the leading edge, enables cell migration to injury sites, supports new vessel formation, reduces excess inflammation, and results in faster wound re-closure and repair matrix deposition in animal models. No new evidence added; all from existing ledger.","cited_claim_ids":["c1"],"cited_source_ids":["s1"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":162,"cost":0.00946625,"prev_hash":"cd3130dc6749519c7e7e44e6a9001a1ba9bf1d6f355be9123a1721375a791651","hash":"18560ac828bd85e1c712e706d4f24d97ce3fd49947459c92962388026e8e9ca2"},{"seq":38,"id":"k39","ts":"2026-07-06T02:31:41.538Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism per ledger: TB-500 (Tβ4 fragment) binds free G-actin, freeing monomers for new filament assembly at the cell's leading edge, enabling cell migration toward injury sites; migrating cells then release signals supporting new vessel formation and reduced excess inflammation, resulting in faster wound re-closure and repair matrix deposition in animal models (c1, s1; c2, s2). No new evidence added; ledger lists 35 sources total (1 human safety, 2 human wound-healing, 28 preclinical/mechanistic, 10 anecdotal).","cited_claim_ids":["c1","c2"],"cited_source_ids":["s1","s2"],"needs_user_info":[],"gaps":["No human orthopaedic data; human data remain sparse overall."],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":197,"cost":0.00955375,"prev_hash":"18560ac828bd85e1c712e706d4f24d97ce3fd49947459c92962388026e8e9ca2","hash":"59bd2aa79aa2614fab24e508fd44e34c15583c078a61f6e5ff4c67ee4aa84620"},{"seq":39,"id":"k40","ts":"2026-07-06T03:08:06.235Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism in the ledger: TB-500 (Tβ4 fragment) binds free G-actin inside cells, freeing actin monomers for new filament assembly at the leading edge, enabling cell migration toward injury sites; migrating cells then release signals supporting new vessel formation and reduced excess inflammation, resulting in faster wound re-closure and repair-matrix deposition (primarily in animal models). Core claim c1 (tier human, weight 0.8, source s1) states Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration. Step-by-step logic chain and regeneration framing are given in the body_excerpt. No new evidence; all mechanism claims drawn from existing ledger sources only.","cited_claim_ids":["c1"],"cited_source_ids":["s1"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":202,"cost":0.00956625,"prev_hash":"59bd2aa79aa2614fab24e508fd44e34c15583c078a61f6e5ff4c67ee4aa84620","hash":"8c4fa4ec65f0f46438fc1675fb2ee1101d8a806bc86da001574daba806392aa4"},{"seq":40,"id":"k41","ts":"2026-07-07T03:41:55.298Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism from the TB-500 ledger: TB-500 (fragment of thymosin beta-4) binds free G-actin inside cells, freeing actin monomers for new filament assembly at the leading edge of a cell. This enables cell migration toward injury sites. Migrating cells release signals that support new vessel formation and reduce excess inflammation. The net result is faster wound re-closure and faster deposition of repair matrix in animal models (c1, s1; c2, s2).","cited_claim_ids":["c1","c2"],"cited_source_ids":["s1","s2"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":169,"cost":0.00948375,"prev_hash":"8c4fa4ec65f0f46438fc1675fb2ee1101d8a806bc86da001574daba806392aa4","hash":"540b9e98bcff734ddae8995c8164c4cf67f9a027ce6f548d59633a7cc8d6fb7b"},{"seq":41,"id":"k42","ts":"2026-07-07T03:43:31.426Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented TB-500 mechanism in the ledger centers on actin sequestration: TB-500 binds free G-actin, freeing monomers for new filament assembly at the leading edge of cells, enabling migration toward injury sites, release of signals supporting vessel formation and reduced excess inflammation, resulting in faster wound re-closure and repair matrix deposition in animal models (c1, c2). Human data are limited to a Phase 1 safety study showing good tolerability with no dose-limiting toxicity (c3) and a Phase 2 topical trial showing accelerated healing in some stasis/pressure ulcer patients (c4). Preclinical sources confirm wound healing acceleration in rat models (c2). All other claims are anecdotal or quote-gated with low effective weight; no interaction_risk or limitations-slot claims are present in the topology. The ledger records 35 sources total, predominantly preclinical or anecdotal.","cited_claim_ids":["c1","c2","c3","c4"],"cited_source_ids":["s1","s2","s3","s4"],"needs_user_info":[],"gaps":["No population usage data","Human orthopaedic data lacking","No published Phase IIa AMI trial results"],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":272,"cost":0.00974125,"prev_hash":"540b9e98bcff734ddae8995c8164c4cf67f9a027ce6f548d59633a7cc8d6fb7b","hash":"35a3a173d3b3d682c03787b336698158b5ff28ba61333d209f59728823921724"},{"seq":42,"id":"k43","ts":"2026-07-07T03:44:15.774Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism in the ledger: TB-500 (synthetic fragment of thymosin beta-4) binds free G-actin inside cells, freeing actin monomers for new filament assembly at the cell's leading edge. This enables cell migration toward injury sites; migrating cells then release signals supporting new vessel formation and reduced excess inflammation. Net result observed in animal models is faster wound re-closure and repair-matrix deposition. Core mechanism claim (c1) is supported by review source s1. Preclinical support for accelerated re-epithelialization in rat wound models (c2) from source s2. No new evidence beyond ledger contents.","cited_claim_ids":["c1","c2"],"cited_source_ids":["s1","s2"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":197,"cost":0.00955375,"prev_hash":"35a3a173d3b3d682c03787b336698158b5ff28ba61333d209f59728823921724","hash":"0e7a48a4302d4cb62808dc8bf24231d95267931fc7129498e799fa450ebf9374"},{"seq":43,"id":"k44","ts":"2026-07-07T03:46:26.419Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism in the ledger: TB-500 (synthetic fragment of thymosin beta-4) binds free G-actin, freeing monomers for new filament assembly at the cell leading edge, enabling repair-cell migration to injury sites; migrating cells then release signals supporting vessel formation and reduced excess inflammation, yielding faster wound re-closure and repair-matrix deposition in animal models (c1 from s1; steps 1–5 in body excerpt). Core claim is actin sequestration promoting cell migration, angiogenesis, and inflammation modulation (c1). Preclinical support includes rat full-thickness wound models showing accelerated re-epithelialization (c2 from s2). Human data are limited to one Phase 1 safety study (well tolerated, no dose-limiting toxicity, c3 from s3) and two wound-healing trials (c4 from s4; c16 from s15, quote-gated). No new evidence added; interaction_risk and limitations slots contain no safety signals for this query.","cited_claim_ids":["c1","c2","c3","c4","c16"],"cited_source_ids":["s1","s2","s3","s4","s15"],"needs_user_info":[],"gaps":["No dosing, patient-specific, or combination-safety data in ledger for this query"],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":298,"cost":0.00980625,"prev_hash":"0e7a48a4302d4cb62808dc8bf24231d95267931fc7129498e799fa450ebf9374","hash":"74e9c058bd4b28148ce1b8c3718856acc5d7d621a4da806d77b1eb401dcb4ddc"},{"seq":44,"id":"k45","ts":"2026-07-07T03:48:51.561Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism per ledger: TB-500 (Tβ4 fragment) binds free G-actin, freeing monomers for new filament assembly at the leading edge, enabling cell migration toward injury. Migrating cells then release signals supporting angiogenesis and reduced excess inflammation, yielding faster wound re-closure and repair-matrix deposition in animal models (c1 tier human from s1; c2 tier preclinical from s2). No new evidence added; all claims drawn from existing ledger entries.","cited_claim_ids":["c1","c2"],"cited_source_ids":["s1","s2"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":163,"cost":0.00946875,"prev_hash":"74e9c058bd4b28148ce1b8c3718856acc5d7d621a4da806d77b1eb401dcb4ddc","hash":"caf6ba3cce4c9b8902c02a1cc627e460a1911e207f8653e03ec52db51d65f883"},{"seq":45,"id":"k46","ts":"2026-07-07T03:50:54.727Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented TB-500 mechanism in the ledger centers on actin sequestration: TB-500 binds free G-actin (c1), freeing monomers for new filament assembly at the cell leading edge, enabling cell migration to injury sites, release of signals supporting angiogenesis, and modulation of inflammation. Net effect reported as faster wound re-closure and repair-matrix deposition in animal models. Source s1 (review) states thymosin beta-4 “plays a vital role in the repair and regeneration of injured cells and tissues.” Preclinical support includes rat full-thickness wound models (c2, source s2). Human data are limited to safety (c3, source s3) and specific wound-healing signals (c4, source s4); no new evidence added.","cited_claim_ids":["c1","c2","c3","c4"],"cited_source_ids":["s1","s2","s3","s4"],"needs_user_info":[],"gaps":["No human orthopaedic efficacy data; product quality/adulteration concerns noted but no interaction_risk claims present."],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":253,"cost":0.00969375,"prev_hash":"caf6ba3cce4c9b8902c02a1cc627e460a1911e207f8653e03ec52db51d65f883","hash":"b3f221b54c9ebf946086dfe2a5c5887c06b5dd38e4294b753954eb641337783d"},{"seq":46,"id":"k47","ts":"2026-07-07T04:07:29.867Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism in the ledger: TB-500 (synthetic fragment of thymosin beta-4) binds free G-actin inside cells. This frees actin monomers for new filament assembly at the leading edge of a cell, allowing repair cells to migrate toward injury sites. Migrating cells then release signals that support new vessel formation and reduce excess inflammation, resulting in faster wound re-closure and repair matrix deposition in animal models. Core claim (c1, source s1) states Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration. Preclinical support (c2, source s2) shows accelerated re-epithelialization in rat wound models. Human data on mechanism itself are absent; safety (c3, source s3) and limited wound-healing signals (c4, source s4) exist but do not address mechanism in humans.","cited_claim_ids":["c1","c2","c3","c4"],"cited_source_ids":["s1","s2","s3","s4"],"needs_user_info":[],"gaps":["No direct human mechanistic studies; all mechanism data are preclinical or inferred from animal/cell models."],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":273,"cost":0.00974375,"prev_hash":"b3f221b54c9ebf946086dfe2a5c5887c06b5dd38e4294b753954eb641337783d","hash":"5509a422b8745a6dc0f20e042bc265f85f49e994b1066d07794f87376fb64541"},{"seq":47,"id":"k48","ts":"2026-07-07T04:09:37.821Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism from ledger: TB-500 (Tβ4 fragment) binds free G-actin, frees monomers for new filament assembly at the leading edge, enabling cell migration toward injury; migrating cells then release signals supporting new vessel formation and reducing excess inflammation, producing faster wound re-closure and repair-matrix deposition in animal models (c1, c2). No new evidence supplied; all claims drawn from existing topology only.","cited_claim_ids":["c1","c2"],"cited_source_ids":["s1","s2"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":154,"cost":0.00944625,"prev_hash":"5509a422b8745a6dc0f20e042bc265f85f49e994b1066d07794f87376fb64541","hash":"ab263366f2ff7400c14502a429f38f481000e24a7db92a369d3f9a34b358f8e9"},{"seq":48,"id":"k49","ts":"2026-07-07T04:40:44.976Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism of TB-500 (Tβ4 fragment) in the ledger: binds free G-actin, sequesters it, frees monomers for new filament assembly at the leading edge of cells, enabling cell migration to injury sites; migrating cells then release signals supporting angiogenesis and reduced excess inflammation, leading to faster wound re-closure and repair-matrix deposition in animal models. Core claim supported by review source s1 (c1) and mechanistic description in the body; no new evidence added. Safety-first: no interaction_risk or limitations-slot claims present for mechanism. All human data remain sparse; most evidence preclinical or anecdotal.","cited_claim_ids":["c1"],"cited_source_ids":["s1"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":188,"cost":0.00953125,"prev_hash":"ab263366f2ff7400c14502a429f38f481000e24a7db92a369d3f9a34b358f8e9","hash":"c1aea3464e0f39f0466de2d324c20e6349e59dfd3246ee530fafcc6b842c0049"},{"seq":49,"id":"k50","ts":"2026-07-07T05:18:10.092Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented mechanism from the ledger: TB-500 (Tβ4 fragment) binds free G-actin inside cells, freeing actin monomers for new filament assembly at the leading edge; this enables cell migration toward injury sites, release of signals supporting new vessel formation, and modulation of inflammation, leading to faster wound re-closure and repair matrix deposition in animal models. Core claims: c1 (actin sequestration, cell migration, angiogenesis, inflammation modulation; tier human, source s1), c3 (Phase 1 IV safety/tolerability in healthy volunteers; tier human, source s3), c4 (Phase 2 topical acceleration in some stasis/pressure ulcer patients; tier human, source s4), c2 (rat wound re-epithelialization increase; tier preclinical, source s2). No new evidence; human data sparse, most evidence preclinical or anecdotal. Quote-gated claims (e.g., c6, c13, c16, c27, c40, c41, c42, c46) treated as low-confidence. No interaction_risk/limitations claims present in the provided topology.","cited_claim_ids":["c1","c3","c4","c2"],"cited_source_ids":["s1","s3","s4","s2"],"needs_user_info":[],"gaps":["No interaction_risk or limitations-slot claims available","No dosing, patient-specific, or combination safety data","Human orthopaedic and systemic data lacking per s6"],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7249,"tokens_out":335,"cost":0.00989875,"prev_hash":"c1aea3464e0f39f0466de2d324c20e6349e59dfd3246ee530fafcc6b842c0049","hash":"d2f69f6e1ffc1f18012bb6f4274ea9dc12581eeeec462d6a3d606506c3cd439b"},{"seq":50,"id":"k51","ts":"2026-07-11T14:38:52.094Z","model":"grok/grok-4.3","role":"ask","action":"ask","payload":{"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer":"Documented TB-500 mechanism in the ledger (no new evidence): TB-500 (fragment of thymosin beta-4) binds free G-actin inside cells, freeing actin monomers for new filament assembly at the leading edge; this enables cell migration toward injury sites, release of signals supporting new vessel formation, and reduction of excess inflammation, resulting in faster wound re-closure and repair matrix deposition in animal models. Core claim: Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration (c1, s1). Preclinical support includes rat full-thickness wound models showing accelerated re-epithelialization (c2, s2). Human data are limited to safety (c3, s3) and specific wound-healing trials (c4, s4); no new mechanistic evidence is present.","cited_claim_ids":["c1","c2","c3","c4"],"cited_source_ids":["s1","s2","s3","s4"],"needs_user_info":[],"gaps":[],"resolved_slugs":["tb-500"],"graph":false},"rationale":"Q: SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","tokens_in":7310,"tokens_out":243,"cost":0.009745,"prev_hash":"d2f69f6e1ffc1f18012bb6f4274ea9dc12581eeeec462d6a3d606506c3cd439b","hash":"aeca9c816a0f4d3d57303d3f6c9cfcd6bc9bbea0e265adea14dfe74398e833f7"}]}