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The trials used full-length thymosin beta-4 (Tβ4), a 43-amino-acid protein the body makes in nearly every tissue. Most vials sold as \"TB-500\" contain a synthetic fragment — the acetylated seven-amino-acid piece (Ac-LKKTETQ) that holds the actin-binding activity — chosen because it's cheaper to make. That single fact reshapes how you should read every efficacy and safety claim below. This page covers what Tβ4 actually does, what has and hasn't been shown in humans, the fragment problem, real dosing and reconstitution, the cancer question that defines its risk, its ban in sport, and where it sits in a disc-recovery stack. Zero prior knowledge assumed.\n\n## What it actually is\n\nThymosin beta-4 is the body's main G-actin-sequestering peptide. Actin is the protein a cell uses to build and tear down its internal skeleton; controlling that is how a cell changes shape and crawls. Tβ4 binds actin monomers one-to-one and regulates that machinery, which is why it shows up wherever tissue is rebuilding — wounds, healing heart, migrating repair cells.\n\n## TB-500 is not thymosin beta-4 — read this before anything else\n\nThe distinction is routinely buried by vendors and it is central:\n\n- **Thymosin beta-4 (Tβ4):** the full 43-amino-acid protein used in every legitimate human and animal trial (IV cardiac, RGN-259 eye drops, wound studies).\n- **\"TB-500\":** a marketed synthetic fragment, the acetylated heptapeptide Ac-LKKTETQ (residues 17-23, ~889 Da), sold as a stable, cheaper stand-in. It reproduces the actin-binding activity but is not the molecule trialed clinically.\n\n[[embed:source:s17]]\n\nTo make it worse, full-length Tβ4 is also cleaved in the body to a different active fragment (Ac-SDKP), and some products sold as \"TB-500\" actually contain that instead. So \"TB-500\" is not even one consistent substance across vendors — you often cannot know which molecule you received. Efficacy and safety data for full Tβ4 cannot simply be assumed to transfer to whatever is in the vial.\n\n## One short motif does the healing\n\nThe repair-relevant part of Tβ4 is that seven-amino-acid actin-binding motif, and the same motif drives angiogenesis and endothelial cell migration — the growth of new blood vessels.\n\n[[embed:source:s1]]\n\nThat matters for a disc because tendon, ligament, and disc are poorly vascularized, and blood supply is the rate-limiter on healing them. A repair mechanism that is intrinsically pro-angiogenic is aimed straight at that bottleneck. On paper.\n\n## The human record: one clear win, several honest misses\n\nIn animal wound models the effect is clean — topical or systemic Tβ4 sped skin regrowth by 42-61% while adding collagen and vessels.\n\n[[embed:source:s2]]\n\nIn humans, full Tβ4 went into proper randomized, placebo-controlled trials for chronic wounds (pressure ulcers, venous stasis ulcers). Honest result: safe and well tolerated, but the primary healing endpoints did not reach statistical significance.\n\n[[embed:source:s3]]\n\nThe one indication where human data turned clearly positive is the eye. The ophthalmic formulation RGN-259 significantly improved dry-eye signs and symptoms versus placebo in Phase 2 trials.\n\n[[embed:source:s18]]\n\nSo the truthful summary is narrow: one positive human indication (dry eye), wound trials that were safe but unproven, and — for tendon, ligament, muscle, and disc — no confirmatory human trial at all.\n\n[[embed:source:s10]]\n\n## Heart, stroke, ligament: the preclinical case\n\nThe animal repair record is broad and consistent with the mechanism. After a heart attack, Tβ4 given locally and systemically shrank infarct size and improved function via cell-survival pathways (ILK/Akt) with less scarring — and the systemic result matters, because it shows the peptide reaches a distant injury and acts there.\n\n[[embed:source:s9]]\n\nIn a rat embolic stroke it improved neurological outcome through remyelination and axonal remodeling.\n\n[[embed:source:s19]]\n\nAnd in the tissue class closest to a disc stack, it improved ligament healing (rat MCL) both structurally and mechanically.\n\n[[embed:source:s11]]\n\n## How people dose and reconstitute it\n\nNo human dose-finding trial of the TB-500 fragment exists, so every protocol is practitioner/anecdotal — folklore, not medicine.\n\n- **Dose (anecdotal):** a loading phase around 4-6 mg per week (split into two injections) for 4-6 weeks, then maintenance ~2-2.5 mg weekly or every other week, total cycle 8-12 weeks, then time off. These mg-scale numbers apply to the fragment; the full-Tβ4 trials dosed completely differently (e.g. micrograms/kg IV in the cardiac trial), so the anecdotal mg figures have no validated basis.\n- **Route:** subcutaneous or intramuscular injection; no oral activity (it's digested).\n- **Reconstitution:** lyophilized powder mixed with bacteriostatic water; swab the stopper, run diluent down the wall, swirl — don't shake. Refrigerate at 2-8 °C, protect from light, avoid freeze-thaw; commonly cited stable ~28 days once mixed. These are vendor guidelines, not pharmacopeial stability data.\n\n## The cancer question — this is the real safety story\n\nHere the angiogenesis mechanism cuts against it. Tβ4 is overexpressed in many solid tumors, and there it is associated with more migration, metastasis, and blood-vessel growth.\n\n[[embed:source:s20]]\n\nThe literature is genuinely two-directional — in multiple myeloma Tβ4 behaves as a tumor suppressor — but the practical point stands: the same pro-angiogenic, pro-migration activity that plausibly helps a healing tendon is the activity implicated in tumor progression.\n\n[[embed:source:s21]]\n\nThe sane default that falls out of this: treat active malignancy or a significant cancer history as a contraindication. This is a sharper safety concern than BPC-157 carries, where the tumor evidence actually points the other way.\n\n## Banned in sport, and heavily policed\n\nIf you compete in anything drug-tested, stop here. TB-500/Tβ4 is on the WADA Prohibited List, banned at all times under the peptide-hormones/growth-factors section via its catch-all language.\n\n[[embed:source:s12]]\n\nIt's not theoretical enforcement: it became infamous in the Australian NRL supplements scandal, it's a well-known horse-racing dope, and athletes have taken multi-year bans for it.\n\n## What people report\n\nThe anecdote layer runs almost entirely through BPC-157 + TB-500 stacks, and it's specifically the tendon-and-back crowd — torn biceps and forearm tendons, chronic Achilles and patellar tendinitis, and sacral/back pain.\n\n[[embed:source:s15]]\n\n[[embed:source:s16]]\n\nUncontrolled, confounded, self-selected, and — given the fragment problem — often not even a known molecule. Real people, not real evidence.\n\n## Where it fits for the spine\n\nIn the stack, TB-500 is the systemic repair signal that complements BPC-157's more locally-studied effects; both push angiogenesis and cell migration into the poorly-vascularized tissue a disc is made of, and Tβ4's anti-fibrotic bias (repair over scar) is the appealing part. But it is theory stacked on an identity problem: no one has tested TB-500 against a human disc, the fragment may not match the trialed molecule, and the cancer-mechanism caution is real. It belongs in the framework in the disc-stack, herniated-disc, and degenerative-disc-disease pages — with those caveats attached, not stripped off.\n\n## Proven, unproven, and the catch\n\nProven: Tβ4 regulates actin and drives angiogenesis; it heals animal wounds and improves human dry eye in an RCT; it's anti-fibrotic and reaches distant injuries systemically in animals. Unproven: that it heals tendon, ligament, or disc in people. The catch specific to this compound: the product sold as \"TB-500\" is usually a fragment, not the trialed protein, so even the transferable evidence may not apply to what's in the syringe. And the angiogenesis that helps healing is the same mechanism that argues against use in cancer.\n\n*Not medical advice. TB-500 is sold for research use only, is not an approved treatment, and is banned in tested sport. Nothing here is a dosing or treatment recommendation.*\n","claims":[{"id":"c4","text":"Tb4 reached genuine randomized, double-blind, placebo-controlled human trials for chronic wounds (pressure and venous stasis ulcers), where it was safe but did not hit statistical significance on primary healing endpoints.","tier":"human","effective_weight":0.8,"source_ids":["s3","s4","s5"]},{"id":"c5","text":"The ophthalmic Tb4 formulation RGN-259 showed positive Phase II human efficacy for dry-eye signs and symptoms via corneal epithelial repair — the strongest controlled human efficacy signal for the peptide.","tier":"human","effective_weight":0.8,"source_ids":["s7"]},{"id":"c8","text":"Across multiple chronic human wound types Tb4 has been reported to promote faster repair, extending its regenerative case into diseased human tissue.","tier":"human","effective_weight":0.8,"source_ids":["s13"]},{"id":"c9","text":"TB-500 and thymosin beta-4 are on the WADA Prohibited List and banned at all times for competitive athletes.","tier":"human","effective_weight":0.8,"source_ids":["s12"]},{"id":"c3","text":"In controlled animal wound models, Tb4 accelerated skin regeneration (reepithelialization up 42-61%) while increasing collagen deposition and angiogenesis.","tier":"preclinical","effective_weight":0.5,"source_ids":["s2"]},{"id":"c6","text":"In preclinical cardiac injury, both local and systemic Tb4 dosing reduced infarct size and improved function via cardiomyocyte survival (ILK/Akt) and angiogenesis.","tier":"preclinical","effective_weight":0.5,"source_ids":["s8","s9"]},{"id":"c7","text":"Tb4 improved ligament healing histologically and mechanically in a rat MCL model, but a 2026 scoping review confirms tendon, ligament, muscle and spine/disc evidence remains overwhelmingly animal-stage with no confirmatory human musculoskeletal trials.","tier":"preclinical","effective_weight":0.5,"source_ids":["s11","s10"]},{"id":"c1","text":"TB-500 is a synthetic version of thymosin beta-4, the body's principal G-actin-sequestering peptide, which regulates the actin dynamics that govern cell migration — the molecular basis for its role in tissue repair.","tier":"mechanistic","effective_weight":0.3,"source_ids":["s1","s4"]},{"id":"c2","text":"The same seven-amino-acid actin-binding motif that gives Tb4 its structural function also drives angiogenesis and endothelial migration, so new blood-vessel growth is intrinsic to how it repairs tissue.","tier":"mechanistic","effective_weight":0.3,"source_ids":["s1"]},{"id":"c10","text":"Real-world users self-treating tendon, tendinitis and spine/sacral injuries with TB-500 (usually stacked with BPC-157) report reduced pain and improved range of motion, but these are uncontrolled, confounded anecdotes.","tier":"anecdotal","effective_weight":0.3,"source_ids":["s14","s15","s16"]}],"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/14500546/","title":"The actin binding site on thymosin beta4 promotes angiogenesis","quote":"we find that a seven amino acid actin binding motif of thymosin beta4 is essential for its angiogenic activity.","claim_ids":["c1","c2"]},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/10469335/","title":"Thymosin beta4 accelerates wound healing","quote":"Addition of Tbeta4 topically or intraperitoneally increased reepithelialization by 42% over saline controls at 4 d and by as much as 61% at 7 d post-wounding.","claim_ids":["c3"]},{"id":"s3","type":"pubmed","url":"https://clinicaltrials.gov/study/NCT00382174","title":"Randomized, Double-Blind, Placebo-Controlled Study of Thymosin Beta 4 in Patients With Pressure Ulcers","quote":"evaluate the safety, tolerability and effectiveness of Thymosin Beta 4 administered topically in patients with Pressure Ulcers","claim_ids":["c4"]},{"id":"s4","type":"pubmed","url":"https://clinicaltrials.gov/study/NCT00832091","title":"Randomized, Double-Blind, Placebo-Controlled Study of Thymosin Beta 4 in Patients With Venous Stasis Ulcers","quote":"a synthetically-produced copy of a naturally occurring 43 amino acid peptide that has wound healing and anti-inflammatory properties and can up-regulate the expression of laminin-5.","claim_ids":["c1","c4"]},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/17495250/","title":"Thymosin beta-4 and venous ulcers: a European prospective, randomized study","quote":"When review safety data show no-dose-limiting adverse events, a new group will be enrolled.","claim_ids":["c4"]},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/26056426/","title":"Thymosin beta 4 ophthalmic solution for dry eye: a randomized, placebo-controlled, Phase II clinical trial","quote":"This study confirms the efficacy of 0.1% Tbeta4 as a topical treatment for relief of signs and symptoms of dry eye.","claim_ids":["c5"]},{"id":"s8","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3843122/","title":"Cardioprotection by systemic dosing of thymosin beta four following ischemic myocardial injury","quote":"Tbeta4 administered throughout the study reduced infarct size and resulted in significant improvements in hemodynamic performance.","claim_ids":["c6"]},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/17600280/","title":"Thymosin beta4 is cardioprotective after myocardial infarction","quote":"thymosin beta4 treatment resulted in upregulation of ILK and Akt activity in the heart, enhanced early myocyte survival, and improved cardiac function.","claim_ids":["c6"]},{"id":"s10","type":"pubmed","url":"https://doi.org/10.3390/app16126202","title":"Thymosin Beta-4 and TB-500 in Tissue Healing, Regeneration, and Musculoskeletal Repair: A Scoping Review","quote":"the evidence base is heavily weighted toward preclinical and mechanistic work, with human musculoskeletal data sparse","claim_ids":["c7"]},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/23523891/","title":"Thymosin beta4 enhances the healing of medial collateral ligament injury in rat","quote":"Local administration of Tbeta4 promotes the healing process of MCL, both histologically and mechanically, in a rat model.","claim_ids":["c7"]},{"id":"s12","type":"news","url":"https://www.bscg.org/blogs/single/tb-500-status-risks-and-bans-in-sport-and-military","title":"TB-500 - Status, Risks, and Bans in Sport and Military","quote":"The World Anti-Doping Agency (WADA) lists TB-500 under 'Growth Factors and Growth Factor Modulators' as a prohibited substance","claim_ids":["c9"]},{"id":"s13","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31649007/","title":"Thymosin beta4: potential to treat epidermolysis bullosa and other severe dermal injuries","quote":"Thymosin beta4 promotes faster repair in various chronic human wounds, including pressure ulcers, stasis ulcers, and epidermolysis bullosa lesions.","claim_ids":["c8"]},{"id":"s14","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/ypyy1v/initial_impressions_with_bpc157_and_tb500_for/","title":"Initial impressions with BPC-157 and TB-500 for tendon repair","quote":"Inflammation and pain is significantly reduced. ROM is improving for repaired bicep. Unfortunately no control for comparison.","claim_ids":["c10"]},{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1cnx3vj/bpc_157_tb_500_tendinitis_experience/","title":"BPC 157 / TB 500 tendinitis experience","quote":"I would strongly and without reservation recommend this combo to anyone with tendinitis. Remember that you still have to do the work though!","claim_ids":["c10"]},{"id":"s16","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/sjml9z/my_story_and_bpc157tb500_ghrp2_observations_so_far/","title":"My story and BPC-157/TB-500, GHRP-2 observations so far","quote":"chronic pain without trauma or known cause since 1 year ago. Started out in my sacrum (specifically S5 segment)","claim_ids":["c10"]},{"id":"s17","type":"news","url":"https://www.bscg.org/blogs/single/tb-500-status-risks-and-bans-in-sport-and-military","title":"TB-500 - Status, Risks, and Bans (BSCG)","quote":"TB-500 is a synthetic heptapeptide (Ac-LKKTETQ) that corresponds to amino acids 17-23 of thymosin beta-4","claim_ids":[]},{"id":"s18","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/25826322/","title":"Thymosin beta4 improves signs and symptoms of severe dry eye in a phase 2 randomized trial (Cornea 2015)","quote":"RGN-259-treated group had 35.1% reduction of ocular discomfort compared with vehicle control (P = 0.0141)","claim_ids":[]},{"id":"s19","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/20627173/","title":"Thymosin beta4 improves functional neurological outcome in a rat model of embolic stroke","quote":"Tbeta4 improves neurological functional outcome after embolic stroke in rats.","claim_ids":[]},{"id":"s20","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/14625258/","title":"Role of thymosin beta4 in tumor metastasis and angiogenesis (JNCI 2003)","quote":"Thymosin beta4 may stimulate tumor metastasis by activating cell migration and angiogenesis.","claim_ids":[]},{"id":"s21","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/19833631/","title":"Thymosin beta4 has tumor suppressive effects in multiple myeloma","quote":"Tbeta4 overexpression led to significantly decreased proliferative and migratory capacities and increased sensitivity to apoptosis-induction.","claim_ids":[]}],"voxels":{"slug":"tb-500","counts":{"divs":25,"voxels":10,"sources":20,"edges":17},"note":"slim bundle — full voxels at /api/articles/tb-500/voxels"},"constitution":{"url":"https://miscsubjects.com/api/articles/constitution"},"provenance":[{"action":"ask","model":"grok/grok-4.3","ts":"2026-07-07T03:48:51.561Z","hash":"7808a4c6229e058e","tokens_in":7249,"tokens_out":163},{"action":"ask","model":"grok/grok-4.3","ts":"2026-07-07T03:50:54.727Z","hash":"3771fced9dc2ebdf","tokens_in":7249,"tokens_out":253},{"action":"ask","model":"grok/grok-4.3","ts":"2026-07-07T04:07:29.867Z","hash":"e7abd0ef1b6bfdde","tokens_in":7249,"tokens_out":273},{"action":"ask","model":"grok/grok-4.3","ts":"2026-07-07T04:09:37.821Z","hash":"9719fc186d02847b","tokens_in":7249,"tokens_out":154},{"action":"ask","model":"grok/grok-4.3","ts":"2026-07-07T04:40:44.976Z","hash":"bb95d6973c573523","tokens_in":7249,"tokens_out":188},{"action":"ask","model":"grok/grok-4.3","ts":"2026-07-07T05:18:10.092Z","hash":"562b241572f73a30","tokens_in":7249,"tokens_out":335},{"action":"ask","model":"grok/grok-4.3","ts":"2026-07-11T14:38:52.094Z","hash":"629b2c9bee5e191e","tokens_in":7310,"tokens_out":243},{"action":"voxel_divide","model":"owner","ts":"2026-07-17T02:42:11.927Z","hash":"5fec39af3770cd4c","tokens_in":0,"tokens_out":0}],"contributions":[{"id":"k1","ts":"2026-06-29T08:31:03.974Z","model":"grok/grok-4.3","role":"writer","action":"redraft","rationale":"","hash":"2581d9a5b173bcbdb6019f5285227235146bb2c809b2d7cd95917c7e927c625e"},{"id":"k2","ts":"2026-06-29T09:36:04.257Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 1","hash":"1430d570145a1a3348efda398c6aa2d21048250fdf88ff891b86d1d5f800b89f"},{"id":"k3","ts":"2026-06-29T09:36:23.605Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 2","hash":"96c34347140c407859ef8b7d5018d6f03c085b4793b3ae410902e483e08b8bd8"},{"id":"k4","ts":"2026-06-29T09:36:52.043Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 3","hash":"2bf9bb1f37da1ee0820988614b920366a66a3f0361f6cc8c90bf2ebb4aec80d2"},{"id":"k5","ts":"2026-06-29T09:37:13.143Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 4","hash":"b533d4b87bacd85a3e7718fc494638645795dfdf36eb3fcadcd46707cb23d98e"},{"id":"k6","ts":"2026-06-29T11:01:12.671Z","model":"kimi/moonshot-v1-8k","role":"collaborator","action":"collaborate","rationale":"I added explicit gaps in knowledge and named who claims what from anecdotes as instructed, as I am not Grok and my role is to contribute to the ledger with tier-honest claims.","hash":"103701951b257bb712aee25c571061389b6d0506da4e900a2f7abccfa9829789"},{"id":"k7","ts":"2026-06-29T11:04:30.643Z","model":"gemini/gemini-2.5-flash","role":"collaborator","action":"collaborate","rationale":"As Gemini, I've added three tier-honest claims to address explicit gaps in knowledge (what_is_unknown) and clarify the status of ongoing research, using only provided source IDs. 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documented about TB-500 mechanism in the ledger (no new evidence)?","answer_preview":"Documented TB-500 mechanism in the ledger (no new evidence): TB-500 (fragment of thymosin beta-4) binds free G-actin inside cells, freeing actin monomers for new filament assembly at the leading edge; this enables cell migration toward injury sites, release of signals supporting new vessel formation, and reduction of excess inflammation, resulting in faster wound re-closure and repair matrix deposition in animal models. Core claim: Tβ4 promotes cell migration, angiogenesis, and modulates inflammation via actin sequestration (c1, s1). Preclinical support includes rat full-thickness wound models showing accelerated re-epithelialization (c2, s2). Human data are limited to safety (c3, s3) and specific wound-healing trials (c4, s4); no new mechanistic evidence is present.","confidence":"high","status":"answered","parent_node_id":null,"gaps":[],"needs_user_info":[],"cited_claim_ids":["c1","c2","c3","c4"],"cited_source_ids":["s1","s2","s3","s4"],"channel":"selftest","author":"graph_selftest","hash":"390da20d84640e5b48bd7c8dbfe6333b645fee1429f06acadaf67bbe59dd4e77"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_241eb02b","ts":"2026-07-11T14:38:41.428Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what does the catalogue say now about anecdotes?","answer_preview":"The catalogue lists three tiers of herniated-disc anecdotes for BPC-157: (1) one Reddit user with L4-L5 herniation reported reduced radicular pain after 8 weeks of BPC-157 plus physical therapy (global_id bpc-157:c5, tier=anecdotal, weight=0.3); (2) several self-test posts describe reduced back or knee pain after eight weeks but include no imaging follow-up (bpc-157 section “What people say on Reddit”); (3) duplicate nausea reports (multiple instances of the same anecdote, each labeled anecdotal n=1, weight=0.3). No other slugs in the topology contain herniated-disc anecdotes. All listed items are pre-ranked as low-weight anecdotal claims; interaction_risk / limitations claims (c120, c67) are cited first per safety-first ordering.","confidence":"medium","status":"enriched","parent_node_id":null,"gaps":["No imaging-confirmed outcomes; no long-term follow-up; no interaction data specific to herniated-disc patients or common spine medications."],"needs_user_info":[],"cited_claim_ids":["c5","c120","c67"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"48f991e2315a93cbf21a35b1c623cef22caf053ca87390f380aa6bfe85563d5a"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_50c640ac","ts":"2026-07-11T14:38:17.208Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what peptide stack does the catalogue cover, and what gaps remain?","answer_preview":"Catalogue covers BPC-157 (bpc-157) and TB-500 (tb-500) in the context of herniated-disc recovery. One anecdotal claim (global_id recovery-stack-herniated-disc:c5) describes a single user reporting reduced radicular pain after 8 weeks of BPC-157 plus physical therapy for L4-L5 herniation. Additional anecdotal claims note BPC-157/TB-500 combinations for systemic tissue and tendon healing (bpc-157:c111). Limitations claims state human data are sparse, long-term safety unknown, and no dosing or protocol recommendations exist (bpc-157:c120, c67). No dedicated stack articles for herniated discs appear in the topology beyond the intro and BPC/TB-500 mentions.","confidence":"low","status":"enriched","parent_node_id":null,"gaps":["No controlled human trials for herniated-disc outcomes","No data on BPC-157/TB-500 interactions or safety in disc pathology","No coverage of other peptides (e.g., ARA-290) for herniated discs in the provided slugs"],"needs_user_info":[],"cited_claim_ids":["bpc-157:c5","bpc-157:c111","bpc-157:c120","bpc-157:c67"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"44acb22aa47103bebdd2e83cff2f68f753634aae351dc69043ce6e762dc28117"},{"node_id":"qn_tb_500_selftest_graph_what_is_documented_about_t_1b217ea4","ts":"2026-07-07T05:18:10.136Z","primary_slug":"tb-500","slugs":["tb-500"],"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer_preview":"Documented mechanism from the ledger: TB-500 (Tβ4 fragment) binds free G-actin inside cells, freeing actin monomers for new filament assembly at the leading edge; this enables cell migration toward injury sites, release of signals supporting new vessel formation, and modulation of inflammation, leading to faster wound re-closure and repair matrix deposition in animal models. Core claims: c1 (actin sequestration, cell migration, angiogenesis, inflammation modulation; tier human, source s1), c3 (Phase 1 IV safety/tolerability in healthy volunteers; tier human, source s3), c4 (Phase 2 topical acceleration in some stasis/pressure ulcer patients; tier human, source s4), c2 (rat wound re-epithelialization increase; tier preclinical, source s2). No new evidence; human data sparse, most evidence preclinical or anecdotal. Quote-gated claims (e.g., c6, c13, c16, c27, c40, c41, c42, c46) treated as low-confidence. No interaction_risk/limitations claims present in the provided topology.","confidence":"medium","status":"gap","parent_node_id":null,"gaps":["No interaction_risk or limitations-slot claims available","No dosing, patient-specific, or combination safety data","Human orthopaedic and systemic data lacking per s6"],"needs_user_info":[],"cited_claim_ids":["c1","c3","c4","c2"],"cited_source_ids":["s1","s3","s4","s2"],"channel":"selftest","author":"graph_selftest","hash":"f841cae37d5443fc5dd3d9e65c256f4421e08a358874306957f6cbb824e53bda"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_7d3887e7","ts":"2026-07-07T05:18:02.500Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what does the catalogue say now about anecdotes?","answer_preview":"Catalogue lists one direct herniated-disc anecdote: c5 (global_id bpc-157:c5) — one Reddit user with L4-L5 herniation reported reduced radicular pain after 8 weeks of BPC-157 plus PT (anecdotal, n=1, tier=anecdotal, weight=0.3). Additional anecdotes exist for tendon/muscle/gut issues (e.g., c101, c111) but are not disc-specific. No interaction_risk or limitations-slot claims appear for herniated discs. Multiple duplicate nausea reports (c6, c122–c162) are catalogued as anecdotal negative outcomes.","confidence":"medium","status":"enriched","parent_node_id":null,"gaps":["No controlled human data for herniated discs; anecdotes are n=1, self-reported, no imaging follow-up."],"needs_user_info":[],"cited_claim_ids":["bpc-157:c5","bpc-157:c6","bpc-157:c101","bpc-157:c111"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"9e2dce074b1cc5ba18ae5541e0c30d9b36bbe047f91880ce0470704a828b6545"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_5f30a319","ts":"2026-07-07T05:17:49.886Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what peptide stack does the catalogue cover, and what gaps remain?","answer_preview":"Catalogue covers: BPC-157 (preclinical tendon/muscle/gut models + 1 anecdotal L4-L5 herniation report of reduced radicular pain after 8 weeks with PT — c5:bpc-157); BPC-157 + TB-500 anecdotal stack for systemic tissue/tendon healing (c111:bpc-157); recovery-stack-herniated-disc and bpc-ara-herniated-disc slugs exist but contain no populated claims in the provided topology. Gaps: no human trials, no imaging outcomes, no interaction_risk data, no ARA-290 or TB-500 standalone herniated-disc claims, long-term safety unknown (c67:bpc-157), and all human evidence is sparse/pilot only. No dosing or treatment information is present.","confidence":"medium","status":"enriched","parent_node_id":null,"gaps":["no human controlled data for disc herniation","no interaction data","no ARA-290 or TB-500 herniated-disc coverage in topology","long-term safety absent"],"needs_user_info":["specific disc levels and symptoms","current medications or conditions","prior treatments tried"],"cited_claim_ids":["c5","c67","c111","c120"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"55704c06abb3c3fee07a6aa6e20c9ff75edf4e45de4cabd4e5e735d720ee1168"},{"node_id":"qn_tb_500_selftest_graph_what_is_documented_about_t_6e5d6ef8","ts":"2026-07-07T04:40:45.011Z","primary_slug":"tb-500","slugs":["tb-500"],"question":"SELFTEST GRAPH — What is documented about TB-500 mechanism in the ledger (no new evidence)?","answer_preview":"Documented mechanism of TB-500 (Tβ4 fragment) in the ledger: binds free G-actin, sequesters it, frees monomers for new filament assembly at the leading edge of cells, enabling cell migration to injury sites; migrating cells then release signals supporting angiogenesis and reduced excess inflammation, leading to faster wound re-closure and repair-matrix deposition in animal models. Core claim supported by review source s1 (c1) and mechanistic description in the body; no new evidence added. Safety-first: no interaction_risk or limitations-slot claims present for mechanism. All human data remain sparse; most evidence preclinical or anecdotal.","confidence":"high","status":"answered","parent_node_id":null,"gaps":[],"needs_user_info":[],"cited_claim_ids":["c1"],"cited_source_ids":["s1"],"channel":"selftest","author":"graph_selftest","hash":"ca930d58df03f2cb35e1c68fff036bee705821cfb7cfd8685a2742879f4a3cb0"},{"node_id":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_4527b1d6","ts":"2026-07-07T04:40:41.667Z","primary_slug":"bpc-157","slugs":["bpc-157","recovery-stack-herniated-disc","bpc-ara-herniated-disc","ara-290-herniated-disc","tb-500","ara-290","recovery-stack-intro"],"question":"SELFTEST GRAPH — I have herniated discs: what does the catalogue say now about anecdotes?","answer_preview":"The catalogue lists two BPC-157 herniated-disc anecdotes (global_id bpc-157:c5 and bpc-157:c6). c5 is a single Reddit-style self-report of reduced radicular pain after 8 weeks with PT (tier:anecdotal, weight 0.3). c6 is a single self-report of nausea leading to discontinuation (tier:anecdotal, weight 0.3). No other herniated-disc anecdotes appear in the listed slugs. Interaction_risk / limitations claims (bpc-157:c120, bpc-157:c67) are present and should be cited first for safety questions. All anecdotes are quote_gated:false but carry low weight; the topology contains no controlled human data on disc herniation.","confidence":"medium","status":"gap","parent_node_id":null,"gaps":["No human imaging follow-up data","No controlled trials for disc herniation","Long-term safety unknown"],"needs_user_info":[],"cited_claim_ids":["bpc-157:c5","bpc-157:c6","bpc-157:c120","bpc-157:c67"],"cited_source_ids":[],"channel":"selftest","author":"graph_selftest","hash":"1f4bcadeebf10d15569dc3a4292ca98c8dde8cf468081be16de33381f7c82677"}],"evidence":[{"ingest_id":"ev_c80ff6a253ba","ts":"2026-06-29T11:04:30.643Z","slug":"tb-500","question_node_id":null,"channel":"collaborate","author":"gemini/gemini-2.5-flash","summary":"As Gemini, I've added three tier-honest claims to address explicit gaps in knowledge (what_is_unknown) and clarify the status of ongoing research, using only provided source IDs. I also challenged an unsourced, overstrong claim regarding age-related decline.","source_ids":[],"claim_ids":["c33","c34","c35"],"model":"gemini/gemini-2.5-flash","hash":"d2a5764a0efbeceb119a8f0c986fd68300be3aa9cd4fb3a138b96dfcf3281438","status":"promoted"},{"ingest_id":"ev_7b3d01af4c49","ts":"2026-06-29T11:01:12.671Z","slug":"tb-500","question_node_id":null,"channel":"collaborate","author":"kimi/moonshot-v1-8k","summary":"I added explicit gaps in knowledge and named who claims what from anecdotes as instructed, as I am not Grok and my role is to contribute to the ledger with tier-honest claims.","source_ids":[],"claim_ids":["c30","c31"],"model":"kimi/moonshot-v1-8k","hash":"305c1e5d46709458e62575f3cf7a318075ff46751f145bcbfd65b3bd3397ebc1","status":"promoted"}],"edges":[{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_5f127446","to":"s1","type":"cites_source"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_5f127446","to":"s2","type":"cites_source"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_5f127446","to":"s3","type":"cites_source"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_5f127446","to":"s4","type":"cites_source"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_5f127446","to":"c1","type":"cites_claim"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_5f127446","to":"c2","type":"cites_claim"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_5f127446","to":"c3","type":"cites_claim"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_5f127446","to":"c4","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_241eb02b","to":"c5","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_241eb02b","to":"c120","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_241eb02b","to":"c67","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_50c640ac","to":"bpc-157:c5","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_50c640ac","to":"bpc-157:c111","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_50c640ac","to":"bpc-157:c120","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_50c640ac","to":"bpc-157:c67","type":"cites_claim"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_1b217ea4","to":"s1","type":"cites_source"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_1b217ea4","to":"s3","type":"cites_source"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_1b217ea4","to":"s4","type":"cites_source"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_1b217ea4","to":"s2","type":"cites_source"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_1b217ea4","to":"c1","type":"cites_claim"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_1b217ea4","to":"c3","type":"cites_claim"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_1b217ea4","to":"c4","type":"cites_claim"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_1b217ea4","to":"c2","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_7d3887e7","to":"bpc-157:c5","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_7d3887e7","to":"bpc-157:c6","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_7d3887e7","to":"bpc-157:c101","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_7d3887e7","to":"bpc-157:c111","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_5f30a319","to":"c5","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_5f30a319","to":"c67","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_5f30a319","to":"c111","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_5f30a319","to":"c120","type":"cites_claim"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_6e5d6ef8","to":"s1","type":"cites_source"},{"from":"qn_tb_500_selftest_graph_what_is_documented_about_t_6e5d6ef8","to":"c1","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_4527b1d6","to":"bpc-157:c5","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_4527b1d6","to":"bpc-157:c6","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_4527b1d6","to":"bpc-157:c120","type":"cites_claim"},{"from":"qn_bpc_157_selftest_graph_i_have_herniated_discs_wh_4527b1d6","to":"bpc-157:c67","type":"cites_claim"}],"counts":{"questions":8,"evidence":2,"edges":37}},"verification":{"provenance":{"valid":true,"entries":63,"head":"5fec39af3770cd4c0e85af9a2bb2855b636fcfb0b17229556f0b029b21bea6e2"},"sources":{"valid":false,"broken_at":0}},"counts":{"claims":10,"sources":20,"provenance":63,"contributions":51,"questions":8,"evidence_ingests":2,"voxel_edges":17},"transport":"Open every URL in this bundle with your browser or web / URL-fetch tool. Do NOT run them with curl, a shell, or a code sandbox — those model environments have no network (the host fails to resolve / DNS error) and will wrongly report the site unreachable when it is fine. Opening the link IS the call.","llm_manifest":{"version":"1","site":"https://miscsubjects.com","purpose":"Peptide evidence articles with hash-chained source ledgers, tiered claims, and a question graph. LLMs should READ bundles/URLs and WRITE back via ingest — never invent doses.","read":{"human_page":"https://miscsubjects.com/a/tb-500","bundle_json":"https://miscsubjects.com/api/articles/tb-500/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/tb-500/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/tb-500/topology","question_graph":"https://miscsubjects.com/api/articles/tb-500/question-graph","sources":"https://miscsubjects.com/api/articles/tb-500/sources","provenance":"https://miscsubjects.com/api/articles/tb-500/provenance","contributions":"https://miscsubjects.com/api/articles/tb-500/contributions","graph_topology":"https://miscsubjects.com/api/articles/tb-500/graph-topology?question={question}","voxels":"https://miscsubjects.com/api/articles/tb-500/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","health":"https://miscsubjects.com/api/articles/tb-500/health","repair":"POST https://miscsubjects.com/api/protocol/repair","list_articles":"https://miscsubjects.com/api/articles","graph_canvas":"https://miscsubjects.com/graph.html?slugs=tb-500","graph_yield":"https://miscsubjects.com/api/graph?slugs=tb-500&layer=yield","obsidian_vault":"https://miscsubjects.com/api/articles/obsidian-vault?slugs=tb-500","graph_query":"https://miscsubjects.com/api/v1/query?from=tb-500&kind=claim&where=tier=human"},"ask":{"description":"Answer only from topology; creates a question_node with gaps.","api":"POST https://miscsubjects.com/api/protocol/ask","body":{"slug":"{slug}","question":"string"},"imessage":"tb-500|your question","router_tag":"[ARTICLE_ASK]tb-500|question[/ARTICLE_ASK]","auth":"x-terminal-key header for API; iMessage/WhatsApp via miscsubjects build"},"ingest":{"description":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","api":"POST https://miscsubjects.com/api/protocol/ingest","body":{"slug":"{slug}","evidence":"paste text","question_node_id":"optional qn_..."},"imessage":"ingest tb-500|q:{node_id}|paste evidence","router_tag":"[ARTICLE_INGEST]tb-500|evidence[/ARTICLE_INGEST]","tiers":["human","preclinical","anecdotal","mechanistic","speculative"]},"claim":{"description":"Prompt-injection style POST — one claim voxel with who_claims + posted_by provenance.","api":"POST https://miscsubjects.com/api/protocol/claim","body":{"slug":"{slug}","text":"one assertion","tier":"human|preclinical|anecdotal|mechanistic|speculative","who_claims":"study author, platform, or model id","source_ids":"optional [s1]"},"imessage":"claim tb-500|tier|assertion — who claims it?","router_tag":"[ARTICLE_CLAIM]tb-500|tier|assertion[/ARTICLE_CLAIM]","slots":["what_it_is","who_claims_what","what_is_known","what_is_unknown","mechanism","limitations","disclaimer"]},"tiers":{"human":0.8,"preclinical":0.5,"anecdotal":0.3,"mechanistic":0.3,"speculative":0.1},"invariants":["Self-explaining — every API JSON has _self; every paste widget has §SELF; root index at /api/articles/system-map","Append-only — revisions preserved at ?rev=n","Source chain verifies integrity, not truth","Answers must cite claim ids and source ids from topology","Not medical advice"],"constitution":{"version":3,"principle":"Articles are voxel graphs of claims — not prose blobs. Every assertion is a claim atom with tier, weight, source_ids, and posted_by provenance.","slots":[{"id":"what_it_is","required":true,"answers":"What is the object in plain literal language?"},{"id":"who_claims_what","required":true,"answers":"Who claims what, from which source and evidence class?"},{"id":"what_is_known","required":true,"answers":"What opened evidence establishes under the article's domain profile"},{"id":"what_is_unknown","required":true,"answers":"What is NOT known — explicit gaps"},{"id":"mechanism","required":false,"answers":"Proposed mechanism (mechanistic tier only)"},{"id":"limitations","required":true,"answers":"Limits of the evidence and exact unresolved questions"},{"id":"disclaimer","required":false,"answers":"Domain-specific safety statement when the subject requires one"}],"claim_rules":["One claim = one falsifiable assertion. No compound claims.","Every claim must declare tier: human|preclinical|anecdotal|mechanistic|speculative|system.","system tier = architecture/design axioms (not biological mechanism). Use for protocol self-definition.","A software/build claim also declares evidence_class in extra: publisher_claim|source_code|runtime_receipt|independent_test|owner_observation|unknown.","Publisher documentation proves the publisher made and documented a claim. It is not independent runtime proof.","Source code proves an implementation exists. A successful receipt proves one invocation. Neither proves general reliability or field superiority.","Comparison claims name the population, common axis, capture time, and selection method. No top-N, percentile, uniqueness, or absence claim exists without that record.","Sourced claims must cite source_ids from the hash-chained ledger.","Unsourced claims must set source_status: unsourced and why_material.","posted_by is mandatory on every new claim (model id, human, or channel).","No medical advice, no doses, no 'you should take'.","Bad information is retracted (status:retracted), never deleted — retraction event stays on ledger.","Adversary challenges link via challenges[] / challenged_by[] — target may be downweighted.","Leaked secrets are scrubbed to [REDACTED:secret-leak] with scrub_events tombstone — honest audit trail."],"source_rules":["Every source is a voxel edge: type, url, exact quote, summary, found_by, accessed_at.","Sources hash-chain — prev/hash on append.","Anecdotal sources must name platform (reddit|x|youtube|imessage|user_entry).","Software sources classify publisher documentation, repository source, release, runtime receipt, independent test, and third-party analysis separately.","A comparison table cell is empty until a claim voxel cites at least one source voxel. Model prose alone is not evidence."],"writing_rules":["Literal nouns and verbs. No prestige labels, category inflation, engagement language, or decorative technical vocabulary.","Decorative language is text that implies importance, novelty, category, mood, or sophistication without naming an observed object, action, result, source, or limit. Delete it.","No frontier, ecosystem, substrate, agentic-native, unmeasured-zone, make-the-ruler, category-defining, revolutionary, or living-system metaphors.","A sentence remains only when it names a concrete thing, reports a change, explains a number, cites evidence, states an exact unknown, or directly answers the question.","Technical nouns are allowed only when literal. Define the first use by what the named code or data object stores or does.","State the observed object before naming a category for it.","Keep the evidentiary boundary beside the exact claim it limits.","Unknown means unknown. Missing evidence does not become absence."],"software_comparison_axes":["product_boundary","primary_user","unit_of_composition","runtime_and_durability","agent_coordination","model_support","environment_reach","tool_and_integration_model","knowledge_and_memory","observability_and_receipts","outside_contribution","self_editing","governance_and_authority","deployment_model","maturity_and_adoption"],"normandy_contract":{"purpose":"Each outside-model session reads the current graph, receives one empty slot, and adds data that was not already stored.","slots":[{"id":"opened_source","stores":"One opened source with URL, title, evidence class, observed time, and the exact fact it establishes."},{"id":"source_citing_claim","stores":"One new claim that cites a stored source id and names one comparison axis."},{"id":"overlap","stores":"One evidenced capability both systems have."},{"id":"build_only_in_reviewed_target","stores":"One evidenced capability present here and not established for the named reviewed target."},{"id":"target_only_in_build_review","stores":"One evidenced capability present in the named target and not established here."},{"id":"contradiction","stores":"One source-backed contradiction attached to the exact current claim hash."},{"id":"limit","stores":"One exact limit narrower than the standing global-rank boundary."},{"id":"question","stores":"One unresolved question whose answer would change a named comparison cell."},{"id":"rule_proposal","stores":"One proposed evidence or writing rule prompted by a concrete failure."},{"id":"capability_effect","stores":"One demonstrated capability, the input it accepted, the state it changed, and the output or external effect it produced."},{"id":"failure_effect","stores":"One observed defect, its frequency, its consequence, its repair state, and the evidence that it did or did not recur."},{"id":"maintenance_cost","stores":"One measured operator, model, time, money, or intervention cost attached to a named function."},{"id":"value_effect","stores":"One measured change in speed, control, recoverability, retained knowledge, or completed work caused by a named feature."}],"standing_answer_limits":["A global rank across invisible private systems is unknown.","Missing outside evidence is not proof that an outside system lacks a capability.","A successful receipt proves one run, not general reliability.","Counts show stored scale or activity, not value, correctness, or superiority.","Hobbyist, ambitious, coherent, messy, advanced, and interesting are labels, not comparison findings."],"no_repeat_rules":["A repeated standing limit is context, not a new contribution.","An exact or near-duplicate claim is rejected and points to the stored claim.","A duplicate source does not complete an assignment.","A response completes only after at least one new graph object lands.","The exact owner-facing answer is stored as an article contribution; an exact or near-repeat answer is rejected before other operations run.","The assignment record stores the graph snapshot, target, axis, slot, capability fingerprint, and resulting object ids."],"assignment":"GET /api/normandy?assignment=<id>","append":"POST /api/protocol/voxel-batch {assignment_id,key,actor,operations[]}"},"mutation_rules":["Open questions, support, and objections append to discourse and do not rewrite the standing claim.","Source and claim append requires a scoped article capability; every append records provenance and a receipt.","Existing text edits use the current voxel hash. A stale hash writes nothing.","Revisions, retractions, absorbed voxels, rejected contributions, and contradictions remain readable."],"ontology_rules":["Peptide articles (bpc-157, tb-500) are tree roots.","Condition articles (bpc-157-glp1-gut-damage) branch from peptides.","Stack articles (wolverine-stack-glp1) compose peptides — never duplicate peptide mechanism prose.","If an article has no parent embeds and is not a root peptide → sprawl candidate.","Misstep = duplicate scope with another slug; merge or reparent via embeds."],"post_protocol":{"claim":"POST /api/protocol/claim","source":"POST /api/protocol/sources","ingest":"POST /api/protocol/ingest","webhook":"POST /api/articles/<slug>/webhook {kind:claim|source}","imessage_claim":"claim {slug}|{tier}|your assertion — who claims it, source?","imessage_ingest":"ingest {slug}|evidence paste","software_landscape":"GET /api/build-landscape?next=1&lane=field|build|opposition|synthesis","queue_population":"POST /api/build-landscape {action:queue_targets, cohort, query, sort, captured_at, source_url, targets[]}"}},"this_article":{"slug":"tb-500","url":"https://miscsubjects.com/a/tb-500","bundle_url":"https://miscsubjects.com/api/articles/tb-500/bundle?format=markdown"},"voxel_procedure":{"what":"Every article has a human side (/a/tb-500) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"tb-500\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"tb-500\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"tb-500\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"tb-500\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"tb-500\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"tb-500\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/tb-500/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/tb-500/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/tb-500#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."}},"api_urls":{"bundle":"https://miscsubjects.com/api/articles/tb-500/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/tb-500/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/tb-500/topology","voxels":"https://miscsubjects.com/api/articles/tb-500/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","question_graph":"https://miscsubjects.com/api/articles/tb-500/question-graph","ask":"https://miscsubjects.com/api/protocol/ask","ingest":"https://miscsubjects.com/api/protocol/ingest","claim":"https://miscsubjects.com/api/protocol/claim","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown"}}