{"slug":"tb-500-ibd","verification":{"valid":true,"entries":4,"head":"2ae7c0bc45d6728410384ec7ed3d773ceea38c9912ee78975e9f556a32fd4bb3"},"count":4,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/28127198/","title":"Recombinant adeno-associated virus carrying thymosin β4 gene","quote":"AAV-Tβ4-treated mice displayed distinctly attenuated colon injuries and reduced the apoptosis rates in colonic mucosal epithelia... reduced inflammatory cell infiltration and alleviated oxidative stress... modulated colonic TNF-α, IL-1β, and IL-10 levels","summary":"2017 mouse colitis study showing protective effects of Tβ4 delivery.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:36:44.946Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"73711e3e90a9cb734241e895da985f6beecb346a9ab2f46d66767aef0e2e34f6"},{"id":"s2","type":"review","url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.767785/full","title":"Progress on the Function and Application of Thymosin β4","quote":"In a mouse colitis model resembling Crohn’s disease, AAV-Tβ4-treated mice displayed distinctly attenuated colon injuries...","summary":"2021 review summarizing the mouse IBD data and calling for further research.","claim_ids":["c1","c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:36:44.946Z","link_status":"ok","quote_status":"unverified","prev":"73711e3e90a9cb734241e895da985f6beecb346a9ab2f46d66767aef0e2e34f6","hash":"f4a329f773815c029ee28ba948b41749b7655f403b2a404226dcb5818c8c835d"},{"id":"s3","type":"review","url":"https://en.wikipedia.org/wiki/Thymosin_beta-4","title":"Thymosin beta-4","quote":"administration of thymosin β4 can promote migration of cells, formation of blood vessels, maturation of stem cells, survival of various cell types and lowering of the production of pro-inflammatory cytokines","summary":"Summary of established mechanistic actions from cell and animal studies.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:36:44.946Z","link_status":"ok","quote_status":"unverified","prev":"f4a329f773815c029ee28ba948b41749b7655f403b2a404226dcb5818c8c835d","hash":"946eb65271971035c756c809fcfb0e592546de026d85ad7b8fd5448afee2d146"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/UlcerativeColitis/comments/1socjtd/bpc157_and_tb500_seem_to_be_helping_a_lot/","title":"BPC-157 and TB-500 seem to be helping a lot?","quote":"Tried BPC-157 and TB-500 injections a few weeks ago, did two doses and immediately my symptoms went away","summary":"Example of positive anecdotal report in UC subreddit.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:36:44.946Z","link_status":"ok","quote_status":"unverified","prev":"946eb65271971035c756c809fcfb0e592546de026d85ad7b8fd5448afee2d146","hash":"2ae7c0bc45d6728410384ec7ed3d773ceea38c9912ee78975e9f556a32fd4bb3"}]}