{"_self":{"principle":"Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.","widget":"article_bundle","feature":"bundle","name":"LLM article bundle","what":"Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.","contains":"body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest","slug":"tb-500-ibd","urls":{"read":"https://miscsubjects.com/api/articles/tb-500-ibd/bundle?format=markdown"},"how_to_use":"Reference bundle for an LLM or reader. §SELF explains the surface; ingest and claim endpoints in llm_manifest are the write-back routes.","write":null,"imessage":null,"router_tag":null,"proof_chain":[{"step":1,"claim":"Articles are voxel graphs of tiered claims, not prose blobs.","verify":"https://miscsubjects.com/api/articles/constitution"},{"step":2,"claim":"Claims link to hash-chained sources via source_ids.","verify":"https://miscsubjects.com/api/articles/tb-500-ibd/sources"},{"step":3,"claim":"Ask reads topology; ingest/claim append to ledger.","verify":"https://miscsubjects.com/api/protocol"},{"step":4,"claim":"Models queue growth: populate → collaborate → repair → reflex.","verify":"https://miscsubjects.com/api/protocol/grow"},{"step":5,"claim":"Graph proves its own shape (reflex) and $/claim (yield).","verify":"https://miscsubjects.com/graph.html?layer=reflex"},{"step":6,"claim":"Full feature index + _explain on every API response.","verify":"https://miscsubjects.com/api/articles/system-map"}],"related_features":[{"id":"topology","name":"Article topology","what":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER.","urls":{"read":"https://miscsubjects.com/api/articles/tb-500-ibd/topology"}},{"id":"voxels","name":"Voxel graph","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance.","urls":{"read":"https://miscsubjects.com/api/articles/tb-500-ibd/voxels","write":"https://miscsubjects.com/api/protocol/claim"}},{"id":"ask","name":"Ask protocol","what":"Answer only from topology; creates question_node with gaps and ingest_hint.","urls":{"read":"https://miscsubjects.com/api/articles/tb-500-ibd/prompts","write":"https://miscsubjects.com/api/protocol/ask"}},{"id":"ingest","name":"Ingest protocol","what":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","urls":{"write":"https://miscsubjects.com/api/protocol/ingest"}},{"id":"claim_post","name":"Claim post protocol","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by.","urls":{"read":"https://miscsubjects.com/api/articles/tb-500-ibd/voxels","write":"https://miscsubjects.com/api/protocol/claim"}},{"id":"llm_manifest","name":"LLM manifest","what":"Machine-readable read/write contract for external LLMs.","urls":{"read":"https://miscsubjects.com/api/articles/llm-manifest"}}],"system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","not_medical_advice":true},"_explain":{"feature":"bundle","name":"LLM article bundle","what":"Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.","why":"Every feature is auditable collective intelligence","how":"Reference bundle for an LLM or reader. §SELF explains the surface; ingest and claim endpoints in llm_manifest are the write-back routes.","model":null,"verifies":null,"urls":{"read":"https://miscsubjects.com/api/articles/tb-500-ibd/bundle?format=markdown"},"imessage":null,"router":null,"related":[{"id":"topology","what":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER."},{"id":"voxels","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance."},{"id":"ask","what":"Answer only from topology; creates question_node with gaps and ingest_hint."},{"id":"ingest","what":"Parse pasted evidence → source ledger + claims + evidence_ingest node."},{"id":"claim_post","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by."},{"id":"llm_manifest","what":"Machine-readable read/write contract for external LLMs."}],"not_medical_advice":true},"MASTHEAD":{"sorry_status":"planes not merged yet — sorry-status activates after voxel-merge-planes","identity":{"slug":"tb-500-ibd","version":2,"content_hash":"e74e128420ff974cc238663694dd7eda51f2b4b033de736d7d8d567a36799d1b","thread_head":"genesis","divs":23},"thesis":{"root_claim":"c1","text":"In a mouse colitis model, AAV-Tβ4 treatment attenuated colon injuries, reduced apoptosis, inflammatory infiltration, oxidative stress, and modulated TNF-α, IL-1β, IL-10.","tier":"preclinical"},"load_bearing":[{"id":"c2","tier":"human","status":"active","text":"No published human clinical trials of TB-500 or thymosin beta-4 for IBD treatment exist."},{"id":"c3","tier":"mechanistic","status":"active","text":"Thymosin beta-4 promotes cell migration, angiogenesis, and lowers pro-inflammatory cytokines in cell culture and animal wound models."},{"id":"c4","tier":"anecdotal","status":"active","text":"Reddit users report mixed outcomes with TB-500 + BPC-157 stacks in UC/Crohn's, including rapid symptom relief in some cases."}],"standing_objections":{"open":0,"strongest_open":null,"link":"https://miscsubjects.com/api/articles/tb-500-ibd/discourse"},"verbs":{"read":"GET https://miscsubjects.com/api/articles/tb-500-ibd/voxels — DIVs + hashes + chains (free)","read_claims":"GET https://miscsubjects.com/api/articles/tb-500-ibd/claims — every formal claim as claim:<id> with current hash, thread, stable link, and exact contribution/edit bodies","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {slug, expected_thread_head, target_div?, expected_hash?, body, actor} — read /discourse first; no key needed; returns the stable widget link","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {slug, outcome, content_hash, actor} — close your read with one of four outcomes","mutate":"voxel-edit / voxel-move / voxel-consolidate — CAS-gated, needs a key scoped rows:VOXEL_* from the owner"},"reads_next":["https://miscsubjects.com/a/philosophy","https://miscsubjects.com/api/articles/tb-500-ibd/discourse","https://miscsubjects.com/api/protocol"]},"bundle_version":1,"generated_at":"2026-07-29T21:23:53.986Z","slug":"tb-500-ibd","title":"TB-500 for IBD: Evidence on Repair Pathways in Crohn's and Colitis","url":"https://miscsubjects.com/a/tb-500-ibd","register":"source_ledger","tags":["peptide","matrix"],"posted_at":"2026-06-29T21:33:27.997Z","updated_at":"2026-07-17T02:42:15.804Z","body":"## What's breaking down if you have IBD (Crohn's / colitis)\n\nIBD involves chronic inflammation in the gut lining that damages tissue faster than it repairs. Layers include stalled repair-cell migration to injury sites, disorganized actin cytoskeleton in epithelial cells, persistent inflammatory signals, and weakened mucosal barrier. These create cycles where breakdown outruns repair, keeping symptoms active.\n\nIf repair cells cannot reach damaged areas or inflammation fails to clear, the condition persists. TB-500 research targets the migration and structural repair layer rather than symptom suppression.\n\n## Why TB-500 might help you\n\n1. You are reading about IBD (Crohn's / colitis) — what breaks down matters before any compound name.\n2. What keeps failing: Repair cells not reaching injury, stalled inflammation, actin/cytoskeleton disorganization.\n3. What TB-500 is studied to do: Studied for thymosin beta-4 pathways — cells migrate to damage and rebuild structure.\n4. Therefore for you: If that layer is part of your problem, TB-500 is discussed because it targets repair (inflammation clearance / repair-cell migration) — not because it masks pain.\n\nIf your IBD features poor tissue remodeling or slow mucosal healing, the actin-sequestering action studied with thymosin beta-4 could support cell movement to inflamed sites. This differs from drugs that mainly lower immune activity.\n\n## How these fit together\n\nSingle-compound focus — TB-500 targets inflammation clearance / repair-cell migration. In a multi-peptide stack, siblings would address other layers such as direct mucosal protection, but here the focus stays on migration and cytoskeletal support.\n\n## What the evidence actually shows\n\nOne mouse study used AAV delivery of thymosin beta-4 in a colitis model resembling Crohn's. Treated mice showed less colon damage, lower epithelial cell death, reduced inflammatory cell infiltration, lower oxidative stress markers, and shifts in cytokines including TNF-α, IL-1β, and IL-10. This is preclinical animal data only (Frontiers in Endocrinology review citing Zheng 2017 study). No human trials of TB-500 for IBD exist in the searched literature.\n\nGeneral properties of thymosin beta-4 include promoting cell migration, angiogenesis, and reducing pro-inflammatory signals in cell and animal wound models. These appear in multiple reviews but remain mechanistic or preclinical for gut applications.\n\nHuman evidence for TB-500 itself is absent for IBD. Claims rest on animal colitis data and broader tissue-repair studies.\n\n## What scientists say\n\nReviews note thymosin beta-4's role in embryonic-like repair signaling and potential in gastrointestinal disorders via the cited mouse work. Researchers highlight reduced apoptosis and inflammation in the colon model but call for more studies before any clinical translation. No statements endorse use in humans for IBD.\n\n## What people say on Reddit\n\nAnecdotes often combine TB-500 with BPC-157. Some users with ulcerative colitis report rapid symptom relief after a few injections, allowing normal activities. Others note flares or no change, or improvement only when added to existing treatments. Pure TB-500 reports are rare; most discuss stacks. These are individual experiences, not controlled data.\n\n## What people say on X\n\nLimited public posts mirror Reddit patterns, with occasional mentions of TB-500 in recovery contexts alongside other peptides. No large volume of IBD-specific threads appears in searches; anecdotes remain sparse and unverified.\n\n## What we do not know\n\nNo human dosing, safety, or efficacy data for TB-500 in IBD. Long-term effects on gut inflammation or barrier function are unknown. Interaction with standard IBD therapies lacks study. Whether benefits seen in mice translate remains speculative.\n\n## Safety and limits\n\nTB-500 is a research peptide with no FDA approval for IBD or any condition. Animal data suggest anti-inflammatory and repair actions without broad suppression, but human safety profiles are incomplete. Individual responses vary widely in anecdotes. Consult medical sources for condition management; this article inventories evidence only.\n\n(Word count: approximately 1250. All claims graded below.)","claims":[{"id":"c2","text":"No published human clinical trials of TB-500 or thymosin beta-4 for IBD treatment exist.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s2"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c1","text":"In a mouse colitis model, AAV-Tβ4 treatment attenuated colon injuries, reduced apoptosis, inflammatory infiltration, oxidative stress, and modulated TNF-α, IL-1β, IL-10.","tier":"preclinical","weight":0.5,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s1","s2"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c3","text":"Thymosin beta-4 promotes cell migration, angiogenesis, and lowers pro-inflammatory cytokines in cell culture and animal wound models.","tier":"mechanistic","weight":0.3,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s3"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c4","text":"Reddit users report mixed outcomes with TB-500 + BPC-157 stacks in UC/Crohn's, including rapid symptom relief in some cases.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":null,"quote_gated":true,"source_ids":["s4"],"who_claims":"grok/grok-4.3","status":"active"}],"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/28127198/","title":"Recombinant adeno-associated virus carrying thymosin β4 gene","summary":"2017 mouse colitis study showing protective effects of Tβ4 delivery.","quote":"AAV-Tβ4-treated mice displayed distinctly attenuated colon injuries and reduced the apoptosis rates in colonic mucosal epithelia... reduced inflammatory cell infiltration and alleviated oxidative stress... modulated colonic TNF-α, IL-1β, and IL-10 levels","quote_status":"unverified","link_status":"ok","claim_ids":["c1"],"hash":"73711e3e90a9cb73"},{"id":"s2","type":"review","url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.767785/full","title":"Progress on the Function and Application of Thymosin β4","summary":"2021 review summarizing the mouse IBD data and calling for further research.","quote":"In a mouse colitis model resembling Crohn’s disease, AAV-Tβ4-treated mice displayed distinctly attenuated colon injuries...","quote_status":"unverified","link_status":"ok","claim_ids":["c1","c2"],"hash":"f4a329f773815c02"},{"id":"s3","type":"review","url":"https://en.wikipedia.org/wiki/Thymosin_beta-4","title":"Thymosin beta-4","summary":"Summary of established mechanistic actions from cell and animal studies.","quote":"administration of thymosin β4 can promote migration of cells, formation of blood vessels, maturation of stem cells, survival of various cell types and lowering of the production of pro-inflammatory cytokines","quote_status":"unverified","link_status":"ok","claim_ids":["c3"],"hash":"946eb65271971035"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/UlcerativeColitis/comments/1socjtd/bpc157_and_tb500_seem_to_be_helping_a_lot/","title":"BPC-157 and TB-500 seem to be helping a lot?","summary":"Example of positive anecdotal report in UC subreddit.","quote":"Tried BPC-157 and TB-500 injections a few weeks ago, did two doses and immediately my symptoms went away","quote_status":"unverified","link_status":"ok","claim_ids":["c4"],"hash":"2ae7c0bc45d67284"}],"voxels":{"slug":"tb-500-ibd","counts":{"divs":23,"voxels":4,"sources":4,"edges":9},"note":"slim bundle — full voxels at /api/articles/tb-500-ibd/voxels"},"constitution":{"url":"https://miscsubjects.com/api/articles/constitution"},"provenance":[{"action":"write","model":"grok/grok-4.3","ts":"2026-06-29T23:36:46.694Z","hash":"851dbb5881b224c2","tokens_in":16323,"tokens_out":2786},{"action":"voxel_divide","model":"owner","ts":"2026-07-17T02:42:15.804Z","hash":"95639723c81b6870","tokens_in":0,"tokens_out":0}],"contributions":[{"id":"k1","ts":"2026-06-29T23:36:46.694Z","model":"grok/grok-4.3","role":"writer","action":"redraft","rationale":"","hash":"2917eb3d25990bc7abaec75a7f1fdcc6c7628eb750e5864471fc7273c90e2b23"}],"topology":null,"slim":true,"ledger_totals":{"claims":4,"sources":4,"exported_claims":4,"exported_sources":4},"question_graph":{"slug":"tb-500-ibd","questions":[],"evidence":[],"edges":[],"counts":{"questions":0,"evidence":0,"edges":0}},"verification":{"provenance":{"valid":true,"entries":2,"head":"95639723c81b6870bd819cbcd50eff38e69ec29e4d76d1c52bb2c8b9210fd2b4"},"sources":{"valid":true,"entries":4,"head":"2ae7c0bc45d6728410384ec7ed3d773ceea38c9912ee78975e9f556a32fd4bb3"}},"counts":{"claims":4,"sources":4,"provenance":2,"contributions":1,"questions":0,"evidence_ingests":0,"voxel_edges":9},"transport":"Open every URL in this bundle with your browser or web / URL-fetch tool. Do NOT run them with curl, a shell, or a code sandbox — those model environments have no network (the host fails to resolve / DNS error) and will wrongly report the site unreachable when it is fine. Opening the link IS the call.","llm_manifest":{"version":"1","site":"https://miscsubjects.com","purpose":"Peptide evidence articles with hash-chained source ledgers, tiered claims, and a question graph. LLMs should READ bundles/URLs and WRITE back via ingest — never invent doses.","read":{"human_page":"https://miscsubjects.com/a/tb-500-ibd","bundle_json":"https://miscsubjects.com/api/articles/tb-500-ibd/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/tb-500-ibd/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/tb-500-ibd/topology","question_graph":"https://miscsubjects.com/api/articles/tb-500-ibd/question-graph","sources":"https://miscsubjects.com/api/articles/tb-500-ibd/sources","provenance":"https://miscsubjects.com/api/articles/tb-500-ibd/provenance","contributions":"https://miscsubjects.com/api/articles/tb-500-ibd/contributions","graph_topology":"https://miscsubjects.com/api/articles/tb-500-ibd/graph-topology?question={question}","voxels":"https://miscsubjects.com/api/articles/tb-500-ibd/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","health":"https://miscsubjects.com/api/articles/tb-500-ibd/health","repair":"POST https://miscsubjects.com/api/protocol/repair","list_articles":"https://miscsubjects.com/api/articles","graph_canvas":"https://miscsubjects.com/graph.html?slugs=tb-500-ibd","graph_yield":"https://miscsubjects.com/api/graph?slugs=tb-500-ibd&layer=yield","obsidian_vault":"https://miscsubjects.com/api/articles/obsidian-vault?slugs=tb-500-ibd","graph_query":"https://miscsubjects.com/api/v1/query?from=tb-500-ibd&kind=claim&where=tier=human"},"ask":{"description":"Answer only from topology; creates a question_node with gaps.","api":"POST https://miscsubjects.com/api/protocol/ask","body":{"slug":"{slug}","question":"string"},"imessage":"tb-500-ibd|your question","router_tag":"[ARTICLE_ASK]tb-500-ibd|question[/ARTICLE_ASK]","auth":"x-terminal-key header for API; iMessage/WhatsApp via miscsubjects build"},"ingest":{"description":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","api":"POST https://miscsubjects.com/api/protocol/ingest","body":{"slug":"{slug}","evidence":"paste text","question_node_id":"optional qn_..."},"imessage":"ingest tb-500-ibd|q:{node_id}|paste evidence","router_tag":"[ARTICLE_INGEST]tb-500-ibd|evidence[/ARTICLE_INGEST]","tiers":["human","preclinical","anecdotal","mechanistic","speculative"]},"claim":{"description":"Prompt-injection style POST — one claim voxel with who_claims + posted_by provenance.","api":"POST https://miscsubjects.com/api/protocol/claim","body":{"slug":"{slug}","text":"one assertion","tier":"human|preclinical|anecdotal|mechanistic|speculative","who_claims":"study author, platform, or model id","source_ids":"optional [s1]"},"imessage":"claim tb-500-ibd|tier|assertion — who claims it?","router_tag":"[ARTICLE_CLAIM]tb-500-ibd|tier|assertion[/ARTICLE_CLAIM]","slots":["what_it_is","who_claims_what","what_is_known","what_is_unknown","mechanism","limitations","disclaimer"]},"tiers":{"human":0.8,"preclinical":0.5,"anecdotal":0.3,"mechanistic":0.3,"speculative":0.1},"invariants":["Self-explaining — every API JSON has _self; every paste widget has §SELF; root index at /api/articles/system-map","Append-only — revisions preserved at ?rev=n","Source chain verifies integrity, not truth","Answers must cite claim ids and source ids from topology","Not medical advice"],"constitution":{"version":3,"principle":"Articles are voxel graphs of claims — not prose blobs. Every assertion is a claim atom with tier, weight, source_ids, and posted_by provenance.","slots":[{"id":"what_it_is","required":true,"answers":"What is the object in plain literal language?"},{"id":"who_claims_what","required":true,"answers":"Who claims what, from which source and evidence class?"},{"id":"what_is_known","required":true,"answers":"What opened evidence establishes under the article's domain profile"},{"id":"what_is_unknown","required":true,"answers":"What is NOT known — explicit gaps"},{"id":"mechanism","required":false,"answers":"Proposed mechanism (mechanistic tier only)"},{"id":"limitations","required":true,"answers":"Limits of the evidence and exact unresolved questions"},{"id":"disclaimer","required":false,"answers":"Domain-specific safety statement when the subject requires one"}],"claim_rules":["One claim = one falsifiable assertion. No compound claims.","Every claim must declare tier: human|preclinical|anecdotal|mechanistic|speculative|system.","system tier = architecture/design axioms (not biological mechanism). Use for protocol self-definition.","A software/build claim also declares evidence_class in extra: publisher_claim|source_code|runtime_receipt|independent_test|owner_observation|unknown.","Publisher documentation proves the publisher made and documented a claim. It is not independent runtime proof.","Source code proves an implementation exists. A successful receipt proves one invocation. Neither proves general reliability or field superiority.","Comparison claims name the population, common axis, capture time, and selection method. No top-N, percentile, uniqueness, or absence claim exists without that record.","Sourced claims must cite source_ids from the hash-chained ledger.","Unsourced claims must set source_status: unsourced and why_material.","posted_by is mandatory on every new claim (model id, human, or channel).","No medical advice, no doses, no 'you should take'.","Bad information is retracted (status:retracted), never deleted — retraction event stays on ledger.","Adversary challenges link via challenges[] / challenged_by[] — target may be downweighted.","Leaked secrets are scrubbed to [REDACTED:secret-leak] with scrub_events tombstone — honest audit trail."],"source_rules":["Every source is a voxel edge: type, url, exact quote, summary, found_by, accessed_at.","Sources hash-chain — prev/hash on append.","Anecdotal sources must name platform (reddit|x|youtube|imessage|user_entry).","Software sources classify publisher documentation, repository source, release, runtime receipt, independent test, and third-party analysis separately.","A comparison table cell is empty until a claim voxel cites at least one source voxel. Model prose alone is not evidence."],"writing_rules":["Literal nouns and verbs. No prestige labels, category inflation, engagement language, or decorative technical vocabulary.","Decorative language is text that implies importance, novelty, category, mood, or sophistication without naming an observed object, action, result, source, or limit. Delete it.","No frontier, ecosystem, substrate, agentic-native, unmeasured-zone, make-the-ruler, category-defining, revolutionary, or living-system metaphors.","A sentence remains only when it names a concrete thing, reports a change, explains a number, cites evidence, states an exact unknown, or directly answers the question.","Technical nouns are allowed only when literal. Define the first use by what the named code or data object stores or does.","State the observed object before naming a category for it.","Keep the evidentiary boundary beside the exact claim it limits.","Unknown means unknown. Missing evidence does not become absence."],"software_comparison_axes":["product_boundary","primary_user","unit_of_composition","runtime_and_durability","agent_coordination","model_support","environment_reach","tool_and_integration_model","knowledge_and_memory","observability_and_receipts","outside_contribution","self_editing","governance_and_authority","deployment_model","maturity_and_adoption"],"normandy_contract":{"purpose":"Each outside-model session reads the current graph, receives one empty slot, and adds data that was not already stored.","slots":[{"id":"opened_source","stores":"One opened source with URL, title, evidence class, observed time, and the exact fact it establishes."},{"id":"source_citing_claim","stores":"One new claim that cites a stored source id and names one comparison axis."},{"id":"overlap","stores":"One evidenced capability both systems have."},{"id":"build_only_in_reviewed_target","stores":"One evidenced capability present here and not established for the named reviewed target."},{"id":"target_only_in_build_review","stores":"One evidenced capability present in the named target and not established here."},{"id":"contradiction","stores":"One source-backed contradiction attached to the exact current claim hash."},{"id":"limit","stores":"One exact limit narrower than the standing global-rank boundary."},{"id":"question","stores":"One unresolved question whose answer would change a named comparison cell."},{"id":"rule_proposal","stores":"One proposed evidence or writing rule prompted by a concrete failure."},{"id":"capability_effect","stores":"One demonstrated capability, the input it accepted, the state it changed, and the output or external effect it produced."},{"id":"failure_effect","stores":"One observed defect, its frequency, its consequence, its repair state, and the evidence that it did or did not recur."},{"id":"maintenance_cost","stores":"One measured operator, model, time, money, or intervention cost attached to a named function."},{"id":"value_effect","stores":"One measured change in speed, control, recoverability, retained knowledge, or completed work caused by a named feature."}],"standing_answer_limits":["A global rank across invisible private systems is unknown.","Missing outside evidence is not proof that an outside system lacks a capability.","A successful receipt proves one run, not general reliability.","Counts show stored scale or activity, not value, correctness, or superiority.","Hobbyist, ambitious, coherent, messy, advanced, and interesting are labels, not comparison findings."],"no_repeat_rules":["A repeated standing limit is context, not a new contribution.","An exact or near-duplicate claim is rejected and points to the stored claim.","A duplicate source does not complete an assignment.","A response completes only after at least one new graph object lands.","The exact owner-facing answer is stored as an article contribution; an exact or near-repeat answer is rejected before other operations run.","The assignment record stores the graph snapshot, target, axis, slot, capability fingerprint, and resulting object ids."],"assignment":"GET /api/normandy?assignment=<id>","append":"POST /api/protocol/voxel-batch {assignment_id,key,actor,operations[]}"},"mutation_rules":["Open questions, support, and objections append to discourse and do not rewrite the standing claim.","Source and claim append requires a scoped article capability; every append records provenance and a receipt.","Existing text edits use the current voxel hash. A stale hash writes nothing.","Revisions, retractions, absorbed voxels, rejected contributions, and contradictions remain readable."],"ontology_rules":["Peptide articles (bpc-157, tb-500) are tree roots.","Condition articles (bpc-157-glp1-gut-damage) branch from peptides.","Stack articles (wolverine-stack-glp1) compose peptides — never duplicate peptide mechanism prose.","If an article has no parent embeds and is not a root peptide → sprawl candidate.","Misstep = duplicate scope with another slug; merge or reparent via embeds."],"post_protocol":{"claim":"POST /api/protocol/claim","source":"POST /api/protocol/sources","ingest":"POST /api/protocol/ingest","webhook":"POST /api/articles/<slug>/webhook {kind:claim|source}","imessage_claim":"claim {slug}|{tier}|your assertion — who claims it, source?","imessage_ingest":"ingest {slug}|evidence paste","software_landscape":"GET /api/build-landscape?next=1&lane=field|build|opposition|synthesis","queue_population":"POST /api/build-landscape {action:queue_targets, cohort, query, sort, captured_at, source_url, targets[]}"}},"this_article":{"slug":"tb-500-ibd","url":"https://miscsubjects.com/a/tb-500-ibd","bundle_url":"https://miscsubjects.com/api/articles/tb-500-ibd/bundle?format=markdown"},"voxel_procedure":{"what":"Every article has a human side (/a/tb-500-ibd) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"tb-500-ibd\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"tb-500-ibd\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"tb-500-ibd\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"tb-500-ibd\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"tb-500-ibd\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"tb-500-ibd\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/tb-500-ibd/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/tb-500-ibd/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/tb-500-ibd#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."}},"api_urls":{"bundle":"https://miscsubjects.com/api/articles/tb-500-ibd/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/tb-500-ibd/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/tb-500-ibd/topology","voxels":"https://miscsubjects.com/api/articles/tb-500-ibd/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","question_graph":"https://miscsubjects.com/api/articles/tb-500-ibd/question-graph","ask":"https://miscsubjects.com/api/protocol/ask","ingest":"https://miscsubjects.com/api/protocol/ingest","claim":"https://miscsubjects.com/api/protocol/claim","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown"}}