{"slug":"tb-500-cognition","verification":{"valid":true,"entries":6,"head":"89c32a028a01ae75c4e87fb582077df664a41ce16802b86b72f65d9cc3c34500"},"count":6,"sources":[{"id":"s0","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/22324420/","title":"Neuroprotective and neurorestorative effects of thymosin β4 treatment initiated 6 hours after traumatic brain injury in rats","quote":"Tβ4 treatment initiated 6 hours postinjury significantly improved sensorimotor functional recovery and spatial learning, reduced cortical lesion volume and hippocampal cell loss, and enhanced cell proliferation and neurogenesis","summary":"2012 rat TBI study with behavioral and histological outcomes.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:39:58.331Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"de2651784db84ed2ba0b6e231d84d7e9d4962dcac872d9f6d2e6d762d2e29102"},{"id":"s3","type":"review","url":"https://www.innerbody.com/thymosin-beta-4-and-tb-500","title":"TB4 and TB-500 Peptide Therapy | What to Know in 2026","quote":"more clinical research is needed before these potential benefits can be considered applicable to humans","summary":"2026 review noting limited human trials and absence of cognitive data.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:39:58.331Z","link_status":"ok","quote_status":"verified","prev":"de2651784db84ed2ba0b6e231d84d7e9d4962dcac872d9f6d2e6d762d2e29102","hash":"8a322628fc3a0593a93eaf3f2294e34d86a52ba1b3cb2de7c2e37a7dd64dd495"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41443105/","title":"Thymosin β4-derived peptides alleviate neuroinflammation and cognitive deficits in 5×FAD mice","quote":"TB500 and Ac-SDKP ameliorated cognitive impairments, as evidenced by improved performance in the Morris water maze and novel object recognition tests","summary":"2026 Alzheimer’s mouse model study with cognitive testing.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:39:58.331Z","link_status":"ok","quote_status":"verified","prev":"8a322628fc3a0593a93eaf3f2294e34d86a52ba1b3cb2de7c2e37a7dd64dd495","hash":"9e748e79b4c9da0477bc764e5502f6ae8cf636a475ee76450e7e98c00e1bf6e7"},{"id":"s9","type":"reddit","url":"https://www.reddit.com/r/BodyOptimization/comments/1tbgluq/tb500_improved_memory_in_alzheimers_mice_without/","title":"TB-500 Improved Memory in Alzheimer's Mice Without...","quote":"A new study just published in International Immunopharmacology tested it in an Alzheimer’s model","summary":"Reddit discussion of the 2026 mouse cognition study.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:39:58.331Z","link_status":"ok","quote_status":"unverified","prev":"9e748e79b4c9da0477bc764e5502f6ae8cf636a475ee76450e7e98c00e1bf6e7","hash":"5d9556981fee9e7f2828c6f702f7ee7ea6ccc6ce783c7c765e7bf93b29b0b6c7"},{"id":"s21","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/22324420/","title":"Neuroprotective and neurorestorative effects of thymosin β4 treatment initiated 6 hours after traumatic brain injury in rats","quote":"Compared with saline administration, Tβ4 treatment initiated 6 hours postinjury significantly improved sensorimotor functional recovery and spatial learning","summary":"Confirms behavioral recovery metrics.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:39:58.331Z","link_status":"ok","quote_status":"verified","prev":"5d9556981fee9e7f2828c6f702f7ee7ea6ccc6ce783c7c765e7bf93b29b0b6c7","hash":"58aa9e40ef2fb0af172ce61645282e966972402cce86b685d50a82fec7c0ecbf"},{"id":"s22","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41443105/","title":"Thymosin β4-derived peptides alleviate neuroinflammation and cognitive deficits in 5×FAD mice","quote":"TB500 and SDKP inhibited microglial M1 polarization and neuroinflammation... alleviated cognitive deficits","summary":"Details anti-inflammatory and memory outcomes.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:39:58.331Z","link_status":"ok","quote_status":"unverified","prev":"58aa9e40ef2fb0af172ce61645282e966972402cce86b685d50a82fec7c0ecbf","hash":"89c32a028a01ae75c4e87fb582077df664a41ce16802b86b72f65d9cc3c34500"}]}