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Per-claim provenance."}],"not_medical_advice":true},"slug":"ss-31","title":"ss 31","register":"standard","tags":[],"updated_at":"2026-07-17T02:42:00.791Z","body_excerpt":"## Overview\nEvidence is being populated by Grok web search.","ranking":"safety-first (interaction_risk/limitations), then quote-gated effective_weight","claims":[],"sources":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/39940712/","title":"Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential","quote":"Elamipretide (SS-31, MTP-131, Bendavia) is a mitochondria-targeting tetrapeptide designed to treat mitochondrial dysfunction via binding to cardiolipin.","summary":"2025 review on structure, mechanism, and therapeutic potential of elamipretide/SS-31.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"bb94fd22df1e1d6b4b61f8bdae72311180a2a8894b864d74ca3b42df1fd7d753"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40299935/","title":"SS-31: A promising therapeutic agent against bleomycin-induced pulmonary fibrosis","quote":"The mitochondria-targeting drug SS-31 exhibited potential in mitigating bleomycin-induced pulmonary fibrosis, improving mitochondrial function.","summary":"2025 study on SS-31 for pulmonary fibrosis.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"160bd24b353243e98c218a5626549246bb6b28e93d33db944b57ecb42ad221d6"},{"id":"s3","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/41260682/","title":"Elamipretide: The first cardiolipin-directed mitochondrial therapeutic for Barth syndrome approved under accelerated approval","quote":"On September 19, 2025, the U.S. Food and Drug Administration (FDA) granted accelerated approval to elamipretide, the first therapy directly targeting the mitochondrial etiology of BTHS.","summary":"2026 review on FDA approval of elamipretide for Barth syndrome.","claim_ids":[],"link_status":"ok","quote_status":"verified","hash":"13d748e783bbfac19e12e856aa1b599a0e74bf1161f8d7064f0dd39822d4fe17"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42082001/","title":"Elamipretide (SS-31) Promotes Recovery by Preserving Mitochondrial Bioenergetics and Neural Remodeling after Spinal Cord Injury","quote":"Elamipretide (SS-31) is a mitochondria-targeting peptide with potential neuroprotective effects. Here, we investigated whether SS-31 improves functional outcomes after contusive SCI.","summary":"2026 study on SS-31 for spinal cord injury recovery.","claim_ids":[],"link_status":"ok","quote_status":"verified","hash":"2019b0e2b346fa9e95fe89ef7d5e4c5348b850e681756a421aeed1c4e414b1d8"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40169521/","title":"Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high ...","quote":"Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 ( elamipretide ) and development of a high ...","summary":"2025 preclinical evaluation of SS-31/elamipretide for aging-related cerebral issues.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"318bd948430332571b54b6a8c36754e5c02bc68e83bf269ae94e59b09107354f"},{"id":"s6","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/38237649/","title":"Application research of novel peptide mitochondrial-targeted antioxidant SS-31 in mitigating mitochondrial dysfunction","quote":"Elamipretide ( SS-31 ), a novel synthetic mitochondrial-targeted antioxidant, has emerged as a promising candidate with extensive therapeutic potential.","summary":"2024 review on SS-31 applications for mitochondrial dysfunction, including clinical trials overview.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"4e483a2b6c530606a9d5097a0e2f60d92a9e57627eb095e8744bbaa8c009b647"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38648553/","title":"Effect of Elamipretide on the Vitrification of Mouse Ovarian ...","quote":"SS-31 improved the cryopreservation of ovarian tissues, and 100 μmol/L SS-31 was found to be the most effective.","summary":"2024 study showing SS-31 protects ovarian tissue during cryopreservation via mitochondrial and antioxidant effects.","claim_ids":[],"link_status":"ok","quote_status":"verified","hash":"7b44e211a037ef95b80b00743c65a634121f1c72065a90b93d73d16389395d40"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38688894/","title":"Mitochondrial antioxidant elamipretide improves learning ...","quote":"Elamipretide ( SS-31 ), a novel mitochondrion-targeted antioxidant, was proven to improve mitochondrial dysfunction, the inflammatory response, synaptic ...","summary":"2024 study on elamipretide improving learning and memory.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"b3df080ff836610ed7a06fea08a80b375bb26c1fce189cfd1ae652873ebb04e9"}],"anecdotal_sources":[],"scientific_sources":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/39940712/","title":"Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential","quote":"Elamipretide (SS-31, MTP-131, Bendavia) is a mitochondria-targeting tetrapeptide designed to treat mitochondrial dysfunction via binding to cardiolipin.","summary":"2025 review on structure, mechanism, and therapeutic potential of elamipretide/SS-31.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"bb94fd22df1e1d6b4b61f8bdae72311180a2a8894b864d74ca3b42df1fd7d753"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40299935/","title":"SS-31: A promising therapeutic agent against bleomycin-induced pulmonary fibrosis","quote":"The mitochondria-targeting drug SS-31 exhibited potential in mitigating bleomycin-induced pulmonary fibrosis, improving mitochondrial function.","summary":"2025 study on SS-31 for pulmonary fibrosis.","claim_ids":[],"link_status":"ok","quote_status":"unverified","hash":"160bd24b353243e98c218a5626549246bb6b28e93d33db944b57ecb42ad221d6"},{"id":"s3","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/41260682/","title":"Elamipretide: The first cardiolipin-directed mitochondrial therapeutic for Barth syndrome approved under accelerated approval","quote":"On September 19, 2025, the U.S. Food and Drug Administration (FDA) granted accelerated approval to elamipretide, the first therapy directly targeting the mitochondrial etiology of BTHS.","summary":"2026 review on FDA approval of elamipretide for Barth syndrome.","claim_ids":[],"link_status":"ok","quote_status":"verified","hash":"13d748e783bbfac19e12e856aa1b599a0e74bf1161f8d7064f0dd39822d4fe17"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42082001/","title":"Elamipretide (SS-31) Promotes Recovery by Preserving Mitochondrial Bioenergetics and Neural Remodeling after Spinal Cord Injury","quote":"Elamipretide (SS-31) is a mitochondria-targeting peptide with potential neuroprotective effects. 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