{"slug":"ss-31","verification":{"valid":true,"entries":3,"head":"fdc9b92588c0add7f7e10e470d9c454aee8e266c52b5aec38f887d8bb672499e"},"count":3,"models":["grok-4.3"],"yield":{"passes":3,"energy_spent_rows":0,"total_cost_usd":0,"waste_cost_usd":0,"total_tokens":0,"material_outputs":0,"usd_per_output":null,"models":[{"model":"grok-4.3","passes":3,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T16:49:54.424Z","model":"grok-4.3","role":"writer","action":"draft","payload":{"title":"ss 31","register":"standard","body":"## Overview\nEvidence is being populated by Grok web search.","claims":[],"sources":[]},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"genesis","hash":"c0d0dabc3c0ebe6034b698e89122a2701a3819f8d143bfc64b2b711ea52f7b24"},{"seq":1,"id":"k2","ts":"2026-06-29T16:50:18.283Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/39940712/","title":"Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential","quote":"Elamipretide (SS-31, MTP-131, Bendavia) is a mitochondria-targeting tetrapeptide designed to treat mitochondrial dysfunction via binding to cardiolipin.","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40299935/","title":"SS-31: A promising therapeutic agent against bleomycin-induced pulmonary fibrosis","quote":"The mitochondria-targeting drug SS-31 exhibited potential in mitigating bleomycin-induced pulmonary fibrosis, improving mitochondrial function.","link_status":"ok","quote_status":"unverified"},{"id":"s3","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/41260682/","title":"Elamipretide: The first cardiolipin-directed mitochondrial therapeutic for Barth syndrome approved under accelerated approval","quote":"On September 19, 2025, the U.S. Food and Drug Administration (FDA) granted accelerated approval to elamipretide, the first therapy directly targeting the mitochondrial etiology of BTHS.","link_status":"ok","quote_status":"verified"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42082001/","title":"Elamipretide (SS-31) Promotes Recovery by Preserving Mitochondrial Bioenergetics and Neural Remodeling after Spinal Cord Injury","quote":"Elamipretide (SS-31) is a mitochondria-targeting peptide with potential neuroprotective effects. Here, we investigated whether SS-31 improves functional outcomes after contusive SCI.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"c0d0dabc3c0ebe6034b698e89122a2701a3819f8d143bfc64b2b711ea52f7b24","hash":"f91bd1b1284928b21d5aa3bfb9ad54b31b4f3dc1a4dcb31fa2b35dc47ab267b8"},{"seq":2,"id":"k3","ts":"2026-06-29T16:50:43.739Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40169521/","title":"Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high ...","quote":"Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 ( elamipretide ) and development of a high ...","link_status":"ok","quote_status":"unverified"},{"id":"s6","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/38237649/","title":"Application research of novel peptide mitochondrial-targeted antioxidant SS-31 in mitigating mitochondrial dysfunction","quote":"Elamipretide ( SS-31 ), a novel synthetic mitochondrial-targeted antioxidant, has emerged as a promising candidate with extensive therapeutic potential.","link_status":"ok","quote_status":"unverified"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38648553/","title":"Effect of Elamipretide on the Vitrification of Mouse Ovarian ...","quote":"SS-31 improved the cryopreservation of ovarian tissues, and 100 μmol/L SS-31 was found to be the most effective.","link_status":"ok","quote_status":"verified"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38688894/","title":"Mitochondrial antioxidant elamipretide improves learning ...","quote":"Elamipretide ( SS-31 ), a novel mitochondrion-targeted antioxidant, was proven to improve mitochondrial dysfunction, the inflammatory response, synaptic ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"f91bd1b1284928b21d5aa3bfb9ad54b31b4f3dc1a4dcb31fa2b35dc47ab267b8","hash":"fdc9b92588c0add7f7e10e470d9c454aee8e266c52b5aec38f887d8bb672499e"}]}