{"slug":"ss-31-trigeminal","verification":{"valid":true,"entries":3,"head":"15a6a775208231790bc3a3f2d671d3702b3cfc31561d7a775da64a3cb5ff15b9"},"count":3,"sources":[{"id":"s1","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10240765/","title":"SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/PGC-1α positive feedback loop","quote":"Our results showed that repeated IS infusion impaired mitochondrial function, mitochondrial ultrastructure and mitochondrial homeostasis in the trigeminal nucleus caudalis (TNC). These IS-induced damages in TNC were reversed by SS-31. In addition, IS-induced nociceptive responses were simultaneously alleviated.","summary":"Mouse study linking SS-31 to TNC mitochondrial repair and reduced pain behaviors.","claim_ids":["c1","c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:45:01.099Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"7f888b58592f2ef655df86edf4614728e718f7db38894a9e4c88ed6720397a27"},{"id":"s2","type":"review","url":"https://www.alzdiscovery.org/uploads/cognitive_vitality_media/SS-31-Cognitive-Vitality-For-Researchers.pdf","title":"SS-31 (also known as Elamipretide®, Bendavia®, and MTP-131) Cognitive Vitality For Researchers","quote":"SS-31 binds to cardiolipin, a lipid exclusively expressed on the inner mitochondrial membrane... modulates the hydrophobic interaction between cytochrome c and cardiolipin and function of cytochrome c.","summary":"Mechanism review of cardiolipin binding and mitochondrial effects.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:45:01.099Z","link_status":"ok","quote_status":"unverified","prev":"7f888b58592f2ef655df86edf4614728e718f7db38894a9e4c88ed6720397a27","hash":"c281d912f12facb06e4dc6452a9753134cfb1363b12d6b0f2bb96a07b83280be"},{"id":"s3","type":"reddit","url":"https://www.reddit.com/r/cfs/comments/1j2upcm/my_experience_treating_my_mecfs_with/","title":"My Experience Treating my ME/CFS with mitochondrial peptides","quote":"My second dosage given my shortness of breathe and an awful migraine.","summary":"User report of migraine-like side effect with SS-31.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:45:01.099Z","link_status":"ok","quote_status":"unverified","prev":"c281d912f12facb06e4dc6452a9753134cfb1363b12d6b0f2bb96a07b83280be","hash":"15a6a775208231790bc3a3f2d671d3702b3cfc31561d7a775da64a3cb5ff15b9"}]}