{"slug":"ss-31-tirzepatide","verification":{"valid":true,"entries":7,"head":"c663e2a6be6709fa403fa4fb896b4bb1d4fcfddcd6b79c0f8865d97466c32779"},"count":7,"sources":[{"id":"s1","type":"review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/","title":"Elamipretide: A Review of Its Structure, Mechanism of Action ...","quote":"Preclinical studies have shown that Elamipretide reduces fibrosis in heart tissue by mitigating mitochondrial dysfunction and oxidative stress.","summary":"Comprehensive review of SS-31 mechanism and trial results.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:43:59.569Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"f91d34ed38851e0c3bab2856dfe332765bf2228f559726fee1da7e2b58338393"},{"id":"s7","type":"news","url":"https://www.fightaging.org/archives/2025/10/fda-approval-for-mitochondrial-therapeutic-elamipretide-formerly-ss-31/","title":"FDA Approval for Mitochondrial Therapeutic Elamipretide...","quote":"The approval of FORZINITY is supported by the efficacy and safety data from the TAZPOWER clinical trial.","summary":"Reports 2025 FDA approval details.","claim_ids":["c2","c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:43:59.569Z","link_status":"ok","quote_status":"unverified","prev":"f91d34ed38851e0c3bab2856dfe332765bf2228f559726fee1da7e2b58338393","hash":"cf006b8c95b8cb8bfcd9526982fcf30822d00dfedbecf2fd2305326c02f3b420"},{"id":"s9","type":"news","url":"https://hub.jhu.edu/2025/09/25/fda-approves-barth-syndrome-treatment/","title":"FDA approves drug for treatment of rare mitochondrial disorder","quote":"In the extension of the trial, eight patients improved their ability to walk in six-minute increments, with an average improvement of 96.1 meters per person over their baseline.","summary":"Details TAZPOWER extension outcomes and approval.","claim_ids":["c2","c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:43:59.569Z","link_status":"ok","quote_status":"verified","prev":"cf006b8c95b8cb8bfcd9526982fcf30822d00dfedbecf2fd2305326c02f3b420","hash":"1bce06fabeaddd12879235149ab6b69615afbfd1cf24d01090737ef3616dd4c1"},{"id":"s16","type":"medical","url":"https://coremedicalwellness.com/glp-1-medications-for-weight-loss-back-pain-and-knee-pain-relief/","title":"GLP-1 Medications for Weight Loss and Pain Relief","quote":"Every extra pound of body weight places several additional pounds of force on your knees and lower back with every step you take.","summary":"Explains mechanical load reduction from weight loss.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:43:59.569Z","link_status":"ok","quote_status":"verified","prev":"1bce06fabeaddd12879235149ab6b69615afbfd1cf24d01090737ef3616dd4c1","hash":"2b0dd5d56ef58e63aa065755f91eaa99ce51ab683d454507aba6d8b6b25d850b"},{"id":"s17","type":"review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10861994/","title":"The Body weight Reducing Effects of Tirzepatide...","quote":"Tirzepatide elicited substantial weight reduction in individuals both with and without T2D...","summary":"Summarizes weight-loss efficacy data.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:43:59.569Z","link_status":"ok","quote_status":"unverified","prev":"2b0dd5d56ef58e63aa065755f91eaa99ce51ab683d454507aba6d8b6b25d850b","hash":"97b7ec5d5342ddb9d7d123e7aabd3700bf2144bc051ae5375b64054c177afe09"},{"id":"s18","type":"medical","url":"https://nwregen.com/articles/beyond-the-scale-the-surprising-benefits-of-tirzepatide-for-joint-and-metabolic-health/","title":"The Benefits of Tirzepatide for Joint and Metabolic Health","quote":"For every pound of excess weight, the joints can experience up to four additional pounds of pressure with each step.","summary":"Reiterates the 4:1 load ratio in joint context.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:43:59.569Z","link_status":"ok","quote_status":"verified","prev":"97b7ec5d5342ddb9d7d123e7aabd3700bf2144bc051ae5375b64054c177afe09","hash":"52b194c7c77ce6a693ec4547dcadab93b7e3d8b7cebe814a03b8dbd83a9cb7b3"},{"id":"s12","type":"news","url":"https://www.ircm.qc.ca/en/news-detail/an-exceptional-event-treatment-for-a-rare-genetic-disorder-co-discovered-at-the-ircm-approved-by-the-fda","title":"An Exceptional Event: Treatment for a Rare Genetic ...","quote":"the Food and Drug Administration (FDA) of the USA granted approval of elamipretide (SS-31), also known as Forzinity, as the first treatment option for the mitochondrial disease Barth Syndrome","summary":"Confirms 2025 FDA approval.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:43:59.569Z","link_status":"ok","quote_status":"unverified","prev":"52b194c7c77ce6a693ec4547dcadab93b7e3d8b7cebe814a03b8dbd83a9cb7b3","hash":"c663e2a6be6709fa403fa4fb896b4bb1d4fcfddcd6b79c0f8865d97466c32779"}]}