{"slug":"ss-31-semaglutide","verification":{"valid":true,"entries":5,"head":"c19d59625d92df22baca2956aa3311341e001efdc296f4fd460901b6dfa6fa77"},"count":5,"sources":[{"id":"s1","type":"pubmed","url":"https://www.pnas.org/doi/10.1073/pnas.2002250117","title":"Mitochondrial protein interaction landscape of SS-31","quote":"SS-31 is a synthetic peptide that improves mitochondrial function... The synthetic tetrapeptide, elamipretide (SS-31), improves mitochondrial function...","summary":"Details SS-31 cardiolipin binding and effects on mitochondrial complexes.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:47:00.007Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"f8ecf37e7a7e67148bb421dfa6b39b44c0c8dc6a8616393d0b47cdaad2028f4d"},{"id":"s2","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT03323749","title":"A Trial to Evaluate Safety and Efficacy of Elamipretide in Primary Mitochondrial Myopathy","quote":"This is a multicenter phase 3 randomized, double-blind, parallel-group, placebo-controlled trial...","summary":"Phase 3 protocol and design confirming primary endpoint assessment.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:47:00.007Z","link_status":"ok","quote_status":"unverified","prev":"f8ecf37e7a7e67148bb421dfa6b39b44c0c8dc6a8616393d0b47cdaad2028f4d","hash":"67fb06a6761c24c0b4028c36553024981d77340a5c58747a6de7674ef1fc5b58"},{"id":"s3","type":"pubmed","url":"https://www.nature.com/articles/s41598-024-64368-y","title":"SS-31 treatment ameliorates cardiac mitochondrial dysfunction in a mouse model of Barth syndrome","quote":"The collected data showed that a long exposure to the peptide (48 weeks) resulted in a significant improvement in performance on the 6-Minute Walk Test...","summary":"Reports open-label functional improvements from TAZPOWER extension.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:47:00.007Z","link_status":"ok","quote_status":"unverified","prev":"67fb06a6761c24c0b4028c36553024981d77340a5c58747a6de7674ef1fc5b58","hash":"0a19d6113cec213f507ccb9fb32828aa9542695f8e661910ce4f6665f46b6618"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39366019/","title":"Semaglutide exposure and its association with adverse lumbar fusion outcomes","quote":"Semaglutide exposure appears to be associated with a higher likelihood of additional lumbar fusion surgeries within 1 year post-TLIF.","summary":"Observational human data on post-surgical outcomes with semaglutide.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:47:00.007Z","link_status":"ok","quote_status":"unverified","prev":"0a19d6113cec213f507ccb9fb32828aa9542695f8e661910ce4f6665f46b6618","hash":"be079c797973a2609f41d977f1b0de92dbe610dea408b68df5d65ab9e4dd82bd"},{"id":"s5","type":"other","url":"https://spineteamtexas.com/resources/blog/back-pain-and-glp-1-assisted-weight-loss-a-new-path-to-relief/","title":"Back Pain and GLP-1 Assisted Weight Loss","quote":"For someone who loses 30 pounds, this could mean up to 120 pounds less pressure on the spine during movement.","summary":"Clinical blog explaining mechanical load reduction with weight loss.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:47:00.007Z","link_status":"ok","quote_status":"verified","prev":"be079c797973a2609f41d977f1b0de92dbe610dea408b68df5d65ab9e4dd82bd","hash":"c19d59625d92df22baca2956aa3311341e001efdc296f4fd460901b6dfa6fa77"}]}