{"slug":"ss-31-nsaids","verification":{"valid":true,"entries":5,"head":"a345289337289816b68e175c879e32c4a8e79fc4ce294cf8652ce8109491dd9d"},"count":5,"sources":[{"id":"s0","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31747905/","title":"Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice","quote":"These findings indicate that LPS-induced memory impairment can be attenuated by the mitochondrion-targeted antioxidant elamipretide.","summary":"Rodent study showing SS-31 protection in LPS inflammation model.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:50:59.741Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"915af4ed997197769acf098b0b09ca70dfdea7e4f30c657437fd453bc0b912df"},{"id":"s2","type":"news","url":"https://www.fightaging.org/archives/2025/10/fda-approval-for-mitochondrial-therapeutic-elamipretide-formerly-ss-31/","title":"FDA Approval for Mitochondrial Therapeutic Elamipretide, Formerly SS-31","quote":"The approval of FORZINITY is supported by the efficacy and safety data from the TAZPOWER clinical trial.","summary":"Reports 2025 FDA approval for Barth syndrome.","claim_ids":["c5"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:50:59.741Z","link_status":"ok","quote_status":"unverified","prev":"915af4ed997197769acf098b0b09ca70dfdea7e4f30c657437fd453bc0b912df","hash":"0e1c908ddcd1cdf454bf1ae940632427aa59e396f7723d829b16ef270bcb6f35"},{"id":"s5","type":"other","url":"https://biomeme.com/applications/wellness/peptide-evidence/ss-31/","title":"SS-31 (Elamipretide) — Peptide Evidence Score","quote":"By stabilizing cardiolipin, SS-31 improves mitochondrial bioenergetics, reduces electron leak and ROS production.","summary":"Mechanism summary.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:50:59.741Z","link_status":"ok","quote_status":"unverified","prev":"0e1c908ddcd1cdf454bf1ae940632427aa59e396f7723d829b16ef270bcb6f35","hash":"e6ab73679e02ddcaf58de06ab66c48ff4e0277c5a153fd0d0f2a5c1af88cc0cf"},{"id":"s10","type":"other","url":"https://www.bettermedspa.com/treatments/core-spark-ss-31-elamipretide","title":"Core Spark (SS-31 Elamipretide) Lincoln Park, Chicago","quote":"patients taking nephrotoxic medications (certain antibiotics, chronic NSAID use) should discuss this with their provider before starting.","summary":"Clinical caution note on NSAIDs.","claim_ids":["c7"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:50:59.741Z","link_status":"ok","quote_status":"verified","prev":"e6ab73679e02ddcaf58de06ab66c48ff4e0277c5a153fd0d0f2a5c1af88cc0cf","hash":"6e706ca2ca670dc5937d2f24df3885e4ccbd1307d6449147506415692a95af9b"},{"id":"s11","type":"pubmed","url":"https://www.mdpi.com/1422-0067/26/3/944","title":"Elamipretide: A Review of Its Structure, Mechanism of Action...","quote":"Consequently, the interaction of Elamipretide with cardiolipin allows for the stabilization of mitochondrial cristae, a reduction in oxidative stress, and the enhancement of ATP production.","summary":"Detailed mechanism review.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:50:59.741Z","link_status":"http_403","quote_status":"unverified","prev":"6e706ca2ca670dc5937d2f24df3885e4ccbd1307d6449147506415692a95af9b","hash":"a345289337289816b68e175c879e32c4a8e79fc4ce294cf8652ce8109491dd9d"}]}