{"slug":"ss-31-neuropathy","verification":{"valid":true,"entries":4,"head":"2cd73f80fe459e362738ca06485252ae3525a1ba91fccf9f10f21c73b83d0f98"},"count":4,"sources":[{"id":"s1","type":"review","url":"https://biomeme.com/applications/wellness/peptide-evidence/ss-31/","title":"SS-31 (Elamipretide) — Peptide Evidence Score","quote":"SS-31 selectively targets and stabilizes cardiolipin in the inner mitochondrial membrane... improves mitochondrial bioenergetics, reduces electron leak and ROS production","summary":"Mechanism summary from evidence framework page.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:50:59.740Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"d42598e176ddffe3107cfe5e6310367c3bd52079c308159cd483cabb6ad186b6"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/37923251/","title":"Elamipretide Topical Ophthalmic Solution for the Treatment of Subjects with Leber Hereditary Optic Neuropathy: A Randomized Trial","quote":"This study aimed to assess the safety, tolerability, and potential efficacy of topical elamipretide in patients affected with Leber hereditary optic neuropathy (LHON).","summary":"Phase II human trial details for LHON.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:50:59.740Z","link_status":"ok","quote_status":"verified","prev":"d42598e176ddffe3107cfe5e6310367c3bd52079c308159cd483cabb6ad186b6","hash":"b689dbe517c13c8e8d6d21707464468403094da716b7756a3a2490e03bf8ad4d"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/31747905/","title":"Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice","quote":"These findings indicate that LPS-induced memory impairment can be attenuated by the mitochondrion-targeted antioxidant elamipretide.","summary":"Mouse study abstract detailing mitochondrial and behavioral outcomes.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:50:59.740Z","link_status":"ok","quote_status":"verified","prev":"b689dbe517c13c8e8d6d21707464468403094da716b7756a3a2490e03bf8ad4d","hash":"61137f50721f64d0efe385b9771ce7aae9bbd4a2b3434a872c66e3fb4ef58c5b"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/cfs/comments/1j2upcm/my_experience_treating_my_mecfs_with/","title":"My Experience Treating my ME/CFS with mitochondrial peptide SS-31","quote":"I can wiggle my toes in bed and feel them now. Ten years later! I 100% believe this is from the SS-31.","summary":"User anecdote on sensory recovery.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T23:50:59.740Z","link_status":"ok","quote_status":"unverified","prev":"61137f50721f64d0efe385b9771ce7aae9bbd4a2b3434a872c66e3fb4ef58c5b","hash":"2cd73f80fe459e362738ca06485252ae3525a1ba91fccf9f10f21c73b83d0f98"}]}